scholarly journals Effects of a Single Dose of BURN-XT™ on Resting Metabolic Rate, Substrate Oxidation, and Various Indices of Affect

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Michael La Monica ◽  
Tim Ziegenfuss ◽  
Hector Lopez
Keyword(s):  
Blood Pressure ◽  
Single Dose ◽  
Metabolic Rate ◽  
Weight Management ◽  
Resting Metabolic Rate ◽  
Vital Signs ◽  
Resting Energy Expenditure ◽  
Substrate Oxidation ◽  
Double Blind ◽  
Over The Counter

Introduction: Many consumers use dietary supplements in the hopes of increasing energy and burning more calories, which if sustained over time may help accelerate weight loss. The purpose of this clinical trial was to investigate the effects of an over-the-counter thermogenic supplement called Burn-XT™ (BXT) on metabolic rate, substrate oxidation, and various psychometric indices of affect that impact weight management.  Methods: Using a double-blind, placebo-controlled, cross-over design, 16 women and 10 men (29.3 ± 7.3 yr, 169.4 ± 8.6 cm, 75.5 ± 14.3 kg) underwent two testing sessions: placebo (PL) and BXT.  Seated metabolic rate and substrate oxidation, vital signs, and anchored visual analogue scale (VAS) assessments of energy, mood, motivation, focus, fatigue, concentration, and appetite were made before supplementation and hourly for three hours post-ingestion. Two-factor (2x4) factorial ANOVAs and paired sample t-tests (corrected for multiple comparisons) were used for analyses. Results: Significant increases in metabolic rate (oxygen consumption) were noted at 60 minutes in BXT (+11.9 mL O2/min) vs. PL (-2.5 mL O2/min), p = 0.004, d = -0.74.  Only BXT increased metabolic rate compared to baseline at 60 minutes (+11.9 mL O2/min, p = 0.021, d = -0.53) and 120 minutes (+12.1 mL O2/min, p = 0.019, d = -0.54).  The AUC for resting energy expenditure increased more in BXT vs. PL (p = 0.007, d = -0.57).  VAS detected significant improvements in energy, mood, focus, and concentration for BXT vs. PL at 120 and 180 minutes (all p < 0.05, d = -0.58 to -0.68).  In all cases, within-group changes from baseline for these VAS parameters were significant (all p < 0.05, d = -0.76 to -1.38) in BXT but not in PL.  No within or between group differences in appetite, substrate oxidation, or heart rate were noted.  Small (~3-4 mm Hg), but statistically significant (p < 0.05, d = -0.51 to -0.69) increases in diastolic blood pressure were noted in BXT at 60, 120, and 180 min vs. PL; and in systolic blood pressure at 60 min vs. PL. In all cases, values remained within normal clinical hemodynamic ranges. Conclusions: A single dose of BXT safely increased metabolic rate, energy, mood, focus, and concentration. Given that these factors are known to favorably impact weight management, future studies should determine whether daily supplementation with BXT reduces body weight and improves body composition.

DHA supplementation decreases resting metabolic rate in healthy young females

2020 ◽  
Vol 45 (2) ◽  
pp. 221-225
Author(s):  
Sebastian Jannas-Vela ◽  
Shannon L. Klingel ◽  
David M. Mutch ◽  
Lawrence L. Spriet
Keyword(s):  
Sex Differences ◽  
Energy Expenditure ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Resting Energy Expenditure ◽  
Substrate Oxidation ◽  
Acid Supplementation ◽  
Young Females ◽  
Independent Effects ◽  
Healthy Females

This study examined the independent effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid supplementation on resting metabolic rate (RMR) and substrate oxidation in young healthy females and males. EPA or DHA supplementation had no effect on RMR and substrate oxidation in males, while DHA reduced RMR by ∼7% (p < 0.01) in females. In conclusion, these data establish potential sex differences on RMR in response to DHA supplements. Novelty Supplementing with DHA decreases resting energy expenditure in healthy young females but not males.

scholarly journals 9.14 Relation Between Resting Metabolic Rate and Blood Pressure in Overweight-Obese People: Effect of Gender

2008 ◽  
Vol 15 (3) ◽  
pp. 274-274
Author(s):  
G. Seghieri ◽  
F. Cipollini ◽  
E. Arcangeli ◽  
G. Fabbri ◽  
I. Chiti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Obese People

scholarly journals Effect of capsinoids on energy metabolism in human subjects

2009 ◽  
Vol 103 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Jose E. Galgani ◽  
Donna H. Ryan ◽  
Eric Ravussin
Keyword(s):  
Blood Pressure ◽  
Energy Metabolism ◽  
Metabolic Rate ◽  
Human Subjects ◽  
Acute Effect ◽  
Molecular Structures ◽  
Acute Effects ◽  
Axillary Temperature ◽  
Double Blind ◽  
Different Doses

Capsinoids are non-pungent compounds with molecular structures similar to capsaicin, which has accepted thermogenic properties. To assess the acute effect of a plant-derived preparation of capsinoids on energy metabolism, we determined RMR and non-protein respiratory quotient (NPRQ) after ingestion of different doses of the capsinoids. Thirteen healthy subjects received four doses of the capsinoids (1, 3, 6 and 12 mg) and placebo using a crossover, randomised, double-blind trial. After a 10 h overnight fast as inpatients, RMR was measured by indirect calorimetry for 45 min before and 120 min after ingesting capsinoids or placebo. Blood pressure and axillary temperature were measured before ( − 55 and − 5 min) and after (60 and 120 min) dosing. Before dosing, mean RMR was 6247 (se92) kJ/d and NPRQ was 0·86 (se0·01). At 120 min after dosing, metabolic rate and NPRQ remained similar across the four capsinoids and placebo doses. Capsinoids also had no influence on blood pressure or axillary temperature. Capsinoids provided in four doses did not affect metabolic rate and fuel partitioning in human subjects when measured 2 h after exposure. Longer exposure and higher capsinoids doses may be required to cause meaningful acute effects on energy metabolism.

scholarly journals Alcohol and its acute effects on resting metabolic rate and diet-induced thermogenesis

1990 ◽  
Vol 64 (2) ◽  
pp. 413-425 ◽  
Author(s):  
Jan A. Weststrate ◽  
Ingrid Wunnink ◽  
Paul Deurenberg ◽  
Joseph G. A. J. Hautvast
Keyword(s):  
Energy Expenditure ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Resting Energy Expenditure ◽  
Random Order ◽  
Systematic Difference ◽  
Control Treatment ◽  
Diet Induced Thermogenesis ◽  
The Impact ◽  
Thermic Effect

The impact of alcohol (ethanol) on resting energy expenditure of male non-obese volunteers was determined in two studies. In the first study the thermic effect of alcohol on resting metabolic rate (RMR) was assessed in ten male non-obese volunteers. In the second study the impact of alcohol on diet-induced thermogenesis (DIT) was determined in twelve male non-obese volunteers. Energy expenditure was measured with a ventilated-hood system. RMR was measured for 60 min with the subjects in a fasting state. In the first study subjects received in random order 20 g alcohol in concentrations of 75, 180 and 300 ml/I water respectively. After measurement of the RMR the thermic effect of alcohol was measured for 90 min. In the second study volunteers received in random order and in duplicate either a meal of food (2 MJ) plus an alcoholic aperitif (20 g alcohol in a 180 ml/1 solution) or an isoenergetic meal of food alone (2.55 MJ) plus a placebo aperitif containing no alcohol. DIT was measured for 240 min. Alcohol induced a significant thermic effect, which varied between 0.22 and 0.30 kJ/min. No systematic difference in DIT was observed among the different concentrations. DIT was not significantly affected by the ingestion of alcohol. Total DIT was 219 (SE 14) kJ for the alcohol treatment and 185 (SE 20) kJ for the control treatment. The results do not support the suggestion that alcohol is less efficiently used as an energy source in comparison with, for example, fats and carbohydrates.

scholarly journals 1099. Evaluation of the Safety and Pharmacokinetics (PK) following Administration of Single and Multiple Doses of Anti-Staphylococcal Lysin, LSVT-1701, in Healthy Adult Subjects

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S641-S641
Author(s):  
Mary Beth Wire ◽  
Soo youn Jun ◽  
In-Jin Jany ◽  
Jun Gi Hwang ◽  
David Huang
Keyword(s):  
Single Dose ◽  
Healthy Adult ◽  
Phase 1 ◽  
Vital Signs ◽  
Time Data ◽  
Serum Samples ◽  
Double Blind ◽  
Dose Study ◽  
Clinically Significant ◽  
New Treatments

Abstract Background LSVT-1701 is an anti-staphylococcal phage lysin being developed for treatment of MRSA infections in combination with SoC antibiotics. The safety and PK of single ascending doses of LSVT-1701 0.1 to 10 mg/kg in healthy adult volunteers were previously described (Jun, et.al, AAC 2017;61:e02629-16). We further evaluated the safety and PK of multiple ascending doses of LSVT-1701 in healthy adult subjects. Methods Study ITB-101-1b was a Phase 1, randomized, double-blind, placebo-controlled, multiple ascending dose study. 8 subjects were randomized 3:1 to active:placebo in each cohort. LSVT-1701 was administered as a 6 mg/kg single dose and twice daily (BID) doses of 1.5, 3.0, and 4.5 mg/kg for 4 days (24h between Doses 1-2, 12h between Doses 2-6). Study drugs were administered as a 1-hour IV infusion. Serial serum samples were collected over 24 hours following the first and last doses for measurement of LSVT-1701 concentrations by a validated ELISA method. PK analysis of LSVT-1701 concentration-time data was done using noncompartmental methods. Safety was assessed by AEs, clinical labs, vital signs, and ECG. Results 30/32 (94%) subjects completed the study. No subjects withdrew due to AEs, and there were no severe AEs, no serious AEs, and no deaths. AEs were of mild (97%) to moderate (3%) intensity and were reported by all subjects in the LSVT-1701 6 mg/kg single dose group and 1-3 (17-50%) of subjects receiving 1.5 to 4.5 mg/kg BID or placebo. The most common AEs of headache, chills, rigors, and fever generally lasted for ≤2 days with or without acetaminophen treatment, and no clinically significant changes in blood pressure, heart rate, ECG, or clinical labs (other than transient increases in CRP) were observed. Infusion site reactions (erythema, pain, induration, warmth) were observed with BID administration of LSVT-1701, but not with the single 6 mg/kg dose or placebo. LSVT-1701 exposure increased greater than in proportion to dose and t1/2 was concentration-dependent, increasing with higher doses. No accumulation in LSVT-1701 exposure was observed. Summary of LSVT-1701 PK Parameters Summary of LSVT-1701 PK Parameters Conclusion The safety and PK profile of LSVT-1701 is favorable for evaluation in patients with S. aureus infections, including bacteremia and infective endocarditis, for which new treatments are needed. Disclosures Mary Beth Wire, Pharm#, Lysovant (Consultant) Soo youn Jun, PhD, iNtRON Biotechnology (Consultant) In-Jin Jany, PhD, iNtRON (Consultant) Jun Gi Hwang, PhD, Lysovant (Consultant) David Huang, MD, PhD, Lysovant (Consultant)

scholarly journals The Relationship Between Modified Nordic Diet and Resting Metabolic Rate Among Overweight and Obese Participants: A Cross Sectional Study

2020 ◽  
Author(s):  
Ghazaleh Khalili ◽  
Atieh Mirzababaei ◽  
Farideh Shiraseb ◽  
Khadijeh Mirzaei
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Metabolic Rate ◽  
Body Mass ◽  
Resting Metabolic Rate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lower Odds ◽  
Nordic Diet

Abstract Objective: Obesity as a worldwide phenomenon is a multifactorial condition. Healthy diets have effect on obesity related factors like resting metabolic rate (RMR). In present study, we investigate association between adherence to modified Nordic diet and RMR among overweight and obese participants.Methods: We enrolled 404 overweight and obese (BMI ≥25 kg/m2) women aged 18-48 years in this cross-sectional study. For each participant anthropometrics measurements, biochemical tests and blood pressure were evaluated. RMR was measured by indirect calorimetry. RMR/kg was also measured. Modified Nordic diet score was measured using a validated 147-item food frequency questionnaire (FFQ).Results: Among all participants, the mean and standard deviation (SD) for age and body mass index (BMI) were 36.67 years (SD=9.10) and 31.26 kg/m2 (SD=4.29). There was a significant association between RMR/kg status and age, body mass index (BMI), RMR (P<0.001), respiratory quotient (RQ), fat percentage (P= 0.01), systolic blood pressure (SBP) (P= 0.03), and diastolic blood pressure (DBP) (P= 0.04), after adjustment for age, BMI, energy intake and physical activity. Participants with the highest adherence to modified Nordic diet had lower odds of hypometabolic status after adjusting for confounders and it was significant (odds ratio (OR) = 3.15, 95% CI= 0.97-10.15, P=0.05).Conclusions: The present results indicate that adherence to modified Nordic diet is associated with lower odds of hypometabolic status in overweight and obese women. However more studies are needed to confirm our findings.

scholarly journals Reduced Cardiovascular Capacity and Resting Metabolic Rate in Men with Prostate Cancer Undergoing Androgen Deprivation: A Comprehensive Cross-Sectional Investigation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Bradley A. Wall ◽  
Daniel A. Galvão ◽  
Naeem Fatehee ◽  
Dennis R. Taaffe ◽  
Nigel Spry ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Oxygen Uptake ◽  
Metabolic Rate ◽  
Androgen Deprivation Therapy ◽  
Maximal Oxygen Uptake ◽  
Resting Metabolic Rate ◽  
Androgen Deprivation ◽  
Cross Sectional

Objectives. To investigate if androgen deprivation therapy exposure is associated with additional risk factors for cardiovascular disease and metabolic treatment-related toxicities.Methods. One hundred and seven men (42–89 years) with prostate cancer undergoing androgen deprivation therapy completed a maximal graded objective exercise test to determine maximal oxygen uptake, assessments for resting metabolic rate, body composition, blood pressure and arterial stiffness, and blood biomarker analysis. A cross-sectional analysis was undertaken to investigate the potential impact of therapy exposure with participants stratified into two groups according to duration of androgen deprivation therapy (<3 months and ≥3 months).Results. Maximal oxygen uptake (26.1 ± 6.0 mL/kg/min versus 23.2 ± 5.8 mL/kg/min,p=0.020) and resting metabolic rate (1795 ± 256 kcal/d versus 1647 ± 236 kcal/d,p=0.005) were significantly higher in those with shorter exposure to androgen deprivation. There were no differences between groups for peripheral and central blood pressure, arterial stiffness, or metabolic profile.Conclusion. Three months or longer exposure to androgen deprivation therapy was associated with reduced cardiorespiratory capacity and resting metabolic rate, but not in a range of blood biomarkers. These findings suggest that prolonged exposure to androgen deprivation therapy is associated with negative alterations in cardiovascular outcomes. Trial registry is:ACTRN12609000200280.

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