COMPARATIVE PHARMACEUTICAL EVALUATION OF VARIABLE RETAIL PRICED MEDICINES CONTAINING BIOPHARMACEUTICAL CLASSIFICATION SYSTEM CLASS-II OR CLASS-IV DRUGS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (4) ◽  
pp. 63-73
Author(s):  
Mahesh S. Soni ◽  
◽  
Atmaram P. Pawar ◽  
Chellampillai Bothiraja ◽  
Vinod L. Gaikwad ◽  
...  
Keyword(s):  
Classification System ◽  
Ex Vivo ◽  
Class Ii ◽  
Non Invasive ◽  
Everted Gut Sac ◽  
The Right ◽  
Biopharmaceutical Classification System ◽  
Selection Of ◽  
Class Iv

The purpose of the present study is to highlight the discriminations if any, between the quality of low and high-cost medicines, which would help to select the right brand of medicine. In the present work, brands of medicines having high, medium, and low prices containing either of biopharmaceutical classification system class-II or class-IV drugs were comparatively evaluated for different pharmacopoeial standards as well as for biopharmaceutical classification system solubility and permeability. An ex vivo permeability test was carried out using a simple and non-invasive everted gut sac technique. Insignificant variation in pharmaceutical quality and permeability of the tested three types of brands was observed; however, the study could not consider the state of quality assurance facilities and parameters used while manufacturing these medicines. The study will help to make aware and assure medical and pharmacy practitioners and consumers for the selection of quality quality generic medicines.

scholarly journals Development of a BCS Class II Drug Microemulsion for Oral Delivery: Design, Optimization, and Evaluation

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Marwa Tlijani ◽  
Mohamed Ali Lassoued ◽  
Badr Bahloul ◽  
Souad Sfar
Keyword(s):  
Droplet Size ◽  
Oral Delivery ◽  
Classical Method ◽  
Ex Vivo ◽  
Physical Stability ◽  
Class Ii ◽  
Bcs Class Ii ◽  
Everted Gut Sac ◽  
Hydrophilic Lipophilic Balance ◽  
New Perspective

Our work is aimed at exploring the composition and the properties of microemulsion (ME), as a drug delivery system, to enhance the permeability across the gastrointestinal (GI) barrier of fenofibrate, a BCS class II drug. It is a prodrug that is converted rapidly after oral administration into a major active metabolite which is the fenofibric acid. It undergoes a nearly complete presystemic metabolism. Its main drawback is the low bioavailability of the metabolite. A quick selection of excipients was made based on the capacity of solubilization and the value of hydrophilic-lipophilic balance. The classical method of ME development was coupled with the factorial design in order to minimize the droplet size using a low concentration of surfactant. The optimized ME showed a droplet size of 48.5 nm and physical stability. The passive permeability evaluated using Sartorius was 1.6 times higher than that of the free drug. The ex vivo technique, performed using the everted gut sac model, showed a 2.5-fold higher permeability. This suggests that the carrier-mediated uptake/efflux may present the dominant transport mechanism of fenofibrate. The use of the excipients that inhibit GI P-glycoprotein may be a new perspective. Thus, this paper shows that the composition and the characteristics of ME may be explored to increase the permeability of fenofibrate across the GI membrane.

scholarly journals Web Based Decision Support System yo Determine yhe Appropriate Packaging of Ethnic and Traditional Indonesian Foods

2018 ◽  
Vol 14 (2) ◽  
Author(s):  
Latifah Nurbaiti ◽  
Kudang Boro Seminar ◽  
Nugraha Edhi Suyatma
Keyword(s):  
Decision Support ◽  
Decision Support System ◽  
Support System ◽  
Food Packaging ◽  
Active Packaging ◽  
Web Based ◽  
The Right ◽  
Oxygen Barriers ◽  
Selection Of

Culinary efforts, especially ethnic and traditional snacks attract many people to Indonesia. Maintaining the quality of snacks for consumers requires a good packaging technique. Food packaging consists of a wide variety of packaging options that match the characteristics of each snack; this is no easy task. Decision support systems can help to facilitate decisions made regarding selection of the right packaging. This paper focuses on identifying snacks, types of packaging and active packaging parameters to build a decision support system in order to determine appropriate packaging. Types of packaging are determined using fuzzy Sugeno 4 parameters: fat, water activity, shelf-life and price. Active packaging of the snacks is done using the if-else rule with parameterised types of packaging, preservatives, oxygen barriers and water vapour barriers. The end result of this research is a web-based decision support system, which recommends types of packaging and active packaging for snacks.

scholarly journals Adjustments in the tetrazolium test methodology for assessing the physiological quality of chickpea seeds

2019 ◽  
Vol 41 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Humberto Alencar Paraíso ◽  
Delacyr da Silva Brandão Junior ◽  
Ramon Ivo Soares Avelar ◽  
Candido Alves da Costa ◽  
Luan Souza de Paula Gomes ◽  
...  
Keyword(s):  
Seed Quality ◽  
Class Ii ◽  
Class I ◽  
Class Iii ◽  
Test Methodology ◽  
Physiological Quality ◽  
Tetrazolium Test ◽  
Class Iv

Abstract: Quick tests are essential tools to evaluate seed quality. The objective of this study was to adapt the methodology of tetrazolium test, by identifying the most suitable pre-conditioning parameters of imbibition temperature and duration, and tetrazolium solution concentrations, in order to assess the physiological quality of chickpea seeds. Also, this work proposed the separation of lots in classes, according to the viability and vigor of the seeds. Three lots of chickpeas (lot 1 - BRS Aleppo C1, lot 2 - BRS Aleppo basic, and lot 3 - Cicero) were evaluated. They were analyzed according to three combinations of imbibition temperature and duration (41 °C for 4 hours, 41 ºC for 6 hours, and 30 ºC for 18 hours) and two tetrazolium concentrations (0.1% and 0.5%). The imbibition at 41 °C for 4 or 6 hours, and at 30 ºC for 18 hours allowed clear visualization of injuries in the seeds after immersion in 0.1% tetrazolium solution. The intense coloration formed by the 0.5% solution of this salt prevented the differentiation of the types of damage. In addition, it was possible to separate the seeds into four classes: class I (viable and vigorous, without damages), class II (viable and vigorous, with superficial injuries), class III (viable and non-vigorous), and class IV (non-viable).

MODIFIKASI MODEL PEMBELAJARAN MIND MAPPING DENGAN STRATEGI PEMBELAJARAN TUGAS DAN PAKSA

2019 ◽  
Vol 2 ◽  
Author(s):  
Dini Yuliani ◽  
Mutiara Bhayangkari ◽  
Maria Ulfah
Keyword(s):  
Learning Strategies ◽  
Learning Process ◽  
Intellectual Development ◽  
Learning Strategy ◽  
Student Discipline ◽  
Learning Models ◽  
Mind Mapping ◽  
The Right ◽  
Selection Of

This writing aims to improve students' understanding by modifying learning models with appropriate learning strategies that are considered based on the characteristics and intellectual development of students to improve learning outcomes. The learning process in Indonesia is currently still centered on teachers which causes students' memory and understanding to be still low. This is the background for the purpose of mind mapping learning models, namely making patterned visual and graphical subject matter that can help strengthen and recall information that has been studied. The selection of the right learning strategy can improve the results that will be obtained from the application of learning models in the classroom. Forced and forced learning strategies are chosen to complement and perfect the implementation of mind mapping learning models in the classroom. This strategy aims to train students' independence and discipline in learning through assignments given with clear time limits and strict penalties if there are students not completing their assignments properly. The combination of mind mapping learning models with forced and task learning strategies can be an alternative to improve the quality of learning in schools. With the increase in thinking power accompanied by student discipline in learning, the learning process in the classroom will run well and get maximum results so that the objectives of the learning can be achieved. For educators it is recommended to implement mind mapping learning models with forced and forced learning strategies in schools, so that learning objectives can be achieved optimally.

scholarly journals REBRANDING PRODUK KERIPIK JAMUR TIRAM UNTUK PENINGKATAN PENJUALAN PADA UMKM SPORAMUSHROOM

2020 ◽  
Vol 4 (1) ◽  
pp. 77-83
Author(s):  
Andi Iva Mundiyah ◽  
Dudi Septiadi ◽  
Sharfina Nabila ◽  
Ni Made Wirastika Sari ◽  
Ni Made Zeamita
Keyword(s):  
Pearl Oyster ◽  
Oyster Mushroom ◽  
Brand Marketing ◽  
Medium Enterprise ◽  
Oyster Mushrooms ◽  
The Right ◽  
Almost All ◽  
Product Sales ◽  
Selection Of

ABSTRACT Small-Medium Enterprise (SME) “Sporamushroom” which processes pearl-oyster mushrooms into pearl-oyster mushroom chips is located on Jalan Pelita, Makassar City. Pearl-oyster mushrooms are rich in nutrition and have savory taste and chicken-like texture, so that almost all people like it. The problem faced by SME “Sporamushroom” lies in the packaging of the mushroom chips that are not attractive and are not able to preserve the quality of the products contained therein. In addition, the mushroom chips brand have not been determined. The results of the activities carried out indicate the need for assistance and information sharing about the types of packaging for processed chips, so that the packaging will be produced accordingly, which is aluminum plastic packaging that is suitable for processed chip products. From the brand aspect, the selection of the right and easy-to-remember brand has an effect on product sales. The JAMBUL brand was chosen as the brand of pearl-oyster mushroom chips because it is easy to be remembered and has appropriate philosophy behind it. Key words: brand, marketing, packaging, SME

scholarly journals PENETAPAN BRAND AMBASSADOR SEBAGAI UPAYA STRATEGI KOMUNIKASI PEMASARAN “RUANGGURU” DI ERA PANDEMI COVID-19

2021 ◽  
Vol 5 (1) ◽  
pp. 66
Author(s):  
Ni Putu Stiti Ayuningtyas ◽  
Ni Luh Putu Sariani ◽  
Desak Made Sukarnasih
Keyword(s):  
Communication Strategies ◽  
Communication Strategy ◽  
Marketing Communication ◽  
The Future ◽  
The Right ◽  
Brand Ambassadors ◽  
Selection Of

ABSTRAKKegiatan pembelajaran saat pandemi di Indonesia dilakukan secara daring. Perlu adanya dukungan media pembelajaran seperti yang disediakan oleh Ruang guru. Ruang guru merupakan penyedia media pembejaran yang bisa diakses menggunakan internet, sehingga memudahkan guru dan siswa saat proses belajar. Dengan persaingan yang terus bertumbuh, Ruang guru perlu memilih strategi komunikasi pemasaran yang tepat, salah satunya dengan menunjuk brand ambassador. Tahun 2021, telah dipilih lima brand ambassadors baru yang berasal dari kalangan artis. Pengabdian dilakukan untuk mengetahui perkembangan strategi komunikasi pemasaran Ruang guru melalui pemilihan brand ambassadors dan seperti apa respon masyarakat terkait hal tersebut. Metode pengabdian melalui proses tahapan, pelaksanaan, dan evaluasi. Diketahui bahwa masyarakat setuju akan terpilihnya brand ambassador Ruangguru 2021 dan dinilai mampu meningkatkan positif perusahaan. Teori strategi komunikasi pemasaran yang dilakukan adalah pull, push, dan profle strategies. Hasil akhir kegiatan PKL menunjukkan sebanyak 40 responden setuju atas pemilihan brand ambassador, diantaranya 28% memilih Prilly Latuconsina sebagai “ikon” Ruang guru paling sesuai. Selain itu, banyak pengguna yang setuju atas terpilihnya kelima brand ambassadors karena prestasi serta rekam jejak yang baik dari masing-masing brand ambassador. Saran yang dapat diberikan adalah kedepannya Ruang guru harus lebih meningkatkan kualitas konten dan lebih selektif memilih brand ambassador agar sesuai dengan visi dan misi perusahaan. Kata kunci: brand ambassador; pemasaran; ruang guru. ABSTRACTLearning activities during the pandemic in Indonesia are carried out online. There needs to be support for learning media such as those provided by Ruang guru. With the high rivalry in this industry, Ruangguru needs to choose the right marketing communication strategy, one of which is by appointing a brand ambassador. In 2021, five new brand ambassadors have been selected from among the artists. This community dedication held to know the effect of Ruang guru’s brand ambassadors and what’s public responses to it. The method is through a process of stages, implementation, and evaluation. The marketing communication strategies used are pull, push, and profile strategies. The final result showed that 40 respondents agreed with the selection of brand ambassadors and they be able to increase the company's positivity and of which 28% chose Prilly Latuconsina as the most compatible Ruang guru "icon". In addition, many users agree with the selection of the five brand ambassadors because of the achievements and good track records of each brand ambassador. Recommendations that can be given are that in the future Ruang guru should further improve the quality of content and be more selective in choosing brand ambassadors to fit in the company's vision and mission. Keywords: brand ambassador; marketing; ruang guru.

scholarly journals Tree Species Selection in Street Planting: It’s relationship with issues in urban area

2017 ◽  
Vol 2 (6) ◽  
pp. 185 ◽  
Author(s):  
Ramly Hasan ◽  
Noriah Othman ◽  
Faridah Ismail
Keyword(s):  
Tree Species ◽  
Urban Areas ◽  
Careful Consideration ◽  
Urban Life ◽  
Species Selection ◽  
The Public ◽  
Quality Of Urban Life ◽  
The Right ◽  
Selection Of

Trees in urban areas are an invaluable resource. Careful consideration and attention should be given to tree species selection. “Right tree at the right place” is the key to get the benefits offered by the tree. Objectives have been formulated as follows (i) to investigate the selection of tree species at selected local councils (ii) to analyse the issues related to the selection of the tree species looking at the public perspectives. A mixed method approach was undertaken in the data collection. Future considerations of the tree species as street planting based on the findings can reduce problems thus increase the quality of urban life.

Sign in / Sign up

Export Citation Format

Share Document