A REVIEW OF PHARMACOLOGICAL SCREENING METHODS FOR EXPERIMENTALLY INDUCED POLYCYSTIC OVARIAN DISEASE (PCOD)

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (07) ◽  
pp. 7-21
Author(s):  
Ramesh Selvaraj ◽  
Srikanth Jeyabalan ◽  
Soumya Vasu ◽  
Venkatesh Palaniyappan ◽  
Sharfudeen Settu ◽  
...  

PCOD is a complex heterogenous metabolic disorder affecting 10 % of women at their reproductive age. A well effective treatment for a complete cure for PCOD is still a challenge and evaluation of new strategies to treat this disease is of great priority. This review focuses on two aspects of PCOD, namely types of rodent screening models and diagnosis of major parameters. A fully convincing animal model to study PCOD is still a challenge as they are multi-ovular species. But in many ways, the rodent models are similar to human PCOD. This study explores on the parallels and problems associated with the use of different rodent models. Oligo- or anovulation, clinical or biochemical hyperandrogenism and polycystic ovaries constitute the key clinical features on which the diagnosis should be based. Determination of diagnosis parameters such as estrus cyclicity, insulin sensitivity, lipid profile, anti-oxidant status, weight of reproductive system and histopathological features of ovary are discussed along with the currently available treatment methods for PCOD.

Author(s):  
Suha J. Witwit

Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary axis. It affect about 4-17% of women in reproductive age and about 3-10% of patients with polycystic ovaries. Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe.it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level. The aim of the study is To evaluate the effectiveness of vitamin B6 in reducing serum prolactin in Hyperprolactinemic patient. Compare this effect to that of cabergoline.


Author(s):  
Krishna Reddy BV ◽  
Avinash Kumar Reddy G ◽  
Sujitha V ◽  
Manasa A

DM otherwise diabetes is now a days an epidemic with the percentage of patient population rising to almost 10% of the world population. Out of all the DM complications, cataract leads the way contributing to disabilities to about 60% of diabetic population. But the pathogenesis of DM cataract is still a half-understood area of medicine there by posing a problem in the therapy. The data that we have till now gives us enough evidence to advocate the oxidative stress has a major role for the pathogenesis of DM complications like DMnephropathy, DMneuropathy, and cardiac hypertrophy, which suggests the oxidative stress is a central feature of diabetes. In the current research, the pharmacological evaluation of Fisetin for its DM based anti-cataract property was performed. This research concentrates to estimate the possible involvement of Nrf-2 / heme oxygenase (HO)-pathway in the observed therapeutic effect, if any. The data obtained in this study also indicate that the observed beneficial effects mainly due to activation of Nrf2/HO-1 pathway. These effects probably result in increased tissue anti-oxidant status as well as decreased free radical production, which ultimately responsible for the observed beneficial effects of Fisetin against hyperglycemia-induced cataract.


Author(s):  
Ольга Александровна Судакова ◽  
Михаил Вадимович Фролов ◽  
Алина Сергеевна Позднякова ◽  
Евгений Владимирович Белов ◽  
Данаил Красимирович Назлиев

Статья посвящена изучению сопутствующей патологии, у женщин репродуктивного возраста, обращающихся в стационар с жалобами на нарушения менструального цикла (НМЦ). Актуальность данной тематики не вызывает сомнения, так как с каждым годом в России и во всем мире регистрируется все большее количество случаев НМЦ. По мнению ряда авторов, данные нарушения могут составлять до 50% всех патологий женской половой сферы. Большой интерес представляет и изучение ряда сопутствующих заболеваний, которые могут отягощать течение НМЦ или наоборот, приводить к их развитию. Целью работы стал анализ разнообразной сопутствующей патологии при НМЦ, с выявлением основных причин нарушений менструального цикла у женщин фертильного возраста. Объектами исследования стали 300 пациенток, с диагнозом НМЦ, которые были разделены на 3 группы, в зависимости от уровня лечебного учреждения, где они проходили обследование - по 100 пациенток: проходивших обследование в больнице скорой медицинской помощи, обследующиеся в женской консультации и проходящие лечение сопутствующей онкопатологии в областном онкологическом диспансере. В дальнейшем проводилась дополнительное деление в каждой группе на 2 подгруппы, в зависимости от того был ли НМЦ впервые выявленным или повторно выявленным. В самой работе проводился подробный анализ сопутствующей патологии у женщин в зависимости от группы и их возраста. Определялись не только «пораженные» системы органов, но и проводился углубленный анализ по нозологиям. Работа интересна еще и тем, что в ней у всех пациенток на протяжении исследования определялся уровень стресса и наличие возможных депрессивных состояний. Определение наиболее вероятных причин НМЦ стало завершающим этапом исследования. Полученные данные могут приблизить практикующих акушеров-гинекологов к более полному пониманию различных нарушений менструального цикла, что в целом, положительно скажется на качестве и эффективности оказываемой медицинской помощи The article is devoted to the study of concomitant pathology in women of reproductive age who go to the hospital with complaints of menstrual irregularities (NMC). The relevance of this topic is beyond doubt, since every year in Russia and around the world an increasing number of cases of NMC are registered. According to a number of authors, these violations can account for up to 50% of all pathologies of the female genital area. Of great interest is the study of a number of concomitant diseases that can aggravate the course of NMC or, conversely, lead to their development. The aim of the work was to analyze a variety of concomitant pathologies in NMC, with the identification of the main causes of menstrual irregularities in women of fertile age. The objects of the study were 300 patients diagnosed with NMC, who were divided into 3 groups, depending on the level of the medical institution where they were examined - 100 patients each: who were examined in an emergency hospital, examined in an antenatal clinic and undergoing treatment for concomitant oncopathology in the regional oncological dispensary. Subsequently, an additional division was carried out in each group into 2 subgroups, depending on whether the NMC was newly detected or re-identified. In the work itself, a detailed analysis of comorbidities in women was carried out, depending on the group and their age. Not only the "affected" organ systems were identified, but an in-depth analysis of nosologies was also carried out. The work is also interesting in that during the study the level of stress and the presence of possible depressive states were determined in all patients. Determination of the most probable causes of NMC was the final stage of the study. The data obtained can bring practicing obstetricians and gynecologists closer to a more complete understanding of various menstrual irregularities, which, in general, will have a positive effect on the quality and effectiveness of medical care


1990 ◽  
Vol 9 ◽  
pp. 14
Author(s):  
Nicholas H. Hunt ◽  
Roland Stocker ◽  
Martin Kopp ◽  
Shane B. Thomas
Keyword(s):  

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Tatjana Ruskovska ◽  
Eugene H. J. M. Jansen ◽  
Risto Antarorov

Background. Various biomarkers and assays have been used for assessment of (anti)oxidant status in hemodialysis patients, including those intended for measurement of serum total (anti)oxidants, most often as a part of panel biomarkers.Methods. Serum (anti)oxidant status was measured in 32 chronically hemodialyzed patients and in 47 healthy persons, using two oxidations and three antioxidant assays.Results. The patients before the hemodialysis session have had higher values of total oxidants in comparison to the healthy persons, with a further increase during the hemodialysis. These findings were confirmed with both oxidation assays, but they differ in the percentage of increase and the statistical significance. All three antioxidant assays showed significantly higher values of the total serum antioxidants in the patients before the hemodialysis session in comparison to the healthy persons, and their significant decrease during the hemodialysis. However, the assays differ in the percentage of decrease, its statistical significance, and the correlations with uric acid.Conclusion. The variability of results of total (anti)oxidants which are obtained using different assays should be taken into account when interpreting data from clinical studies of oxidative stress, especially in complex pathologies such as chronic hemodialysis.


Drug Research ◽  
2018 ◽  
Author(s):  
Bijan Oskouei ◽  
Soheil Abbaspour-Ravasjani ◽  
Seyed Jamal Musavinejad ◽  
Seyed Ahmad Salehzadeh ◽  
Alireza Abdolhosseinzadeh ◽  
...  

2012 ◽  
Vol 25 (4) ◽  
pp. 961-972 ◽  
Author(s):  
Stephen P. Slocombe ◽  
QianYi Zhang ◽  
Kenneth D. Black ◽  
John G. Day ◽  
Michele S. Stanley

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