COMBINATORIAL DRUGS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (08) ◽  
pp. 5-6
Author(s):  
Nagaraj Rao ◽  

At the University of Sydney’s Westmead Applied Research Center in Australia, Professor Clara Chow's team has discovered in a long-duration study that a combination of four drugs commonly used to treat blood pressure - at only a quarter of their usual doses - is much more effective in getting blood pressure under control compared to the standard treatment with one or two drugs. The new combination could remarkably bring the blood pressure under control in 80% of the participants within 12 weeks. The four drugs were given in the form of a pill. Apart from the lower concentrations of the drugs required, ease of administering and patient compliance of the new quadruple strategy are obvious additional advantages. This discovery, published recently in Lancet, might contribute to basic changes in the management of patients having high blood pressure. Professor Chow laments that control of hypertension is not ideal anywhere, and in some regions such as Africa fewer than one in ten have it under control. The prevalence of hypertension is expected to increase to 29%(!) of the global population in four years from now

1973 ◽  
Vol 184 (1077) ◽  
pp. 399-402

Analysis of data from a large number of patients can sometimes produce information unobtainable from smaller series. The Glasgow Blood-Pressure Clinic was set up as an organization capable of collecting a large number of patients with high blood pressure, investigating these cases in a standardized fashion and analysing the data by use of the computer. Information from more than 1000 cases attending the clinics held at four of the major Glasgow hospitals has now been obtained. In each of the clinics, data are collected on a proforma designed to enable storage and subsequent analysis via the University KDF9 computer. The system has recently been extended for use in a field survey of hypertension in a neighbouring borough (Renfrew). An outline of the system is discussed and illustrated by reference to some of the analyses so far carried out.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
C. Aparicio-Cercós ◽  
M. Alacreu ◽  
L. Salar ◽  
L. Moreno Royo

Abstract The purpose of this study was to estimate the prevalence of high blood pressure (HBP) in adolescents of the Valencian Autonomous Community (VC) in Spain. Besides, its association with other risk factors related to cardiovascular disease (CVD) or arterial hypertension (AHT) in order to increase our knowledge of public health and to provide advice about healthy diets. We conducted a multicentre, observational, cross-sectional, epidemiological study in a sample of 4402 adolescents from 15 schools during the 2015–2016 school year. The participants were aged between 11 and 18 years, and any individuals already diagnosed with AHT were excluded. In addition to the Physical Activity Questionnaire for Adolescents (PAQ-A), Evaluation of the Mediterranean Diet Quality Index (KIDMED), a lifestyle habits survey, the waist-to-height ratio (WtHR), and body mass index (BMI) were calculated for each participant. Informed Consent was obtained from Parents of the adolescents involved in the current study. The study received approval from the University ethics committee and all procedures were conducted in accordance with the tenets of the Declaration of Helsinki. Chi-squared, Student t-tests, and ANOVA statistical analyses showed that 653 (14.8%) adolescents had previously undiagnosed HBP and that was significantly associated with male sex (p < 0.001), age over 15 years (p < 0.05), and height, weight, waist circumference, WtHR, BMI, and skipping breakfast. Based on the data we obtained in this study, the modifiable factors that influence HBP in adolescents were WtHR, BMI, and skipping breakfast.


EDIS ◽  
2017 ◽  
Vol 2017 (6) ◽  
Author(s):  
Linda B. Bobroff

High blood pressure, or hypertension, can cause serious health problems. It makes your heart work harder and can damage your blood vessels even if you feel okay. Everyone should have their blood pressure checked regularly. If you have certain risk factors, you are more likely to have high blood pressure. This 6-page fact sheet is a major revision that discusses risk factors and ways to reduce risk.


2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.


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