scholarly journals Prevalence and Associated Risk Factors of Anaemia in Children Aged Six Months to Fifteen Years Admitted to University Teaching Hospital, Lusaka, Zambia

2020 ◽  
Vol 4 (1) ◽  
pp. 10-21
Author(s):  
M. N. Inambao ◽  
◽  
V Mulenga ◽  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Teaching Hospital ◽  
Severe Anaemia ◽  
University Teaching ◽  
Bivariate Analysis ◽  
Age Group ◽  
Cell Disease ◽  
The Mean ◽  
Associated Risk Factors

Background: Anaemia is a public health problem globally affecting 293.1 million children and 28.5% of these children are in sub-Saharan Africa. The aim of this study was to determine the prevalence of anaemia and the associated risk factors of anaemia in children aged 6 months to 15 years admitted to the University Teaching Hospital. There have been no studies done at University Teaching Hospital to establish the burden of anaemia in children. Methods: A cross-sectional study was conducted from July 2016 to December 2016. 351 children were recruited through convenient sampling methods. Data collection sheet was used to collect socio-demographic and anthropometry data. The prevalence, associated risk factors of anaemia, and morphological types of anaemia were determined after blood investigations were done. Data analysis was done using SPSS version 21.0. The association between predictors and outcome variables were measured using logistic regression and bivariate analysis. Ethical permission was obtained, consent from parents/guardians was taken and confidentiality was maintained. Results: A total of 351 children were studied. The mean age was 3 years (IOR 2-7 years). 45.9% were females and 54.1% were males (P=0.12). The mean cell volume was 74. 5fL.Malnourished children were 37.9% among those who were anaemic as compared to 33.7% in the non-anaemic group. 7.4% of children had positive malaria by rapid diagnostic test (RDT). 23.8% had a positive sickling test. The prevalence of anaemia was 161/351 (45.9%). Mild, moderate, severe anaemia was 47/161(29%), 86/161(53%) and 28/161(17%) respectively. The age group 6 months to 5 years was the most affected with 59% mildly, 69.8% moderately and 71.4% severely anaemic. On bivariate analysis malnutrition, HIV, malaria, age and sex were not associated with anaemia and there was no statistical difference. Logistic regression analysis revealed that the presence of haemoglobin S was the only risk factor independently strongly associated with Anaemia (CI-0.2-0.7), p-value of 0.001. Conclusion: Anaemia is a health problem at University Teaching hospital and the under-five age group is the most affected. Predictors of mild, moderate and severe anaemia is sickle cell disease. Therefore, improving on early screening of sickle cell disease and investigating the role of iron deficiency anaemia are some of the strategies to be advocated.

scholarly journals Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

2020 ◽  
Vol 1 (6) ◽  
pp. 175-181
Author(s):  
Raymond Mpanjilwa Musowoya ◽  
Patrick Kaonga ◽  
Alick Bwanga ◽  
Catherine Chunda-Lyoka ◽  
Christopher Lavy ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Clinical Manifestations ◽  
Classification Systems ◽  
University Teaching ◽  
Cell Disease ◽  
Tertiary Teaching ◽  
Musculoskeletal Manifestations

Aims Sickle cell disease (SCD) is an autosomal recessive inherited condition that presents with a number of clinical manifestations that include musculoskeletal manifestations (MM). MM may present differently in different individuals and settings and the predictors are not well known. Herein, we aimed at determining the predictors of MM in patients with SCD at the University Teaching Hospital, Lusaka, Zambia. Methods An unmatched case-control study was conducted between January and May 2019 in children below the age of 16 years. In all, 57 cases and 114 controls were obtained by systematic sampling method. A structured questionnaire was used to collect data. The different MM were identified, staged, and classified according to the Standard Orthopaedic Classification Systems using radiological and laboratory investigations. The data was entered in Epidata version 3.1 and exported to STATA 15 for analysis. Multiple logistic regression was used to determine predictors and predictive margins were used to determine the probability of MM. Results The cases were older median age 9.5 (interquartile range (IQR) 7 to 12) years compared to controls 7 (IQR 4 to 11) years; p = 0.003. After multivariate logistic regression, increase in age (adjusted odds ratio (AOR) = 1.2, 95% confidence interval (CI) 1.04 to 1.45; p = 0.043), increase in the frequency of vaso-occlusive crisis (VOC) (AOR = 1.3, 95% CI 1.09 to 1.52; p = 0.009) and increase in percentage of haemoglobin S (HbS) (AOR = 1.18, 95% CI 1.09 to 1.29; p < 0.001) were significant predictors of MM. Predictive margins showed that for a 16-year-old the average probability of having MM would be 51 percentage points higher than that of a two-year-old. Conclusion Increase in age, frequency of VOC, and an increase in the percentage of HbS were significant predictors of MM. These predictors maybe useful to clinicians in determining children who are at risk. Cite this article: Bone Joint Open 2020;1-6:175–181.

scholarly journals Predictors of musculoskeletal manifestations in paediatric patients presenting with sickle cell disease at a tertiary teaching hospital in Lusaka, Zambia

2020 ◽  
Vol 1 (6) ◽  
pp. 175-181
Author(s):  
Raymond Mpanjilwa Musowoya ◽  
Patrick Kaonga ◽  
Alick Bwanga ◽  
Catherine Chunda-Lyoka ◽  
Christopher Lavy ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Clinical Manifestations ◽  
Classification Systems ◽  
University Teaching ◽  
Cell Disease ◽  
Tertiary Teaching ◽  
Musculoskeletal Manifestations

Aims Sickle cell disease (SCD) is an autosomal recessive inherited condition that presents with a number of clinical manifestations that include musculoskeletal manifestations (MM). MM may present differently in different individuals and settings and the predictors are not well known. Herein, we aimed at determining the predictors of MM in patients with SCD at the University Teaching Hospital, Lusaka, Zambia. Methods An unmatched case-control study was conducted between January and May 2019 in children below the age of 16 years. In all, 57 cases and 114 controls were obtained by systematic sampling method. A structured questionnaire was used to collect data. The different MM were identified, staged, and classified according to the Standard Orthopaedic Classification Systems using radiological and laboratory investigations. The data was entered in Epidata version 3.1 and exported to STATA 15 for analysis. Multiple logistic regression was used to determine predictors and predictive margins were used to determine the probability of MM. Results The cases were older median age 9.5 (interquartile range (IQR) 7 to 12) years compared to controls 7 (IQR 4 to 11) years; p = 0.003. After multivariate logistic regression, increase in age (adjusted odds ratio (AOR) = 1.2, 95% confidence interval (CI) 1.04 to 1.45; p = 0.043), increase in the frequency of vaso-occlusive crisis (VOC) (AOR = 1.3, 95% CI 1.09 to 1.52; p = 0.009) and increase in percentage of haemoglobin S (HbS) (AOR = 1.18, 95% CI 1.09 to 1.29; p < 0.001) were significant predictors of MM. Predictive margins showed that for a 16-year-old the average probability of having MM would be 51 percentage points higher than that of a two-year-old. Conclusion Increase in age, frequency of VOC, and an increase in the percentage of HbS were significant predictors of MM. These predictors maybe useful to clinicians in determining children who are at risk. Cite this article: Bone Joint Open 2020;1-6:175–181.

scholarly journals Poisoning cases attending emergency department in Dhulikhel Hospital- Kathmandu University Teaching Hospital

1970 ◽  
Vol 7 (2) ◽  
pp. 152-156 ◽  
Author(s):  
SB Marahatta ◽  
J Singh ◽  
R Shrestha ◽  
R Koju
Keyword(s):  
Emergency Department ◽  
Teaching Hospital ◽  
Acute Poisoning ◽  
Oral Route ◽  
University Teaching ◽  
Social Aspects ◽  
Age Group ◽  
Phosphorus Poisoning ◽  
The Mean ◽  
One Year

Objective: The objective of the present study is to evaluate the characteristics of acute poisoning cases admitted to emergency department over a one year period. The demographic, clinical and psycho-social aspects of the patients were analysed. Materials and methods: A hospital based study was carried out in the emergency department, Kathmandu University Teaching Hospital/ Dhulikhel Hospital, Dhulikhel analysing the data of the poisoning cases attended for one year. The study was carried out amongst inpatients attending emergency with acute poisoning. Results: A total of 54 patients were admitted to the emergency department with acute poisoning. The female-to-male ratio was 1.34:1. Most poisoning occurred in the age group of above 40 years. The mean ages of female and male were 29.87 ±14.85 years and 35.54±15.02 years respectively. By occupation 40.38% of the cases were farmers. Only 35.29% of the patients were illiterate. 79.24% of the cases intentionally consume the poison. Organ phosphorus poisoning (OP) was the most common poisoning. Oral route was the commonest route of poisoning accounting 98.1%. Sixty-six percentage (66.66%) of the cases had the poison stored in their home with 27.7% bought from the market once needed. Among the cases of acute poisoning 5.55% were fatal. Conclusion: The following conclusions were reached: (1) females were at greater risk for poisoning than males, (2) self-poisoning cases constituted the majority of all poisonings, and (3) the main agents of self-poisoning were OP poisoning. Key words: poisoning; insecticides; organophosphorus DOI: 10.3126/kumj.v7i2.2711 Kathmandu University Medical Journal (2009) Vol.7, No.2 Issue 26,152-156

scholarly journals Prevalence and predictive risk factors of hypertension in patients hospitalized in Kamenge Military hospital and Kamenge University teaching hospital in 2019: A fixed effect modelling study in Burundi

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260225
Author(s):  
Arnaud Iradukunda ◽  
Emmanuel Nene Odjidja ◽  
Stephane Karl Ndayishima ◽  
Egide Ngendakumana ◽  
Gabin Pacifique Ndayishimiye ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Infectious Diseases ◽  
Teaching Hospital ◽  
University Teaching ◽  
Retrospective Data ◽  
High Burden ◽  
Referral Hospitals ◽  
Predictive Risk ◽  
Associated Risk Factors

Introduction Hypertension is a major threat to public health globally. Especially in sub-Saharan African countries, this coexists with high burden of other infectious diseases, creating a complex public health situation which is difficult to address. Tackling this will require targeted public health intervention based on evidence that well defines the at risk population. In this study, using retrospective data from two referral hospitals in Burundi, we model the risk factors of hypertension in Burundi. Materials and methods Retrospective data of a sample of 353 randomly selected from a population of 4,380 patients admitted in 2019 in two referral hospitals in Burundi: Military and University teaching hospital of Kamenge. The predictive risk factors were carried out by fixed effect logistic regression. Model performance was assessed with Area under Curve (AUC) method. Model was internally validated using bootstrapping method with 2000 replications. Both data processing and data analysis were done using R software. Results Overall, 16.7% of the patients were found to be hypertensive. This study didn’t showed any significant difference of hypertension’s prevalences among women (16%) and men (17.7%). After adjustment of the model for cofounding covariates, associated risk factors found were advanced age (40–59 years) and above 60 years, high education level, chronic kidney failure, high body mass index, familial history of hypertension. In absence of these highlighted risk factors, the risk of hypertension occurrence was about 2 per 1000 persons. This probability is more than 90% in patients with more than three risk factors. Conclusion The relatively high prevalence and associated risk factors of hypertension in Burundi raises a call for concern especially in this context where there exist an equally high burden of infectious diseases, other chronic diseases including chronic malnutrition. Targeting interventions based on these identified risk factors will allow judicious channel of resources and effective public health planning.

scholarly journals Prevalence of and associated risk factors for pterygium in the high altitude communities of Upper Mustang, Nepal

2014 ◽  
Vol 6 (1) ◽  
pp. 65-70 ◽  
Author(s):  
IM Maharjan ◽  
E Shreshth ◽  
B Gurung ◽  
S Karmacharya
Keyword(s):  
Risk Factors ◽  
High Altitude ◽  
Public Health Problem ◽  
Age Group ◽  
Cross Sectional ◽  
Significant Public Health ◽  
The Mean ◽  
Associated Risk Factors ◽  
The Right ◽  
Severe Grade

Objective: To determine the prevalenceof and associated risk factors for pterygiumin the high altitude communities of the Upper Mustang region of Nepal, near the Tibet border. Materials and methods: Six villages of the Upper Mustang were selected based on the concentration of population. All subjects were permanent residents aged 16 years and older, and recruited through a household census with mobilization of local monks who had been trained as interviewers, and people were invited to attend the eye clinic for a complete examination. A cross-sectional studywas conducted which included the parameters oflaterality, severity, occupation, age, sex and altitude of residence. Results:The study population comprised 1,319 individuals of which 637 (48.29%) weremale and682 (51.71%) were female.The overall prevalence of pterygium, was 10.08% (133 of 1,319), with 42.86% for males and 57.14% for females. The mean age of the subjects was45.83 years and the mean SD 17.94. The majority of the subjects had a unilateral pterygium. The right eye(n=63) was predominately affected, in 57.80% of the total subjects. Farmers and construction workers, which comprised of 36.09% and 28.57% respectively, had a higher prevalence of pterygium. The most affected age group was the 66 to 75 years group (n=31: 23.31%). The prevalence increased linearly with age. The severe Grade III and Grade IV pterygium were predominant in the age group of 56-65 years, comprising 28.58% of all the cases;the less severe Grade I was also predominant in the same age group,with 23.56%, and Grade II (0-2 mm) was predominant in the age group of 46-55, with 31.03%. Conclusion: Pterygiumisa significant public health problem in the high altitude communities of Nepal. It is more prevalent amongst the farmers than in the other professionals. DOI: http://dx.doi.org/10.3126/nepjoph.v6i1.10774 Nepal J Ophthalmol 2014; 6 (2): 65-70

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