Antioxidant properties of ethanol and fractions of ocimum gratissimum leave in paracetamol-induced oxidative stress in Wistar albino rats.

2016 ◽  
Vol 6 (2) ◽  
pp. 66
Author(s):  
ukpabiugo ukpabiugo ◽  
Jacinta Chigozie ◽  
Patrick Iwuanyanwu ◽  
kingsley Chukwuemeka ◽  
Monanu Okechukwu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Properties ◽  
Albino Rats ◽  
Ocimum Gratissimum ◽  
Wistar Albino Rats

Antioxidant properties of Rosa pisiformis and its protective effect against isoproterenol-induced oxidative stress in rats / Rosa pisiformis’in antioksidant özellikleri ve izoproterenol ile ratlarda oluşturulan okdidatif strese karşı koruyucu etkisi

2016 ◽  
Vol 41 (4) ◽  
Author(s):  
Mahire Bayramoğlu ◽  
Suat Ekin ◽  
Hatice Kızıltaş ◽  
Gökhan Oto ◽  
Ebru Altındal Susen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Tissue ◽  
Histopathological Examination ◽  
Antioxidant Properties ◽  
Albino Rats ◽  
Cardiac Tissues ◽  
Positive Effects ◽  
Icp Ms ◽  
Wistar Albino Rats ◽  
Method R

AbstractObjective: In this study, Rosa pisiformis was evaluated for its antioxidant activity, vitamin (A, E, C), trace element (Fe, Cu, Zn, Mn, Cr, Se) and mineral (Ca, K, Mg, Na) levels, in addition to its cardioprotective effects on cardiac tissue antioxidant enzymes (GSH-Px, SOD, CAT) during isoproterenol (ISO) - induced oxidative stress.Methods: In the study, vitamin and mineral analysis was carried out using HPLC and ICP-MS method, R. P. antioxidant and antiradical properties were determined using spectrophotometer. Forty wistar albino rats were divided into four groups: control (0.9% NaCl), ISO (100 mg/kg), ISO (100 mg/kg) + R. P. (300 mg/kg) and R. P. (300 mg/ kg). ISO was injected subcutaneously into rats twice at an interval of 24 h for two consecutive days (on 28Results: The results of the study indicated that R. P. fruit and leaves contain high levels of minerals and vitamins and possess antioxidant and antiradical activity and its fruits have positive effects on cardiac tissues. The results are supported with significant changes in antioxidant enzyme levels and histopathological examination.Conclusion: This study demonstrates that R. P. fruits in particular can be used to treat and prevent cardiac diseases.

Effects of erdosteine on cyclosporin-A-induced nephrotoxicity

2011 ◽  
Vol 31 (6) ◽  
pp. 565-573 ◽  
Author(s):  
M Tutanc ◽  
V Arica ◽  
N Yılmaz ◽  
A Nacar ◽  
I Zararsiz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cyclosporin A ◽  
Protective Role ◽  
Control Group ◽  
Albino Rats ◽  
Protective Mechanism ◽  
Antioxidant Parameters ◽  
Group 2 ◽  
Wistar Albino Rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

scholarly journals Thymoquinone Attenuates Diethylnitrosamine Induction of Hepatic Carcinogenesis Through Antioxidant Signaling

2010 ◽  
Vol 3 (4) ◽  
pp. 254-261 ◽  
Author(s):  
Mohamed M. Sayed-Ahmed ◽  
Abdulaziz M. Aleisa ◽  
Salim S. Al-Rejaie ◽  
Abdulaziz A. Al-Yahya ◽  
Othman A. Al-Shabanah ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Mrna Expression ◽  
Nigella Sativa ◽  
Antioxidant Properties ◽  
Cancer Chemoprevention ◽  
Thiobarbituric Acid ◽  
Albino Rats ◽  
Hepatic Carcinogenesis ◽  
Group 2 ◽  
Wistar Albino Rats

Hepatocellular carcinoma accounts for about 80–90% of all liver cancer and is the fourth most common cause of cancer mortality. Although there are many strategies for the treatment of liver cancer, chemoprevention seems to be the best strategy for lowering the incidence of this disease. Therefore, this study has been initiated to investigate whether thymoquinone (TQ),Nigella sativaderived-compound with strong antioxidant properties, supplementation could prevent initiation of hepatocarcinogenesis-induced by diethylnitrosamine (DENA), a potent initiator and hepatocarcinogen, in rats. Male Wistar albino rats were divided into four groups. Rats of Group 1 received a single intraperitoneal (I.P.) injection of normal saline. Animals in Group 2 were given TQ (4 mg/kg/day) in drinking water for 7 consecutive days. Rats of Group 3 were injected with a single dose of DENA (200 mg/kg, I.P.). Animals in Group 4 were received TQ and DENA. DENA significantly increased alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin, thiobarbituric acid reactive substances (TBARS) and total nitrate/nitrite (NOx) and decreased reduced glutathione (GSH), glutathione peroxidase (GSHPx), glutathione-s-transferase (GST) and catalase (CAT) activity in liver tissues. Moreover, DENA decreased gene expression of GSHPx, GST and CAT and caused severe histopathological lesions in liver tissue. Interestingly, TQ supplementation completely reversed the biochemical and histopathological changes induced by DENA to the control values. In conclusion, data from this study suggest that: (1) decreased mRNA expression of GSHPx, CAT and GST during DENA-induced initiation of hepatic carcinogenesis, (2) TQ supplementation prevents the development of DENA-induced initiation of liver cancer by decreasing oxidative stress and preserving both the activity and mRNA expression of antioxidant enzymes.

Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats

2020 ◽  
Vol 113 ◽  
pp. 104622 ◽  
Author(s):  
Shahenda Mahgoub ◽  
Anas O. Sallam ◽  
Hazem K.A. Sarhan ◽  
Amal A.A. Ammar ◽  
Sameh H. Soror
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Albino Rats ◽  
Wistar Albino Rats

Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue

2004 ◽  
Vol 20 (6-10) ◽  
pp. 141-147 ◽  
Author(s):  
Alpaslan Terzi ◽  
Mustafa Iraz ◽  
Semsettin Sahin ◽  
Atilla Ilhan ◽  
Nuri Idiz ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Liver Tissue ◽  
Antioxidant Properties ◽  
Albino Rats ◽  
Protective Agent ◽  
Protective Effects ◽  
Oxidant Injury ◽  
Sod Activity ◽  
Significant Difference ◽  
Wistar Albino Rats

Rotenone, an insecticide of botanical origin, causes toxicity through inhibition of complex I of the respiratory chain in mitochondria. This study was undertaken to determine whether rotenone-induced liver oxidant injury is prevented by erdosteine, a mucolytic agent showing antioxidant properties. There were four groups of Male Wistar Albino rats: group one was untreated as control; the other groups were treated with erdosteine (50 mg/kg per day, orally), rotenone (2.5 mg/mL once and 1 mL/kg per day for 60 days, i.p.) or rotenone plus erdosteine, respectively. Rotenone treatment without erdosteine increased xanthine oxidase (XO) enzyme activity and also increased lipid peroxidation in liver tissue P < 0.05). The rats treated with rotenone plus erdosteine produced a significant decrease in lipid peroxidation and XO activities in comparison with rotenone group PB / 0.05). Erdosteine treatment with rotenone led to an increase in catalase (CAT) and superoxide dismutase (SOD) activities in comparison with the rotenone group PB / 0.05). There was no significant difference in nitric oxide (NO) level between groups. There were negative correlations between CAT activity and malondialdehyde (MDA) level (r= -0.934, P <0.05) with between CAT and SOD activities (r= -0.714, P <0.05), and a positive correlation between SOD activity and MDA level (r= 0.828, P <0.05) in rotenone group. In the rotenone plus erdosteine group, there was a negative correlation between XO activity and NO level in liver tissue (r= -0.833, P -0.05). In the light of these findings, erdosteine may be a protective agent for rotenone-induced liver oxidative injury in rats.

Aspartame induced cardiac oxidative stress in Wistar albino rats

2016 ◽  
Vol 30 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Arbind Kumar Choudhary ◽  
Lognatahan Sundareswaran ◽  
Rathinasamy Sheela Devi
Keyword(s):  
Oxidative Stress ◽  
Albino Rats ◽  
Wistar Albino Rats
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