Lead induced thyroid dysfunction in Wistar albino rats and its amelioration with <i>Ocimum sanctum </i>leaf extract and #8211; a hormonal and histopathological study

2012 ◽  
Vol 1 (1) ◽  
pp. 12
Author(s):  
Karamala Sujatha ◽  
Chinthamaneni Srilatha ◽  
Tammineedu Rao ◽  
Pidugu Amaravathi
Keyword(s):  
Leaf Extract ◽  
Thyroid Dysfunction ◽  
Ocimum Sanctum ◽  
Albino Rats ◽  
Histopathological Study ◽  
Wistar Albino Rats

Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level

2009 ◽  
Vol 25 (1) ◽  
pp. 49-57 ◽  
Author(s):  
H Wang ◽  
Z Yang ◽  
B Zhou ◽  
H Gao ◽  
X Yan ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Thyroid Dysfunction ◽  
Albino Rats ◽  
Histopathological Study ◽  
Free T4 ◽  
Serum T3 ◽  
Group 5 ◽  
Group 2 ◽  
Wistar Albino Rats ◽  
The Impact

To assess the roles of dietary protein (Pr) and calcium (Ca) level associated with excessive fluoride (F) intake and the impact of dietary Pr, Ca, and F on thyroid function, 144 30-day-old Wistar albino rats were randomly allotted to six groups of 24 (female:male = 1:1). The six groups were fed (1) a normal control (NC) diet (17.92% Pr, 0.85% Ca = NC group); (2) the NC diet and high F (338 mg NaF [=150 mg F ion]/L in their drinking water = NC+F group); (3) low Pr and low Ca diet (10.01% Pr, 0.24% Ca = LPrLCa group); (4) low Pr and low Ca diet plus high F = LPrLCa+F group; (5) high Pr and low Ca diet plus high F (25.52% Pr, 0.25% Ca = HPrLCa+F group); and (6) low Pr and high Ca diet plus high F (10.60% Pr, 1.93% Ca = LPrHCa+F group). The areas of thyroid follicles were determined by Image-Proplus 5.1, and triiodothyronine (T3), free T3 (FT3), thyroxine (T4), and free T4 (FT4) levels in serum were measured by radioimmunoassay. The histopathological study revealed obviously flatted follicular epithelia cells and hyperplastic nodules, consisting of thyroid parafollicular cells that appeared by excessive F ingestion, on the 120th day. Pr or Ca supplementation reverses the F-induced damage in malnutrition. The serum T3, FT3, T4, and FT4 levels in the NC+F group were significantly decreased and significantly increased in the LPrLCa+F group. Thus, excessive F administration induces thyroid dysfunction in rats; dietary Pr and Ca level play key roles in F-induced thyroid dysfunction.

Acute Toxicity Assessment of Ethanolic Leaf Extract of Macrotyloma uniflorum L. on Wistar Albino Rats

2017 ◽  
Vol 24 (1) ◽  
pp. 22 ◽  
Author(s):  
S. Priyanga ◽  
S. Hemmalakshmi ◽  
B. Vidya ◽  
P. Chella Perumal ◽  
V. K. Gopalakrishnan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Toxicity Assessment ◽  
Albino Rats ◽  
Macrotyloma Uniflorum ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

Hypolipidemic effect of prepared Polyherbal formulations in Wistar albino rats

2021 ◽  
pp. 4314-4320
Author(s):  
Ranjan Kumar Giri ◽  
Sunil Kumar Kanungo ◽  
Saroj Kumar Patro ◽  
Minaketan Sahoo ◽  
Dibya Sundar Panda
Keyword(s):  
Elevated Serum ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Study ◽  
Oral Glucose ◽  
Hypolipidemic Effect ◽  
Standard Drug ◽  
Wistar Albino Rats

Lipid lowering effect of polyherbal formulations using eight different plants was evaluated in triton and diet induced hyperlipidemic models of wistar albino rats. Formulations such as Tablet, Syrup and Suspension inhibited the elevation in serum cholesterol and triglyceride levels on Triton WR 1339 administration rats. The formulations at the same dose level significantly attenuated the elevated serum total cholesterol and triglycerides with an increase in high-density lipoprotein cholesterol in high-fat diet-induced hyperlipidemic rats. The standard drug Niacin showed slightly better effects. The treatment with herbal formulations produced 30-35 percentage improvement in oral glucose tolerance. Similarly all the formulations also reduced the elevated C-reactive protein which is a marker of Hyperlipidemia. In histopathological study it was found that treatment of polyherbal formulation significantly reduced the plaque size in aorta compared with HFD treated control group. The outcome of the study reveals the lipid lowering activity of polyherbal formulations in dyslipidaemic conditions by interfering with the biosynthesis of cholesterol and utilization of lipids.

scholarly journals Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

2019 ◽  
Vol 10 (03) ◽  
pp. 259-271
Author(s):  
Loyce Nakalembe ◽  
Josephine N. Kasolo ◽  
Edward Nyatia ◽  
Aloysius Lubega ◽  
Godfrey S. Bbosa
Keyword(s):  
Leaf Extract ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Phytolacca Dodecandra ◽  
Crude Leaf Extract ◽  
Anti Inflammatory ◽  
Wistar Albino Rats

Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats

2017 ◽  
Vol 13 (1) ◽  
pp. 45-51
Author(s):  
S.B. Obakiro ◽  
L. Bunalema ◽  
J. Gakunga-Nd ◽  
E. Nyatia ◽  
J.P. Waako
Keyword(s):  
Eucalyptus Globulus ◽  
Leaf Extract ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Phyto-nutrient composition and antioxidative potential of ethanolic leaf extract of Sida acuta in wistar albino rats

2015 ◽  
Vol 14 (49) ◽  
pp. 3264-3269 ◽  
Author(s):  
P. Nwankpa ◽  
O. G. Chukwuemeka ◽  
G. C. Uloneme ◽  
C. C. Etteh ◽  
P. Ugwuezumba ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Nutrient Composition ◽  
Albino Rats ◽  
Sida Acuta ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

scholarly journals Antioxidant and Hepatoprotective Potentials of Lasimorpha senegalensis Schott Leaf Extract on Carbon Tetrachloride-induced Liver Damage in Rats

2020 ◽  
pp. 70-78
Author(s):  
Chinyere Blessing Chigor ◽  
Felix Ifeanyi Nwafor ◽  
Edith Ugwuja ◽  
Chisimdi S. Obi
Keyword(s):  
Liver Damage ◽  
Leaf Extract ◽  
Liver Enzymes ◽  
Radical Scavenging Activity ◽  
Research Work ◽  
Radical Scavenging ◽  
Albino Rats ◽  
Endogenous Antioxidants ◽  
Wistar Albino Rats

Aims: The present study assessed the antioxidant and hepatoprotective potentials of the methanolic leaf extract of Lasimorpha senegalensis – a medicinal plant used by the indigenous people of Nigeria to treat hepatitis and feverish conditions. Place and Duration of Study: The research work was conducted in the Department of Pharmacognosy and Environmental Medicine and Department of Plant Science and Biotechnology, both in the University of Nigeria, Nsukka, from May to August, 2019. Methodology: Phytochemical analyses and acute toxicity study of the sample followed standard procedures. In vitro antioxidant assay was by DPPH and H2O2 models. A total of 25 male Wistar albino rats (120 – 150 g) were grouped into five, each group with five animals. Hepatotoxicity was induced with carbontetrachloride (1 ml/kg). The treatment groups (3-5) received extract (200 and 400 mg/kg) and Silymarin (100 mg/kg). Endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase), plasma malondialdehyde and liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphate) were determined after treatment. Results: The results showed the leaf extract had appreciable amounts of bioactive phytochemicals and free radical scavenging activity (IC50 of 0.52 mg/ml and 0.71 mg/ml for DPPH and H2O2 respectively) with no toxicity at 5000 mg/kg. The extract also elevated the endogenous antioxidants and significantly (p ≤ .05) reduced lipid peroxidase and liver enzymes. Conclusion: This report justifies the local use of this plant in the management of various diseases related to oxidative stress and liver damage.

scholarly journals Effects of Tagetes erecta gel on experimentally induced oral ulcer model in rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1844-1848
Author(s):  
Lakshana S ◽  
Vijayalakshmi S ◽  
Dinakar J ◽  
Asok Kumar K
Keyword(s):  
Leaf Extract ◽  
Oral Ulcer ◽  
Albino Rats ◽  
Tagetes Erecta ◽  
Phytochemical Screening ◽  
Standard Drug ◽  
Ulcer Model ◽  
African Marigold ◽  
Wistar Albino Rats ◽  
Erect Leaf

Tagetes erecta(African marigold) has various medicinal values. The present study has been undertaken to evaluate the effects of extracts of the fresh leaves and flowers of Tagetes erecta on oral ulcer models in Wistar albino rats. The anti-ulcer activity of the extracts of tagetes erecta (2.5% and 5%) was compared between the leaf and flower and also with the standard drug, Triamcinolone. Phytochemical screening of plant extract, extract action on oral ulcer and histopathology analysis were carried out. Tagetes erecta leaf and flower extracts have showed the presence of alkaloids, flavonoids, and carotenoids. Results showed that Tagetes erect leaf extract showed significant oral ulcer protective activity (83.6%)  when compared with the standard drug Triamcinolone. In the present work, it can be concluded that the hydro alcoholic leaf and flower extractHistopathologys of Tagetes erectagel have better potential against oral ulcer which supports the traditional claims in folklore medicine.

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