Treatment options in people with COVID19: Selecting the best armamentarium against the novel virus

2020 ◽  
pp. 1
Author(s):  
Khalid Shaikh ◽  
Chandrama Shrestha ◽  
Deep Dutta
Keyword(s):  
Treatment Options ◽  
The Novel ◽  
Novel Virus

scholarly journals Psychological support in times of COVID-19: the Essen community-based CoPE concept

2020 ◽  
Vol 42 (3) ◽  
pp. 649-650 ◽  
Author(s):  
Alexander Bäuerle ◽  
Eva-Maria Skoda ◽  
Nora Dörrie ◽  
Juliane Böttcher ◽  
Martin Teufel
Keyword(s):  
Mental Health ◽  
Treatment Options ◽  
Metropolitan Region ◽  
Federal State ◽  
The Novel ◽  
Individual Freedom ◽  
Community Based ◽  
Psychological Burden ◽  
Ruhr Area ◽  
Novel Virus

Abstract The SARS CoV-2-virus (COVID-19) pandemic is pushing national and international structures to their limits. Little is known about treatment options to combat the novel virus, but the same applies to the effects of COVID-19 on people’s mental health. In Germany, as in many other countries, governmental actions impact peoples’ individual freedom. These highly necessary actions to slow down the spread of the virus, however, are a burden to the community. We established a structured concept to support psychological burdened people in Essen, which is located in the Ruhr area, a metropolitan region with more than 5.1 million inhabitants in the heart of the federal state North Rhine Westphalia. The psychological burden following the spread of the virus and individual restrictions should not be neglected.

scholarly journals Sex Differences in Spatial Activity and Anxiety Levels in the COVID-19 Pandemic from Evolutionary Perspective

2021 ◽  
Vol 13 (3) ◽  
pp. 1110
Author(s):  
Olga Semenova ◽  
Julia Apalkova ◽  
Marina Butovskaya
Keyword(s):  
Environmental Risks ◽  
Economic Losses ◽  
General Level ◽  
The Novel ◽  
Health Attitudes ◽  
Spatial Activity ◽  
Sexual Specialization ◽  
The Face ◽  
Novel Virus ◽  
Virus Spreading

Despite the enforced lockdown regime in late March 2020 in Russia, the phenomenon of the continued virus spreading highlighted the importance of studies investigating the range of biosocial attributes and spectrum of individual motivations underlying the permanent presence of the substantial level of spatial activity. For this matter, we conducted a set of surveys between March and June 2020 (N = 492). We found that an individual’s health attitude is the most consistent factor explaining mobility differences. However, our data suggested that wariness largely determines adequate health attitudes; hence, a higher level of wariness indirectly reduced individual mobility. Comparative analysis revealed the critical biosocial differences between the two sexes, potentially rooted in the human evolutionary past. Females were predisposed to express more wariness in the face of new environmental risks; therefore, they minimize their mobility and outdoor contacts. In contrast to them, the general level of spatial activity reported by males was significantly higher. Wariness in the males’ sample was less associated with the novel virus threat, but to a great extent, it was predicted by the potential economic losses variable. These findings correspond to the evolutionary predictions of sexual specialization and the division of family roles.

scholarly journals COVID 19 Dawn from Wuhan: “The Number Game”

2020 ◽  
Vol 32 (3) ◽  
pp. 564-568
Author(s):  
Sumit Chawla ◽  
Harinder Singh ◽  
Bharti Chawla
Keyword(s):  
Case Fatality ◽  
Epidemiological Data ◽  
Unknown Etiology ◽  
The Novel ◽  
Time Data ◽  
Public Health Response ◽  
Expected Time ◽  
Hospitalization Rates ◽  
Health Response ◽  
Novel Virus

On 31st December 2019, China informed local WHO office of "cases of pneumonia of unknown etiology detected in Wuhan. As of 6th May 2020, there are nearly 3.6 million cases of corona virus infection and approximately 0.25 million deaths worldwide. The real-time data regarding the actual number of cases, as it originates from the epicenter is the key to the estimation of the case fatality rate, hospitalization rates, expected timeline of arrival of contagion, and other epidemiological data. The novel virus has no available literature pertaining to its epidemiological parameters, on which experts can base their estimates and hence the challenge in planning for epidemic management. Bolstering this challenge are the reports alleging under-reporting by Chinese authorities. Alleged toned down numbers could have led to erroneously low estimates contributing to inadequate public health response globally. We conducted a simulation on epidemiological model of COVID-19 to find out expected time off arrival of infections and mortality in different countries and compared this to actual data.

scholarly journals Transforaminal Epidural Balloon Adhesiolysis via a Contralateral Interlaminar Retrograde Foraminal Approach: A Retrospective Analysis and Technical Considerations

2020 ◽  
Vol 9 (4) ◽  
pp. 981
Author(s):  
Chan-Sik Kim ◽  
Yeon-Jin Moon ◽  
Jae Won Kim ◽  
Dong-Min Hyun ◽  
Shill Lee Son ◽  
...  
Keyword(s):  
Iliac Crest ◽  
Treatment Options ◽  
Balloon Catheter ◽  
Radicular Pain ◽  
Treatment Modalities ◽  
Foraminal Stenosis ◽  
The Novel ◽  
Lumbar Foraminal Stenosis ◽  
Transforaminal Approach ◽  
Technical Considerations

Several treatment modalities have been proposed for foraminal stenosis, but the treatment options remain unsatisfactory. Previous studies have shown that transforaminal balloon adhesiolysis may be effective in patients with refractory lumbar foraminal stenosis. However, in patients with a high iliac crest, balloon catheter insertion may be difficult via a conventional transforaminal approach (particularly targeting the L5–S1 foramen). It has been reported that an epidural catheter can be placed easily by a contralateral interlaminar retrograde foraminal approach. Therefore, we applied this approach to L5–S1 transforaminal balloon adhesiolysis in patients with a high iliac crest. We retrospectively analyzed data from 22 patients who underwent combined epidural adhesiolysis and balloon decompression (balloon adhesiolysis) using the novel foraminal balloon catheter via a contralateral interlaminar retrograde foraminal approach. The pain intensity significantly decreased over the three-month period after balloon adhesiolysis (p < 0.001). There were no complications associated with the balloon procedure. The present study suggests that balloon adhesiolysis for L5-S1 foramen via a contralateral interlaminar retrograde foraminal approach may be an effective alternative for patients with a high iliac crest and refractory lumbar radicular pain due to lumbar foraminal stenosis. In addition, detailed procedural aspects are described here.

Ultrasound-guided TriVex™-powered phlebectomy for debulking of peripheral vascular anomalies – A novel treatment technique

2019 ◽  
Vol 34 (8) ◽  
pp. 523-529
Author(s):  
Kurosh Parsi ◽  
Mina Kang ◽  
Anthony Trimboli
Keyword(s):  
Treatment Options ◽  
Symptom Relief ◽  
Surgical Excision ◽  
Target Lesion ◽  
Vascular Anomalies ◽  
Treatment Technique ◽  
The Novel ◽  
Ultrasound Guided ◽  
Surgical Debulking ◽  
Fibrofatty Tissue

Background Large vascular anomalies on the trunk or limbs are rare and prove challenging to treat. Currently, treatment options include conservative management, embolisation, sclerotherapy or surgical excision. Once the lesion has been embolised, or if it spontaneously involutes, the residual fibrofatty tissue may be painful and require debulking. Surgical debulking may be associated with complicated wound healing, infection, scarring and may not be not feasible for large lesions. Method We present our technique of using TriVex™-powered phlebectomy to debulk vascular anomalies. Our modification involved performing sclero-emobolisation on the target lesion first to mitigate the risk of haematoma formation. We also used ultrasound guidance to increase the precision and eliminate the use of TriVex™ illuminator. Results Excellent symptom relief and cosmetic outcome were achieved in three patients treated using this method. Conclusion We believe the novel technique of ultrasound-guided TriVex™-powered system provides a viable alternative to surgical debulking of large or complex vascular anomalies.

scholarly journals A Novel RNA Virus, Macrobrachium rosenbergii Golda Virus (MrGV), Linked to Mass Mortalities of the Larval Giant Freshwater Prawn in Bangladesh

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1120
Author(s):  
Chantelle Hooper ◽  
Partho P. Debnath ◽  
Sukumar Biswas ◽  
Ronny van Aerle ◽  
Kelly S. Bateman ◽  
...  
Keyword(s):  
Virus Assembly ◽  
Rna Virus ◽  
Macrobrachium Rosenbergii ◽  
Freshwater Prawn ◽  
The Novel ◽  
Protein Motifs ◽  
Giant Freshwater Prawn ◽  
Yellow Head Virus ◽  
Novel Virus ◽  
Mass Mortalities

Mass mortalities of the larval stage of the giant freshwater prawn, Macrobrachium rosenbergii, have been occurring in Bangladesh since 2011. Mortalities can reach 100% and have resulted in an 80% decline in the number of hatcheries actively producing M. rosenbergii. To investigate a causative agent for the mortalities, a disease challenge was carried out using infected material from a hatchery experiencing mortalities. Moribund larvae from the challenge were prepared for metatranscriptomic sequencing. De novo virus assembly revealed a 29 kb single-stranded positive-sense RNA virus with similarities in key protein motif sequences to yellow head virus (YHV), an RNA virus that causes mass mortalities in marine shrimp aquaculture, and other viruses in the Nidovirales order. Primers were designed against the novel virus and used to screen cDNA from larvae sampled from hatcheries in the South of Bangladesh from two consecutive years. Larvae from all hatcheries screened from both years were positive by PCR for the novel virus, including larvae from a hatchery that at the point of sampling appeared healthy, but later experienced mortalities. These screens suggest that the virus is widespread in M. rosenbergii hatchery culture in southern Bangladesh, and that early detection of the virus can be achieved by PCR. The hypothesised protein motifs of Macrobrachium rosenbergii golda virus (MrGV) suggest that it is likely to be a new species within the Nidovirales order. Biosecurity measures should be taken in order to mitigate global spread through the movement of post-larvae within and between countries, which has previously been linked to other virus outbreaks in crustacean aquaculture.

scholarly journals COVID-19 and the Heart

2020 ◽  
pp. 1-5 ◽  
Author(s):  
Chaitanya Rojulpote ◽  
Karthik Gonuguntla ◽  
Shivaraj Patil ◽  
Abhijit Bhattaru ◽  
Paco Bravo
Keyword(s):  
Cardiovascular System ◽  
The Novel ◽  
Health Crisis ◽  
Risk Of Death ◽  
Increased Risk ◽  
The World ◽  
Significant Burden ◽  
Coronary Syndromes ◽  
Novel Virus ◽  
Underlying Mechanisms

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19) has resulted in a global health crisis. Prior to the arrival of this viral pandemic, the world was already plagued with a significant burden of cardiovascular disease. With the introduction of the novel virus, the world now faces a double jeapordy. Early reports have suggested an increased risk of death in individuals with underlying cardio-metabolic disorders. The exact effects of COVID-19 on the cardiovascular system are not well determined, however lessons from prior viral epidemics suggest that such infections can trigger acute coronary syndromes, arrhythmias and heart failure via direct and indirect mechanisms. In this article, we aimed to discuss the effects and potential underlying mechanisms of COVID -19 as well as potential implications of treatments targeted against this virus on the cardiovascular system.

In Vivo Performance of a Novel, Anatomically Shaped, Total Meniscal Prosthesis Made of Polycarbonate Urethane: A 12-Month Evaluation in Goats

2017 ◽  
Vol 45 (12) ◽  
pp. 2824-2834 ◽  
Author(s):  
Anne C.T. Vrancken ◽  
Gerjon Hannink ◽  
Wojciech Madej ◽  
Nico Verdonschot ◽  
Tony G. van Tienen ◽  
...  
Keyword(s):  
Treatment Options ◽  
Wear Particles ◽  
The Novel ◽  
Stifle Joint ◽  
Physiological Loading ◽  
Polycarbonate Urethane ◽  
Sham Surgery

Background: Injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, the treatment options for symptomatic patients with total meniscectomy are limited. Therefore, we developed a novel, anatomically shaped, total meniscal implant made of polycarbonate urethane. Purpose: To evaluate the in vivo performance of this novel total meniscal implant. The assessment particularly focused on the implant’s response to long-term physiological loading in a goat model and its chondroprotective capacity in comparison to clinically relevant controls. Study Design: Controlled laboratory study. Methods: Surgery was performed to the stifle joint of 26 female Saanen goats, subdivided into 4 groups: implant, allograft, total meniscectomy, and sham surgery. The sham group’s contralateral joints served as nonoperated controls. After 12 months of follow-up, investigators evaluated implant wear, deformation, and the histopathological condition of the synovium and cartilage. Results: Wear of the implant’s articulating surfaces was minimal, which was confirmed by the absence of wear particles in the synovial fluid. Implant deformation was limited. However, one implant failed by complete tearing of the posterior horn extension. No differences in cartilage histopathological condition were observed for the implant, allograft, and meniscectomy groups. However, locally, the cartilage scores for these groups were significantly worse than those of the nonoperated controls. Conclusion: Whereas this study demonstrated that the novel implant is resistant to wear and that deformation after 12 months of physiological loading is acceptable, reinforcement of the implant horns is necessary to prevent horn failure. Although the implant could not protect the cartilage from developing degenerative changes, the progression of damage was similar in the allograft group. Clinical Relevance: This novel polycarbonate urethane implant may have the potential to become an alternative treatment for symptomatic patients with total meniscectomy.

scholarly journals SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 231 ◽  
Author(s):  
Firas A. Rabi ◽  
Mazhar S. Al Zoubi ◽  
Ghena A. Kasasbeh ◽  
Dunia M. Salameh ◽  
Amjad D. Al-Nasser
Keyword(s):  
Vaccine Development ◽  
Current Knowledge ◽  
Treatment Options ◽  
The Novel ◽  
Clinical Criteria ◽  
Health Authorities ◽  
Close Relationship ◽  
Public Health Authorities ◽  
Molecular Information ◽  
Novel Coronavirus

In December 2019, a cluster of fatal pneumonia cases presented in Wuhan, China. They were caused by a previously unknown coronavirus. All patients had been associated with the Wuhan Wholefood market, where seafood and live animals are sold. The virus spread rapidly and public health authorities in China initiated a containment effort. However, by that time, travelers had carried the virus to many countries, sparking memories of the previous coronavirus epidemics, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and causing widespread media attention and panic. Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. Here we present a summary of current knowledge regarding the novel coronavirus and the disease it causes.

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