Correlation of bleeding time and clotting time with ABO blood grouping among 1-year medical students

Author(s):  
Shankar Gupta ◽  
Pritika Dutta ◽  
Shomi Anand ◽  
Rajeev Kanchan
1970 ◽  
Vol 1 (4) ◽  
pp. 135-140 ◽  
Author(s):  
Bedanta Roy ◽  
Indrajit Banerjee ◽  
Brijesh Sathian ◽  
Monami Mondal ◽  
Chhanchu Gopal Saha

Background Blood group, Bleeding Time and Clotting time are clinically useful tests, extensively used during blood transfusion, platelet disorders and a variety of forms of treatment in hospitals. The objective of our study was to assess the country wise distribution of blood groups and to compare the country wise bleeding time and clotting time with respect to blood group. Material and Methods This Observational Study has been performed at Manipal College of Medical Sciences, during the period of 1st May 2010 to 31st August–2011. The study was carried out on the undergraduate medical students of Basic sciences and included assessment of Bleeding time, Clotting time and Blood grouping by standard procedures. Results 261 medical students participated in the study. Among the Nepalese students, 30.5% had blood group A, 28.9% B, 5.5% AB and remaining 35.2% O. among the Indian students, 22.8% were blood group A, 45.7% B, 7.6% AB and 23.9% O. In Sri Lankan students, 22% had blood group A, 19.5% B, 4.9% AB, and 53.7% blood group O. Among Nepalese students, BT was higher in blood group A (163.85 seconds) as compared to Indians (154.29Sec) and Sri Lankans (133.33 sec). Nepalese students with AB blood group had higher BT (171.43 sec). Indian students with blood group A had comparatively higher clotting time (328.57 sec) followed by Nepali (276.15 sec) and then Sri Lankan students (270 sec). Girls are 4.432 times more prone for bleeding time greater than 4 minutes and 2.453 times for clotting time value above 6 minutes as compared to males. Conclusion Our study suggests that O blood group is predominant in Nepalese students while Blood group B was the most common blood group in the Indian students. We found higher BT and CT in females, which are more prominent in Indians, so this gender disparity is an additional risk factor for them. Health Ministries of respective countries have to improve the proper health care policies required for prevention and management of blood group diseases, bleeding time and clotting time related disorders like Hypoprothrombinemia and Thrombocytopenia.http://dx.doi.org/10.3126/nje.v1i4.5755 Nepal Journal of Epidemiology 2011;1(4):135-140


2020 ◽  
Vol 1 (2) ◽  
pp. 19-23
Author(s):  
Seerina Adhikari Manandhar ◽  
Mrigendra Amatya

Introduction: Blood grouping, bleeding time (BT) and clotting time (CT) are important hematological parameters investigated before any surgical procedure. The association of blood groups with many diseases are established, such as epistaxis with blood group “O”. This study aimed to assess the relationship of BT and CT among different blood groups and to find any gender difference in these parameters. Materials and methods: A cross-sectional observational study was conducted among healthy medical students. Blood grouping was done by agglutination method, BT by Duke’s method, and CT by capillary tube method. Mean bleeding and clotting times (seconds) were compared among groups. Results: The study was completed in 351 students (160 males, 191 females), with age ranging from 19-23 years. Both BT and CT values were highest in the blood type O, BT was lowest in type B, and CT was lowest in type AB, although the differences were statistically not significant (p>0.15). Females had higher values of BT as well as CT than males (p values <0.001). A very highly significant correlation between the bleeding and clotting times was also noticed (Pearson’s correlation coefficient, P = 0.495, p<0.001). Conclusions: The study hinted a tendency for higher risk for hemorrhagic condition and lower risk for thrombotic event in blood group O compared to groups A, B or AB. Multicentric study including larger population with the emphasis on finding plasma vWF level may be helpful to verify findings, identify the risk groups, and take prior preventive measures.


1997 ◽  
Vol 77 (06) ◽  
pp. 1148-1153 ◽  
Author(s):  
Kazuhisa G Minamiguchi ◽  
Keiko T Kitazato ◽  
Eiji Sasaki ◽  
Hideki Nagase ◽  
Kenji Kitazato

SummaryWe studied the use of depolymerized holothurian glycosaminoglycan (DHG) as an anticoagulant in experimental beagle-dog hemodialysis using a hollow-fiber dialyzer compared to that using unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), and nafamostat mesilate (FUT). Effectiveness was based on 5 h hemodialysis and no marked clot deposition in the extracorporeal circuit. At effective doses, UFH and LMWH significantly prolonged template bleeding time, in sharp contrast to FUT and DHG, which scarcely prolonged bleeding time during hemodialysis. DHG prolonged activated partial thromboplastin time (APTT) about 6 times that of normal plasma and prolonged thrombin clotting time (TCT) markedly; FUT showed marked APTT prolongation but hardly prolonged TCT in the hemodialysis circuit at the effective dose. The anticoagulant profile of DHG thus differs completely from that of FUT. These results suggest that DHG may be useful as anticoagulant for hemodialysis with low hemorrhagic risk.


2019 ◽  
Vol 2 (1) ◽  
pp. 217-222
Author(s):  
Dhio Emerko Ginting ◽  
Fani Ade Irma ◽  
Sri Rezeki Arbaningsih ◽  
Siti Hajar

WHO telah menetapkan Indonesia sebagai negara dengan jumlah perokok terbesar ketiga. Ada tiga zat kimia yang paling sangat berbahaya, yaitu tar, nikotin, karbon monoksida yang terkandung dalam rokok. Hasil penelitian di Inggris menunjukkan kepada kita bahwa kurang lebih 50% perokok yang merokok sejak remaja mengalami kematian akibat penyakit yang berhubungan dengan kebiasaan merokok mereka. Penelitian ini bertujuan untuk mengetahui tentang pengaruh asap rokok dengan proses kaskade clotting time. Jenis penelitian ini adalah penelitian analitik dengan menggunakan desain cross-sectional. Penelitian ini menggunakan sampel populasi laki-laki di Fakultas Kedokteran di UMSU yang diwawancara untuk mengetahui bahwa mereka merokok atau tidak, setelah itu, sampel diperiksa clotting time dan bleeding time. Data yang terkumpul dianalisis dengan uji chi-square. Hasil penelitian menunjukkan p = 0,000 bahwa ada hubungan merokok dengan clotting time dan bleeding time pada perokok berat dan sedang. Pada perokok berat dan moderat terdapat hubungan bermakna antara penurunan bleeding time dan peningkatan clotting time dengan merokok. Tidak ada hubungan antara clotting time dan merokok pada perokok ringan.


2003 ◽  
Vol 7 (2) ◽  
pp. 145-153
Author(s):  
Yasunari Hisashi ◽  
Tatsuo Shinozuka ◽  
Osamu Ohue ◽  
Setsuko Takei ◽  
Ayako Ro ◽  
...  

2020 ◽  
Vol 7 (4) ◽  
pp. 44-51
Author(s):  
NGUM Lesley NGUM ◽  
Palmer Masumbe Netongo ◽  
Jean Paul Chedjou ◽  
Stephane Herve Mpopo ◽  
Wilfred Mbacham

2018 ◽  
Vol 8 (2) ◽  
pp. 102
Author(s):  
AbhishekSingh Nayyar ◽  
KV Chalapathi ◽  
G Kartheek ◽  
K Pramod ◽  
AbhishekRanjan Pati ◽  
...  

Author(s):  
Arumugam P. ◽  
Swathandran Hamsavardhini ◽  
Ravishankar J.

Background: ABO discrepancies occur whenever the results of red cell grouping and serum grouping are in disagreement. The reasons for discrepancies both clinical and technical have to be sorted out. Further analysis is essential to resolve such discrepancies. If discrepancies are encountered, the interpretation of the ABO grouping has to be delayed until the same has been resolved. The aim of the study was to resolve ABO discrepancies encountered, by serological work up.Methods: All cases of discrepant samples received between August 2014 and May 2016 at the Department of Transfusion Medicine, The Tamilnadu Dr. MGR Medical University, Chennai, India were analyzed to determine the etiology by serological workup.Results: A total of twenty-one samples were analyzed and resolved. Fifteen cases of Type IV discrepancy, two cases of Type II discrepancy, one case Type III discrepancy, one case Type I discrepancy and two cases of technical errors were identified.Conclusions: ABO discrepancies can be resolved serologically if properly worked up. As ABO blood grouping is indispensible in blood transfusion service, it is imperative to resolve such discrepancies before transfusion.


1969 ◽  
Vol 3 (2) ◽  
pp. 318-322
Author(s):  
MUHAMMAD KHALID ◽  
NAILA ASLAM ◽  
MUHAMMAD SIYAR ◽  
RASHID AHMAD

OBJECTIVE: To find out the distribution of ABO and Rh (D) blood groups among blood donors in districtMardan and to help transfusion services in the area.STUDY DESIGN: Cross sectional descriptive study.MATERIALS AND METHODS: The study was conducted in DHQ Hospital Mardan from 1st January2012 to 31st December 2012. A total of 2893 healthy adult, blood donors (both volunteer and directed) fromdistrict Mardan were included. Two ml of blood anti-coagulated with EDTA was taken and both ABO andRh (D) blood groups were determined using commercially available anti-sera of Biolaboratories. Thedistribution ofABO and Rh blood groups in the local community were then calculated.RESULTS: Among ABO blood groups “ B” (27.97%) was the most prevalent, followed by “0” (27.93%),“ A” (24.75%) and “ AB” (19.36%). Group Rh positive (94.30%) was more prevalent than Rh negative(5.70%). Similarly 0+ve (26.65%) was most frequent followed by B+ve (26.17%), A+ve (23.16%), AB+ve(18.32%), B've(1.80%),Ave(l.59%),O ve( 1.28%) and ABve( 1.04%).CONCLUSION: Blood group 'B' was most frequent among the ABO blood groups and Rh (D) positiveamong Rh blood groups while0+vewas the most frequent blood group in the study population.KEYWORDS: ABO Blood grouping, Rh (D) blood grouping, Mardan.


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