Evaluation of protective role of nifedipine on lipid peroxidation using reduced glutathione as model marker

2012 ◽  
Vol 1 (2) ◽  
pp. 97 ◽  
Author(s):  
Supratim Ray ◽  
Selim Mondal ◽  
Nilanta Dana
Keyword(s):  
Lipid Peroxidation ◽  
Reduced Glutathione ◽  
Protective Role

Protective role of Royal Jelly (honeybee) on genotoxicity and lipid peroxidation, induced by petroleum wastewater, inAllium cepaL. root tips

2009 ◽  
Vol 30 (11) ◽  
pp. 1205-1214 ◽  
Author(s):  
Zafer Türkmen ◽  
Kültiğin Çavuşoğlu ◽  
Kürşat Çavuşoğlu ◽  
Kürşad Yapar ◽  
Emine Yalçin
Keyword(s):  
Lipid Peroxidation ◽  
Royal Jelly ◽  
Protective Role ◽  
Root Tips

Protective Role of Raphanus Sativus Root Extract on Paracetamol-Induced Hepatotoxicity in Albino Rats

2007 ◽  
Vol 77 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Chaturvedi ◽  
George ◽  
Machacha
Keyword(s):  
Lipid Peroxidation ◽  
Raphanus Sativus ◽  
Thiobarbituric Acid ◽  
Protective Role ◽  
Albino Rats ◽  
Root Extract ◽  
Dependent Manner ◽  
Dose Dependent ◽  
Serum Glutamate

The methanol extract of Raphanus sativus root extract showed a protective effect on paracetamol-induced hepatotoxicity in a dose-dependent manner. Degree of lipid peroxidation caused by paracetamol was measured in terms of thiobarbituric acid reactive substances (TBARS) and protection was measured in reference to serum glutamate oxaloacetate transaminase (SGOT), serum glutamate aspartate transaminase (SGPT), and blood and hepatic levels of antioxidants like glutathione and catalase. Administration of extract along with paracetamol showed significant protection. Levels of TBARS were found to be low, activities of SGOT and SGPT were low, while hepatic glutathione levels were significantly higher in experimental rats that received the mixture of paracetamol and the extract as compared to rats that received paracetamol only. Activities of catalase were also high in all experimental groups. Thus this study indicates the involvement of Raphanus sativus root extract with antioxidants like glutathione and catalase in rendering protection against paracetamol-induced lipid peroxidation and hepatotoxicity.

A Preliminary Clinical Study of Cyclophosphamide with Reduced Glutathione Asc Uroprotector

1989 ◽  
Vol 75 (3) ◽  
pp. 257-258 ◽  
Author(s):  
Maria Teresa Nobile ◽  
Maria Giuseppina Vidili ◽  
Marco Benasso ◽  
Marco Venturini ◽  
Michele Tedeschi ◽  
...  
Keyword(s):  
Clinical Study ◽  
Reduced Glutathione ◽  
Protective Role ◽  
Experimental Models ◽  
Microscopic Hematuria ◽  
Clinical Use ◽  
Thiol Compound ◽  
Preliminary Results

Reduced glutathione (GSH) has been reported to be an effective protector against cyclophosphamide-induced urotoxicity in experimental models, providing protection comparable to that of mesna. This paper describes our preliminary results of the clinical use of GSH in combination with cyclophosphamide. GSH was administered i.v. in two divided doses of 2.5 g, 15 min before and 30 min after escalating doses of cyclophosphamide ranging from 1.2 up to 1.6 g/m2 (1-h infusion). GSH was well tolerated and did not produce unexpected toxicity. The lack of bladder damage, including microscopic hematuria, supports the protective role of this thiol compound.

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