scholarly journals TOXICOLOGICAL STUDY OF SURYASHEKHARA RASA

2020 ◽  
Vol 8 (10) ◽  
pp. 4610-4616
Author(s):  
Shanta Patil ◽  
Surekha S Medikeri
Keyword(s):  
Acute Toxicity ◽  
Functional Group ◽  
Research Work ◽  
Toxic Substance ◽  
Signs And Symptoms ◽  
Toxicity Study ◽  
Acute Administration ◽  
Acute Toxicity Study ◽  
Albino Mice ◽  
Harmful Effects

Suryashekhara Rasa is unique mercurial preparation, which contains Parada, Gandhaka, Hingula and Vatsanabha. The quantity of Vatsanabha is equal to the sum of other ingredients, and also its antidote (Tankana) is not mentioned in this formulation. To ensure that the drug is devoid of toxicity and harmful effects, assessing the level of toxicity is important. So, this research work is an attempt to perform acute and sub-acute toxicity evaluation of Suryashekhara Rasa. Acute toxicity study of test drug was carried at a limit dose of 2000mg/kg orally in albino mice. For sub-acute toxicity Suryashekhara rasa was adminis-tered at therapeutic equivalent dose (TED) (0.35mg/kg bw po), TED x 2 (0.70mg/kg bw po) TED x 5 (1.75 mg/kg bw po) for 28 days. Acute toxicity result showed that drug did not produce any signs and symptoms of toxicity or mortality up to an oral dose of 2000 mg/kg in albino mice. The data generated during sub-acute toxicity study are indicated that it is mild toxic substance for sub-acute administration at TED dose level, may be because of alkanes which are found in functional group of aconitum ferox.

scholarly journals Preliminary acute toxicity study on imidacloprid in Swiss albino mice

2013 ◽  
Vol 6 (12) ◽  
pp. 955-959 ◽  
Author(s):  
Preeti Bagri ◽  
Vinod Kumar ◽  
Anil Kumar Sikka ◽  
Joginder Singh Punia
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Swiss Albino Mice ◽  
Acute Toxicity Study ◽  
Albino Mice

Acute and 28-days repeated dose sub-acute toxicity study of gallic acid in albino mice

2019 ◽  
Vol 101 ◽  
pp. 71-78 ◽  
Author(s):  
Bhavesh C. Variya ◽  
Anita K. Bakrania ◽  
Prem Madan ◽  
Snehal S. Patel
Keyword(s):  
Acute Toxicity ◽  
Gallic Acid ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Acute Toxicity Study ◽  
Albino Mice

scholarly journals Anti-tussive activity of Shwasakuthara Rasa a Herbomineral formulation prepared with and without Kajjali (Black Sulphide of Mercury) in SO2 induced cough in Swiss albino mice

2016 ◽  
Vol 5 (2) ◽  
pp. 50-52
Author(s):  
B R Bhagyalakshmi ◽  
◽  
R Galib ◽  
Mukesh Nariya ◽  
PK Prajapati ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Sulphur Dioxide ◽  
Respiratory Diseases ◽  
Female Rats ◽  
Control Group ◽  
Acute Administration ◽  
Cough Reflex ◽  
Acute Toxicity Study ◽  
Albino Mice

Introduction: Kajjali is considered as the base in maximum Rasa Yogas (Herbo-mineral formulations). Shwasakuthara Rasa (SKR) is a well-known herbo-mineral formulation indicated in different kinds of Shwasa (respiratory diseases) and Kasa (cough) having Kajjali as a base ingredient. The present study is to evaluate the acute toxicity and anti-tussive activity of SKR one prepared with Kajjali (SKR1) and another without Kajjali (SKR2) in sulphur dioxide induced cough model in albino mice. Materials and Methods: Acute toxicity study was carried as per the OECD 425 guideline in wistar female rats. Anti-tussive activity was carried out against sulphur dioxide-induced cough reflex in mice. Results: Animals did not manifest any signs of toxicity and mortality at the dose of 2000mg/kg body weight, orally. Both test drugs (32.5 mg/kg, po) showed significant reduction in cough reflexes compared with control. SKR1 showed pronounced anti-tussive activity followed by SKR2 when compared to control group. Conclusion: The presence of Kajjali in the formulation is safe on acute administration and further enhances anti-tussive activity of the formulation may be due to increasing bioavailability of Ayurvedic formulation.

scholarly journals Moringa oleifera hydorethanolic leaf extract induced acute and sub-acute hepato-nephrotoxicity in female ICR-mice

2021 ◽  
Vol 104 (4) ◽  
pp. 003685042110042
Author(s):  
Abdullahi Aliyu ◽  
Mohd Rosly Shaari ◽  
Nurul Syahirah Ahmad Sayuti ◽  
Farhan Hanif Reduan ◽  
Shanmugavelu Sithambaram ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Acute Toxicity ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Toxicity Study ◽  
Acute Administration ◽  
Oral Gavage ◽  
Icr Mice ◽  
Sinusoidal Dilatation ◽  
Acute Toxicity Study

Moringa oleifera (M. oleifera) Lam belongs to the family Moringaceae. It is an important multipurpose tree that is largely distributed globally and has been used almost in every aspect of traditional medicine for the treatment of various illnesses including cancers, diabetes mellitus, asthma, arthritis, etc. This study investigated the effects of oral acute and sub-acute administration of M. oleifera hydroethanolic leaf extract (MOHE) in ICR-mice. Its major phenolic compounds were also determined. Ten (10) female, 8-week old mice were grouped into control and treatment groups for acute toxicity study. A dose of 2000 mg/kg MOHE was given once to the treatment group via oral gavage. However, for the sub-acute toxicity study, 25 mice were grouped into groups A (control), B (125 mg/kg), C (250 mg/kg), D (500 mg/kg) and E (1000 mg/kg). MOHE was given via oral gavage to groups B, C, D and E daily for 28 days. Group A received only distilled water. The mice were sacrificed at the end of the experiments and samples were collected for evaluation. The results of the chemical profiling of MOHE revealed the presence of glucomoringin, niaziminine, quercetin and kaempferol as the major compounds. The treated mice in the acute toxicity study were slightly anaemic and showed evidence of stress leukogram. Moreover, a slight increase in creatinine, significant increases in AST and CK, hepatic degeneration and necrosis, none-obstructive sinusoidal dilatation, renal tubular necrosis, interstitial nephritis and renal interstitial oedema were observed. It is concluded that the LD50 of MOHE is higher than 2000 mg/kg. However, oral administration of MOHE causes acute mild anaemia and moderate hepato-nephrotoxicity in ICR-mice. Its major phenolic compounds are glucomoringin, niaziminine, quercetin and kaempferol.

An experiemental study to evaluate the principle Trini Dravyani Nati Upayunjita w.s.r. to Kshara (Alkali)

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Amrita Paul ◽  
Umapati C. Baragi ◽  
Kashinath Hadimur ◽  
R. A. Deshmukh
Keyword(s):  
Acute Toxicity ◽  
Adverse Effects ◽  
Dose Level ◽  
Behavioral Changes ◽  
Toxicity Study ◽  
Fixed Dose ◽  
Albino Rats ◽  
Acute Administration ◽  
Acute Toxicity Study ◽  
Acute Study

Background: In Charaka Samhita it has been mentioned that three medicinal substances viz. Pippali (Piper longum), Kshara (alkali) and Lavana (salt) can be used as emergency medicine, but they should not be consumed in excess (Ati Upayunjita). If they are consumed in excess quantity they will cause several adverse effects in the body. Hence in the present study Kshara has been evaluated in experimental animals in two different phases viz. acute administration at graded doses as part of acute toxicity study and sub-acute administration at fixed dose level, as part of sub-acute toxicity study, to assess the possible adverse effects if any. Objectives: To evaluate the acute and sub-acute toxic effect of Kshara in albino rats to establish the principle of Trini Dravyani Nati Upayunjita. Materials and Methods: Wister strain albino rats of either sex weighing between 150 - 200g body weights were used for experimental study. The experiment was carried out as per ‘Ayush Guidelines’ after the IAEC clearance. For Acute Toxicity - 9 Albino rats were used and for Sub-Acute Toxicity - 12 Albino rats were used. The dose calculation was done on the basis of body surface area ratio using the table of ‘Paget and Barnes rule’. Results: In Acute toxicity study no mortality and behavioral changes were observed when the drug Kshara was studied after two dose level i.e. TED X 5 and TED X 10. In Sub-acute study some behavioral changes (including cage side behavior) were observed. No mortality was observed in any of the groups. Discussion: Acute toxicity study of Kshara showed no immediate and evident toxic signs and mortality within 24 hours of observation. In Sub-acute toxicity study in all four groups, no mortality or evident toxic effects were observed, however some mild histopathological changes were observed in sub-acute study.

EVALUATION OF TOXICITY AND ANTIASTHMATIC POTENTIAL OF AN AYURVEDIC FORMULATION ON EXPERIMENTAL ANIMALS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (02) ◽  
pp. 61-67
Author(s):  
Manisha Sahu ◽  
Raj K. Tiwari ◽  
Vikas Sharma ◽  
Shiv S. Shukla ◽  
Ravindra K. Pandey ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Chronic Toxicity ◽  
Marked Decrease ◽  
Signs And Symptoms ◽  
Toxicity Study ◽  
Experimental Animals ◽  
Acute Toxicity Study ◽  
Guinea Pig Model ◽  
Dose Levels ◽  
Oral Acute Toxicity

The aim of this study was to explore acute and chronic toxicity as well as antiasthmatic potential of the ayurvedic formulation Nayopayam Kashayam on experimental animals. The present study was targeted for the study of its toxicity profile along with its antiasthmatic activity. The acute toxicity study was carried out using OECD 425 CPCSEA guideline in albino wistar rats. Oral acute toxicity study was performed at 2000mg/kg orally, which was considered as limit dose. The chronic toxicity study was carried out with administration of Nayopayam Kashayam at three therapeutic equivalent doses i.e. TED (45mg/kg, orally), TEDx5 (225 mg/kg, orally) and TEDx10 (450 mg/kg, orally) for 90 days. Further, antiasthmatic study was carried out using histamine-induced bronchospasm in guinea pig model. The results of acute toxicity studies showed that drug did not create any signs and symptoms of toxicity and no mortality was shown to an oral dose of 2000 mg/kg in rats. The results of chronic toxicity study showed that the drug even at level as high as dose of TEDx10 had no significant effect at all on hematological and body weight parameters, however mild to moderate unfavorable changes in kidney and liver were indicated. The experiential changes were not seen at the lower dose levels. The drug also showed a marked decrease in hiccups of asthma during antiasthmatic study. Hence, it is suggested that the Nayopayam Kashayam, prepared as per the traditional method, is secured/safe for utilization and treatment of asthma at the therapeutic dose level.

Sign in / Sign up

Export Citation Format

Share Document