scholarly journals Bauhinia guianensis Aubl., a Plant from Amazon Biome with Promising Biologically Active Properties: A Systematic Review

2021 ◽  
Vol 15 (29) ◽  
pp. 76-81
Author(s):  
Rosemary de Carvalho Rocha Koga ◽  
Abrahão Victor Tavares de Lima Teixeira dos Santos ◽  
Rosângela do Socorro Ferreira Rodrigues Sarquis ◽  
José Carlos Tavares Carvalho
Keyword(s):  
Systematic Review ◽  
Biologically Active

scholarly journals SPIRULINA – A WONDER NUTRACEUTICAL AGAINST CANCER: A REVIEW

2021 ◽  
Vol 21 (No 1) ◽  
Author(s):  
Kawalpreet Kaur ◽  
Saranjeet Kaur
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Biologically Active ◽  
Human Cell Lines ◽  
Endonuclease Activity ◽  
Blue Green Alga ◽  
Skin Cancers ◽  
Mechanism Of Carcinogenesis ◽  
Induction Of Apoptosis

Spirulina, a filamentous and spiral-shaped blue-green alga, contains an array of bioactive compounds and has emerged to be a nutraceutical. It has a unique blend of around 70 biologically active compounds which enhances its therapeutic significance. Its role against carcinogenesis can be attributed to its antioxidant and anti-inflammatory properties due to the presence of ingredients like C-Phycocyanin, ?-Carotene, Calcium Spirulan, Linoleic and Linolenic acids. Spirulina extracts were shown to enhance endonuclease activity, DNA repair and induction of apoptosis in cells. Some studies also reported myelosuppression and enhanced immune function. Murine studies indicated there was a possibility of reversing the mechanism of carcinogenesis, particularly in oral, stomach, breast and skin cancers as well as in doxorubicin, cyclophosphamide and DBMA-induced tumours. Spirulina also appeared to reduce cardio-, nephro- and hepato-toxicity in rodents. The chemo and radioprotective effect of Spirulina was also observed in various carcinogenic human cell lines. The C-phycocyanin component was shown to induce apoptosis in HeLa cells in vitro. Commercially available Spirulina is administered as an adjunct to chemotherapy. The evidence of effectiveness of Spirulina in cancer is extremely limited as far as the clinical trials are concerned. The Spirulina studies conducted on various types of carcinogenesis show a degree of similitude but are in a haphazard state. The current anatomization is an attempt on part of the authors to coalesce all the contemporaneous data and create a systematic review.

scholarly journals Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

2019 ◽  
Vol 12 (4) ◽  
pp. 172 ◽  
Author(s):  
Renata Matraszek-Gawron ◽  
Mirosława Chwil ◽  
Paulina Terlecka ◽  
Michał M. Skoczylas
Keyword(s):  
Systematic Review ◽  
Antidepressant Activity ◽  
Biologically Active ◽  
World Health ◽  
Depression Symptoms ◽  
Bioactive Substances ◽  
Treatment Of Depression ◽  
Potential Alternative ◽  
Health Organization ◽  
Pharmaceutical Agents

Herbal therapy is a potential alternative applied to pharmacological alleviation of depression symptoms and treatment of this disorder, which is predicted by the World Health Organization (WHO) to be the most serious health problem worldwide over the next several years. It has been well documented that many herbs with psychotropic effects have far fewer side effects than a variety of pharmaceutical agents used by psychiatrists for the treatment of depression. This systematic review presents literature data on the antidepressant activity of representatives of the genera Hemerocallis (H. fulva and H. citrina Baroni, family Xanthorrhoeaceae) and Gladiolus (G. dalenii, family Iridaceae) and on biologically active compounds and their mechanisms of action to consider the application of herbal preparations supporting the treatment of depression.

Nobiletin a Biologically Active Phytoconstituent: Systematic Review

2021 ◽  
Vol 11 (3) ◽  
pp. 204-211
Author(s):  
Alok P Singh ◽  
Jai B Kandpal ◽  
Rajeev K Sharma ◽  
Havagiray Chitme
Keyword(s):  
Systematic Review ◽  
Biologically Active

scholarly journals Antimicrobial Activity of Cerium Oxide Nanoparticles on Opportunistic Microorganisms: A Systematic Review

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Isabela Albuquerque Passos Farias ◽  
Carlos Christiano Lima dos Santos ◽  
Fábio Correia Sampaio
Keyword(s):  
Systematic Review ◽  
Antimicrobial Activity ◽  
Cerium Oxide ◽  
Biologically Active ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Chloride Salt ◽  
Synthesis Of Nanoparticles ◽  
New Antibiotics ◽  
Meta Analyses

An evaluation of studies of biologically active nanoparticles provides guidance for the synthesis of nanoparticles with the goal of developing new antibiotics/antifungals to combat microbial resistance. This review article focuses on the physicochemical properties of cerium oxide nanoparticles (CeNPs) with antimicrobial activity. Method. This systematic review followed the Guidelines for Transparent Reporting of Systematic Reviews and Meta-Analyses. Results. Studies have confirmed the antimicrobial activity of CeNPs (synthesized by different routes) using nitrate or chloride salt precursors and having sizes less than 54 nm. Conclusion. Due to the lack of standardization in studies with respect to the bacteria and CeNP concentrations assayed, comparisons between studies to determine more effective routes of synthesis are difficult. The mechanism of CeNP action likely occurs through oxidative stress of components in the cell membrane of the microorganism. During this process, a valence change occurs on the CeNP surface in which an electron is gained and Ce4+ is converted to Ce3+.

scholarly journals Examining Evidence of Benefits and Risks for Pasteurizing Donor Breastmilk

2021 ◽  
Vol 1 (3) ◽  
pp. 408-425
Author(s):  
Margaret E. Coleman ◽  
D. Warner North ◽  
Rodney R. Dietert ◽  
Michele M. Stephenson
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Health And Safety ◽  
Biologically Active ◽  
Evidence Map ◽  
Analysis Methodology ◽  
Benefit Risk Assessment ◽  
Starting Point ◽  
Microbial Risks ◽  
State Of The Science

An evidence map is visualized as a starting point for deliberations by trans-disciplinary stakeholders, including microbiologists with interests in the evidence and its influence on health and safety. Available evidence for microbial benefits and risks of the breastmilk ecosystem was structured as an evidence map using established risk analysis methodology. The evidence map based on the published literature and reports included the evidence basis, pro- and contra-arguments with supporting and attenuating evidence, supplemental studies on mechanisms, overall conclusions, and remaining uncertainties. The evidence basis for raw breastmilk included one benefit–risk assessment, systematic review, and systematic review/meta-analysis, and two cohort studies. The evidence basis for benefits was clear, convincing, and conclusive, with supplemental studies on plausible mechanisms attributable to biologically active raw breastmilk. Limited evidence was available to assess microbial risks associated with raw breastmilk and pasteurized donor milk. The evidence map provides transparent communication of the ‘state-of-the-science’ and uncertainties for microbial benefits and risks associated with the breastmilk microbiota to assist in deeper deliberations of the evidence with decision makers and stakeholders. The long-term aims of the evidence map are to foster deliberation, motivate additional research and analysis, and inform future evidence-based policies about pasteurizing donor breastmilk.

scholarly journals Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2194
Author(s):  
Monica Guberti ◽  
Stefano Botti ◽  
Maria Teresa Capuzzo ◽  
Sara Nardozi ◽  
Andrea Fusco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Current Knowledge ◽  
Pediatric Population ◽  
Case Series ◽  
Early Period ◽  
Well Being ◽  
Bovine Colostrum ◽  
Biologically Active ◽  
Cochrane Library ◽  
System Response

Colostrum is the first secretion of mammalian glands during the early period after birth giving. Its components are biologically active and have beneficial effects on new-born growth and well-being. Bovine colostrum has the highest concentration of these substances and its supplementation or application may provide health benefits. This systematic review was conducted to update current knowledge on bovine colostrum effects including all administration routes on healthy and sick subjects. Full texts or abstracts of twenty-eight papers as reports of systematic reviews, randomized controlled trials, observational studies and case series were included after searches in Medline, Embase, Cochrane Library and Cinahl databases. The full texts of selected studies were assessed for quality using validated tools and their results were summarized in different categories. Studies were highly heterogeneous as regards to population, intervention, outcome and risk of bias. Bovine colostrum topical application was shown effective on vaginal dryness related symptoms limitation. Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen, modulating immune system response and reducing intestinal permeability in healthy and sick subjects. Conflicting results were provided in pediatric population and little evidence is available on its use with older adults. Further studies are mandatory to better understand all factors influencing its activity.

scholarly journals A systematic review on the efficacies and therapeutic interventions of homoeopathic medicines in combating viral disorders with implications in the currently undergoing homoeopathic treatment efforts of SARS-CoV-2 infection (COVID-19)

2021 ◽  
Vol 19 (3) ◽  
pp. 27-39
Author(s):  
Joy Kumar Dey ◽  
Anupam Mukherjee ◽  
Sanjay Kumar Dey ◽  
Abhishek Pramanik ◽  
Shashi Giri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Middle Eastern ◽  
Biologically Active ◽  
Therapeutic Interventions ◽  
In Vivo Studies ◽  
The Public ◽  
Corona Virus ◽  
Global Epidemiology

The prevalence of Severe Acute Respiratory Syndrome- Corona Virus-2 (SARS-CoV-2) has undergone a historic transition from December 2019 to June 2020. Under the current circumstances, SARS-CoV-2 has become a key problem for the public health and economic steadiness of the global fraternity. Based on ample evidences from the global epidemiology of SARS-CoV-2 and MERS-CoV (Middle Eastern Respiratory Syndrome- Corona virus) scientists and physicians strappingly consider these viruses share structural and functional similarities of selected biologically active enzymes namely, 3CLpro, PLpro and RdRp. Ultra-diluted homoeopathic medicine has the legacy to combat infectious as well as viral diseases since last two centuries. Thus, a systematic review on existing antiviral homoeopathic therapies was done in the current study and the need of appropriate clinical validation with proper in vitro as well as in vivo studies prior to make clinical endorsements in treating Covid-19 patients with homoeopathic medicines has been explained. A brief summary of the currently undergoing or recently completed homoeopathic treatments of COVID-19 has also been provided to attract many more similar homoeopathic treatment attempts to combat COVID-19.

Characterization of photosystem II with the atomic-force microscope

1992 ◽  
Vol 50 (2) ◽  
pp. 1146-1147
Author(s):  
Kathleen M. Marr ◽  
Mary K. Lyon
Keyword(s):  
Photosystem Ii ◽  
Atomic Force Microscope ◽  
Three Dimensional ◽  
Biologically Active ◽  
Atomic Force ◽  
Freeze Etching ◽  
Image Averaging ◽  
Oxygen Evolving ◽  
Averaging Techniques

Photosystem II (PSII) is different from all other reaction centers in that it splits water to evolve oxygen and hydrogen ions. This unique ability to evolve oxygen is partly due to three oxygen evolving polypeptides (OEPs) associated with the PSII complex. Freeze etching on grana derived insideout membranes revealed that the OEPs contribute to the observed tetrameric nature of the PSIl particle; when the OEPs are removed, a distinct dimer emerges. Thus, the surface of the PSII complex changes dramatically upon removal of these polypeptides. The atomic force microscope (AFM) is ideal for examining surface topography. The instrument provides a topographical view of individual PSII complexes, giving relatively high resolution three-dimensional information without image averaging techniques. In addition, the use of a fluid cell allows a biologically active sample to be maintained under fully hydrated and physiologically buffered conditions. The OEPs associated with PSII may be sequentially removed, thereby changing the surface of the complex by one polypeptide at a time.

Depletion and Reconstitution of Active E. Coli Ribosomes

1975 ◽  
Vol 33 ◽  
pp. 640-641
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Protein Biosynthesis ◽  
Large Subunit ◽  
High Resolution Electron Microscopy ◽  
Small Subunit ◽  
Structure And Function ◽  
Biologically Active ◽  
Biological Macromolecules ◽  
E Coli ◽  
Resolution Electron ◽  
And Function

Correlations between structure and function of biological macromolecules have been studied intensively for many years, mostly by indirect methods. High resolution electron microscopy is a unique tool which can provide such information directly by comparing the conformation of biopolymers in their biologically active and inactive state. We have correlated the structure and function of ribosomes, ribonucleoprotein particles which are the site of protein biosynthesis. 70S E. coli ribosomes, used in this experiment, are composed of two subunits - large (50S) and small (30S). The large subunit consists of 34 proteins and two different ribonucleic acid molecules. The small subunit contains 21 proteins and one RNA molecule. All proteins (with the exception of L7 and L12) are present in one copy per ribosome.This study deals with the changes in the fine structure of E. coli ribosomes depleted of proteins L7 and L12. These proteins are unique in many aspects.

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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