scholarly journals Percutaneous Transforaminal Epidural Injection Method in an Experimental Rat: Minimally Invasive Drug Delivery Method to Spinal Epidural Space

2012 ◽  
Vol 36 (5) ◽  
pp. 640 ◽  
Author(s):  
Nack Hwan Kim ◽  
Sang Heon Lee ◽  
Seok Jun Lee
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Epidural Space ◽  
Epidural Injection ◽  
Delivery Method ◽  
Injection Method ◽  
Transforaminal Epidural Injection ◽  
Spinal Epidural

scholarly journals Spinal epidural hematoma occurring at a distance from the transforaminal epidural injection site

Medicine ◽  
2019 ◽  
Vol 98 (30) ◽  
pp. e16654
Author(s):  
Sang-In Kim ◽  
Dong-Hyun Lee ◽  
Sun-Hee Kim ◽  
Yong-Hyun Cho
Keyword(s):  
Injection Site ◽  
Epidural Hematoma ◽  
Epidural Injection ◽  
Spinal Epidural Hematoma ◽  
Transforaminal Epidural Injection ◽  
Spinal Epidural

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Utility of current sialendoscopes in the sinonasal cavity

2015 ◽  
Vol 129 (9) ◽  
pp. 870-873
Author(s):  
C R Kieliszak ◽  
T R Khoury ◽  
A Singh ◽  
A S Joshi
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Paranasal Sinuses ◽  
Sphenoid Sinus ◽  
Mucosal Biopsy ◽  
Before And After ◽  
Invasive Method ◽  
Cannulation Success ◽  
Cadaveric Model ◽  
Sphenoid Sinuses

AbstractObjectives:This study assessed the utility of current sialendoscopes in the paranasal sinuses in a cadaveric model and evaluated novel uses for sialendoscopes.Methods:Currently available sialendoscopes were used for visualisation and performing interventions in the paranasal sinuses. Ten cadaver heads were studied before and after dissection. Outcomes included ostia identification, sinus cannulation, success of mucosal biopsy collection and image clarity.Results:Marchal and Erlangen sialendoscopes were found to be effective for both visualising and cannulating the sphenoid sinuses before and after dissection. Both types demonstrated poor maxillary ostia visualisation without dissection, but did allow treatment after antrostomy. Larger diameter sialendoscopes were associated with the lowest image distortion during maxillary ostia assessment. Mucosal biopsy collection within the sphenoid sinus, but not in the maxillary sinus, was possible before dissection.Conclusion:Sialendoscopes can be used for visualisation and performing interventions in the sinonasal cavity, but their utility is mainly limited to the sphenoid sinus. They may be considered a minimally invasive method for drug delivery and/or biopsy collection in the post-operative setting for all sinuses. Design improvements are suggested.

Future Interventional Oncology Catheter-Based Therapies

2017 ◽  
Vol 01 (03) ◽  
pp. 225-232
Author(s):  
Christopher Noda ◽  
Mihail Roubhaka ◽  
Resmi Charalel ◽  
Abdulrahman Masrani ◽  
Olaguoke Akinwande
Keyword(s):  
Minimally Invasive ◽  
Interventional Oncology ◽  
Complete Removal ◽  
Systemic Delivery ◽  
Delivery Method ◽  
Viral Therapy ◽  
Attractive Option ◽  
Rapid Pace ◽  
Invasive Techniques ◽  
All Diseases

AbstractMinimally invasive techniques in the treatment of cancer continue to develop at a rapid pace. Although surgical resection currently remains the only option for a complete cure, not all diseases are amenable to complete removal. This leaves opportunities to develop effective downstaging techniques as well as palliative care. In the realm of minimally invasive oncologic techniques, catheter-based therapies are an attractive option because malignancies require a blood supply to remain active. The intra-arterial (IA) delivery of specific tumoricidal drugs has been shown to be a successful delivery method in a variety of different cancers, and it is currently a progressive area of research. There is work both to increase the delivery specificity of oncologic drugs, including SW43 sigma receptor ligand and nanoparticle research. In addition, oncolytic viral therapy and 3-bromopyruvate have become increasingly more attractive tumoricidal drug prospects. In the future, the success of these therapies will ultimately determine the degree to which IA delivery will compete with the systemic delivery of drugs in the treatment of cancer.

scholarly journals A comprehensive review on buccal patches

2020 ◽  
Vol 13 (1) ◽  
pp. 130-135
Author(s):  
Seema ◽  
Kapil kumar ◽  
Deepak Teotia
Keyword(s):  
Drug Delivery ◽  
Oral Cavity ◽  
Systemic Circulation ◽  
Drug Formulation ◽  
Delivery Method ◽  
Modern Approach ◽  
Comprehensive Review ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Buccal Patches are the type of drug formulation that has normally a different course of administration through the buccal mucosa for drug delivery. The product is placed between upper gingiva (gums) and cheek to treat local and systemic conditions. Buccal patch have good accessibility to the membranes that line the oral cavity. These patches tend to help drug enter directly into the systemic circulation escaping hepatic first pass metabolism. This type of drug delivery method is considered useful for elevating the bioavailability of drugs. This review is a thorough study to apprehend the procedures involved in assessment of buccal patches and the modern approach towards this type of drug delivery. This article intends to analyze the overall profile of Buccal Patches and scope of future advances.

scholarly journals Design and Analysis of Mechanical Microswimmers

2021 ◽  
Keyword(s):  
Drug Delivery ◽  
Reynolds Number ◽  
Minimally Invasive ◽  
Human Body ◽  
Biomedical Applications ◽  
Head Capsule ◽  
Ansys Fluent ◽  
Capsule Type ◽  
Spherical Head ◽  
Surgical Operations

The fascinating field in present civilization scenario at the edge of science is micro-swimmers, which is a combination of bio physics with self-propulsion mechanisms involving swimming strategies at low Reynolds number. These micro swimming robots offer many advantages in biomedical applications such as drug delivery to some specific locations in our human body and also conducting some surgical operations like opening of blocked arteries etc. In recent times, blocked arteries become a major case in the medical world. This is can be diagnosed by Angioplasty (is a minimally invasive, endovascular procedure to widen narrowed or obstructed arteries or veins, typically to treat arterial atherosclerosis) method. So this is the main reason to choose the aorta as our domain for analysis purpose. This paper presents a micro-swimmer with three different heads they are spherical head, Capsule type head and Tapered cylindrical or elliptical head and modelled using SOLIDWORKS and analysis in ANSYS FLUENT.

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