Relationship Between Serum Vitamin D Levels and Symptoms of Depression in Stroke Patients

Introduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore whether vitamin D played a role in the gender difference in DVT.Materials and Methods: A total of 444 patients with acute stroke were recruited, which were divided into the DVT group (n = 222) and the non-DVT group (n = 222). Serum vitamin D levels were measured after admission and were split into three categories, including deficiency (<50 nmol/L), insufficiency (52.5–72.5 nmol/L), and sufficiency (more than 75 nmol/L). Hierarchical regression analysis was adopted to analyze the relationship between gender and DVT, controlling the confounding factors.Results: Females showed a higher proportion of DVT than males (60.7 vs. 42.5%, p < 0.001), and lower serum vitamin D levels than males (53.44 ± 16.45 vs. 69.43 ± 23.14, p < 0.001). Moreover, serum vitamin D levels were lower in the DVT group than in the non-DVT group (59.44 ± 19.61 vs. 66.24 ± 23.86, p < 0.001). Besides, the DVT group showed a lower proportion of vitamin D sufficiency than the non-DVT group (21.2 vs. 32.9%, p < 0.05). Hierarchical regression analysis showed that females had 2.083-fold (p < 0.001, unadjusted model) and 1.413-fold (p = 0.155, adjusted model) risk to develop DVT. In addition, the sufficiency status of vitamin D showed an independent protective effect on DVT (unadjusted model OR, 0.504, p = 0.004; adjusted model OR, 0.686, p = 0.011).Conclusion: Females had a higher risk of DVT than males, and vitamin D may play an essential role in this relationship. Further studies are needed to explore whether vitamin D supplementation could reduce DVT risk in stroke patients, especially females.

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PYSCHOLOGICAL CONSEQUENCES OF VITAMIN D DEFICIENCY IN SENIOR CITIZENS OF BANGALORE CITY

10.36106/ijsr/2913698 ◽

2020 ◽

pp. 1-4

Author(s):

Jyothi Vybhavi V. S.

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Psychological Health ◽

Serum Vitamin ◽

The Elderly ◽

Serum Vitamin D ◽

Symptoms Of Depression ◽

Bangalore City ◽

Vitamin D Levels ◽

25 Oh Vitamin D

The older population is at a high risk of Vitamin-D deficiency due to decreased cutaneous synthesis and dietary intake of Vitamin-D. Results from previous studies examining associations between serum 25- hydroxyvitamin D (25(OH)D) concentrations and depressive symptoms are equivocal. Hence this study was undertaken in order to find the association between vitamin D and symptoms of depression, anxiety and stress in a cross-sectional analysis of a population-based sample of elderly residing in Bangalore city. The objectives of this study are 1. To assess Serum 25(OH) Vitamin-D in the elderly. 2. To assess symptoms of depression, anxiety and stress in the elderly with different levels of Vitamin-D. This study involved 80 healthy elderly subjects with consideration of inclusion and exclusion criteria. Written informed consent was taken. For each subject, fasting blood sample of 4ml was collected for Serum 25(OH) Vitamin-D assessment. Anthropometric measurements were taken. 24-hour dietary recall, General History Questionnaire and Mental health symptoms were assessed using the 21-item Depression Anxiety Stress Scales (DASS-21). Associations between serum 25(OH)D concentrations and total DASS-21 scores and subscale scores of depression, anxiety and stress were explored using negative binomial regression, adjusting for age, race, BMI and physical activity. The comparison of Serum Vitamin-D levels and DASS-21 components showed that the mean scores for Depression, anxiety and Stress were significantly higher in the Vitamin-D deficient participants, indicating that the Vitamin-D deficient participants had worst Psychological consequences. It can be concluded that a significant correlation was found between Serum Vitamin-D deficiency and poor psychological health. Based on the results of this study, psychological health for elderly can be improved by providing regular examinations and checking their Serum Vitamin-D levels and supplementing Vitamin-D to the elderly to enhance their quality of Life.

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STUDY OF VITAMIN D LEVELS AND ITS CORRELATION WITH AMBULATORY STATUS IN STROKE SURVIVORS : A CROSS SECTIONAL STUDY.

10.36106/ijsr/3817658 ◽

2020 ◽

pp. 1-3

Author(s):

Sakshi Jain ◽

Vinay Kanaujia ◽

Dhirendra Kumar Singh ◽

Banoth Kiran Kumar

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Modified Rankin Scale ◽

Sectional Study ◽

Stroke Patients ◽

Cross Sectional ◽

Serum Vitamin D ◽

Ambulatory Status ◽

Vitamin D Levels

Background – Stroke can lead to impaired mobility and disability. There are chances of decreased exposure to sunlight and decreased Vitamin D levels after stroke. This study was done to assess the vitamin D status in stroke survivors and its correlation with duration and ambulatory status of stroke. Methods – This cross sectional study included 100 patients of stroke. Patients were assessed after history and examination for their Serum Vitamin D levels, ambulatory status by Modified Rankin Scale (MRS). MRS grade 1-3 were considered ambulatory and MRS grade 4 and 5 were considered non ambulatory. Statistical analysis was done using chi square test for qualitative variables, unpaired t test for quantitative variables, and pearson correlation. P value < 0.05 was taken significant. Results –72 patients had Vitamin D levels less than 30ng/ml (20.42 ± 5.89 ng/ml). Significant negative correlation was observed between duration of stroke and Serum Vitamin D levels. Out of 41 non ambulatory patients, 38 were Vitamin D deficient (P<0.05). negative Correlation was present in Modified Rankin Scale and Serum Vitamin D levels. Conclusion –Vitamin D Deficiency is present in chronic non ambulatory stroke patients.

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

PEDIATRICS ◽

10.1542/peds.2011-2644d ◽

2012 ◽

Vol 129 (3) ◽

pp. X11-X11

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Maternal Serum ◽

Neurocognitive Development ◽

Serum Vitamin D ◽

Vitamin D Levels

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Faculty Opinions recommendation of Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3437965.3141061 ◽

2010 ◽

Author(s):

Leonard Bacharier ◽

Avraham Beigelman

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children With Asthma

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Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-4/004 ◽

2020 ◽

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Serum Vitamin ◽

Persistent Asthma ◽

Food Allergies ◽

P Value ◽

Serum Vitamin D ◽

Asthma Exacerbations ◽

Vitamin D Levels ◽

Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to ﬁnd out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically signiﬁcant. Results: Children who had exposure to animal dander had signiﬁcantly lower asthma exacerbations per year (p-value <0.046). There was no signiﬁcant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no signiﬁcant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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