Quality of Life Among Multiple Sclerosis Patients in Terms of Mental Health

This study aimed to identify the mental health quality of life among patients with multiple sclerosis in Jordan. Thus, a descriptive quantitative design was used on a total of (N=100) Multiple Sclerosis patients that were randomly selected by using convenience sampling from the Health Insurance Center in the capital Amman, Jordan. Outcome measurement tools were the demographic data form and the Multiple Sclerosis Quality of Life-54 (MSQOL-54) Scale. The demographic data form consisted of questions about: age in years, gender, stage of multiple scleroses, and physical activities. The Multiple Sclerosis Quality of Life-54 (MSQOL-54) consisted of two domains the physical health composite and the mental health composite. In this study the mental health composite were used by the participants. The results revealed that the QOL- Mental Health Composite among patients with multiple sclerosis was 33.9 + 33.6. Moreover, there was no significant difference in score for male and females p=.874. In addition, there was no significant difference in QOL mental health scores for the age groups p=.165. Finally, there was a significant difference in scores for participants and non-participants in physical activity p=.000. Accordingly, this research concluded that Multiple sclerosis patients’ have a low quality of life in terms of mental health. In addition, practicing physical activities have a positive effect on the quality of mental health among multiple sclerosis patients.

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Predicting improvement of quality of life and mental health over 18-months in multiple sclerosis patients

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2021.103093 ◽

2021 ◽

pp. 103093

Author(s):

Irene Gil-González ◽

María Ángeles Pérez-San-Gregorio ◽

Rupert Conrad ◽

Agustín Martín-Rodríguez

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Multiple Sclerosis Patients

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Comparison of Cognitive Rehabilitation versus Donepezil Therapy on Memory Performance, Attention, Quality of Life, and Depression among Multiple Sclerosis Patients

Neurology Research International ◽

10.1155/2020/8874424 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Mohammad Mahdi Shahpouri ◽

Majid Barekatain ◽

Mahgol Tavakoli ◽

Omid Mirmosayyeb ◽

Ali Safaei ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Cognitive Rehabilitation ◽

Digit Span ◽

Memory Performance ◽

Intergroup Comparison ◽

Multiple Sclerosis Patients ◽

Memory Questionnaire

Background. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that affects cognitive performance and leads to depression and decreased quality of life (QOL). The current study aims to assess the effects of cognitive rehabilitation versus donepezil therapy on memory, attention, depression, and QOL in MS patients compared to placebo and control groups. Methods. Eighty MS patients were randomly selected from parallel randomized trials and divided into four groups: A: cognitive rehabilitation (10 sessions of 120 minutes), B: control (no intervention), C: donepezil (10 mg daily), and D: placebo. Patients received the intervention for three months. They were assessed for cognitive status, depression, and QOL prior to the intervention and immediately after that using abbreviated mental test (AMT), prospective and retrospective memory questionnaire (PRMQ), everyday memory questionnaire (EMQ), digit span, MSQOL-54, and second edition Beck depression inventory (BDI). We compared scores between groups after the intervention, as well as the progression of scores in every single group. Results. The cognitive rehabilitation group showed improvement in EMQ, RPMQ, digit span, physical and mental health subscales of MSQOL54, and depression P < 0.05 . We observed the same effect for donepezil except for the digit span test P = 0.15 . Intergroup comparison of scores showed the superiority of cognitive rehabilitation over donepezil in digit span, depression, and mental health scores. Conclusion. Both donepezil and cognitive rehabilitation effectively improve memory performance, attention, depression, and QOL in MS patients. Cognitive rehabilitation is superior altogether. This study is registered with the Iranian registry of clinical trials http://clinicaltrials.gov/ct2/show/IRCT2016042227522N1.

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Effect of Aerobic Exercise Program on Quality of Life in Male Patients with Multiple Sclerosis

Journal of Shahid Sadoughi University of Medical Sciences ◽

10.18502/ssu.v28i8.4454 ◽

2020 ◽

Author(s):

Mojtaba Dehestani Ardakani

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Aerobic Exercise ◽

Repeated Measures ◽

Therapeutic Approach ◽

Exercise Program ◽

Repeated Measures Analysis ◽

Significant Difference ◽

Multiple Sclerosis Patients

Introduction: The purpose of this study was to determine the effect of aerobic exercise program on quality of life in multiple sclerosis men as a complementary therapeutic approach to multiple sclerosis. Methods: This was a semi-experimental study. The statistical sample consisted of 60 people was selected by the available sampling method from Kahrizak Nursing Home where was also a member of the Iranian MS society. They were randomly divided into control and test groups. After an introductory session of the patients with the aims and intervention method in the experimental group, 27 sessions of 60 minutes of aerobic exercise program were performed in 9 weeks. Data collection tools consisted of a demographic questionnaire, a short quality of life (SF-8) questionnaire, and self-report checklist with a significant level of p≤0.05. Descriptive statistical tests, independent t-test and repeated measures analysis of variance were used for analysis using SPSS version 16 statistical software with a significance level of p≤0.05. Results: The results showed that there was no significant different between the two groups in terms of the total score (df = 48 = T 21.1, p = 0.23) and dimensions of quality of life (Physical: df = 48, T = 1.31, p = 0.19; mental: df = 48, t = 0.96, p = 0.31) There was no significant difference between the control and experimental groups. The results of repeated measures analysis of variance showed that there was a significant difference between the experimental and control groups in terms of quality of life dimensions. Conclusion: In general, aerobic exercise, which was chosen as an exercise program in this study, improves the quality of life of multiple sclerosis patients. Therefore, this complementary therapeutic approach is recommended as an effective and cost-effective method in cost and time, as well as the ability to learn and easy to administer to multiple sclerosis patients.

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Development of a cross-cultural item bank for measuring quality of life related to mental health in multiple sclerosis patients

Quality of Life Research ◽

10.1007/s11136-015-0948-0 ◽

2015 ◽

Vol 24 (9) ◽

pp. 2261-2271 ◽

Cited By ~ 1

Author(s):

Pierre Michel ◽

Pascal Auquier ◽

Karine Baumstarck ◽

Jean Pelletier ◽

Anderson Loundou ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Item Bank ◽

Cross Cultural ◽

Multiple Sclerosis Patients

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Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review

Nutrients ◽

10.3390/nu13124207 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4207

Author(s):

Dominika Głąbska ◽

Aleksandra Kołota ◽

Katarzyna Lachowicz ◽

Dominika Skolmowska ◽

Małgorzata Stachoń ◽

...

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Systematic Review ◽

Vitamin D ◽

Depressive Symptoms ◽

Positive Influence ◽

Vitamin D Supplementation ◽

Multiple Sclerosis Patients

Vitamin D has a promising role in multiple sclerosis (MS) management, and it has been found to be beneficial for patients’ mental health, which is reduced in MS patients. The aim of the present study was to conduct a systematic review of the literature to assess the influence of vitamin D supplementation on mental health in MS patients. The systematic review was registered in the PROSPERO database (CRD42020155779) and it was conducted on the basis of the PRISMA guidelines. The search procedure was conducted using PubMed and Web of Science databases and it included studies published up until September 2021. Six studies were included in the systematic review. The risk of bias was analyzed using the Newcastle–Ottawa Scale (NOS). Within the included studies, there were two studies randomized against placebo and four other prospective studies. The studies presented vitamin D interventions randomized against placebo or not randomized, while supplementation was applied for various durations—from 4 weeks to 12 months, or the studies compared patients who applied vitamin D supplementation and those who did not apply it and verified the effect of the supplementation after a number of years. The mental health outcomes that were assessed included quality of life, depression/depressive symptoms, and fatigue as an additional element. The majority of studies supported the positive influence of vitamin D on the mental health of MS patients, including the study characterized as having the highest quality (randomized against placebo with the highest NOS score). All the studies that assessed the quality of life indicated the positive influence of vitamin D while the studies that did not find a positive influence of vitamin D were conducted for depression/depressive symptoms. In spite of the fact that only a small number of studies have been conducted so far, and only two studies were randomized against a placebo, some conclusions may be formulated. The systematic review allowed us to conclude that there may be a positive effect of vitamin D supplementation in MS patients, which was stated in all of the studies analyzing quality of life, as well as in one study analyzing depressive symptoms. Considering that vitamin D deficiency is common in MS patients, and the potential positive influence of supplementation on the quality of life, supplementation should be applied at least in doses that cover the recommended intake.

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Quality of life in multiple sclerosis patients in Spain

Multiple Sclerosis Journal ◽

10.1191/1352458502ms851oa ◽

2002 ◽

Vol 8 (6) ◽

pp. 527-531 ◽

Cited By ~ 20

Author(s):

C-H Chang ◽

D Cella ◽

O Fernández ◽

G Luque ◽

P de Castro ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Well Being ◽

Cross Sectional Study ◽

Self Report ◽

Regression Analyses ◽

Cross Sectional ◽

Scale Scores ◽

Multiple Sclerosis Patients

Objective: The cross-sectional study evaluated the psychometric properties of the Functional Assessment of Multiple Sclerosis (FAMS) Spanish version and its use in measuring quality of life (QOL) of multiple sclerosis (MS) patients in Spain. Methods: The FAMS is a factorially derived self-report scale designed to assess six primary aspects of QOL of patients with MS: Mobility, Symptoms, Emotional Well-Being, General Contentment, Thinking and Fatigue, and Family/Social Well-Being. Its Spanish translated version was used to assess QOL of 625 MS patients recruited in an outpatient clinic setting from 58 hospitals in Spain. Internal consistency of the Spanish FAMS was evaluated. Multiple regression analyses were performed to identify significant predictors from demographic, clinical and treatment characteristics, and Kurtzke Expanded Disability Status Scale (EDSS) scores in predicting FAMS scale scores. Results: Most of the patients are females (66%), and 74% were of the relapsing-remitting (RR) clinical subtype. Cronbach’s alpha coefficients were high (range=0.78-0.96), indicating subscale homogeneity comparable to that of the original English version. Linear multivariate regression analyses revealed that the EDSS is a dominant variable in predicting all the FAMS subscales, especially mobility (R2=0.51) and the total scores. Conclusions: The Spanish FAMS is a psychometrically valid instrument that allows clinicians and clinical researchers the ability to measure the QOL concerns of MS patients in Spain.

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Fatigue, mood and quality of life improve in MS patients after progressive resistance training

Multiple Sclerosis Journal ◽

10.1177/1352458509360040 ◽

2010 ◽

Vol 16 (4) ◽

pp. 480-490 ◽

Cited By ~ 129

Author(s):

U. Dalgas ◽

E. Stenager ◽

J. Jakobsen ◽

T. Petersen ◽

HJ Hansen ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Resistance Training ◽

Beneficial Effect ◽

Control Group ◽

Progressive Resistance Training ◽

Multiple Sclerosis Patients ◽

Progressive Resistance

Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few. Fatigue, mood and quality of life were studied in patients with multiple sclerosis following progressive resistance training leading to improvement of muscular strength and functional capacity. Fatigue (Fatigue Severity Scale, FSS), mood (Major Depression Inventory, MDI) and quality of life (physical and mental component scores, PCS and MCS, of SF36) were scored at start, end and follow-up of a randomized controlled clinical trial of 12 weeks of progressive resistance training in moderately disabled (Expanded Disability Status Scale, EDSS: 3—5.5) multiple sclerosis patients including a Control group ( n = 15) and an Exercise group ( n = 16). Fatigue (FSS > 4) was present in all patients. Scores of FSS, MDI, PCS—SF36 and MCS—SF36 were comparable at start of study in the two groups. Fatigue improved during exercise by —0.6 (95% confidence interval (CI) —1.4 to 0.4) a.u. vs. 0.1 (95% CI —0.4 to 0.6) a.u. in controls ( p = 0.04), mood improved by —2.4 (95% CI —4.1 to 0.7) a.u. vs. 1.1 (—1.2 to 3.4) a.u. in controls ( p = 0.01) and quality of life (PCS—SF36) improved by 3.5 (95% CI 1.4—5.7) a.u. vs. —1.0 (95% CI —3.4—1.4) a.u. in controls ( p = 0.01). The beneficial effect of progressive resistance training on all scores was maintained at follow-up after further 12 weeks. Fatigue, mood and quality of life all improved following progressive resistance training, the beneficial effect being maintained for at least 12 weeks after end of intervention.

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Mindfulness in Motion for People with Multiple Sclerosis: A Feasibility Study

International Journal of MS Care ◽

10.7224/1537-2073.2015-095 ◽

2017 ◽

Vol 19 (5) ◽

pp. 225-231 ◽

Cited By ~ 9

Author(s):

Rachel M. Gilbertson ◽

Maryanna D. Klatt

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Multiple Sclerosis ◽

Mindfulness Meditation ◽

Short Form ◽

Physical Symptoms ◽

Future Research ◽

Five Facet Mindfulness Questionnaire ◽

Anxiety Depression

Background: Mindfulness in Motion is an 8-week mindfulness-based intervention that uses yoga movement, mindfulness meditation, and relaxing music. This study examined the feasibility of using Mindfulness in Motion in people with multiple sclerosis (MS) and the effect of this program on stress, anxiety, depression, fatigue, and quality of life in people with MS. Methods: Twenty-two people with MS completed the 8-week mindfulness program as well as assessments 1 week before and after the intervention. Results: Pre/post comparison of four self-reported questionnaires—the Mental Health Inventory, 36-item Short Form Health Status Survey, Modified Fatigue Impact Scale, and Five Facet Mindfulness Questionnaire—showed significant improvement in physical functioning, vitality, and mental health. Specifically, improvements were seen in anxiety, depression, and positive affect; cognitive, psychosocial, and overall functioning regarding fatigue; and mindfulness in the areas of observing, acting with awareness, nonjudgment, and nonreactivity. Conclusions: Due to the uncertainty in disease progression associated with MS, and the multiplicity of mental and physical symptoms associated with it, programming that addresses anxiety, depression, and fatigue is a key area of future research in MS disease management. Mindfulness in Motion proved to be a feasible program yielding positive results, supporting the need for research to determine the extent to which the program can improve quality-of-life outcomes for people with MS.

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Memory performance in multiple sclerosis patients correlates with central brain atrophy

Multiple Sclerosis Journal ◽

10.1191/1352458506ms1286oa ◽

2006 ◽

Vol 12 (4) ◽

pp. 428-436 ◽

Cited By ~ 28

Author(s):

H Hildebrandt ◽

H K Hahn ◽

J A Kraus ◽

A Schulte-Herbrüggen ◽

B Schwarze ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Brain Atrophy ◽

Motor Performance ◽

Memory Performance ◽

Cognitive Tests ◽

Duration Of Symptoms ◽

Central Brain ◽

Multiple Sclerosis Patients

Objective To assess whole brain and central brain atrophy as well as their differential relation to memory, cognitive performance, fatigue, depression and quality of life in patients with relapsingremitting multiple sclerosis (RRMS). Methods A 3D flow compensated gradient recalled T1-weighted MRI was acquired in 45 RRMS patients. An automated analysis tool was used to calculate brain parenchymal fraction (BPF) and ventricular brain fraction (VF). All patients were assessed with neuropsychological tests focusing on memory and self-rating scales for depression, fatigue and quality of life. Age corrected partial correlations between brain atrophy, motor performance, psychological scales and test scores were calculated. Results BPF correlated moderately (0.35≤r<0.5) with duration of symptoms and disease, the Expanded Disability Status Scale (EDSS), the upper extremity motor performance, and with mental aspects of quality of life. VF correlated moderately with EDSS, upper and lower extremity motor performance and memory functions. Neither BPF nor VF correlated with fatigue and depression. Results of several cognitive tests correlated moderately with depression and fatigue, the Paced Auditory Serial Addition Test (PASAT) showing the largest correlation. Conclusions Memory performance shows a correlation with relative ventricular size in RRMS patients, indicating the strategic location of the ventricle system along the structures of the limbic system and its vulnerability in MS. The PASAT and several other cognitive tests show moderate correlations with depression and fatigue, arguing for an inter relation between the cognitive functioning and the emotional state of patients. However, this relation is independent of measurable brain atrophy.

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