scholarly journals Study of healing effects of the “Fomitop” gel on artificial burn wounds

2021 ◽  
Vol 31 (3) ◽  
pp. 20-26
Author(s):  
Undraa Bold ◽  
Gerelt Gaadan ◽  
Byambajav Tseesuren ◽  
Undrakhbayar Tserendorj ◽  
Naranmandakh Shinen
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Healing Rate ◽  
Histological Analysis ◽  
Micrococcus Luteus ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Standard Group ◽  
Burn Wounds ◽  
Wound Healing Rate

As a result of previous studies, we have established the “Fomitop” gel with extracts from the fungus Fomitopsis officinalis has antibacterial properties against some strains such as Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, and Enterococcus faecalis. Based on these results, we have conducted this research to identify the “Fomitop” gel has a healing effect on the burn wound. For this purpose, were conducted the comparative analysis of healing effects of the “Fomitop” gel with the standard ointment - silver sulfadiazine cream, on artificial burn wounds created on the back skin of a mouse. Total 27 Balb/c mice were included in the experiment and they are divided into three equivalent groups. In the first treatment, the group was applied to the “Fomitop” gel, the second standard group was applied silver sulfadiazine cream, and the third control group untreated by any ointment. On the 1, 5, 12, 21, and 35th days after wound creation, were taken the histological samples from the wound and near areas of the wound. The wound healing process was evaluated based on histological analysis. The burn wounds of the treatment group of mice (applied “Fomitop” gel) fully healed on the 33rd day of the experiment. While the wound healing rate of the standard group of mice (applied silver sulfadiazine cream) was 92.2% on the same day. And the control group mice wound healing rate was 78% (p<0.05). The results of the histological analysis were confirmed an active regeneration of epithelial cells and wound healing in the treatment group. It was good compared to the standard and control groups. As a result of this study, were determined the “Fomitop” gel application is accelerated the tissue regeneration of burn wounds and so on heals wound in a short time. Фомитоп гелин түрхлэгийн түлэнхийн шарханд үзүүлэх үйлдлийн судалгаа Бид өмнө гүйцэтгэсэн хар модны агил мөөгнөөс бэлтгэсэн “Фомитоп” гелин түрхлэгийн антибиотик төст үйлдлийг шалгах шинжилгээгээр Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Enterococcus faecalis зэрэг бактерийн ургалтыг дарангуйлдаг болохыг илрүүлсэн. Уг үр дүнд үндэслэн “Фомитоп” гелин түрхлэг шархыг идээлүүлэхгүйгээр эдгээх боломжтой эсэхийг тогтоох энэхүү судалгааг гүйцэтгэв. Энэ зорилгоор “Фомитоп” гелин түрхлэгийг хулганы нурууны арьсанд үүсгэсэн химийн гаралтай түлэгдэлтийн зохиомол шарханд үзүүлэх нөлөөг стандарт эм болох мөнгөний сульфадиазин түрхлэгтэй харьцуулан судлав. Судалгаанд Balb/c үүлдрийн нийт 27 цагаан хулганыг тэнцүү тоогоор гурван бүлэгт хувааж хамруулав. Үүнд: 1-р бүлэг-агил мөөгнөөс бэлтгэсэн гелин түрхлэгийг хэрэглэсэн туршилтын бүлэг, 2-р бүлэг-мөнгөний сульфадиазин түрхлэг хэрэглэсэн стандарт бүлэг, 3-р бүлэг түрхлэг хэрэглээгүй хяналтын бүлэг. Шарх үүсгэснээс хойш 1, 5, 12, 21, 35 хоногуудад шарх, түүний ойр орчмын эдээс дээж авч гистологийн шинжилгээ хийж, шархны эдгэрэлтийг үнэлсэн. “Фомитоп” гелин түрхлэгийг хэрэглэсэн эмчилгээний бүлгийн түлэнхийн шарх туршилтын 33 дахь хоногт бүрэн эдгэрсэн бол мөнгөний сульфадиазин түрхлэг хэрэглэсэн стандарт бүлгийн шархны эдгэрэлт тухайн хоногт 92.2%, харин эм хэрэглээгүй хяналтын бүлгийн шархны эдгэрэлт нь 78% байлаа (p<0.05). Мөн гелин түрхлэг хэрэглэсэн бүлэг нь стандарт болон хяналтын бүлэгтэй харьцуулахад түлэнхийн шархны эдгэрэл, хучуур эсийн нөхөн төлжилт идэвхтэй явагдаж байгаа нь гистологийн шинжилгээний үр дүнгээр батлагдав. Судалгааны үр дүнд “Фомитоп” гелин түрхлэг нь түлэнхийн шархны нөхөн төлжилтийг хурдасгах, улмаар богино хугацаанд аниулах үйлдэл үзүүлж байгааг тогтоов.  Түлхүүр үг: Агил мөөг, мөнгөний сульфадиазин, гистологийн шинжилгээ, шархны эдгэрэл

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p &lt; 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Preparation and evaluation of burns wound healing ointment base of leaves and stem bark of Anthocleista djalonensis (L) extract using animal model.

2020 ◽  
Vol 1 (02) ◽  
pp. 25-32
Author(s):  
Chinenye Nnenna Ugwu ◽  
Ezinwanne Nneoma Ezeibe ◽  
Chinekwu Sherridan Nwobi ◽  
Chinelo Charity Eze ◽  
Somtochukwu Amuche Evurani ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Bark ◽  
Positive Control ◽  
Silver Sulfadiazine ◽  
Wound Contraction ◽  
Bark Extract ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wounds ◽  
Ointment Base

BACKGROUND: Burn wounds are inescapable life events especially in low income areas. Contamination of the burn wound site results in localized wound infection, hence the need for potent phytochemicals readily available for wound healing. The use of stem bark of Anthocleista djalonensis efficacy for burn wound has not been evaluated to the best of our knowledge. AIM: The study is aimed at evaluating and comparing the wound healing potential of ointment base of leaves and Stem bark of Anthocleista djalonensis on burn wounds created on wistar albino rats. METHODS: The leaves and Stem bark of Anthocleista djalonensis collected were extracted using 95%v/v methanol and phytochemical analysis conducted. Simple ointments of varying concentrations were formulated to screen for wound healing activity using the burn wound model on experimental rats grouped into six (n=4). Group 1 was treated with silver sulfadiazine cream (positive control), group 2 with ointment base (negative control), group 3 with 1% stem bark extract ointment, group 4 with 2% stem bark ointment, group 5 with 1% leave extract ointment, and group 6 with 2% leave extract ointment.  All animals were anesthetized before the creation of burn wounds. Measurement was taken on day zero and the wound was left untreated for 48 hours in order to allow bacterial colonization before daily treatment of the wound for 16 days. RESULTS: The result of the phytochemical screening revealed that both extract of Anthocleista djalonensis contains flavonoids, tannins and saponins. On day 2, 1% stem bark, 2% stem bark and 1% leaf extract had 16%, 15%, and 10% wound contraction respectively which was higher than the 8.5% wound contraction of silver sulfadiazine. Also as the concentration of the extract increased, the wound healing effect also increased as seen by the percentage wound contraction on day 16 for all treatment.  CONCLUSION: The findings of the study have shown that methanolic extracts of stem bark and leaf of Anthocleista djalonensis contained bioactive constituents which have burn wound healing activity. The stem bark extract showed better activity when compared with the leaf extract and also the positive control (silver sulfadiazine).    

scholarly journals Topical treatment of standardised burns with herbal remedies in model rats

2005 ◽  
Vol 5 (4) ◽  
pp. 50-57 ◽  
Author(s):  
Fahir Bečić ◽  
Nedžad Mulabegović ◽  
Zakira Mornjaković ◽  
Elvedina Kapić ◽  
Senad Prašović ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Herbal Remedies ◽  
Control Group ◽  
Therapeutic Effects ◽  
Skin Area ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing

Experimental studies of burns require the use of different animal models. The aim of this work was to establish experimental model of thermal injuries and to evaluate the effects of topical agents on healing of the burn wounds. Forty female Wistar rats were randomly classified in 4 groups and isolated for 2 weeks before the onset of experiment. Animals were primarily anaesthetized with pentobarbital-sodium and then shaved (skin area of their back with diameters 5 cm x 5 cm). A round metal stamp with contact area of 5 cm2 and total weight of 100 g was heated up to 80°C and then applied without additional pressure on the depilated skin of the back for 14 seconds. This procedure produced a standardized burn wound. Induced burn wounds were immediately drowned in the 4°C-water for 3 s in order to maintain microcirculation. After the inducement of thermal injures, all rats were treated with 1% silver sulfadiazine cream, herbal topical preparations or were not treated at all. Burn wounds were treated twice a day until the healing completion. The result of treatment application was a significant reduction of burn wound diameters. Herbal topical preparations expressed positive therapeutic effects on the parameters of burn wounds. The efficiency of silver sulfadiazine cream in burn wound healing was significantly more expressed in comparison to healing process in control group of animals (p<0,001). We conclude that herbal topical preparations efficiently caused the completion of burn wound healing process without scar formation.

scholarly journals Effect of Combining Immersion Therapy with Shengji Ointment on Wound Healing Rate and Adverse Reaction Rate in Patients with Second-Degree Burn

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yun Guo ◽  
Junjie Yu
Keyword(s):  
Wound Healing ◽  
Adverse Reaction ◽  
Treatment Group ◽  
Reaction Rate ◽  
Healing Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Degree Burn ◽  
Wound Healing Rate ◽  
Second Degree

Objective. To explore the effect of combining immersion therapy with Shengji ointment on wound healing rate and adverse reaction rate (ARR) in patients with second-degree burn. Methods. The data of 80 patients with second-degree burn treated in our hospital from February 2019 to February 2020 were retrospectively analyzed by the means of retrospective study, and the patients were equally divided into the treatment group and the control group according to their admission order, with 40 cases each. Immersion therapy was performed to all patients (7 d); after that, patients in the control group received routine medication (7 d), and those in the treatment group were treated with Shengji ointment until the wounds were healed, so as to compare their wound healing condition, ARRs, levels of inflammatory factors, and infection incidence. Results. Compared with the control group after treatment, the treatment group presented significantly shorter wound healing time (12.14 ± 1.26 vs. 15.98 ± 1.20, P  < 0.001), better wound healing rate and quality ( P  < 0.05), and lower levels of inflammatory factors ( P  < 0.001); no significant between-group difference in ARRs was shown ( P  > 0.05); 34 patients in the treatment group (85.0%) and 26 patients in the control group (65.0%) had no infections, so the incidence rate of infections was significantly lower in the treatment group than in the control group (P < 0.05). Conclusion. Combining immersion therapy with Shengji ointment can reduce the levels of inflammatory factors in patients with second-degree burn, lower the incidence rate of infections, provide the conditions for wound healing, and increase the wound healing rate, which shall be promoted and applied in practice.

scholarly journals The Utility of Novel Fish-Skin Derived Acellular Dermal Matrix (Kerecis) as a Wound Dressing Material

2021 ◽  
Vol 17 (1) ◽  
pp. 39-47
Author(s):  
Tae Hyung Kim ◽  
Jun Ho Park ◽  
Hyun Gyo Jeong ◽  
Syeo Young Wee
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Computer Software ◽  
Acellular Dermal Matrix ◽  
Control Group ◽  
Omega 3 ◽  
Dermal Matrix ◽  
Burn Wounds ◽  
Novel Material ◽  
Acellular Dermal

Background: The newly-approved Kerecis is a piscine acellular dermal xenograft. This piscine acellular dermal matrix (ADM) has specific bioactive lipid mediators, omega-3 polyunsaturated fatty acids, and has a positive effect on the process of wound healing. This study aimed to explore the utility of this novel material by comparing healing rates, and suggest the proper timing for applying Kerecis.<br/>Methods: Patients who visited the hospital with acute or chronic deep dermal wounds from June 2019 to May 2020 were enrolled in the study. A total of 48 patients were assessed. All wounds in the experimental group (n=16) were treated only once with Kerecis and a non-adherent absorptive foam material (Therasorb) to cover the ADM. In the control group, daily conventional dressings were provided. All wounds sizes were measured with mass-market computer software in a method suggested by the authors for the first time.<br/>Results: The mean healing rate proved to be faster in the Kerecis group (P<0.05) versus the control group, and no complications were observed. It was statistically proved that treating burn wounds with the ADM showed better healing rates than the conventional method (P<0.05).<br/>Conclusion: This study establishes that managing wounds with the ADM is likely to heal wounds faster than traditional dressings. In addition, for burn wounds, a prolonged application (10 days vs. 5 days after the onset) showed a better wound healing rate (98.8%±2.5% vs. 67.0%±14.3%, respectively, P=0.029).

scholarly journals Nutrition Supplementation and Education May Increase the Healing Rate in Diabetic Patients with Foot Ulcers (P19-005-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Raedeh Basiri ◽  
Maria Spicer ◽  
Bahram Arjmandi
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Diabetic Foot ◽  
Healing Rate ◽  
High Protein ◽  
Foot Ulcers ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Wound Healing Rate

Abstract Objectives This study examined the effects of high protein dietary supplementation and nutrition education on the healing of diabetic foot ulcers. Methods Twenty-nine adults with diabetic foot ulcers were recruited from the Tallahassee Memorial Hospital Wound Care Clinic. Participants were randomly assigned to treatment (n = 15) or control (n = 14) group. The treatment group received two carbohydrate controlled high protein shakes to consume daily, and was educated regarding adequate intake of low-fat protein sources, fruits, vegetables, complex carbohydrates and minimizing simple carbohydrates. The control group did not receive any intervention. Daily supplementation provided a total of 500 kilocalories, 28 grams of high-quality protein, and approximately 50% of micronutrient requirements. Anthropometric measurements (weight, height, BMI) and wound planimetry were examined at baseline and every four weeks until the wound healed or up to 12 weeks. Results There was no significant difference between the groups at baseline for BMI (mean = 33.8 ± 7 kg/m2), age (mean = 53.34 ± 11.14 years), duration of diabetes (mean = 13 years), duration of wounds (mean 10.8 months) or wound area (mean = 450 mm2). Wound healing rate (decrease in the area of the wound/week) for the treatment group was three times faster than the control group (151.1 mm2/week vs. 45.2 mm2/week respectively). Conclusions Improved nutritional intake using nutritional supplementation and patient education has a strong positive effect on the wound healing rate of diabetic foot ulcers. Faster wound healing improves quality of life and functionality of patients with diabetic foot ulcers. Funding Sources Dissertation award.

scholarly journals Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bingqing Li ◽  
Kun Xu ◽  
Xin Liu
Keyword(s):  
Wound Healing ◽  
Adverse Reactions ◽  
Healing Rate ◽  
Nursing Intervention ◽  
Control Group ◽  
Burn Wound ◽  
Degree Burn ◽  
Experimental Group ◽  
Wound Healing Rate ◽  
Second Degree

Second-degree burn is the most common type of burn wound in the clinics, which presents a deeper wound, skin blisters, white or red bottom, and thick and clear fluid inside, is sensitive to tenderness, and turns white by compression [1, 2]. The aim of this study is to explore the efficacy of applying silver-zinc bacteriostatic cream to patients with second-degree burn under targeted nursing intervention and its effect on wound healing rate. A total of 110 patients with second-degree burn treated in our hospital from January 2019 to June 2021 were selected as the research object for the retrospective study. Between the experimental group and the control group, no statistical differences in patients’ general information were observed ( P > 0.05 ); 1 week, 2 weeks, and 3 weeks after treatment, the visual analogue scale (VAS) pain scores of the experimental group were significantly lower ( P < 0.05 ); and the total incidence rate of adverse reactions was remarkably lower in the experimental group ( P < 0.05 ). On the basis of targeted nursing intervention, applying silver-zinc bacteriostatic cream obtains an obviously better clinical efficacy than silver sulfadiazine ointment in treating second-degree burn and works better in promoting wound healing, relieving pain sensation, and reducing adverse reactions.

scholarly journals The Effects of Topical Vitamin C on Burn Wound Healing

2021 ◽  
Vol 24 (2) ◽  
pp. 204-215
Author(s):  
Mohammad Haddadi ◽  
◽  
Davood Movahedzadeh ◽  
Elaheh Jaghouri ◽  
Hamid Robat Sarpooshi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vitamin C ◽  
Topical Application ◽  
Repeated Measures ◽  
Assessment Tool ◽  
Intervention Group ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wounds

Background and Aim: Topical supplements and vitamins have often been used to accelerate the healing of burn wounds. This study investigated the effects of topical application of vitamin C solution on burn wounds. Methods & Materials: This research was performed on 30 patients with extensive second-degree burns on one or two organs with similar burns. The study subjects were randomly divided into the intervention and control groups. The intervention group received topical application of vitamin C solution in addition to silver sulfadiazine ointment in the burn area; however, only silver sulfadiazine ointment was applied in the burn area in the control group. The wounds were examined and scored on days 1, 3, 7, and 14 using the Bates-Jensen Wound Assessment Tool. The collected data were analyzed in SPSS using repeated-measures Analysis of Variance (ANOVA). Ethical Considerations: This study was approved by the ethics committee of sabzevar university medical sciences. (Code: IR.MEDSAB.REC.1394.60). Results Eighteen of the 30 examined patients were male and 12 were female. Their Mean±SD age and body mass index were 43.03±11.90 years and 27.82±4.08 kg/m2, respectively. Conclusion: The repeated-measures ANOVA data indicated that the study groups were significantly different concerning the final mean scores given to the wounds (P=0.047). In other words, the research groups significantly differed in wound healing; thus, topical application of vitamin C significantly improved wound healing in the study participants.

Effect of Subcutaneous Topical Ozone Therapy on Second-Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
Ebru Ayvazoğlu Soy ◽  
Coşkun Araz ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Burns are one of the most severe traumas, causing coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burns may affect rates of patient survival and reduce complications. We studied the effects of subcutaneous ozone injection on second-degree burn wounds in animal model. For this study, 72 Sprague-Dawley male rats were divided randomly into the following three groups: control group , silver sulfadiazine group, and ozone group; each group was then divided randomly into two subgroups (day 7 or day 14 examination and sacrifice). Superficial partial thickness burns were created on the lower back. In the control group, subcutaneous 0.9% serum saline was injected daily into the burn area. In the silver sulfadiazine group, burns were dressed daily with silver sulfadiazine. In the ozone group, subcutaneous ozone was injected daily into the burn area. We performed tissue hydroxyproline level measurements and histopathological evaluations. When groups were compared in terms of weight change, no significant difference was found between day 7 and day 14. With regard to tissue hydroxyproline levels the ozone group had significantly higher levels on both day 7 and day 14 (P &lt; .001). In histopathological evaluations, we determined that wound healing in the ozone group was significantly higher than in the other groups. We found that subcutaneous ozone therapy was more effective than silver sulfadiazine in the healing process of second-degree burn wounds and could be safely used in the treatment of burn wounds.

scholarly journals Structural Features of Skin Reparative Regeneration of Mature Rats under the Chronic Hyperglycemia

2020 ◽  
Vol 5 (6) ◽  
pp. 72-78
Author(s):  
O. S. Maksymova ◽  
◽  
D. V. Muravsky ◽  
G. F. Tkach
Keyword(s):  
Wound Healing ◽  
Healing Rate ◽  
Reparative Regeneration ◽  
The Body ◽  
Skin Regeneration ◽  
Control Group ◽  
Chronic Hyperglycemia ◽  
Study Results ◽  
The World ◽  
Wound Healing Rate

Diabetes is one of the most common condition in the world which is rightly interpreted as a non-infectious pandemic. The wounds are one of most common traumatic injuries, constitute a significant proportion of surgical pathology and are a serious medical problem throughout the world. The disruption of the carbohydrate exchange has a negative impact on the healing process, which can be long and difficult to treat. The problem of repaired damaged skin of various etiologies remains relevant today. The purpose of our research was to study the microstructural and planimetric features of the skin reparative regeneration of mature rats under the chronic hyperglycemia. Material and methods. The study was conducted on 60 white laboratory mature rats: a control group, a group of animals with chronic hyperglycemia of the body. The chronic hyperglycemia was simulated by the single intraperitoneal administration of streptozotocin (40 mg/kg) and nicotinic acid (1 mg/kg). The wound was formed by cutting out a piece of skin in the interscapular region. The studies were performed on the 7, 14 and 21 days after trauma. The light microscopy was performed using an Olympus BH-2 microscope (Japan), the planimetric analysis was performed using the morphometric program "Digimizer". The statistical analysis was performed using the SPSS-17 software package. Results and discussion. The study results showed that the process of the skin regeneration of mature rats with the chronic hyperglycemia is of the unfinished character and reveals as a violation of the epithelialization process, angiogenesis, keratinization and reorganization of connective tissue into a full-fledged dermis. The main features of the process of post-traumatic skin regeneration of rats with chronic hyperglycemia are the prolongation of the reduction of wound area at the all study stages. The wound healing rate in the rats with the chronic hyperglycemia was the largest on the 21st day of the experiment and was (7.69±1.97) mm2 / day, while in control rats the wound healing rate at the end of the experiment was the lowest and amounted to (2.87±0.32) mm2 / day. The wound healing rate were clearly correlated with the dynamics of wound healing in both groups. Conclusion. In our study, we also observed a prolongation of the inflammatory phase and delayed recovery processes in animals with chronic hyperglycemia. In these animals there was a decrease in the rate of wound healing with a weak tendency to increase it at the end of the experiment. In the control group, on the contrary, the rate of wound healing was higher in the initial stages of the study, and decreased in the end. Speed rates were clearly correlated with the dynamics of wound defect healing in both groups

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