scholarly journals Chemical and biological investigation of the Agaricus silvaticus Schaeff ex. Secr

2014 ◽  
Vol 12 ◽  
pp. 92-97 ◽  
Author(s):  
L Munkhgerel ◽  
N Erdenechimeg ◽  
M Dumaa ◽  
G Zhang ◽  
P Odonmajig ◽  
...  
Keyword(s):  
Spectral Data ◽  
Biological Activities ◽  
Biological Investigation ◽  
Ergosterol Peroxide ◽  
Extensive Analysis ◽  
Ethanol Extracts ◽  
First Time

Extract of Agaricus silvaticus Schaeff ex. Secr fungus have been known to have biological activities, including antibacterial, antiviral, anticancer, antioxidant, anticomplementary and immunostimulating effects. In this study we first time identified that Agaricus silvaticus Schaeff ex. Secr has interferon like activity. We first time isolated the four known compounds such as, mannitol (1), urea (2), ergosterol (3) and ergosterol peroxide (4) from 95% ethanol extracts of Agaricus silvaticus Schaeff ex. Secr in Mongolia. Their structures were elucidated on the basis of extensive analysis of spectral data and by comparison with authentic samples.DOI: http://dx.doi.org/10.5564/mjc.v12i0.180 Mongolian Journal of Chemistry Vol.12 2011: 92-97

scholarly journals Chemical Constituents of the Marine Sponge Aaptos aaptos (Schmidt, 1864) and Their Cytotoxic Activity

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199334
Author(s):  
Do Thi Trang ◽  
Bui Huu Tai ◽  
Dan Thuy Hang ◽  
Pham Hai Yen ◽  
Phan Thi Thanh Huong ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Absolute Configuration ◽  
Marine Sponge ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Extensive Analysis ◽  
First Time ◽  
Tddft Method ◽  
Mcf 7

Seven compounds (1-7) were isolated from the marine sponge Aaptos aaptos living in the Vietnamese sea. Their structures were determined as 2 hours, 5 H,7 H,9 H-9 S-hydroxy-imidazo[1,5- α]pyridine-1,3-dione (1), 3-([9-methylhexadecyl]oxy)propane-1,2-diol 2, 2,3-dihydro-2,3-dioxoaaptamine (3), indol-3-aldehyde (4), methyl indole-3-carboxylate (5) 4-hydroxy-5-(indole-3-yl)−5-oxo-pentan-2-one (6), and thymidine (7) by extensive analysis of HR-ESI-MS, 1D, and 2D NMR spectral data, as well as by comparison of the spectral data with those reported in the literature. In addition, the absolute configuration of 1 was determined from the experimental ECD spectrum and comparison of this with the theoretical ECD calculations using the TDDFT method. Compounds 1 and 2 were isolated from nature for the first time. Compound 3 induced cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values of 41.27 ± 2.63, 40.70 ± 2.65, 34.31 ± 3.43, and 36.63 ± 1.40 µM, respectively.

scholarly journals Biological Activities of Extracts from Different Parts of two Cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata’

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Toshinori Nakagawa ◽  
Ahmed E. Allam ◽  
Koichiro Ohnuki ◽  
Kuniyoshi Shimizu
Keyword(s):  
Active Compound ◽  
Prunus Persica ◽  
Biological Activities ◽  
Natural Antioxidants ◽  
Ethyl Acetate Fraction ◽  
Biological Investigation ◽  
Active Compounds ◽  
Ethanol Extracts ◽  
By Products ◽  
Different Parts

We investigated the antioxidant, anti-lipase and anti-dementia activities of peach ( Prunus persica (L.) Batsch) fruit and its by-products. The ethanol extracts of branch showed relatively high activity in all biological activities. Then, the extract was fractionated, and eight compounds were isolated from the ethyl acetate fraction. Results showed 4,2’,4'-trihydroxy-6'-methoxychalcone 4'- O-β-D-glucopyranoside (5) and quercetin 3- O-β-D-glucopyranoside (7) as newly identified compounds in P. persica. From the biological investigation, it was considered that quercetin 3- O-β-D-glucopyranoside (7) was the main active compound of antioxidant activity. The main active compound of anti-lipase activity in these was oleanolic acid (1). In addition, (+)-4'- O-methylcatechin (4), 4,2’,4'-trihydroxy-6'-methoxychalcone 4'- O-β-D-glucopyranoside (5) and ferulic acid (6) were the main active compounds of anti-dementia activity with acetylcholinesterase inhibitory assay. The results obtained suggested that these active compounds from peach branches of P. persica could be exploited as natural antioxidants, anti-lipase and anti-dementia materials in the future.

scholarly journals CHEMICAL CONSTITUENTS FROM POLYGONATUM KINGIANUM COLL. ET HEMSL. OF VIETNAM

2020 ◽  
Vol 58 (5) ◽  
pp. 549
Author(s):  
Lê Minh Hà
Keyword(s):  
Spectral Data ◽  
Nmr Spectra ◽  
Chemical Constituents ◽  
Dienoic Acid ◽  
2D Nmr ◽  
Ergosterol Peroxide ◽  
2D Nmr Spectra ◽  
First Time

Seven compounds, including two homoisoflavanones 3-(2ʹ-hydroxy-4ʹ-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one (1), disporopsin (2) along with 2-O-methyl-α-D-fructofuranose (3), (E,E)-9-oxooctadeca-10,12-dienoic acid (4), 1-palmitoylglycerol (5), 5α,8α-ergosterol  peroxide (6),  daucosterol (7) were isolated from the rhizomes of Polygonatum kingianum of Vietnam. Their structures were determined by 1D and 2D NMR spectra and by comparison with the reported spectral data. Compounds 3, 4 and 6 are first reported from the genus Polygonatum. Compound 1 and 5 are reported for the first time from Polygonatum kingianum.

scholarly journals Chemical composition and biological activities of the Agaricus mushrooms

2014 ◽  
Vol 14 ◽  
pp. 41-45 ◽  
Author(s):  
L Munkhgerel ◽  
N Erdenechimeg ◽  
B Tselmuungarav ◽  
B Amartuvshin ◽  
Ts Bolor ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Chemical Components ◽  
Scavenging Activity ◽  
Mongolian Flora ◽  
Ethanol Extracts ◽  
First Time

Two species of Agaricus mushroom grown in Mongolia were analyzed for their element content. Biological activity and chemical components study of Agaricus, grown in the Mongolian flora has been investigated for the first time. The ethanol extracts of dried Agaricus sp. mushrooms were analyzed for antioxidant activity on 1,1-diphenyl-2- picrylhydrazyl (DPPH) radicals and interferon-like activity. The ethanol extracts from Agaricus arvensis showed the most potent radical scavenging activity. The IC50 of A. silvaticus and A. arvensis were 216 and 17.75 g/ml respectively. Among the twenty three mushroom extracts, the extracts from A. silvatisus and A. arvensis have shown the interferon-like activity. DOI: http://dx.doi.org/10.5564/mjc.v14i0.197Mongolian Journal of Chemistry 14 (40), 2013, p41-45

scholarly journals Anti Stress Activity of Phytoecdysteroids Isolated from Aerial Part of Silene claviformis

2020 ◽  
pp. 9-17
Author(s):  
Nurmurod Ramazonov ◽  
Ugiloy Yusupova ◽  
Feruza Egamova ◽  
Vladimir Syrov
Keyword(s):  
Biological Activity ◽  
Adrenal Gland ◽  
Protective Effect ◽  
Aerial Part ◽  
Biological Activities ◽  
Biological Investigation ◽  
Uv Lamp ◽  
Peroxidation Processes ◽  
First Time ◽  
Layer Chromatography

Aims: The aim of present study was to isolate the phytoedysteroids from aerial part of Silene claviformis (Caryophyllaceae) and investigate their biological activity. Place and Duration of Study: The investigation were carried out during 2019 and 2020 at  laboratory of the chemistry of glycosides and department of the pharmacological and toxicology of  Institute of the Chemistry of Plant Substances AS RUz, Tashkent, Uzbekistan. Methodology: The phytoecdysteroids were isolated from aerial part of Silene claviformis using chromatographic methods. Thin-layer chromatography made on Silufol UV-254 and Merck plates, Fluka Analytical Germany, by spraying with alcohol solution of vanillin and heating for 1-2 minutes for 90-1000, UV lamp light at 254 nm and 365 nm. Their structures were confirmed by NMR and IR spectroscopy. Sum of phytoecdysteroids was administered at a dose of 10 mg/kg orally. The data obtained during the experiments were processed and analyzed by the method of variation statistics using the Student t-criterion. Results: Silene claviformis contains 2-deoxyecdysterone (1), polypodine B (2), 20-hydroxyecdysone (3), ecdysterone-20,22-acetalisovaleric aldehyde (4),integristeron A (5),cyasterone (6), ecdysterone-20,22-acetalisovalerian (7), 2-deoxy-α-ecdysone (8). The compounds 2 and 6 are reported for the first time from this genus. The biological activity (stress-protective effect) of the mentioned phytoecdysteroids studied for the first time. These compounds were tested on male mice for their biological activities and results showed that, the adrenal gland mass increased in relation to the adrenal gland mass of intact animals by 42.6%, they showed a significant decrease in the content of ascorbic acid and cholesterol by 56.5 and 49.1%, respectively. A significant decrease in glycogen content (by 30.1%) and a noticeable activation of lipid peroxidation processes were noted in the liver, as indicated by an increase of 69.2% in the content of malondialdehyde in the organ. Conclusion: This is the first study reporting an orally biological investigation for Silene claviformis. The sum of phytoecdysteroids showed potent stress-protective activity. The stress-protective effect of phytoecdysteroids was more pronounced in compared the eleutherococcus extract.

Dwindling status of Epimedium Elatum (Morren & Decne) and its geographical distribution in Kashmir Himalaya, India

2018 ◽  
pp. 47-52
Keyword(s):  
Medicinal Plant ◽  
Biological Activities ◽  
Conservation Status ◽  
Natural Populations ◽  
Culture Techniques ◽  
Kashmir Himalayas ◽  
Near Future ◽  
First Time ◽  
Tissue Culture Techniques

Epimedium elatum (Morren & Decne) of family Berberidaceace is a rare perennial medicinal plant, endemic to high altitude forests of Northwestern Himalayas in India. Ethnobotanically, it has been used as an ingredient for treatment of bone-joint disorders, impotence and kidney disorders in Kashmir Himalayas. Phytochemically, it is rich in Epimedin ABC and Icariin; all of these have been demonstrated to possess remarkable biological activities like PDE-5 inhibition (treatment of erectile dysfunction), anticancer, antiosteoporosis antioxidant and antiviral properties. The present investigation reports its traditional usage, comprehensive distribution and conservation status from twenty ecogeographical regions in Kashmir Himalayas, India. The species was reported from Gurez valley for the first time. Numerous threats like excessive grazing, deforestration, habitat fragmentation, tourism encroachment, landslides and excessive exploitation have decreased its natural populations in most of the surveyed habitats. Consequently, its existence may become threatened in near future if timely conservation steps are not taken immediately by concerned stakeholders involved in medicinal plant research. Moreover, use of plant tissue culture techniques is recommended for development of its in vitro propagation protocols. Therefore, introduction of this medicinal plant in botanical gardens, protected sites and development of monitoring programmes are needed for its immediate conservation in Northwestern Himalayas, India.

Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae

2019 ◽  
Vol 20 (4) ◽  
pp. 302-308 ◽  
Author(s):  
Carla R.F. Volobuff ◽  
Pedro C.O. Junior ◽  
Sidney M. dos Santos ◽  
Zefa V. Pereira ◽  
Diego C. Ferreira ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Biological Activities ◽  
Brain Structures ◽  
Acetylcholinesterase Inhibition ◽  
Mato Grosso ◽  
Male Wistar Rats ◽  
First Time ◽  
Mato Grosso Do Sul ◽  
Antiproliferative Activities ◽  
Mcf 7

Background: The genus Psychotria and Palicourea are reported as a source of alkaloids and iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase activities and quantification of the alkaloids of seven species among the genus found in Mato Grosso do Sul region in Brazil. Methods: Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus and striatum by the Ellman method. Results: Alkaloids from Psychotria and Palicourea species were quantified which showed values of 47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50: 34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50: 2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa, P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control. Conclusion: Herein, the present work showed for the first time, anticholinesterasic and antiproliferative activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of alkaloids in the leaves of these species.

scholarly journals Natural products isolated from Casimiroa

2020 ◽  
Vol 18 (1) ◽  
pp. 778-797
Author(s):  
Khun Nay Win Tun ◽  
Nanik Siti Aminah ◽  
Alfinda Novi Kristanti ◽  
Hnin Thanda Aung ◽  
Yoshiaki Takaya
Keyword(s):  
Natural Products ◽  
Spectral Data ◽  
Aromatic Compounds ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Quinoline Alkaloids

AbstractAbout 140 genera and more than 1,600 species belong to the Rutaceae family. They grow in temperate and tropical zones on both hemispheres, as trees, shrubs, and herbs. Casimiroa is one of the genera constituting 13 species, most of which are found in tropical and subtropical regions. Many chemical constituents have been derived from this genus, including quinoline alkaloids, flavonoids, coumarins, and N-benzoyltyramide derivatives. This article reviews different studies carried out on aromatic compounds of genus Casimiroa; their biological activities; the different skeletons of coumarins, alkaloids, flavonoids, and others; and their characteristic NMR spectral data.

Chemical components of the rhizomes of Drynaria fortunei (KUNZE) J. Sm. (polypodiaceae) in Vietnam

2011 ◽  
Vol 76 (9) ◽  
pp. 1133-1139 ◽  
Author(s):  
Pham Thi Nhat Trinh ◽  
Nguyen Cong Hao ◽  
Phan Thanh Thao ◽  
Le Tien Dung
Keyword(s):  
Data Analysis ◽  
Spectral Data ◽  
Phenolic Acid ◽  
Ethanol Extract ◽  
Chemical Components ◽  
Spectroscopic Methods ◽  
Phenylpropanoid Glycoside ◽  
Spectral Data Analysis ◽  
First Time

From the ethanol extract of Drynaria fortunei (KUNZE) J. Sm., a new phenylpropanoid glycoside, fortunamide (1), was isolated and characterized by spectroscopic methods. Together with a new glycoside, 9 known compounds, including three curcuminoids (2–4), two isoprenylated flavonoids (5, 6), two flavonoids (7, 8), one monoterpenoid (9) and one phenolic acid (10) were isolated and identified by spectral data analysis from the rhizomes of Drynaria fortunei (KUNZE) J. Sm. Eight of them were isolated from Drynaria fortunei (KUNZE) J. Sm. for the first time.

Sign in / Sign up

Export Citation Format

Share Document