scholarly journals Chemometric-Assisted Spectrophotometric Method for the Simultaneous Quantitative Determination of Ezetimibe and Simvastatin in Their Combined Dosage Forms

2018 ◽  
Vol 101 (4) ◽  
pp. 1015-1020
Author(s):  
Fernanda Heringer de Souza ◽  
Vítor Todeschini ◽  
Maximiliano da Silva Sangoi
Keyword(s):  
Factorial Design ◽  
Low Cost ◽  
Calibration Procedure ◽  
Dosage Forms ◽  
Multivariate Method ◽  
Environmental Friendly ◽  
Precision And Accuracy ◽  
Full Factorial ◽  
Accuracy Data

Abstract The multivariate method, partial least-squares (PLS), was used as a calibration procedure for the simultaneous UV spectrophotometric determination of ezetimibe and simvastatin in their pharmaceutical forms. The method was developed and satisfactorily validated according to International Conference on Harmonization guidelines with respect to specificity, linearity, precision, accuracy, and robustness. In this study, the PLS algorithms are based on the absorption spectra of 25 different mixtures of drugs obtained by a multilevel factorial design. The method was linear in the concentration range of 2–8 μg/mL for ezetimibe and 4–16 μg/mL for simvastatin (r2 > 0.99; n = 7) at wavelengths of 238 and 247 nm, respectively. The LOD and LOQ were 0.28 and 0.93 μg/mL for ezetimibe and 0.16 and 0.53 μg/mL for simvastatin, respectively. Precision and accuracy data, evaluated by RSD, were lower than 2%. The method, which proved to be robust, was performed with a 2n full-factorial design. The validated method is simple and low cost, has a low use of polluting reagents, and is environmental friendly. Therefore, the proposed method was successfully applied for the simultaneous quantitative analysis of ezetimibe and simvastatin in commercial formulations.

Rapid Determination of Bismuth and Lead in Iron- and Nickel-Base Alloy Chips

1973 ◽  
Vol 27 (6) ◽  
pp. 464-466 ◽  
Author(s):  
M. G. Atwell ◽  
G. S. Golden
Keyword(s):  
Base Alloy ◽  
Rapid Determination ◽  
Lithium Carbonate ◽  
Nickel Base Alloy ◽  
Precision And Accuracy ◽  
Single Standard ◽  
Nickel Base ◽  
Dc Arc ◽  
Accuracy Data

A rapid emission spectographic method for the determination of traces of bismuth and lead in a wide variety of iron- and nickel-base alloys is reported. The sample, in the form of chips, filings, or drillings, is mixed with lithium carbonate, placed in an anode cup electrode, and excited in a dc arc. Detection limits of approximately 0.2 ppm for bismuth and 0.4 ppm for lead may be realized, depending on the alloy. Working curves may be prepared from a single standard of each alloy by using variable weights in a series of electrodes. Precision and accuracy data for a number of alloys are presented.

scholarly journals PRECISION AND ACCURACY PARAMETERS IN STRUCTURED LIGHT 3-D SCANNING

2016 ◽  
Vol XL-5/W8 ◽  
pp. 7-15 ◽  
Author(s):  
E. R. Eiríksson ◽  
J. Wilm ◽  
D. B. Pedersen ◽  
H. Aanæs
Keyword(s):  
State Of The Art ◽  
Low Cost ◽  
Structured Light ◽  
Quantitative Measure ◽  
Calibration Procedure ◽  
Design Parameters ◽  
Precision And Accuracy ◽  
Structured Light Systems ◽  
Encoding Strategy ◽  
Cost Components

Structured light systems are popular in part because they can be constructed from off-the-shelf low cost components. In this paper we quantitatively show how common design parameters affect precision and accuracy in such systems, supplying a much needed guide for practitioners. Our quantitative measure is the established VDI/VDE 2634 (Part 2) guideline using precision made calibration artifacts. Experiments are performed on our own structured light setup, consisting of two cameras and a projector. We place our focus on the influence of calibration design parameters, the calibration procedure and encoding strategy and present our findings. Finally, we compare our setup to a state of the art metrology grade commercial scanner. Our results show that comparable, and in some cases better, results can be obtained using the parameter settings determined in this study.

Simple Determination of Ranitidine in Dosage Forms by In-Phase Selective AC Polarography

1988 ◽  
Vol 71 (2) ◽  
pp. 388-390
Author(s):  
Juan A Squella ◽  
Luis A Zuñiga ◽  
Igor Lemus ◽  
Luis J. Nuñez Vergara
Keyword(s):  
Sample Preparation ◽  
Nitro Group ◽  
Dosage Forms ◽  
Polarographic Method ◽  
Precision And Accuracy

Abstract A new AC polarographic method for the determination of pharmaceutical forms of ranitidine is proposed, based on the electroactivity of the ranitidine nitro group. Individual and composite assays as well as recovery studies are described. Results show adequate precision and accuracy. Sample preparation is easy and no excipient separation is required.

scholarly journals Validation of a green spectrophotometric method for the determination of dropropizine in commercial oral solutions

2020 ◽  
Vol 4 (2) ◽  
pp. 12-18
Author(s):  
Millena Almeida Monsores ◽  
Mikaelly Pereira Caet ◽  
Anna Karolina Mouzer Machado ◽  
Marina Cardoso Nemitz ◽  
Vítor Todeschini ◽  
...  
Keyword(s):  
Spectrophotometric Method ◽  
Low Cost ◽  
Mean Value ◽  
Green Method ◽  
Zero Crossing ◽  
First Order ◽  
Relative Standard ◽  
Full Factorial ◽  
Crossing Point

The present work describes a first-order derivative spectrophotometric (1D-UV) method for determination of dropropizine in commercial oral solutions. The method was developed using ecologically correct solvents and validated according to International Conference on Harmonization (ICH) recommendations. The response was linear in the concentration range of 6–24 μg/mL (r = 0.9997, n = 7) at wavelength 249 nm, which was the zero crossing point of excipient solutions. The detection and quantitation limits were 0.36 and 1.18 μg/mL, respectively. The method showed adequate precision, with a relative standard deviation values lower than 1.41%. Excellent values of accuracy were obtained, with a mean value of 99.44%. The method proved to be robust by a full factorial design evaluation. It is simple, it has low cost, and it has low use of polluting reagents. Minimum environmental hazards observed and the results obtained attest to the reliability of the proposed green method, showing to be specific, linear, precise, accurate and robust. Thus, the validated 1D-UV spectrophotometric method was successfully applied to the quantitative analysis of dropropizine in oral solutions dosage forms, helping to improve quality control and to assure therapeutic efficacy.

scholarly journals A NOVEL SPECTROPHOTOMETRIC DETERMINATION OF METHYLDOPA THROUGH TERNARY COMPLEXATION PROCEDURE USING FE(III), MN(II), AND CO(II) WITH 2-AMINOPYRIDINE

2019 ◽  
pp. 366-371 ◽  
Author(s):  
MUSTAFA JAMAL KHALEEL BICHAN ◽  
FADAM MUTEB ABDOON
Keyword(s):  
Low Cost ◽  
Dosage Forms ◽  
Optimum Conditions ◽  
Pharmaceutical Dosage Forms ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision ◽  
Significant Difference ◽  
Ternary Complexation ◽  
Colored Complexes

Objective: The present study is aimed to find a three simple, low cost, accurate, rapid, and sensitive spectrophotometric methods based on the formation of ternary complexes to assay methyldopa (MTD) in both pure and pharmaceutical dosage forms. Methods: The suggested complexation procedure is based on the formation of ternary complex among MTD, 2-aminopyridine (2-Amp), and different metal cations such as [Fe(III), Mn(II), and Co(II)] to form three complexes of Fe(III)-MTD-2-Amp (A), Mn(II)-MTD-2-Amp (B), and Co(II)-MTD-2-Amp (C) in an aqueous medium. Results: The obtained colored complexes are spectrophotometrically measured for the previously mentioned complexes at 572, 473, and 465 nm, respectively. Under optimum conditions, the complexes exhibited apparent, molar absorptivities of 1810.62, 2954.18, and 2596.8 l/mol/cm, Sandell’s sensitivity of 0.132, 0.08, and 0.092 μg/cm2, and Beer–Lambert’s law is obeyed over the ranges 4–40, 4–32, and 4–40 μg/ml for the three developed methods, respectively. Conclusion: The developed spectrophotometric methods showed excellent results in regard to accuracy and precision with recovery of 99.48±1.62%, 100.24±1.76%, and 100.72±1.65% of the complexes A, B, and C, respectively. The obtained results are compared statistically with a reported method with respect to t- and F-tests and the calculated results displayed no significant difference.

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