Anticancer Properties of Cardiac Glycosides

Beneficial properties of shade trees of tea plantations other than their medicinal properties have been extensively studied. This research was initiated to explore the properties of some shade trees with special emphasis on their antioxidant and antibacterial properties. Leaves from shade tree like Dalbergia sissoo (DS), Cassia siamea (CS), Derris robusta (DR), Leucaena leucocephala (LL), Acacia lenticularis (AL) and Melia azedarach (MA) were used for the study. Characterization of shade tree leaves by determination of moisture, crude fibre and ash content and tests of non polar – polar solvent extracts for steroid, tannins, cardiac glycosides and coumarin, free radical scavenging, ferric reducing power, NO scavenging activities, quantification of Flavonoids and antibacterial activity were conducted. The average moisture, crude fibre and ash percentage of shade tree plants were found to be 62.95, 11.28 and 1.86 respectively. Methanol, ethanol, acetone and ethyl acetate respectively proved to be the most potent solvent for various phytochemical extractions as it gave positive results for tests like tannin, steroid, cardiac glycosides and coumarin. AL (91.46%), DR (92.69%), LL (94.32%) and MA (93.34%) leaf extracts showed a high level of DPPH scavenging activity in their water extracts. In DS (88.11%) and CS (83.23%) maximum DPPH scavenging activity was observed in Diethyl ether and Methanol extracts respectively. Acetone extracts were more active than the water extracts in exhibiting ferric reducing power and NO scavenging activity. Summation of the quantity revealed that DS showed maximum presence of flavonoids and acetone as most potential for isolation of flavonoids. The decreasing order of summative antibacterial activity was recorded in DS, followed by CS, DR, AL, MA and LL. Chloroform showed the highest summative inhibition zone followed by ethanol, ethyl acetate, diethyl ether, acetone, water, hexane, benzene and methanol. The antioxidant and antibacterial potential of shade trees were established.

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Investigation of antiulcer activity of Pergularia extensa Linn

International Journal of Research in Phytochemistry and Pharmacology ◽

10.26452/ijrpp.v9i2.1198 ◽

2020 ◽

Vol 9 (2) ◽

pp. 23-26

Author(s):

Pavani C H

Keyword(s):

Cardiac Glycosides ◽

Methanol Extract ◽

Methanolic Extract ◽

Antiulcer Activity ◽

Acute Oral Toxicity ◽

Gastric Lesions ◽

Oral Toxicity ◽

Control Groups ◽

Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively.

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Anticancer Properties of Safawi Date (Phoenix Dactylifera L.) Seed Extract against Human Breast Adenocarcinoma Cell Line (MCF-7): In-vitro Study

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.03.289 ◽

2020 ◽

Vol 12 (03) ◽

Keyword(s):

In Vitro Study ◽

Phoenix Dactylifera ◽

Breast Adenocarcinoma ◽

Human Breast ◽

Adenocarcinoma Cell Line ◽

Anticancer Properties ◽

Human Breast Adenocarcinoma ◽

Phoenix Dactylifera L ◽

Mcf 7

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Vitamin D as potential therapeutic anticancer agent

Journal of Cancer Science and Therapeutics ◽

10.36879/jcst.19.000106 ◽

2018 ◽

pp. 1-3

Keyword(s):

Vitamin D ◽

Anticancer Activity ◽

Anticancer Agent ◽

Antitumor Agents ◽

Metastatic Potential ◽

Anticancer Properties ◽

Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

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Novel Chemotherapeutic Agents - The Contribution of Scorpionates

Current Medicinal Chemistry ◽

10.2174/0929867325666180914104237 ◽

2020 ◽

Vol 26 (41) ◽

pp. 7452-7475 ◽

Cited By ~ 1

Author(s):

Marta A. Andrade ◽

Luísa M.D.R.S. Martins

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Anticancer Agents ◽

Medicinal Chemistry ◽

Bioinorganic Chemistry ◽

Chemotherapeutic Agents ◽

Great Role ◽

Anticancer Properties ◽

Scorpionate Ligands

: The development of safe and effective chemotherapeutic agents is one of the uppermost priorities and challenges of medicinal chemistry and new transition metal complexes are being continuously designed and tested as anticancer agents. Scorpionate ligands have played a great role in coordination chemistry, since their discovery by Trofimenko in the late 1960s, with significant contributions in the fields of catalysis and bioinorganic chemistry. Scorpionate metal complexes have also shown interesting anticancer properties, and herein, the most recent (last decade) and relevant scorpionate complexes reported for application in medicinal chemistry as chemotherapeutic agents are reviewed. The current progress on the anticancer properties of transition metal complexes bearing homo- or hetero- scorpionate ligands, derived from bis- or tris-(pyrazol-1-yl)-borate or -methane moieties is highlighted.

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From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins

Current Medicinal Chemistry ◽

10.2174/0929867324666170502124227 ◽

2018 ◽

Vol 25 (20) ◽

pp. 2292-2303 ◽

Cited By ~ 4

Author(s):

Negar Talaei Zanjani ◽

Monica Miranda Saksena ◽

Fariba Dehghani ◽

Anthony L. Cunningham

Keyword(s):

Antiviral Activity ◽

Clinical Efficacy ◽

Mechanism Of Action ◽

Therapeutic Agent ◽

Marine Invertebrates ◽

Therapeutic Potential ◽

Biological Functions ◽

Anticancer Properties ◽

Mechanistic Understanding

Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein.

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Recent Progress of Benzimidazole Hybrids for Anticancer Potential

Current Medicinal Chemistry ◽

10.2174/0929867326666190808122929 ◽

2020 ◽

Vol 27 (35) ◽

pp. 5970-6014 ◽

Cited By ~ 3

Author(s):

Md. Jawaid Akhtar ◽

Mohammad Shahar Yar ◽

Vinod Kumar Sharma ◽

Ahsan Ahmed Khan ◽

Zulphikar Ali ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Activities ◽

Alkylating Agents ◽

American Chemical Society ◽

Chemical Society ◽

Benzimidazole Derivatives ◽

Progressive Development ◽

Anticancer Properties ◽

Naturally Occurring ◽

Nitrogenous Base

This review presents the detailed account of factors leading to cancer and design strategy for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for cancer treatment in Cancer facts and figures 2017 American Chemical Society has shown progressive development in fighting cancer. Researchers all over the world in both developed and developing countries are in a continuous effort to tackle this serious concern. Benzimidazole and its derivatives showed a broad range of biological activities due to their resemblance with naturally occurring nitrogenous base i.e. purine. The review discussed benzimidazole derivatives showing anticancer properties through a different mechanism viz. intercalation, alkylating agents, topoisomerases, DHFR enzymes, and tubulin inhibitors. Benzimidazole derivatives act through a different mechanism and the substituents reported from the earlier and recent research articles are prerequisites for the synthesis of targeted based benzimidazole derivatives as anticancer agents. The review focuses on an easy comparison of the substituent essential for potency and selectivity through SAR presented in figures. This will further provide a better outlook or fulfills the challenges faced in the development of novel benzimidazole derivatives as anticancer.

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