scholarly journals New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chien-shan Cheng ◽  
Jiaqiang Wang ◽  
Jie Chen ◽  
Kuei Ting Kuo ◽  
Jian Tang ◽  
...  
Keyword(s):  
Cardiac Glycosides ◽  
Active Constituent ◽  
Anticancer Properties

scholarly journals Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

2005 ◽  
Vol 102 (35) ◽  
pp. 12305-12310 ◽  
Author(s):  
J. M. Langenhan ◽  
N. R. Peters ◽  
I. A. Guzei ◽  
F. M. Hoffmann ◽  
J. S. Thorson
Keyword(s):  
Cardiac Glycosides ◽  
Anticancer Properties

scholarly journals Nanoformulations of α-Mangostin for Cancer Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1993
Author(s):  
Lisna Meylina ◽  
Muchtaridi Muchtaridi ◽  
I Made Joni ◽  
Ahmed Fouad Abdelwahab Mohammed ◽  
Nasrul Wathoni
Keyword(s):  
Drug Delivery ◽  
Cellular Uptake ◽  
Polymeric Nanoparticles ◽  
Cancer Drug ◽  
Garcinia Mangostana ◽  
Active Constituent ◽  
Anticancer Efficacy ◽  
Anticancer Properties ◽  
Cancer Drug Delivery

Natural compounds are emerging as effective agents for the treatment of malignant diseases. The active constituent of α-mangostin from the pericarp of Garcinia mangostana L. has earned significant interest as a plant base compound with anticancer properties. Despite α-mangostin’s superior properties as an anticancer agent, its applications are limited due to its poor solubility and physicochemical stability, rapid systemic clearance, and low cellular uptake. Our review aimed to summarize and discuss the nanoparticle formulations of α-mangostin for cancer drug delivery systems from published papers recorded in Scopus, PubMed, and Google Scholar. We investigated various types of α-mangostin nanoformulations to improve its anticancer efficacy by improving bioavailability, cellular uptake, and localization to specific areas These nanoformulations include nanofibers, lipid carrier nanostructures, solid lipid nanoparticles, polymeric nanoparticles, nanomicelles, liposomes, and gold nanoparticles. Notably, polymeric nanoparticles and nanomicelles can increase the accumulation of α-mangostin into tumors and inhibit tumor growth in vivo. In addition, polymeric nanoparticles with the addition of target ligands can increase the cellular uptake of α-mangostin. In conclusion, nanoformulations of α-mangostin are a promising tool to enhance the cellular uptake, accumulation in cancer cells, and the efficacy of α-mangostin as a candidate for anticancer drugs.

scholarly journals Natural Product Chemistry Research in Iraq

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ali AWAD Al-Jeboory ◽  
Yahya yahya Farid
Keyword(s):  
Cardiac Glycosides ◽  
New Drugs ◽  
Active Constituent ◽  
Isolation And Identification ◽  
Synthetic Drugs ◽  
Chemistry Research ◽  
Prosopis Farcta ◽  
Experimental Tool ◽  
Natural Drugs ◽  
Better Than

Abstract  Today's west an east scientists developed synthetic drugs but because of problems of the side effects and high cost in addition to resistant developed which not happened in using natural drugs this push the scientist in all over the world to look for new drugs from natural compounds. In Iraq. Since 1980 up today we started a plan led by scientist in Chemistry ,Pharmacology, Physician ,Biology in all universities & medical research centers and we started to develop anew methods for extraction ,isolation,identication of active constituent and trying the active constituent biologicaly and Pharmacologicaly in invitro and invivo on experimental animals . We started screening of more than thousand plants which indigenous in Iraq and take the knowledge from folkloric physician and old information about these from ancient books and references we found around two hundred promising plants we developed methods of extraction , isolation using chromatography and trying to evaluate their efficacy .We managed to prepare drugs to treat warts from ficus caria vitexin from cratagus azorolus, prosoptatin anew antihyperlipidemic drug from prosopis farcta etc. A new method of isolation and identification by new phytochemical methods and new experimental tool for each active constituent are as example how to separate alkaloids, cardiac glycosides inotropic agents , polyphenoles etc. In addition to bacteriological ,toxi-pathological methods then pass to prepare anew natural drugs prepared with highly sophisticated methods and with highly efficiency which may be better than synthetic drugs and more safe .

Celastrol, an active constituent of the TCM plant Tripterygium wilfordii, inhibits prostate cancer bone metastasis

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
K Kuchta ◽  
Y Xiang ◽  
S Huang ◽  
Y Tang ◽  
X Peng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Tripterygium Wilfordii ◽  
Active Constituent

Characterization of non polar-polar solvent extracts from some tea plantation shade tree leaves with special reference to antioxidant and antibacterial activities

2020 ◽  
pp. 15-21
Author(s):  
Arindam Ghosh ◽  
Soumya Majumder ◽  
Sumedha Saha ◽  
Malay Bhattacharya
Keyword(s):  
Cardiac Glycosides ◽  
Polar Solvent ◽  
Reducing Power ◽  
Scavenging Activity ◽  
Shade Trees ◽  
Crude Fibre ◽  
Shade Tree ◽  
Dpph Scavenging Activity ◽  
Dpph Scavenging

Beneficial properties of shade trees of tea plantations other than their medicinal properties have been extensively studied. This research was initiated to explore the properties of some shade trees with special emphasis on their antioxidant and antibacterial properties. Leaves from shade tree like Dalbergia sissoo (DS), Cassia siamea (CS), Derris robusta (DR), Leucaena leucocephala (LL), Acacia lenticularis (AL) and Melia azedarach (MA) were used for the study. Characterization of shade tree leaves by determination of moisture, crude fibre and ash content and tests of non polar – polar solvent extracts for steroid, tannins, cardiac glycosides and coumarin, free radical scavenging, ferric reducing power, NO scavenging activities, quantification of Flavonoids and antibacterial activity were conducted. The average moisture, crude fibre and ash percentage of shade tree plants were found to be 62.95, 11.28 and 1.86 respectively. Methanol, ethanol, acetone and ethyl acetate respectively proved to be the most potent solvent for various phytochemical extractions as it gave positive results for tests like tannin, steroid, cardiac glycosides and coumarin. AL (91.46%), DR (92.69%), LL (94.32%) and MA (93.34%) leaf extracts showed a high level of DPPH scavenging activity in their water extracts. In DS (88.11%) and CS (83.23%) maximum DPPH scavenging activity was observed in Diethyl ether and Methanol extracts respectively.  Acetone extracts were more active than the water extracts in exhibiting ferric reducing power and NO scavenging activity. Summation of the quantity revealed that DS showed maximum presence of flavonoids and acetone as most potential for isolation of flavonoids. The decreasing order of summative antibacterial activity was recorded in DS, followed by CS, DR, AL, MA and LL. Chloroform showed the highest summative inhibition zone followed by ethanol, ethyl acetate, diethyl ether, acetone, water,  hexane, benzene and methanol. The antioxidant and antibacterial potential of shade trees were established.

Investigation of antiulcer activity of Pergularia extensa Linn

2020 ◽  
Vol 9 (2) ◽  
pp. 23-26
Author(s):  
Pavani C H
Keyword(s):  
Cardiac Glycosides ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Antiulcer Activity ◽  
Acute Oral Toxicity ◽  
Gastric Lesions ◽  
Oral Toxicity ◽  
Control Groups ◽  
Dose Dependent

This study was based on determination of the antiulcer activity from methanol extract was prepared by using barks of pergularia extensa linn.. Priliminary investigations showed presence of saponins, terpenes, cardiac glycosides, alkaloids and sterols. Based on OECD-423 Guidelines, the pharmacology and acute oral toxicity studies were conducted by using methanolic extract. Ulcer development was prevented by Tannins because of their vasoconstriction effects and due to protein precipitation. Similarly, the Methanolic extract of Pergularia extensa Linn shows triterpenoids and saponins. The phytoconstituents are present in the extract and these could be possible agents which are involved in order to prevent gastric lesions induced by aspirin. When compared to ulcerative control groups, this Pergularia extensa Linn., shows a dose dependent curative ratio. The extracts exhibited an inhibition percentage of 27.18, 45.47 and 61.28 at doses of 100, 200 and 400mg/kg doses respectively. 

Vitamin D as potential therapeutic anticancer agent

2018 ◽  
pp. 1-3
Keyword(s):  
Vitamin D ◽  
Anticancer Activity ◽  
Anticancer Agent ◽  
Antitumor Agents ◽  
Metastatic Potential ◽  
Anticancer Properties ◽  
Chemotherapy Agents

The role of vitamin D is implicated in carcinogenesis through numerous biological processes like induction of apoptosis, modulation of immune system inhibition of inflammation and cell proliferation and promotion of cell differentiation. Its use as additional adjuvant drug with cancer treatment may be novel combination for improved outcome of different cancers. Numerous preclinical, epidemiological and clinical studies support the role of vitamin D as an anticancer agent. Anticancer properties of vitamin D have been studied widely (both in vivo and in vitro) among various cancers and found to have promising results. There are considerable data that indicate synergistic potential of calcitriol and antitumor agents. Possible mechanisms for modulatory anticancer activity of vitamin D include its antiproliferative, prodifferentiating, and anti-angiogenic and apoptic properties. Calcitriol reduces invasiveness and metastatic potential of many cancer cells by inhibiting angiogenesis and regulating expression of the key molecules involved in invasion and metastasis. Anticancer activity of vitamin D is synergistic or additive with the antineoplastic actions of several drugs including cytotoxic chemotherapy agents like paclitaxel, docetaxel, platinum base compounds and mitoxantrone. Benefits of addition of vitamin D should be weighed against the risk of its toxicity.

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