scholarly journals Bioactive Components of Human Milk: Similarities and Differences between Human Milk and Infant Formula

2018 ◽  
Author(s):  
Esmat Aly ◽  
Aliaa Ali Darwish ◽  
Ruben Lopez-Nicolas ◽  
Carmen Frontela-Saseta ◽  
Gaspar Ros-Berruezo
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Bioactive Components ◽  
Similarities And Differences

scholarly journals Human Milk Microbiota and Oligosaccharides: A Glimpse into Benefits, Diversity and Correlations

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1123
Author(s):  
Carole Ayoub Moubareck
Keyword(s):  
Human Milk ◽  
Maternal Diet ◽  
Geographical Location ◽  
Intestinal Barrier ◽  
Bioactive Components ◽  
Bioactive Constituents ◽  
Ongoing Research ◽  
Genetic Significance ◽  
The Rich ◽  
Insight Into

Human milk represents a cornerstone for growth and development of infants, with extensive array of benefits. In addition to exceptionally nutritive and bioactive components, human milk encompasses a complex community of signature bacteria that helps establish infant gut microbiota, contributes to maturation of infant immune system, and competitively interferes with pathogens. Among bioactive constituents of milk, human milk oligosaccharides (HMOs) are particularly significant. These are non-digestible carbohydrates forming the third largest solid component in human milk. Valuable effects of HMOs include shaping intestinal microbiota, imparting antimicrobial effects, developing intestinal barrier, and modulating immune response. Moreover, recent investigations suggest correlations between HMOs and milk microbiota, with complex links possibly existing with environmental factors, genetics, geographical location, and other factors. In this review, and from a physiological and health implications perspective, milk benefits for newborns and mothers are highlighted. From a microbiological perspective, a focused insight into milk microbiota, including origins, diversity, benefits, and effect of maternal diet is presented. From a metabolic perspective, biochemical, physiological, and genetic significance of HMOs, and their probable relations to milk microbiota, are addressed. Ongoing research into mechanistic processes through which the rich biological assets of milk promote development, shaping of microbiota, and immunity is tackled.

Gastroduodenal Motility in Neonates: Response to Human Milk Compared With Cow's Milk Formula

PEDIATRICS ◽  
1987 ◽  
Vol 80 (3) ◽  
pp. 434-438
Author(s):  
T. Tomomasa ◽  
P. E. Hyman ◽  
K. Itoh ◽  
J. Y. Hsu ◽  
T. Koizumi ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Infant Formula ◽  
High Amplitude ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Wave Form ◽  
Fasting State ◽  
Cow's Milk ◽  
Gastroduodenal Motility

It is known that breast milk empties more quickly from the stomach than does infant formula. We studied the difference in gastroduodenal motility between neonates fed with human milk and those fed with infant formula. Twenty-four five-to 36-day-old neonates were fed with mother's breast milk or with a cow's milk-based formula. Postprandlial gastroduodenal contractions were recorded manometrically for three hours. Repetitive, high-amplitude nonmigrating contractions were the dominant wave form during the postprandial period. The number of episodes, duration, amplitude, and frequency of nonmigrating contractions were not different following the different feedings. The migrating myoelectric complex, which signals a return to the interdigestive (fasting) state, appeared in 75% of breast milk-fed infants but only 17% of formula-fed infants (P < .05) within the three-hour recording period. Because contractions were similar following the two meals, but a fasting state recurred more rapidly in breast-fed infants, we conclude that factors other than phasic, nonpropagated antroduodenal contractions were responsible for the differences in gastric emptying between breast milk and formula.

scholarly journals Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: A randomized controlled trial

2021 ◽  
Author(s):  
Elvira Estorninos ◽  
Rachel B Lawenko ◽  
Eisel Palestroque ◽  
Norbert Sprenger ◽  
Jalil Benyacoub ◽  
...  
Keyword(s):  
Immune Response ◽  
Randomized Controlled Trial ◽  
Gut Microbiota ◽  
Human Milk ◽  
Infant Formula ◽  
Controlled Trial ◽  
Immune Defense ◽  
Intact Protein ◽  
Phylogenetic Distance ◽  
Randomized Controlled

Abstract Background Bovine milk-derived oligosaccharides (MOS) containing primarily galacto-oligosaccharides with inherent levels of sialylated oligosaccharides can be added to infant formula to enhance the oligosaccharide profile. Objective To investigate the effects of a MOS-supplemented infant formula on gut microbiota and intestinal immunity. Methods In a double-blind, randomized, controlled trial, healthy-term formula-fed infants aged 21–26 days either received an intact protein cow's milk-based formula (control group, CG, n = 112) or the same formula containing 7.2 g MOS/L (experimental group, EG, n = 114) until age 6 months. Exclusively human milk-fed infants (HFI, n = 70) from an observational study served as reference. Fecal samples collected at baseline, 2.5 and 4 months of age were assessed for microbiota (16S ribosomal ribonucleic acid—based approaches), metabolites and biomarkers of gut health and immune response. Results At age 2.5 and 4 months, redundancy analysis (P = 0.002) and average phylogenetic distance (P < 0.05) showed that the overall microbiota composition in EG was different from CG and closer to that of HFI. Similarly, EG caesarean-born infants were different from CG caesarean- or vaginally-born infants and approaching HFI vaginally-born infants. Relative bifidobacteria abundance was higher in EG vs. CG (P < 0.05) approaching HFI. At age 4 months, counts of Clostridioides difficile and Clostridium perfringens were ∼90% (P < 0.001) and ∼65% (P < 0.01) lower in EG vs. CG, respectively. Mean (95%CI) fecal secretory immunoglobulin A (IgA) in EG was twice that of CG [70 (57,85) vs. 34 (28,42) mg/g, P < 0.001] and closer to HFI. Fecal oral polio vaccine-specific IgA was ∼50% higher in EG vs. CG (P = 0.065). Compared to CG, EG and HFI had lower fecal calcium excretion (by ∼30%) and fecal pH (P < 0.001), and higher lactate concentration (P < 0.001). Conclusions Infant formula with MOS shifts the gut microbiota and metabolic signature closer to that of HFI, has a strong bifidogenic effect, reduces fecal pathogens, and improves intestinal immune response.

Simultaneous pasteurization and homogenization of human milk by combining heat and ultrasound: effect on milk quality

2010 ◽  
Vol 77 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Charles Czank ◽  
Karen Simmer ◽  
Peter E Hartmann
Keyword(s):  
Human Milk ◽  
Milk Proteins ◽  
Food Preservation ◽  
Secretory Iga ◽  
Bioactive Components ◽  
Laser Scattering ◽  
Milk Samples ◽  
Donor Human Milk ◽  
Preservation Technique ◽  
Ultrasound Effect

The combination of ultrasound and heat (thermoultrasound) is an emerging food preservation technique that retains higher quantities of bioactive components compared with current thermal pasteurization practice, but has not yet been assessed for pasteurizing human milk. Artificially contaminated human milk samples were treated with ultrasound (20 kHz, 150 watts) with and without heating. The retention of four human milk proteins was quantified by biochemical assay and laser scattering particle sizing was used to determine the extent of homogenization. While ultrasonic treatment was effective at inactivating Escherichia coli (D4 °C=5·94 min), Staphylococcus epidermidis exhibited resistance (D4 °C=16·01 min). Thermoultrasonic treatment was considerably more effective (Esch. coli D45 °C=1·74 min, D50 °C=0·89 min; Staph. epidermidis D45 °C=2·08 min, D50 °C=0·94 minutes) with a predicted retention (2·8 min treatment, 50°C) of secretory IgA lysozyme, lactoferrin and bile salt stimulated lipase of 91, 80, 77, and 45%, respectively. Homogenization of the milk samples occurred after 5 min and 2 min of ultrasonic and thermoultrasonic treatment, respectively. Thermoultrasonic treatment is an effective method for pasteurizing donor human milk and retaining a greater proportion of bioactive components compared with current practices. However, further studies are required to assess the practicality of applying this technique routinely to donor human milk.

Maltodextrin is a carbohydrate ingredient for the production of baby food

2021 ◽  
pp. 8-11
Author(s):  
Сергей Владимирович Симоненко ◽  
Татьяна Алексеевна Антипова ◽  
Светлана Валерьевна Фелик ◽  
Елена Сергеевна Симоненко
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Nutritional Value ◽  
Food Products ◽  
Artificial Feeding ◽  
Baby Food ◽  
Carbohydrate Component ◽  
Carbohydrate Composition ◽  
Physico Chemical ◽  
Microbiological Parameters

Организация искусственного вскармливания детей включает использование специализированных продуктов детского питания. Основными принципами создания адаптированных детских молочных смесей является приближение их к составу и свойствам женского молока и соответствие особенностям пищеварения и метаболизма ребенка. Немаловажным моментом при этом является адаптация углеводного компонента. В современных формулах детских адаптированных смесей часть лактозы заменена на мальтодекстрин. Целью настоящих исследований являлось изучение пищевой ценности, показателей безопасности отечественного углеводного ингредиента мальтодекстрина и возможности его применения в специализированной пищевой продукции для детского питания. Результаты исследований органолептических, физико-химических и микробиологических показателей опытного образца мальтодекстрина подтвердили соответствие требованиям, предъявляемым к углеводным ингредиентам для производства продуктов детского питания. При исследовании возможности использования отечественного мальтодекстрина в производстве адаптированных продуктов детского питания подтверждена его целесообразность для оптимизации углеводного состава готового продукта. The organization of artificial feeding of children includes the use of specialized baby food products. The main principles of creating adapted infant formula are to approach the composition and properties of human milk and to match the characteristics of the child's digestion and metabolism. An important point in this case is the adaptation of the carbohydrate component. In modern formulas of children's adapted mixtures, part of the lactose is replaced with maltodextrin. The purpose of these studies was to study the nutritional value, safety indicators of the domestic carbohydrate ingredient-maltodextrin and the possibility of its use in specialized food products for baby food. The results of studies of the organoleptic, physico-chemical and microbiological parameters of the maltodextrin prototype confirmed compliance with the requirements for carbohydrate ingredients for the production of baby food. When studying the possibility of using domestic maltodextrin in the production of adapted baby products, its expediency for optimizing the carbohydrate composition of the finished product was confirmed.

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