Distillery Configurations

2019 ◽  
pp. 47-64
Author(s):  
Karl Raitz
Keyword(s):  
Nineteenth Century ◽  
Labor Force ◽  
First Generation ◽  
Second Generation ◽  
High Capacity ◽  
Third Generation ◽  
Early Nineteenth Century ◽  
Railroad Tracks ◽  
Urban Rail ◽  
Capacity Output

Early-nineteenth-century farmers and millers were often craft distillers, mashing and fermenting grain meal in wooden barrels before distilling the liquid in small copper pot stills. Waterwheels powered the first-generation creek-side mills and distilleries. Wood fueled early steam engines; the use of coal required access to better transportation. Second-generation distilleries, operating from the 1830s to the 1880s, used traditional pot stills,although some adopted new column stills, perfected in Scotland, when they began to mechanize. Old still buildings were often modified to accommodate new machinery. Distillers stored whiskey-filled wooden barrels in stack warehouses to age. Industrialization required a larger labor force. By 1880, businesses in Louisville and other river cities were producing steam engines, boilers, and related equipment. Third-generation distilleries operated from the 1880s to 1920; their high-capacity output required more grain and fuel, mandating locations near railroad tracks or navigable rivers. Complementary industries such as cooperages, metal fabricators, slaughterhouses, and tanneries were attracted to urban, rail-side distilleries.

Distillery Configurations

2020 ◽  
pp. 74-113
Author(s):  
Karl Raitz
Keyword(s):  
Nineteenth Century ◽  
Labor Force ◽  
First Generation ◽  
Second Generation ◽  
High Capacity ◽  
Rail Transport ◽  
Third Generation ◽  
Railroad Tracks ◽  
Urban Rail ◽  
Local Residents

Early-nineteenth-century farmers and millers were often craft distillers, mashing and fermenting grain meal in wooden barrels before distilling the liquid beer in small, portable copper pot stills. Waterwheels powered the first generation of creek-side mills and distilleries. Wood fueled early steam engines; coal could not be used until road, river, and rail transport improved. Second-generation distilleries, operating from the 1830s to the 1880s, used traditional pot stills, although some adopted new column stills, perfected in Scotland, when they began to mechanize. Old still buildings were often modified with built-on additions to accommodate new machinery. Distillers stored whiskey-filled wooden barrels in stack warehouses to age, placing the barrels on their sides and stacking them in tiers. Industrialization required a larger labor force, often drawn from family members, local residents, or farm youths if the distillery operated in the countryside. By 1880, businesses in Louisville and other river cities were producing steam engines, boilers, and related equipment. Third-generation distilleries operated from the 1880s to 1920; many were high-capacity operations, and their grain and fuel requirements mandated locations near railroad tracks or navigable rivers. Complementary industries such as cooperages, metal fabricators, slaughterhouses, and tanneries were attracted to urban rail-side distilleries. Overproduction by third-generation distillers glutted the market, and the Whiskey Trust was formed to purchase and close distilleries to reduce overall production and increase prices.

The Brown Mite, Bryobia arborea Morgan and Anderson (Acarina: Tetranychidae), on Apple in Nova Scotia.: I. Influence of Intratree Distribution on the Selection of Sampling Units. II. Differences in Habits and Seasonal Trends in Orchards With Bivoltine and Trivoltine Populations. III. Distribution of Diapause Eggs. IV. Hatching of Diapause Eggs

1965 ◽  
Vol 97 (12) ◽  
pp. 1303-1318 ◽  
Author(s):  
H. J. Herbert
Keyword(s):  
Nova Scotia ◽  
First Generation ◽  
Second Generation ◽  
Central Area ◽  
Third Generation ◽  
Apple Trees ◽  
Seasonal Trends ◽  
Sample Unit ◽  
The Third ◽  
Selection Of

AbstractIn Nova Scotia one leaf cluster with an adjoining 1 inch of twig taken from the inside of each of 10 apple trees replicated four times is an adequate sample unit to measure the density of the brown mite.The brown mite has one generation with a partial second in some orchards and one with a partial second and partial third in others. The first generation adults in the bivoltine and trivoltine populations lay summer eggs on the leaves and twigs, and diapause eggs on tin twigs. The second generation adults in the bivoltine populations lay only diapause eggs; in the trivoltine populations they lay both summer and diapause eggs. The adults of the third generation lay only diapause eggs.The brown mite is found on both the leaves and woody parts of the tree. In orchards with bivoltine populations the proportion of mites on leaves reached a peak of 80% by mid-July, but thereafter gradually decreased to 10% by the end of August. However, in orchards with trivoltine populations the proportion of mites on leaves reached a peak of 80 to 90% by mid-July, remained constant until mid-August, and thereafter decreased to approximately 40% by the end of August.The number of diapause eggs laid by adults of each generation in both the bivoltine and trivoltine populations varies widely. The eggs are deposited on the trunk as well as on the branches, with the heaviest deposition in the central area of the tree. The diapause eggs laid by adults of the first generation are the last to hatch and those laid by the third generation are the first to hatch the following spring.The factors responsible for the differences in the number of generations and in the number of diapause eggs laid are unknown.

Failure properties of 352 explanted silicone-gel breast implants

1996 ◽  
Vol 4 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Walter Peters ◽  
Dennis Smith ◽  
Stanley Lugowski
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Survival Curve ◽  
Breast Implants ◽  
Thick Wall ◽  
Thin Wall ◽  
Third Generation ◽  
Silicone Gel ◽  
Failure Properties

There have been three generations of silicone-gel breast implants. First generation implants (thick wall – thick gel with Dacron patches) were made from 1963 to 1972. Second generation implants (thin wall-thin gel) were made from 1972 until the mid 1980s. The introduction of third generation implants (stronger wall, low-bleed) was geographically dependent. In Canada, Dow Corning Silastic II implants were introduced in 1986, and Surgitek SCL implants were introduced in 1988. In the present study, a total of 352 silicone-gel breast implants were removed from 239 patients between 1981 and 1995. Their failure properties were dependent upon their generation (year of manufacture) and, for second generation implants, their duration in situ. Of the 352 implants, 20 were first generation, and all were fully intact. Twenty-eight were third generation implants, and 27 were fully intact. Failure properties of the 302 second generation implants were dependent upon their duration of implantation. A survival curve indicated that these implants began to fail (by leaking or rupturing) after four years in situ. By six years, 40% had failed. After 12 years, 95% had failed. Of the 171 second generation implants removed between 1991 and 1995, 77% had failed. The failure properties were similar for the three main manufacturers: Dow Corning, Heyer-Schulte and Surgitek. The failure rate for second generation implants is much higher than was previously believed. This is particularly significant in view of the current difficulty in diagnosing implant failure.

scholarly journals “Blood Is a Very Special Juice”: Racialized Bodies and Citizenship in Twentieth-Century Germany

1999 ◽  
Vol 44 (S7) ◽  
pp. 149-169 ◽  
Author(s):  
Fatima El Tayeb
Keyword(s):  
Nineteenth Century ◽  
Twentieth Century ◽  
Second Generation ◽  
Place Of Birth ◽  
Early Nineteenth Century ◽  
Social Democratic ◽  
Democratic Government ◽  
Second Generation Immigrants ◽  
The Social ◽  
Nationality Law

The 1999 plan of the Social Democratic government to adjust Germany's 1913 nationality law has generated an intensely emotional debate. In an unprecedented action, the opposition Christian Democrats managed to gather hundreds of thousands of signatures against the adjustment that would have granted citizenship to second generation “immigrants” born in Germany. At the end of the twentieth century, Germans still strongly cling to the principle ofjus sanguinis. The idea that nationality is not connected ot place of birth or culture but rather to a “national essence” tJiat is somehow incorporated in the subject's blood has been strong in Germany since the early nineteenth century and has been especially decisive for the country's twentieth-century history.

scholarly journals Development of a Divergent Route to Erythrina Alkaloids

Synlett ◽  
2020 ◽  
Vol 31 (04) ◽  
pp. 327-333 ◽  
Author(s):  
Jesper L. Kristensen ◽  
Sebastian Clementson ◽  
Mikkel Jessing ◽  
Paulo J. Vital
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
19Th Century ◽  
First Generation ◽  
Second Generation ◽  
Enantioselective Synthesis ◽  
Third Generation ◽  
Synthetic Strategy ◽  
Erythrina Alkaloids ◽  
The 19Th Century

Erythrina alkaloids were identified at the end of the 19th century and today, more than 100 members of the erythrinane family have been isolated. They are characterized by a unique tetracyclic, α-tertiary spiroamine scaffold. Herein we detail our efforts towards the development of a divergent enantioselective synthesis of (+)-dihydro-β-erythroidine (DHβE) – one of the most prominent members of this intriguing family of natural products.1 Introduction2 Synthetic Strategy2.1 First Generation2.2 Second Generation2.3 Third Generation2.3.1 Radical Endgame2.3.2 Completion of the Total Synthesis3 Conclusion

Brominated β-Alkoxyvinyl Trihalomethyl Ketones as Promising Synthons in Heterocyclic Synthesis

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2008-2016
Author(s):  
Mateus Mittersteiner ◽  
Nilo Zanatta ◽  
Helio G. Bonacorso ◽  
Marcos A. P. Martins
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Building Blocks ◽  
Third Generation ◽  
Cycloaddition Reactions ◽  
Heterocyclic Synthesis

5-Bromo- and 5,5-dibromo-1,1,1-trihalo-4-methoxypent-3-en-2-ones (brominated enones) have proven to be attractive building blocks for the construction of heterocyclic and polyheterocyclic compounds bearing a trihalomethyl moiety through interesting cyclocondensation, alkylation, and cycloaddition reactions. This review compiles all of the reactions conducted with these brominated enones since they were first disclosed in 2001.1 Introduction2 Synthesis and Initial Applications3 Synthesis Using First-Generation Intermediates4 Synthesis Using Second-Generation Intermediates5 Synthesis Using Third-Generation Intermediates6 Conclusions

Evolution of a Chemical Strategy Toward the Synthesis of Unsymmetrically Oxidized Nuphar Alkaloids

Synlett ◽  
2019 ◽  
Vol 30 (14) ◽  
pp. 1632-1642
Author(s):  
Jacob J. Lacharity ◽  
Armen Zakarian
Keyword(s):  
Total Synthesis ◽  
First Generation ◽  
Second Generation ◽  
Third Generation ◽  
Successful Strategy ◽  
Synthesis Design ◽  
Sulfonium Ylide ◽  
Chemical Strategy

Here we describe the frustrations, joys, and unexpected turns experienced in our journey toward a successful strategy directed at the total synthesis of unsymmetrically oxidized Nuphar thioalkaloids. While many adjustments were made to our initial synthesis plan, our general approach to the construction of the central bis(spirothiolane) moiety remained unchanged. Specifically, each iteration of our synthesis design involved the formation of the thiaspirane motif through the stereodivergent coupling of a thietane with a metal carbenoid, followed by a Stevens-type rearrangement of the resulting sulfonium ylide.1 Introduction2 First-Generation Strategy3 Second-Generation Strategy4 Third-Generation Strategy5 Conclusion

scholarly journals Parameters of the seasonal cycle of Corythucha arcuata (Say, 1832) (Heteroptera: Tingidae) in the plains and foothills of the Northwestern Caucasus

2019 ◽  
pp. 101-128
Author(s):  
В.И. Щуров ◽  
А.С. Замотайлов
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Egg Laying ◽  
Day Length ◽  
Fourth Generation ◽  
Third Generation ◽  
Degree Days ◽  
The Third ◽  
Female Immigrant ◽  
Northwestern Caucasus

Развитие первой генерации Corythucha arcuata в предгорьях и низкогорьях Северо-Западного Кавказа начинается в первых числах мая. При нижнем пороге пост-диапаузного развития имаго +11°С и при естественной длине дня ей требуется не менее 43 суток (аккумуляция 333-404 гр.-дн.). Гибель перезимовавших самок в этой зоне наблюдается к концу июня, совпадая с сокращением общей доли самок до 2-7%. В высокогорьях перезимовавшие имаго расселяются и в июне, доживая до июля на ивах и березах. Пик выхода имаго первого поколения приходится на конец июня. Массовая яйцекладка самками первого поколения (начало второго поколения) предваряется миграцией оплодотворенных самок на новые кормовые растения. Развитие преимагиальных стадий второго поколения (без смены кормовых растений) протекает с середины июня. Метаморфоз длится не менее 16-23 суток (361-430 гр.-дн.). Пик выхода имаго второго поколения в конце июля совпадает с массовым расселением, в котором всегда преобладают самки. Третье поколение развивается в августе. Метаморфоз занимает 19-28 суток (329-350 гр.-дн.). Пик выхода имаго третьего поколения приходится на первую декаду сентября. Его предваряет более ранний выход самцов, определяемый по их локальным и региональным миграциями с конца августа. Четвертое поколение является факультативным и развивается (без смены кормовых растений) с конца августа до третьей декады сентября. Развитие преимагиальных стадий этого поколения занимает не менее 26 суток (378 гр.-дн.). Последняя миграция клопов наблюдается в начале-середине октября. Самки третьего поколения первыми уходят в места зимовки в предгорьях и низкогорьях уже в середине сентября. Здесь, в дубовых лесах, зимуют имаго третьего и четвертого поколений обычно с преобладанием самок. В среднегорьях с ними могут зимовать особи-иммигранты второго поколения, но с преобладанием самцов, сохраняющимся с сентября. Development of the first generation of Corythucha arcuata in the climate of the foothills and lowlands of the Northwest Caucasus starts in the early May. With a natural day length and the threshold for post-diapause imago development of 11 °C, it requires 333-404 degree-days and at least 43 days. The death of the overwintered females in this zone is observed by the end of June, coinciding with the reduction of the total portion of females to 2-7%. In the highlands imagoes are dispersing in June as well, surviving until July on willows and birch trees. Peak of the first-generation imago outcome occurs at the end of June. Migration of fertilized females of the first generation to new forage plants is followed by mass egg laying (i.e. beginning of the second generation). During the formation of large nests in the foothills, the flight of bugs is observed even in treeless highlands. Development of the preadult stages of the second generation (without changing feed plants) takes place starting at mid-June. Metamorphosis requires 361-430 degree-days and takes at least 16-23 days. The peak of the emergence of the second generation imagoes at the end of July coincides with their dispersal, which is also dominated by females. The third generation develops in August. It requires 329-350 degree-days and takes 19-28 days. The peak of the emergence of the G3 imagoes falls on the first third of September. It is preceded by anearlier emergence of males, determined by their mass local and regional migrations since the end of August. The fourth generation is obligated and develops (without changing feed plants) from the end of August to the end of September. It requires at least 378 degree-days and takes at least 26 days. Late nymphs resulting from female immigrant of the third generation (on new trees) give imagoes only by mid-October. The last migration of bugs is observed in early to mid-October. Imagoes of the third and fourth generations with the predominance of females hibernate in the oak forests of the foothills and low-mountain. In the midlands they may be accompanied by the overwintering immigrants of the second generation, with the predominance of males, formed in September.

Outcomes of first, second, and third-generation anaplastic lymphoma kinase (ALK) inhibitors in non-small cell lung cancer brain metastases (NSCLCBM).

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2034-2034
Author(s):  
Vineeth Tatineni ◽  
Patrick Joseph O'Shea ◽  
Yasmeen Rauf ◽  
Xuefei Jia ◽  
Erin Sennett Murphy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
First Generation ◽  
Second Generation ◽  
Small Cell ◽  
Third Generation ◽  
Small Cell Lung ◽  
Alk Inhibitors

2034 Background: Non-small cell lung cancer (NSCLC) is the most common cause of brain metastases. ALK, which codes for tyrosine kinase receptors, is rearranged in 4-7% of NSCLC. First-generation ALK inhibitors have restricted efficacy due to poor blood-brain barrier (BBB) penetration and ALK-resistant tumor mutations. Second-generation ALK inhibitors have shown better BBB penetration, while third-generation ALK inhibitors were efficacious even against ALK-resistant mutations. In this retrospective study, we investigated the overall survival (OS) and progression-free survival (PFS) in NSCLCBM patients treated with first, second, and third-generation ALK inhibitors. Methods: NSCLCBM patients between 2010 and 2019 were evaluated. We analyzed data regarding molecular marker status, systemic therapies, and date of progression. OS was defined as the start date of systemic therapy to the date of last follow-up or death. The Cox proportional model was used to estimate OS and PFS. Results: A total of 90 patients had ALK gene rearrangement. 16 ALK positive patients received first-generation ALK inhibitor (crizotinib), with a median age of 59.2 years, 50% of the cohort being female and 83.3% being white. Another 17 patients received second-generation (alectinib, ceritinib, brigatinib) and third-generation ALK inhibitors (lorlatinib), with a combined median age of 52.2 years and a cohort of 52.6% females and 72.2% white patients. The 5-year OS rate was 49% (95% confidence interval (CI) = 24%, 71%) for first-generation ALK inhibitors and 76% (95% CI = 40%, 92%) for second and third-generation ALK inhibitors (p-value (p) = 0.019). The median PFS (mPFS) for patients who received first-generation ALK inhibitors was 45.3 months and for those who received second or third-generation ALK inhibitors was 180.1 months. The respective 5-year PFS rate was 43% (95% CI = 19%, 65%) and 72% (95% CI = 42%, 89%). Conclusions: Newer generations of targeted therapies in NSCLCBM have improved BBB penetration and effectiveness against resistant mutations. We determined that there was a significant 5-year OS benefit in patients who received second and third-generation ALK inhibitors compared to first-generation ALK inhibitors, and a respective trend towards significant PFS benefit in newer-generation ALK inhibitors when compared to first-generation. These results are encouraging, but the effect on intracranial lesion size and response rates should be examined in the future.[Table: see text]

Liutex and Third Generation of Vortex Identification

2021 ◽  
Author(s):  
Yifei Yu ◽  
Charles Nottage ◽  
Oscar Alvarez ◽  
Chaoqun Liu
Keyword(s):  
First Generation ◽  
Second Generation ◽  
Rotation Axis ◽  
Third Generation ◽  
Vortex Identification ◽  
Identification Methods ◽  
Two Generations ◽  
Definition Of ◽  
Rotation Strength ◽  
Better Than

Abstract Scientists developed many vortex identification methods and Liu classified the traditional vortex identification methods into two generations. Vorticity and vorticity-based methods belong to the first generation while eigenvalues-based methods are considered as the second generation, such as Q criterion and λci method. However, although these methods are widely used, there is still room for improvements. People used to consider direction of vorticity is the swirling axis and the magnitude of it is the rotation strength, but the predictions by vorticity does not match the experiment very well which drove scientists to develop the second-generation methods. All the second-generation methods are scalar-valued and as a result they are unable to locate the swirling. Another problem is even though second-generation methods can predict vortex better than vorticity, they are more or less contaminated by shear. To solve these problems, Liu innovated Liutex recently. Liutex is a vector quantity whose direction represents rotation axis and whose magnitude represents rotation strength. Firstly, the physical essence of rotation axis is provided coming with the mathematical definition of swirling axis which is the direction of Liutex. Secondly, orthogonal transformations are used to find out the rigid rotation speed and that speed is defined as the strength of Liutex. Wang later proposed an explicit formula to calculate Liutex strength without doing orthogonal transformations which makes it much easier to apply Liutex method. Some theories dependent on Liutex concept have been proposed these years. Liutex core lines represent the core of vortex which can uniquely and clearly show vortex structure. Principal coordinate is a special coordinate in which it is easy to decompose the velocity gradient tensor into rotation, shear and stretching parts correctly. And principal decomposition is the decomposition in principal coordinate. The Liutex theory system is gradually formed and they are considered as the third generation by Liu.

Sign in / Sign up

Export Citation Format

Share Document