scholarly journals The Effect of Efficient Bioactive Nano-Emulsion Formulation Based on Polylophium involucratum on Improving Quality Features of Green Tiger Pawn Fridge Storage

2019 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzaneh Bahrami ◽  
Hamed Ahari ◽  
Seyyedeh Shima Yousefi
Keyword(s):  
Emulsion Formulation ◽  
Nano Emulsion ◽  
Quality Features

scholarly journals Pemanfaatan Ekstrak Daun Mangrove (Rhizophora mucronata sp.) dengan Variasi Pelarut Sebagai Bahan Aktif Sediaan Farmasi Terapi Anti Kanker

2017 ◽  
Vol 4 (2) ◽  
pp. 68 ◽  
Author(s):  
Anita Ratna Faoziyah ◽  
Wahyu Kurniawan
Keyword(s):  
Drug Loading ◽  
Economic Value ◽  
Tween 80 ◽  
Second Phase ◽  
Rhizophora Mucronata ◽  
Anti Cancer ◽  
Young Leaves ◽  
Research Goal ◽  
Emulsion Formulation ◽  
Nano Emulsion

This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%. Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.

scholarly journals Characterization and Antibacterial Activity of Oil-In-Water Nano-Emulsion Formulation Against Candidatus Liberibacter asiaticus

Plant Disease ◽  
2016 ◽  
Vol 100 (12) ◽  
pp. 2448-2454 ◽  
Author(s):  
C. Y. Yang ◽  
C. A. Powell ◽  
Y. P. Duan ◽  
M. Q. Zhang
Keyword(s):  
Droplet Size ◽  
Peak Concentration ◽  
Candidatus Liberibacter Asiaticus ◽  
Spontaneous Emulsification ◽  
Therapeutic Efficiency ◽  
Oil In Water ◽  
Candidatus Liberibacter ◽  
Emulsion Formulation ◽  
Liberibacter Asiaticus ◽  
Nano Emulsion

Nano-emulsion is a promising delivery system for increasing pesticide use and enhancing the therapeutic efficiency against pathogens. The pathogen Candidatus Liberibacter asiaticus (Las) that causes destructive citrus huanglongbing (HLB) resides in citrus phloem, which makes it difficult to treat with chemicals. Based on various physiochemical characteristics of oils, surfactants, and organic solvents, an oil-in-water (O/W) nano-emulsion formulation was developed and optimized to combat citrus HLB. The nano-emulsion was formulated through a spontaneous emulsification method for efficient delivery of ampicillin into the citrus phloem using bark application. The nano-emulsion that was prepared from Cremophor EL (viscous oil), acetone (water miscibility organic solvent), and Span 80/Tween 80 (surfactant) formed a small droplet size (17.33 ± 0.52 nm) and exhibited an improved absorption rate. Peak concentration was detected at 2 days posttreatment and the maximum concentration (Cmax) and relative bioavailability (RBA) of ampicillin in HLB-affected citrus were 71.86 ± 35.38 ng/g and 267.25% ± 44.1%, respectively. The peak concentration of Amp appeared at 6 days posttreatment in the citrus trees that were treated with Amp alone and their Cmax and RBA were 56.44 ± 32.59 ng/g and 100%, respectively. The same nano-emulsion was used to deliver five different antimicrobials to control citrus HLB through bark application. We found that the droplet size of the antimicrobials in the nano-emulsion was significantly reduced and the nano-emulsion also enhanced the therapeutic efficiency of validoxylamine A alone and in combination with actidione as well as sulfadimoethoxine sodium against Las. Therefore, this study provides an efficient bark application nano-emulsion formulation for citrus HLB control.

Comparison of ocular pharmacokinetics of etoposide and its nanoemulsion after subtenon administration in rabbits

2019 ◽  
Vol 30 (5) ◽  
Author(s):  
Santosh Kumar Patnaik ◽  
Nabanita Halder ◽  
Bhavna Chawla ◽  
Deepti Maithani ◽  
Vasantha Thavaraj ◽  
...  
Keyword(s):  
Systemic Exposure ◽  
Ocular Tissue ◽  
Time Intervals ◽  
Ocular Tissues ◽  
Equal Dose ◽  
Liquid Chromatography Tandem Mass ◽  
Subtenon Injection ◽  
Emulsion Formulation ◽  
Nano Emulsion ◽  
Kinetics Of

Abstract Background Subtenon anticancer drugs are given as an adjunct to systemic chemotherapy for conditions like retinoblatoma. This study evaluated the ocular kinetics of nano-emulsion formulation of etoposide (NanoEt) and compared it with an equal dose of commercially available alcohol-based etoposide formulation in healthy rabbits. Methods A nanoemulsion formulation of NanoEt was developed and then evaluated for its ocular kinetics by subtenon administration in healthy rabbits. After the sterile subtenon administration of the drug, the eyes were enucleated after CO2 euthanasia at time intervals of 2 h, 6 h, 12 h, and 24 h, and ocular tissues, blood, and plasma were separated. The concentration of etoposide in the ocular tissues and blood was quantified using liquid chromatography tandem mass spectrometry (LC MS/MS). Results This study found that subtenon injection of NanoEt showed 24 times higher concentration in rabbit retina compared to an equal dose of conventional marketed formulation. Based on the ocular tissue bioavailability calculations (AUC0-24), the present study revealed that the formulation enhanced 90% ocular bioavailability of etoposide, when it was injected in the form of nano-emulsion in most of the tissues. Conclusions NanoEt has better bioavailability compared to the commercial alcohol-based formulation for subtenon injection. Low systemic exposure showed further advantage for its projected use in retinoblastoma (Rb) as an adjunct therapy. Further studies in Rb animal models are required to evaluate its safety and efficacy, for its clinical utility.

scholarly journals Effects of nano-emulsion preparations of tocopherols and tocotrienols on oxidative stress and osteoblast differentiation

2017 ◽  
Vol 69 (1) ◽  
pp. 149-156 ◽  
Author(s):  
Liang-Song Song ◽  
Zhi-Xin Zhang ◽  
Yang Wang ◽  
Yang Liu ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Osteoblast Differentiation ◽  
Mode Of Delivery ◽  
Antioxidant Properties ◽  
Oxygen Species ◽  
Bone Homeostasis ◽  
Emulsion Formulation ◽  
Nano Emulsion

Tocopherols and tocotrienols are two groups of compounds in the vitamin E family, of which the tocopherols are widely used as antioxidant dietary supplements. Recent studies have shown mixed observations for tocopherol functions in bone homeostasis. We have evaluated the potency of suspension- and nano-emulsion formulation-based delivery of different vitamin E family members in lipopolysaccharide (LPS)-induced oxidative stress and osteoblast differentiation. Our results showed the both tocopherols and tocotrienols could reduce oxidative stress as evaluated by the levels of reactive oxygen species (ROS). Their effects were enhanced when applied in the nano-emulsion mode of delivery due to increased bioavailability. In addition, our results showed that tocotrienols increased osteoblast differentiation, while tocopherols showed reduced osteoblast differentiation, which may be due to their differential effects on SMAD and p65 signaling. Together, these findings indicate that tocotrienols delivered through nano-emulsion exhibit superior antioxidant properties and osteoblast differentiation, and could serve as a better alternative to tocopherol-based vitamin E supplements.

scholarly journals Ginger: A Potential Neutraceutical, An Updated Review

2017 ◽  
Vol 9 (09) ◽  
Author(s):  
Singh Rudra Pratap ◽  
Gangadharappa H. V. ◽  
Mruthunjaya K.
Keyword(s):  
Zingiber Officinale ◽  
Trace Minerals ◽  
Pharmacological Effects ◽  
Traditional Medicines ◽  
Long Term Storage ◽  
Ginger Rhizome ◽  
Emulsion Formulation ◽  
Nano Emulsion ◽  
Term Storage

Ginger (rhizome of Zingiber officinale) belongs to the Zingiberaceae family, is widely used and is most popular as a culinary spice and in Traditional medicines to add flavor for more than thousands of years. It is also used in pharmaceuticals, nutraceuticals and in cosmetics. Ginger contains a fusion of an aroma oils both volatile (zingiberene) and non-volatile (oleoresin) oils and phenolic compounds (gingerol and shogaol, zingerone and paradol). In ginger rhizomes, also contains starch, saccharides, proteins, colouring matter and trace minerals that plays a huge role as a spice ingredient. In ginger, starch comprises of 40 - 60 % w/w, protein is 6.2 - 19.8 %, wax or lipid is 5.7 - 14.5 % and crude fiber is 1.1 - 7.0 % and oleoresin approximately 4 - 7.5 %. Ginger is available in fresh, dried, pickled, preserved, crystallized, candied and powdered or ground form. It is unstable due to acidic environment or as a result of the increase in temperature; presence of light, air, heat and long term storage but it can be enhanced by Nano emulsion formulation. Ginger has shown various pharmacological effects such antioxidant, anti – inflammatory, gastro protective, anti-bacterial, anti-diabetic etc.

Quality Features of Metal Matrix Composite Castings

2013 ◽  
Vol 58 (3) ◽  
pp. 659-662 ◽  
Author(s):  
K. Gawdzińska
Keyword(s):  
Metal Matrix Composite ◽  
Matrix Composite ◽  
Metal Matrix ◽  
Matrix Material ◽  
Quality Characteristics ◽  
Material Quality ◽  
Reinforcement Material ◽  
Composite Casting ◽  
Quality Features

Abstract In this paper it is stated, that a set of quality features of metal matrix composite castings differs from the same set for castings of classic materials, although some features are common for both of these material groups. These features (pertaining to a set of quality characteristics of composite castings) have been named as specific, they have not been determined yet and a description of material quality should be performed (according to the qualitology) on a principle of description of quality characteristics of this product. Therefore, this set of features has been determined. It was proposed to add the following characteristics to the set of specific features of composite castings quality: matrix material, reinforcement material, binding between components and porosity of the composite casting. In this set a sub-set of quality characteristics of composite castings was also determined.

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