scholarly journals Pulmonary Thromboembolism in a Pregnant Patient with Severe COVID19: A Novel Case Report and Review of Literature

2020 ◽  
Vol 15 (5) ◽  
Author(s):  
Armin Zarrintan ◽  
Behdad Boeoofeh ◽  
Masome Rabieipour ◽  
Afshin Mohammadi ◽  
Kamal Khademvatani ◽  
...  
Keyword(s):  
Pulmonary Thromboembolism ◽  
Pulmonary Arteries ◽  
Clinical Signs ◽  
Severe Pneumonia ◽  
Signs And Symptoms ◽  
Pregnant Patient ◽  
Right Ventricular Strain ◽  
Clinical Signs And Symptoms ◽  
Novel Coronavirus ◽  
Present Case Study

Introduction: The novel coronavirus has been shown to infect many bodily organs. Recent studies have suggested that the virus may be capable of causing inappropriate thrombosis formation. In the present case study, we present a pregnant patient who had severe pneumonia caused by the virus; and subsequently developed pulmonary thromboembolism. Case Presentation: A 39-year-old primi-gravid pregnant woman presented to the emergency department with moderate to severe respiratory symptoms and tested positive for SARS-CoV-2. The patient was hospitalized and received routine treatment. The patient had a rapid deterioration of clinical signs and symptoms, coupled with sensations of palpitations and chest discomfort. The patient had an echocardiogram, which was suggestive of right ventricular strain. D-dimer tested positive, and the patient had a CT angiography, showing filling defects in branches of the pulmonary arteries. Conclusions: Pulmonary thromboembolism may be a complicating factor in patients with severe viral pneumonia. In patients with underlying procoagulant conditions, such as pregnancy, the occurrence of Pulmonary Thromboembolism (PTE) should be strongly considered.

scholarly journals Coronavirus Disease-19 and Dentistry: A Review

2020 ◽  
Vol 8 (T1) ◽  
pp. 618-621
Author(s):  
Fareedi Mukram Ali ◽  
Kishor Patil ◽  
Elnur Ibrahim Albashir ◽  
Abdulhamid Aidarous Alamir
Keyword(s):  
Infection Control ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Control Measures ◽  
Clinical Settings ◽  
Related Information ◽  
Infection Control Measures ◽  
Dental Practitioners ◽  
Clinical Signs And Symptoms ◽  
Novel Coronavirus

Novel coronavirus (nCoV) is a novel form of virus with a new strain identified recently in humans. Common clinical signs and symptoms primarily consist of fever, cough, and breathing difficulties. In severe cases, it can results in pneumonia, severe acute respiratory syndrome, kidney failure, and even death. It is important to follow all infection control measures in prevention of the nCoV from spreading and controlling the epidemic situation. The risk of cross infection can be high between dental practitioners and patients due to the features of dental clinical settings. Here, we are summarizing the nCoV related information and infection control measures to be followed in dental practice.

scholarly journals Determinants of hypoxemia in children associated with pneumonia

2015 ◽  
Vol 7 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Pramila Ramawat ◽  
Balkishan Sharma
Keyword(s):  
Clinical Signs ◽  
Severe Pneumonia ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Specific Sign ◽  
Severe Manifestation ◽  
Clinical Signs And Symptoms ◽  
Very High

Background and Objectives: The most severe manifestation of pneumonia is hypoxemia has been shown to be a risk factor for morbidity and mortality. Authors investigated associating factors and determinants of hypoxemia in children with pneumonia.Materials and Methods: A cross-sectional study is designed among children of pediatric outpatient and emergency department that enrolled at Government Multi-Speciality Hospital, Chandigarh. One hundred fifty children recruited for study. The demographic and clinical parameters were recorded. Oxygen saturation measured by pulse oximeter.Results: The prevalence of hypoxemia was 48% and 61 (84.7%) infants aged 1 year found with hypoxemia. Age (p=0.006), respiratory rate (p=0.001) and severity of pneumonia (p=0.001) were strongly associated with hypoxemia. The prevalence of severe and very severe pneumonia among hypoxemic were 56.1% and 73.7% respectively. Central cyanosis (98.7%), peripheral (98.7%) cyanosis, head nodding (97.4%) grunting (96.15%) were highly specific but suprasternal (62.82%), subcostal (43.58%) and intercostal retractions (44.87%) were fairly specific sign. Sensitivity for subcostal (81.94%) and intercostal retractions (83.33%) was very high but was fair for intercostal (83.33%) retraction. Grunting (p=0.009), nasal flaring (p=0.008), subcostal (p=0.001) and intercostal (p=0.000) retractions were strongly but suprasternal retraction was significantly (p=0.024) associated with hypoxemia. Dyspnea (97.22%) was very sensitive while decrease feeding (84.61%) and irritability (83.33%) was highly but lethargy (58.97%) was fairly specific symptom.Conclusions: Study suggested that clinical signs and symptoms such as chest wall retraction, decrease feeding, dyspnea, grunting and nasal flaring in children with pneumonia may be utilized as markers for hypoxemia in conditions where pulse-oximeter isn’t available. This study supports the view of hypoxemia was disabling factor in better functional recovery in severity of pneumonia.Asian Journal of Medical Sciences Vol.7(2) 2015 64-70

scholarly journals The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?

2020 ◽  
Vol 49 (3) ◽  
pp. 717-726 ◽  
Author(s):  
Noah C Peeri ◽  
Nistha Shrestha ◽  
Md Siddikur Rahman ◽  
Rafdzah Zaki ◽  
Zhengqi Tan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mainland China ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Lessons Learned ◽  
Future Research ◽  
The North ◽  
Control And Prevention ◽  
Clinical Signs And Symptoms ◽  
Novel Coronavirus

Abstract Objectives To provide an overview of the three major deadly coronaviruses and identify areas for improvement of future preparedness plans, as well as provide a critical assessment of the risk factors and actionable items for stopping their spread, utilizing lessons learned from the first two deadly coronavirus outbreaks, as well as initial reports from the current novel coronavirus (COVID-19) epidemic in Wuhan, China. Methods Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and COVID-19. Comparisons between the viruses were made. Results Inadequate risk assessment regarding the urgency of the situation, and limited reporting on the virus within China has, in part, led to the rapid spread of COVID-19 throughout mainland China and into proximal and distant countries. Compared with SARS and MERS, COVID-19 has spread more rapidly, due in part to increased globalization and the focus of the epidemic. Wuhan, China is a large hub connecting the North, South, East and West of China via railways and a major international airport. The availability of connecting flights, the timing of the outbreak during the Chinese (Lunar) New Year, and the massive rail transit hub located in Wuhan has enabled the virus to perforate throughout China, and eventually, globally. Conclusions We conclude that we did not learn from the two prior epidemics of coronavirus and were ill-prepared to deal with the challenges the COVID-19 epidemic has posed. Future research should attempt to address the uses and implications of internet of things (IoT) technologies for mapping the spread of infection.

scholarly journals 659 Blocking cytokine IL-1 with anakinra for the prevention of cytokine release syndrome in COVID-19

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A696-A696
Author(s):  
Erik Soule ◽  
Jason Williams ◽  
Matthias Piesche
Keyword(s):  
Respiratory Failure ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Computed Tomography Images ◽  
Pulmonary Damage ◽  
Clinical Signs And Symptoms ◽  
Novel Coronavirus ◽  
Oncology Practice

BackgroundThe novel coronavirus, known as SARS-CoV-2, or COVID-19 became a pandemic in early 2020, causing significant human suffering and economic woes globally. The pathophysiology of acute respiratory failure may be related to a robust immune reaction against the virally infected cells (figure 1). This mechanism is molecularly similar to that of cytokine release syndrome, which is mediated by cytokine IL-1 and can be seen as a complication of immunotherapy.MethodsClinical data from cancer patients treated for cytokine release syndrome were collected from an interventional oncology practice and retrospective analysis was performed.ResultsFive patients were treated for cytokine release syndrome related to administration of immunotherapy agents. Symptoms included hypotension, loss of consciousness, fever, headache, and respiratory failure. Three of these patients were treated with anakinra, with abrogation of symptoms of cytokine release syndrome (table 1). The remaining two patients received glucocorticoids, vasopressors, and respiratory support, suffering progressive symptoms of cytokine release syndrome, and death (table 2).Abstract 659 Figure 1Imaging findings of COVID-19 viral pneumoniaAxial, and coronal computed tomography images in a patient with laboratory proven COVID-19 infection demonstrating diffuse ground glass opacities in a peripheral and peribronchovascular distribution interspersed with areas of frank consolidation.Abstract 659 Table 1Anakinra cohortThree patients who experienced clinical signs and symptoms of cytokine release syndrome after administration of immunotherapy. These patients were treated with anakinra, and survived.Abstract 659 Table 2Glucocorticoids cohortTwo patients who experienced clinical signs and symptoms of cytokine release syndrome after administration of immunotherapy. These patients were treated with glucocorticoids, tacrolimus, and supportive measures, and subsequently died.ConclusionsThe IL-1 inhibitor, anakinra, has shown efficacy in ameliorating signs and symptoms of cytokine release syndrome caused by immunotherapy administration. Mechanistic similarities between cytokine release syndrome and COVID-19 related pulmonary damage suggest that this pharmacotherapeutic intervention could decrease mortality and need for mechanical ventilation in patients infected with COVID-19.ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

scholarly journals Correction to: Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome

Pituitary ◽  
2020 ◽  
Author(s):  
Eliza B. Geer ◽  
Roberto Salvatori ◽  
Atanaska Elenkova ◽  
Maria Fleseriu ◽  
Rosario Pivonello ◽  
...  
Keyword(s):  
Cushing’S Syndrome ◽  
Patient Reported Outcomes ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Cushing's Syndrome ◽  
Original Version ◽  
Patient Reported ◽  
Author Group ◽  
Clinical Signs And Symptoms

The original version of the article unfortunately contained an error in the first name and the surname of one of the authors in the author group. The last author name was incorrectly published as ‘F. Pecori Giraldi’ and the corrected name is ‘Francesca Pecori Giraldi’ (First name: Francesca; Surname: Pecori Giraldi).

scholarly journals A 38-year demographic study of central and peripheral giant cell granulomas of the jaws

2016 ◽  
Vol 15 (2) ◽  
pp. 220-223 ◽  
Author(s):  
Shadi Saghafi ◽  
Reza Zare-Mahmoodabadi ◽  
Narges Ghazi ◽  
Mohammad Zargari
Keyword(s):  
Giant Cell ◽  
Medical Science ◽  
Age Distribution ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Posterior Maxilla ◽  
Frequent Site ◽  
Male Patients ◽  
Clinical Signs And Symptoms ◽  
Anterior Mandible

Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (PGCGs) in Iranian population.Methods: The data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to our department between 1972 and 2010. This 38-year retrospective study was based on existing data. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented. Results: A total of 1019 patients were affected GCGLs including 435 CGCGs and 584 PGCGs during the study. The mean age was 28.91 ± 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases (57.70%), whereas PGCGs were more frequent in males (50.85%). Five hundred and ninety-eight cases of all giant cell lesions (58.7 %) occurred in the mandible. Posterior mandible was the most frequent site for both CGCG and PGCG cases. The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). The majority of patients were asymptomatic. Conclusions: In contrast to most of previous studies PGCGs occur more common in the first decade and also more frequently in male patients. Although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations which may help in the diagnosis and management of these lesions.Bangladesh Journal of Medical Science Vol.15(2) 2016 p.220-223

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