scholarly journals Di(2-ethylhexyl)phthalate (DEHP)

2004 ◽  
Vol 9 (2) ◽  
pp. 89-95
Author(s):  
Arthur A. Strauss
Keyword(s):  
Health Care Professionals ◽  
Human Exposure ◽  
Medical Literature ◽  
High Risk Population ◽  
Potential Toxicity ◽  
Human Carcinogen ◽  
Chemical Agents ◽  
The Status ◽  
Ethylhexyl Phthalate ◽  
Oily Liquid

Di(2-ethylhexyl) phthalate or DEHP is a colorless, oily liquid and notably, with respect to clinical concerns, is soluble in blood and body fluids containing lipoproteins. Despite being listed as a possible human carcinogen in the 1980's, more recent concerns have focused on its potential toxicity as a result of leaching from medical devices into patients via intravenous or enteral routes. Initial discussion of this problem was reported in the medical literature over 20 years ago. This article provides an update on the status of DEHP as a potential reproductive toxin and the potential implications for high-risk population groups (most notably neonates). The use of the precautionary principle for a guidepost in relating human exposure effects to chemical agents, including DEHP, has become a topic relevant to all health care professionals and is discussed herein.

Hidradenitis Suppurativa: A Novel Model of Care and an Integrative Strategy to Adopt an Orphan Disease

2017 ◽  
Vol 22 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Wayne Gulliver ◽  
Ian D. R. Landells ◽  
David Morgan ◽  
Syed Pirzada
Keyword(s):  
Health Care Professionals ◽  
Hidradenitis Suppurativa ◽  
Management Strategies ◽  
Treatment Algorithm ◽  
Orphan Disease ◽  
Model Of Care ◽  
Integrative System ◽  
Inappropriate Treatment ◽  
The Status ◽  
New Treatment

Unnecessary investigations, inappropriate treatment, worsening disease, and frustration for both patients and health care professionals are the hallmarks of hidradenitis suppurativa (HS) management. In light of a new treatment algorithm and biologic therapies made available to patients, an HS model of care is outlined in this article. The recommendations and management strategy presented here have been developed to help address the currently unmet needs of this patient population. The patient-centred model of care and disease management strategies were developed through the guidance and recommendations of HS medical experts in Newfoundland and Labrador. This article lays the foundation for the resources and steps required to change the status of this orphan disease and firmly embed patients with HS within a coordinated and integrative system of care.

Studies of Time of Farmers' Exposure to Hazardous Factors in the Working Environment on Polish Family Farms

2000 ◽  
Vol 44 (22) ◽  
pp. 662-665
Author(s):  
A. Molocznik
Keyword(s):  
Human Exposure ◽  
Thermal Environment ◽  
Working Time ◽  
Working Environment ◽  
Family Farms ◽  
Noise And Vibration ◽  
Agricultural Work ◽  
Chemical Agents ◽  
Work Cycle ◽  
One Year

In order to determine human exposure to hazardous factors of the working environment it is necessary to recognize, apart from their level and intensity, the duration of exposure. This parameter is difficult to measure because of changeable exposure in agriculture, where the work cycle is prolonged to one year, and the daily working time in conditions of exposure to hazardous factors changes irregularly from one day to the next. Studies conducted on typical mixed-production family farms in Poland showed that dust and elements of the thermal environment are the most frequent factors accompanying agricultural work, followed by contact with biological hazards, noise and vibration; whereas the working time in conditions of exposure to chemical agents is the shortest.

Pharmacy Issues: Intravenous Drug Ordering

2001 ◽  
Vol 36 (3) ◽  
pp. 329-332
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
Intravenous Drug ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

Pharmacy Issues: Weight-Based Dosing

2001 ◽  
Vol 36 (7) ◽  
pp. 790-791
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care ◽  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University

This continuing feature will inform readers about the process of implementing, maintaining, and supporting prescriber computer order entry (PCOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of PCOE at the Medical Center.

scholarly journals A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Vaccines ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 37 ◽  
Author(s):  
Liu
Keyword(s):  
Clinical Trials ◽  
Dna Vaccine ◽  
Plasmid Dna ◽  
Dna Vaccines ◽  
Delivery Systems ◽  
Potential Toxicity ◽  
Vaccine Candidates ◽  
The Status ◽  
Experimental Findings ◽  
Theoretical Issues

This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies. While both have been under development since the 1990s, in recent years, significant excitement has turned to mRNA despite the licensure of several veterinary DNA vaccines. Both have required efforts to increase their potency either via manipulating the plasmid DNA and the mRNA directly or through the addition of adjuvants or immunomodulators as well as delivery systems and formulations. The greater inherent inflammatory nature of the mRNA vaccines is discussed for both its potential immunological utility for vaccines and for the potential toxicity. The status of the clinical trials of mRNA vaccines is described along with a comparison to DNA vaccines, specifically the immunogenicity of both licensed veterinary DNA vaccines and select DNA vaccine candidates in human clinical trials.

scholarly journals “Repeated Hierarchies”: Uneven Participation in Research of Ethical Spaces in Hospitals

2019 ◽  
Vol 14 (5) ◽  
pp. 493-495
Author(s):  
Brenda Bogaert ◽  
Catherine Dekeuwer ◽  
Nadja Eggert ◽  
Claire Harpet
Keyword(s):  
Health Care ◽  
Focus Group ◽  
Health Care Professionals ◽  
Group Discussion ◽  
Ethical Reflection ◽  
Full Participation ◽  
The Status ◽  
Study Process ◽  
Participation In Research

We present a case study of uneven participation in a focus group discussion with health care professionals involved in local ethical committees. We conclude that the status of the different participants did not give adequate space for full participation of the members involved. Two commentators were invited to comment on the case study to enable further reflection on the methodology used for the target group. The first reviewer investigated whether research should address power relations and hierarchies of knowledge encountered in the study process. She also discussed whether researchers should be held ethically and politically responsible for the consequences of producing relations and hierarchies. The second reviewer looked at what focus groups say about professional practices in hospitals, what participants are willing (or unwilling) to invest, and what are the conditions for setting up ethical reflection.

P1358THE MONITORING OF FIRST LEVEL IN DIAGNOSIS OF COMPLICATION OF VASCULAR ACCESS: MULTICENTRIC STUDY ON 900 HEMODIALIZED PATIENTS WITH FOLLOW UP TO 5 YEARS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Ersilia Satta ◽  
Carmine Romano ◽  
Carmelo Alfarone ◽  
Sandro Gentile ◽  
Domenico Russo
Keyword(s):  
Vascular Access ◽  
Health Care Professionals ◽  
Venous Pressure ◽  
Duplex Ultrasound ◽  
Patient Characteristics ◽  
Multicentric Study ◽  
Flow Monitoring ◽  
The Status

Abstract Background and Aims Vascular Access (VA) is the lifeline of hemodialysis patient. The universal goal of access monitoring is to identify access stenosis and enable intervention prior to thrombosis; thereby, maximizing access longevity and minimizing morbidity. The advent and use of techniques including dynamic and static venous pressure monitoring, physical examination, access flow measurement, imagining and combined imaging and flow monitoring by duplex ultrasound demonstrate that it is possible to predict which accesses are at high risk for future thrombosis. Currently arteriovenous fistula (AVF) and arteriovenous graft (AVF) have been recognized as the permanent access. This study takes advantage of the opportunity to utilize data from 19 associated Dialysis Clinics to examine trends in VA use, trends in patient characteristics and practice associated with VA. Determine the status quo of the overall information related to the VA to start a five years follow up study with the aims to reduce VA complications 8stenosis and thrombosis) and related hospitalization days to improve patient’s quality of life. Method VA data were collected for each patient at study entry. Practice pattern data from the facility medical director, nurse manager and VA surgeon were also analyzed. We have developed a mask on the management database to implement the first level monitoring of access and collected data at each treatment (Fig.1) Results Average age of 801 patients enrolled was 73,5 years. Native AVF was used by 79%, AVG by 2% and CVC by 19%. As the age increase as well as he use of CVC move from 6% (15-39(years) to 50,5% in patients with more than 85 years. Most frequent complications were: Thrombosis 16,5 %, Infectios 5,5%. Related VA hospitalization days are 28,7 % of total days. Average dialysis goals achieved were: QB 290 ml/Min; blood processed 69,7 L; KT/V:1,35. Conclusion By interpreting collecting data for specific performance measures using accurate reports allow health care professionals to highlight the VA performance/inefficiences and provide correct information to the clinical staff to support them in their daily clinical practice and decision making.

The Training Process (Part 1)

2003 ◽  
Vol 38 (1) ◽  
pp. 84-88 ◽  
Author(s):  
Alicia S. Miller
Keyword(s):  
Health Care Professionals ◽  
Medical Center ◽  
Ohio State University ◽  
State University ◽  
Order Entry ◽  
Training Process ◽  
The Status ◽  
Practical Information ◽  
The Ohio State University ◽  
Computerized Prescriber Order Entry

This continuing feature will inform readers about the process of implementing, maintaining, and supporting computerized prescriber order entry (CPOE) at the Ohio State University Medical Center. (By “prescribers,” we refer to health care professionals authorized to prescribe medications by their states.) Practical information on what worked and what failed will be provided, along with current updates on the status of CPOE at the Medical Center.

scholarly journals A revisit at 16 years for individuals from peri-urban New Delhi for tobacco use and associated oral lesions

2019 ◽  
Vol 4 ◽  
pp. 2057178X1881866 ◽  
Author(s):  
Ravi Mehrotra ◽  
Suzanne Tanya Nethan ◽  
Priyanka Ravi ◽  
Shekhar Grover ◽  
Shashi Sharma ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Tobacco Use ◽  
Health Care Professionals ◽  
Tobacco Cessation ◽  
Positive Association ◽  
Oral Lesions ◽  
Oral Potentially Malignant Disorders ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
The Status

Objectives: India has a high incidence of oral cancer due to multifarious tobacco use. The objective of this study was to assess the status of tobacco-related oral lesions over 16 years, in a screen-detected population. Methods: This cross-sectional study involved home visits of 2000 Delhi residents, previously screened for oral potentially malignant disorders/oral cancer and counseled for tobacco cessation. Their basic demographics and tobacco/alcohol history were noted followed by oral visual examination for any related mucosal abnormalities. The data thus obtained were statistically analyzed. Results: Two hundred and sixty-five individuals (13.2%) could be traced after 16 years. The status of oral lesions varied across the participants, mainly in terms of their location, type, number, and/or presence/absence; no oral malignancies were noted. Most individuals had either a decreased use (34%, p < 0.001) or had quit tobacco (25.7%, p < 0.001); 8.3% individuals from the former and 5.7% from the latter group showed complete lesion(s) regression. The overall change in the tobacco use and oral lesions showed a highly significant positive association ( p < 0.05). Conclusion: A direct relationship exists between tobacco use and oral lesions. Repeated, tobacco cessation counseling provided by health-care professionals is effective. Oral screening of high-risk individuals, along with tobacco cessation, is thus essential.

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