Clinical and epidemiological characterization in the follow-up of newborns with COVID-19: a descriptive study

Introduction COVID-19 disease affects newborns, but its middle and long-term effects are still unclear. Objective To describe the clinical and epidemiological characteristics and follow-up of newborns infected with SARS-CoV-2. Methods An observational and descriptive study. We included newborns with SARS-CoV-2 positive RT-PCR born from SARS-CoV-2 seropositive mothers. Delivery and newborn care were provided at the 'Instituto Nacional Materno Perinatal' from Peru between June 1 and September 30, 2020. Perinatal information was collected from medical records. Remote follow-up and face-to-face evaluations gathered epidemiological and clinical information, in addition to serological and RT-PCR tests for SARS-CoV-2. Descriptive statistics were used for analysis. Results During the study period, 4733 neonates were born at the institution. We found that 1488 (31.4%) were born from seropositive for SARS-CoV-2 mothers. Finally, we included the 34 (2.3%) newborns with positive RT-PCR for SARS-CoV-2. Regarding the included newborns, 29.4% were delivered by cesarean section, 26.5% had low birth weight, 11.8% were preterm, 26.5% were hospitalized, and one died. Twenty-eight had a remote follow-up, and 18 also had a face-to-face follow-up. A total of 64.3% were exclusively breastfed, 28.6% were mixed breastfed, and 7.1% used a substitute formula. The face-to-face evaluation was performed between one and four months of chronological age. We found that 100% had negative control RT-PCR test for COVID-19, 38.9% had a negative serological test (IgM, IgG), and 61.1% positive IgG. Conclusions Neonatal SARS-CoV-2 infection is rare, and most infected infants are asymptomatic. Vaginal delivery, breastfeeding, and joint isolation did not related with complications during hospital care. Infants under remote and in-person follow-up showed favorable clinical evolution during the study period.

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Clinical, Demographic, and Epidemiological Characteristics of Patients Diagnosed with COVID-19 in Zahedan, Southeastern Iran

Modern Care Journal ◽

10.5812/modernc.115121 ◽

2021 ◽

Vol 18 (4) ◽

Author(s):

Behzad Shahi ◽

Faeze Kazemi ◽

Shahaboddin Mashaei ◽

Mahdi Foroughian ◽

Maryam Ziaei ◽

...

Keyword(s):

Vital Signs ◽

Descriptive Study ◽

Descriptive Statistics ◽

Health Centers ◽

Blood Oxygen ◽

Shortness Of Breath ◽

Abo Blood Groups ◽

Rt Pcr ◽

Blood Oxygen Saturation ◽

Epidemiological Characteristics

: As the epidemic spreads, COVID-19 poses a severe threat to the health of communities. Description of epidemiological characteristics of COVID-19 patients helps with the prevention and scientific control of the pandemic. This descriptive study was conducted to describe the clinical, demographic, and epidemiological characteristics of 65 patients suspected of having COVID-19. A research-made questionnaire was used for data collection. Moreover, the patient's vital signs were examined. The samples were classified into the two groups of subjects with positive and negative RT-PCR test. Descriptive statistics were used for the analysis of data. The most common manifestations were fever, shortness of breath, and dry cough. Moreover, the lowest proportion belonged to Rh-negative in all ABO blood groups. The patients were mainly male, about 44 years old, and their first and most common manifestations were fever, shortness of breath, and dry cough. In vital signs examination, reduction of blood oxygen saturation was the most important finding. Health centers need to consider these signs in treating COVID-19 patients.

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Alteration in Status of Olfaction amongst COVID 19 Patients: A Descriptive Study in a Dedicated COVID Hospital of Eastern India

Bengal Journal of Otolaryngology and Head Neck Surgery ◽

10.47210/bjohns.2020.v28i3.375 ◽

2021 ◽

Vol 28 (3) ◽

pp. 241-247

Author(s):

Monoj Mukherjee ◽

Anupam Ray ◽

Arpita Mohanty ◽

Sekhar Paul

Keyword(s):

Indian Population ◽

Complete Recovery ◽

Descriptive Study ◽

Olfactory Dysfunction ◽

Eastern India ◽

Rt Pcr ◽

Number Of Patients ◽

Smell Test ◽

Screening And Diagnosis

Introduction COVID 19 patients present with symptoms of respiratory tract infection as it is caused by SARS Cov-2 which is a β corona virus. A significant number of patients may complain of changes in olfaction either at the onset or later. The incidence, severity and recovery from anosmia/hyposmia varies in different patients. This study was done to investigate the effect of COVID 19 on olfactory dysfunction in the Indian population. Materials & Methods 100 patients admitted with RT-PCR positive reports for SARS Cov-2, in a dedicated COVID hospital in eastern India, were included in this study. Their olfactory function was estimated by pocket smell test (4 items) during ENT examination at bed side. Recovery from anosmia/hyposmia were noted during follow up visits. Results In our study 36% of patients had some alteration in smell. Out of the 36%, 12% had anosmia and 24% had hyposmia. Chances of complete recovery is more in patients suffering from anosmia than hyposmia. Conclusion Changes in smell sensation is a significant marker for screening and diagnosis of cases of COVID 19. Most of the patients recover completely.

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Clinical meanings of rapid serological assay in patients tested for SARS-Co2 RT-PCR

10.1101/2020.04.03.20052183 ◽

2020 ◽

Cited By ~ 5

Author(s):

Angelo VirgilioParadiso ◽

Simona De Summa ◽

Daniela Loconsole ◽

Vito Procacci ◽

Anna Sallustio ◽

...

Keyword(s):

Serological Test ◽

Clinical Information ◽

Consecutive Series ◽

Rt Pcr ◽

Current Standard ◽

Viral Nucleic Acid ◽

Colorimetric Test ◽

Significant Difference ◽

Standard Assay ◽

The Subject

AbstractBackgroundRT-PCR test for identification of viral nucleic acid is the current standard diagnostic method for the diagnosis of COVID-19 disease but technical reasons limit the utilization of this assay onlarge scalescreenings.MethodWe verified in a consecutive series of 191 symptomatic patients the clinical information that new rapid serological colorimetric test qualitatively analyzing IgM/IgG expression can provide with respect to standard assay and with respect to clinical outcome of patients.ResultsRapid serological test showed a sensitivity of 30% and a specificity of 89% with respect to the standard assay but, interestingly, these performances improve after 8 days of symptoms appearance. After 10 days of symptoms the predictive value of rapid serological test is higher than that of standardassay. When the behaviour of the two immunoglobulins was evaluated with respect to time length of symptoms appaerance, no significant difference in immunoglobulins behaviour was shown.ConclusionsThe rapid serological test analyzed in the present study is candidate to provide information on immunoreaction of the subject to COVID-19 exposure.

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Epidemiological characteristics of patients with residual SARS-Cov-2 in Linyi, China

10.1101/2020.06.16.20133199 ◽

2020 ◽

Author(s):

Qiang Pan ◽

Feng Gao ◽

Rensheng Peng ◽

Mingshan Li

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Clinical Information ◽

Control Measures ◽

Rt Pcr ◽

Pharyngeal Swab ◽

Severity Of Disease ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Epidemiological Characteristics ◽

First Time

AbstractPatients with 2019 novel Coronavirus infection are probably show positive testing results again. In order to better treat these patients and provide basis for further control measures, we analyze the epidemiological outcomes and clinical features of patients with residual Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) in Linyi city. From January 23 to March 31 in 2020, epidemiological and clinical information of confirmed patients are collected for analysis. Stool and pharyngeal swab samples are collected for RT-PCR testing. 64 confirmed patients are included and 17 patients present re-positive testing after discharge. For these 17 patients, 70.59% are family aggregated, the interval between first time of negative testing and first time of re-positive testing is 11.82±3.42 days. There is no difference between patients with continued negative testing results and re-positive testing. After discharge, the interval between first time of negative testing and first time of re-positive testing is associated with severity of disease (p=0.013). Besides, the duration from first time to last time of re-positive testing is associated with exposure or contact history (p=0.049) and severity of disease (p=0.001). The analysis reveals epidemiological characteristics of patients with residual SARS-Cov-2 and provide basis for further control measures.

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The SARS-CoV-2 RNA with mild pulmonary consolidation lasts longer in non-severe COVID-19 patients: an observational study

10.21203/rs.3.rs-43643/v2 ◽

2020 ◽

Author(s):

Chi Zhang ◽

Jiawen Li ◽

Jing Mu ◽

Daitao Zhang ◽

He Wang ◽

...

Keyword(s):

Clinical Information ◽

Disease Course ◽

Viral Dynamics ◽

Rt Pcr ◽

Igg Antibody ◽

Dynamic Changes ◽

Pulmonary Consolidation ◽

Lung Consolidation ◽

Almost All

Abstract Background: Since December 2019, COVID-19 has rapidly swept the world. It is particularly important to understand the dynamic changes of the whole disease course of non-severe patients from the onset to the follow-up after discharge.Methods: On February 1, 2020, 18 cases of non-severe COVID-19 appeared in a hospital in Beijing. All patients were SARS-CoV-2 RNA positive by RT-PCR for pharyngeal swabs. We recorded the clinical information and viral dynamics of these patients from the onset of the disease to 2 months after discharge. According to the severity of lung consolidation, 18 patients were divided into two groups (mild pulmonary consolidation group [imaging score ≤10]; severe pulmonary consolidation group [imaging score >10]).Results: Eighteen patients (median age 43) were included, including 14 females. Fever (11/18) and cough (8/18) were the most common symptoms. The duration of SARS-CoV-2 RNA positive in mild pulmonary consolidation group was significantly longer than severe pulmonary consolidation group (the median time was 30 days and 13 days, respectively, P= 0.0031). Two months after discharge, almost all patients were followed up for IgM antibody disappearance and IgG antibody production.Conclusion: In non-severe COVID-19 patients, the positive duration of the SARS-CoV-2 RNA in patients with mild pulmonary consolidation was longer than the severe pulmonary consolidation. However, it is necessary for a large sample to verify our conclusions.

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Spontaneous peripheral nerve palsy with hourglass-like fascicular constriction in the upper extremity

Journal of Neurosurgery ◽

10.3171/2018.8.jns18419 ◽

2019 ◽

Vol 131 (6) ◽

pp. 1876-1886 ◽

Cited By ~ 2

Author(s):

Yang Wang ◽

Ting Liu ◽

Liangsong Song ◽

Zhixin Zhang ◽

Yanan Zhang ◽

...

Keyword(s):

Surgical Intervention ◽

Histopathological Examination ◽

Clinical Manifestations ◽

Clinical Information ◽

Nerve Fibers ◽

Face To Face ◽

Timely Fashion ◽

Electrophysiological Examination ◽

Surgical Treatments

OBJECTIVESpontaneous paralysis from hourglass-like fascicular constriction of peripheral nerves is rare, its clinical manifestations are not well documented, and its pathogenesis remains unknown. The unclear origin of this disorder and difficulty in diagnosis result in its uncertain management. The authors sought to gain a more thorough understanding of this condition through describing the anatomy, clinical features, etiology, and treatment of hourglass-like constriction.METHODSThe authors retrospectively reviewed 20 patients (22 nerves) with hourglass-like constriction. The patients’ clinical information was reviewed. Preoperative sonographic assessment and electrophysiological examination of involved nerves were performed. Surgical treatments included interfascicular neurolysis and neurorrhaphy. Samples of tissue subjected to resected constriction were sent for pathological analysis. The patients had regular face-to-face follow-up visits.RESULTSAcute pain was always the first symptom and was followed by paralysis. Paralysis progression was rapid and serious. Surgical exploration indicated an hourglass-like constricted segment completely unrelated to the compressive structures. Electrophysiological analysis showed severe denervation, and histopathological examination showed inflammatory cell infiltration, demyelination, and reduction of nerve fibers.CONCLUSIONSHourglass-like fascicular constrictive neuropathy has an integrative effect from multiple different mechanisms. Surgical intervention is beneficial for selected patients who do not recover in a timely fashion and have hourglass-like lesions confirmed by preoperative ultrasound imaging. The authors recommend that early surgical intervention of the nerve be offered to patients who do not show any signs of recovery 3 months after onset. Both interfascicular neurolysis and neurorrhaphy are effective treatment methods. Mild to moderate constriction can usually be treated successfully by interfascicular neurolysis alone, whereas more advanced lesions with loss of fascicle continuity (severe constriction) may be best treated with resection and direct neurorrhaphy.

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1089: Prognostic Value of Molecular Staging of Bladder Cancer with RT -PCR Assay for KRT20: Results at 5 Year-Follow-up

The Journal of Urology ◽

10.1016/s0022-5347(18)31303-x ◽

2007 ◽

Vol 177 (4S) ◽

pp. 360-360

Author(s):

Ana Agud ◽

Maria J. Ribal ◽

Lourdes Mengual ◽

Mercedes Marin-Aguilera ◽

Laura Izquierdo ◽

...

Keyword(s):

Bladder Cancer ◽

Prognostic Value ◽

Rt Pcr ◽

Pcr Assay ◽

Molecular Staging

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Psychopathology 8½ Years Post Parasuicide

Crisis ◽

10.1027//0227-5910.20.3.115 ◽

1999 ◽

Vol 20 (3) ◽

pp. 115-120 ◽

Cited By ~ 9

Author(s):

Stephen Curran ◽

Michael Fitzgerald ◽

Vincent T Greene

Keyword(s):

Rating Scales ◽

Psychiatric Morbidity ◽

Parental Bonding ◽

Social Maladjustment ◽

Term Outcome ◽

Long Term Outcome ◽

Face To Face ◽

Long Term Follow Up

There are few long-term follow-up studies of parasuicides incorporating face-to-face interviews. To date no study has evaluated the prevalence of psychiatric morbidity at long-term follow-up of parasuicides using diagnostic rating scales, nor has any study examined parental bonding issues in this population. We attempted a prospective follow-up of 85 parasuicide cases an average of 8½ years later. Psychiatric morbidity, social functioning, and recollections of the parenting style of their parents were assessed using the Clinical Interview Schedule, the Social Maladjustment Scale, and the Parental Bonding Instrument, respectively. Thirty-nine persons in total were interviewed, 19 of whom were well and 20 of whom had psychiatric morbidity. Five had died during the follow-up period, 3 by suicide. Migration, refusals, and untraceability were common. Parasuicide was associated with parental overprotection during childhood. Long-term outcome is poor, especially among those who engaged in repeated parasuicides.

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