scholarly journals Clinical and epidemiological description of Imipenem-resistant Acinetobacter baumannii causing nosocomial infections in a regional teaching hospital in China

2011 ◽  
Vol 5 (12) ◽  
pp. 1527-1531
Author(s):  
Ping Zhang Jing ◽  
Zhu Wan ◽  
Fei Tian Su ◽  
Zhuo Chu Yun ◽  
Yi Chen Bai
Keyword(s):  
Acinetobacter Baumannii ◽  
Teaching Hospital ◽  
Nosocomial Infections

A Global Approach to Control Nosocomial Infections in a Large General Teaching Hospital

2007 ◽  
Vol 3 (2) ◽  
Author(s):  
Bart Gordets ◽  
Bea Heyneman ◽  
Hilde Jannes ◽  
Aline Lenez
Keyword(s):  
Teaching Hospital ◽  
Nosocomial Infections ◽  
Global Approach

scholarly journals Characterization of carbapenem-resistant Acinetobacter baumannii isolates in a Chinese teaching hospital

2015 ◽  
Vol 6 ◽  
Author(s):  
Yaowen Chang ◽  
Guangxin Luan ◽  
Ying Xu ◽  
Yanhong Wang ◽  
Min Shen ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Teaching Hospital ◽  
Carbapenem Resistant ◽  
Chinese Teaching

Extensively drug-resistant Acinetobacter baumannii nosocomial pneumonia successfully treated with a novel antibiotic combination

2021 ◽  
Author(s):  
Noor Zaidan ◽  
J. Patrik Hornak ◽  
David Reynoso
Keyword(s):  
Septic Shock ◽  
Drug Development ◽  
Acinetobacter Baumannii ◽  
Nosocomial Infections ◽  
Drug Resistant ◽  
Access Protocol ◽  
The Poor ◽  
Extensively Drug Resistant ◽  
Poor Outcomes ◽  
Antibiotic Combination

Extremely drug resistant (XDR) Acinetobacter baumannii cause challenging nosocomial infections. We report the case of a patient with XDR A. baumannii pneumonia and septic shock successfully treated with cefiderocol and a novel antibiotic obtained via expanded access protocol. With focused research and drug development efforts, the poor outcomes associated with these infections may be mitigated.

scholarly journals EMERGENCE AND ANTIBIOTIC SENSITIVITY PATTERN OF ACINETOBACTER BAUMANNII IN HOSPITAL FACILITY

2017 ◽  
Vol 10 (3) ◽  
pp. 77
Author(s):  
Anania Arjuna ◽  
Dinobandhu Nandi
Keyword(s):  
Acinetobacter Baumannii ◽  
Nosocomial Infections ◽  
Antibiotic Sensitivity ◽  
Hospital Environment ◽  
Sensitivity Testing ◽  
Hospital Acquired Infection ◽  
Clinical Specimens ◽  
Sensitivity Pattern ◽  
Tract Infections ◽  
Hospital Acquired

ABSTRACTObjective: Nosocomial infections or Hospital acquired infection (HAI) are one of the major threats to hospitalized patients as well as for the hospitalassociated personnel. In last few years there is a gross change in causative agents, new organisms have come out with great threat to hospitals as theypossess antibiotic resistance property e.g. production of biofilm, production of enzymes such as β- lactamases. Among many organisms, Acinetobacterbaumannii has emerged as a potent nosocomial pathogen. Our objective of this study was to find the burden of Acinetobacter baumannii infectionswhich are associated as nosocomial infections and to determine the drug of choice for an effective treatment.Methods: Clinical specimens were collected from patients of different unit of the hospital by maintaining universal precautions and standardmicrobiological protocols. All the respective specimens were cultured in respective culture medium i.e. MacConkey agar, blood agar, chocolate agar,cysteine lactose electrolyte deficient (CLED) agar and, fluid thioglycolate (TG) medium at 37˚C for 24-48 hours. After incubation of 24-48 hours cultureplates were examined for bacterial growth and identification and antibiotic sensitivity test was made by Vitek2 compact.Result: The study was conducted at the department of microbiology from January 2016 to April 2016. A total of 2582 specimens were collected andprocessed for identification and sensitivity testing. Specimens of all age group (2 days- 93 years) and both sexes were processed for identificationof A. baumannii and antibiotic sensitivity testing. A total of 119 isolates (4.60%) of A. baumannii were obtained from 2582 clinical specimens. Themost common infection A. baumannii was found as lower respiratory tract infection (89.07%) followed by abscess (6.72%), septicaemia (2.52%),urinary tract infections (0.84%), and soft tissue infections (0.84%). The maximum sensitivity of A. baumannii isolates were seen to Colistin (CL) (119,100%), followed by Tigecycline (TGC) (63, 52.94%) and Minocycline (MIN) (27, 22.69%). The maximum resistant was observed for Imipenem (IMI),Aztreonam (AZT) and Ticarcillin- clavulanic acid (TIC) (119, 100%).Conclusion: The Gram- negative coccobacillus, Acinetobacter baumannii poses a formidable threat to patients. It has emerged as a superbug inhospital environment particularly in ICU units. The chances of A. baumannii infections increase in the presence of iatrogenic factors like inadequatelong- term antibiotic therapy and new interventions in a medical facility. To control the burden of Acinetobacter infections new therapies suchas combine therapy must be obtained and followed with proper dose as recommend by physicians; along with awareness of the importance ofthis infection should be implicated. Proper sanitation, good housekeeping, sterilization of equipment, hand hygiene, water purification, isolationprocedures and maintaining of the hospital environment, use of infection control practices are some of the measures to control the transmission ofAcinetobacter spp. among hospital personnel.Keywords: Acinetobacter baumannii, Biofilm, β-lactamases, Hospital acquired infection.

scholarly journals The Outbreak of Acinetobacter baumannii over a 19 month Period in a Teaching Hospital Neonatal Intensive Care Unit

2019 ◽  
Vol 04 (02) ◽  
Author(s):  
Hosein Dalili ◽  
Fatemeh Nayeri ◽  
Mamak Shariat ◽  
Nahid Farrokhzad ◽  
Leyla Sahebi
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Acinetobacter Baumannii ◽  
Teaching Hospital ◽  
Neonatal Intensive Care

scholarly journals Complete Genome Sequence of Lytic Bacteriophage LZ35 Infecting Acinetobacter baumannii Isolates

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Zhonghe Guo ◽  
Honglan Huang ◽  
Xiaolin Wu ◽  
Yuchong Hao ◽  
Yanbo Sun
Keyword(s):  
Acinetobacter Baumannii ◽  
Genome Sequence ◽  
Nosocomial Infections ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Opportunistic Pathogen ◽  
Lytic Bacteriophage ◽  
Gram Negative

Acinetobacter baumannii is a Gram-negative opportunistic pathogen that is frequently associated with nosocomial infections. Bacteriophages infecting A. baumannii can be used as effective agents to control these infections. Here, we announce the complete genome sequence of the lytic bacteriophage LZ35 infecting A. baumannii isolates.

scholarly journals Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace

Biomolecules ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 720 ◽  
Author(s):  
Maria Soledad Ramirez ◽  
Robert A. Bonomo ◽  
Marcelo E. Tolmasky
Keyword(s):  
Acinetobacter Baumannii ◽  
Nosocomial Infections ◽  
Acquired Resistance ◽  
Clinical Manifestations ◽  
High Capacity ◽  
Bloodstream Infections ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Wound Infections ◽  
Extensively Drug Resistant

Acinetobacter baumannii is a common cause of serious nosocomial infections. Although community-acquired infections are observed, the vast majority occur in people with preexisting comorbidities. A. baumannii emerged as a problematic pathogen in the 1980s when an increase in virulence, difficulty in treatment due to drug resistance, and opportunities for infection turned it into one of the most important threats to human health. Some of the clinical manifestations of A. baumannii nosocomial infection are pneumonia; bloodstream infections; lower respiratory tract, urinary tract, and wound infections; burn infections; skin and soft tissue infections (including necrotizing fasciitis); meningitis; osteomyelitis; and endocarditis. A. baumannii has an extraordinary genetic plasticity that results in a high capacity to acquire antimicrobial resistance traits. In particular, acquisition of resistance to carbapenems, which are among the antimicrobials of last resort for treatment of multidrug infections, is increasing among A. baumannii strains compounding the problem of nosocomial infections caused by this pathogen. It is not uncommon to find multidrug-resistant (MDR, resistance to at least three classes of antimicrobials), extensively drug-resistant (XDR, MDR plus resistance to carbapenems), and pan-drug-resistant (PDR, XDR plus resistance to polymyxins) nosocomial isolates that are hard to treat with the currently available drugs. In this article we review the acquired resistance to carbapenems by A. baumannii. We describe the enzymes within the OXA, NDM, VIM, IMP, and KPC groups of carbapenemases and the coding genes found in A. baumannii clinical isolates.

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