Anti-microbial susceptibility pattern of micro-organisms associated with urinary tract infections in a tertiary health institution in the Niger Delta Region of Nigeria

2012 ◽  
Vol 6 (23) ◽  
Author(s):  
Kemebradikumo Pondei
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Niger Delta ◽  
Susceptibility Pattern ◽  
Delta Region ◽  
Health Institution ◽  
Niger Delta Region ◽  
Tract Infections ◽  
Micro Organisms

scholarly journals Determination of nitrofurantoin and fosfomycin susceptibility among urinary Escherichia coli isolates

2020 ◽  
Vol 8 (9) ◽  
pp. 3274
Author(s):  
Rachana Kanaujia ◽  
Amit Kumar ◽  
Malay Bajpai
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Urine Samples ◽  
E Coli ◽  
Tract Infections ◽  
Therapeutic Alternatives ◽  
Micro Organisms ◽  
Staphylococcus Spp

Background: Urinary tract infections (UTIs) are one of the most common infections. For treatment of UTIs, there are limited antibiotics due to increased resistance among uropathogens. Two older antibiotics; Nitrofurantoin and Fosfomycin have become novel oral therapeutic options against uropathogens. Aim of the study was to identify UTI causing micro-organisms and evaluate in-vitro activity of nitrofurantoin and fosfomycin against most common isolated organism (E. coli).Methods: Results of urine samples culture and susceptibility testing over a period of 1 year were analysed and included in this study.Results: Micro-organisms were isolated from 568 urine samples. Most commonly isolated organism was Escherichia coli (40.50%), followed by Klebsiella spp. (20.07%) and Staphylococcus spp. (17.07%). Susceptibility of E. coli to nitrofurantoin and fosfomycin was 91.74% and 65.65% respectively. Conclusion: Good activity of nitrofurantoin and fosfomycin against E. coli indicates that these two drugs are potential therapeutic alternatives for urinary tract infections.

Aetiology and antibiotic resistance patterns of urinary tract infections in the elderly: a 6-month study

2013 ◽  
Vol 62 (6) ◽  
pp. 859-863 ◽  
Author(s):  
Elena De Vecchi ◽  
Simona Sitia ◽  
Carlo Luca Romanò ◽  
Cristian Ricci ◽  
Roberto Mattina ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
The Elderly ◽  
Gram Positive ◽  
Development Of Resistance ◽  
Tract Infections ◽  
Almost All ◽  
Micro Organisms ◽  
The Impact

Urinary tract infections (UTIs) are a common cause of bacteraemia in the elderly and are associated with a high probability of hospitalization. Despite the impact of UTIs on health status and quality of life, a limited number of studies have evaluated their aetiology in this population. This study aimed to evaluate the microbial aetiology and pattern of susceptibility of bacteria causing UTIs in the elderly. For this purpose, a retrospective cohort study of elderly residents (n = 472, aged >65 years) in 14 nursing homes in Milan (Italy) and its province was performed. Globally, 393 micro-organisms from 328 samples were isolated: Escherichia coli was the most prevalent (44.8 %), followed by Proteus mirabilis (20.4 %), Providencia spp. (8.9 %), Klebsiella spp. (6.4 %) and Pseudomonas aeruginosa (4.6 %). Enterococci were the most frequently isolated Gram-positive organisms (7.4 %). Almost all Enterobacteriaceae were susceptible to nitrofurantoin, carbapenems and amikacin. Extended-spectrum β-lactamases were detected in 42.1 % of isolates. The most active antibiotics against P. aeruginosa were colistin, amikacin and piperacillin/tazobactam. All Gram-positive organisms were susceptible to glycopeptides and linezolid, and 90 % were susceptible to nitrofurantoin. Fluoroquinolones showed a limited activity against all the tested micro-organisms. Escherichia coli remains the major micro-organism responsible for UTIs in older people, although to a lesser extent than in a younger population. The high rates of resistance observed in this study make careful use of antibiotics advisable to limit further development of resistance.

scholarly journals Prevalence and Antifungal Susceptibility Pattern of Candida species Isolated from Patients with Urinary Tract Infections

2021 ◽  
Vol 7 (4) ◽  
pp. 328-335
Author(s):  
IA Lawal ◽  
OA Osinupebi ◽  
OV Adeosun
Keyword(s):  
Candida Albicans ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Candida Species ◽  
Antifungal Susceptibility ◽  
Diffusion Method ◽  
Susceptibility Pattern ◽  
Agar Disc ◽  
Sensitivity Pattern ◽  
Tract Infections

Background: The presence of Candida species in the urine is termed candiduria, and it is a common form of urinary tract infection (UTI). Many other species of Candida organism apart from Candida albicans are known with increasing the occurrence of resistance to available antifungal agents. Objectives: To determine the prevalence and sensitivity pattern of Candida isolates obtained from urine samples of diagnosed urinary tract infections. Methods: Midstream urine of patients attending the Lagos University Teaching Hospital, Ikeja Lagos, were collected and inoculated on Sabouraud Dextrose Agar (SDA). Microbiological processing was done with Gram reaction, germ tube test, CHROME agar TM and sugar fermentation test using API 32C system. Antifungal susceptibility tests were done using the agar disc diffusion method. Results: Candida species were obtained from 36 (12.9%) of 280 patients with UTI. Candida albicans (CA) had the highest frequency (12; 33.3%) compared to 24 (66.7%) for Non-albicans Candida (NAC). The speciation of Candida using Chrome Agar showed some misidentification from the API32C identification, but there was a significant correlation between API32C and Chrome Agar methods (r = 0. 9793). Half of the C. albicans species were sensitive to fluconazole while C. hellenica was only sensitive to Nystatin. The C. parapsilopsis had the highest susceptibility pattern, with 86% and 71% for fluconazole and ketoconazole, respectively. Generally, ketoconazole had the highest effectiveness on Candida species. Conclusion: This study demonstrated the role of Candida species in UTIs and their high susceptibility to ketoconazole.

scholarly journals Distribution of Respiratory Tracy Infectious Diseases in Relation to Particulate Matter (PM2.5) Concentration in Selected Urban Centres in Niger Delta Region of Nigeria

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Tamuno-owunari Perri ◽  
Vincent Ezikornwor Weli ◽  
Bright Poronakie ◽  
Tombari Bodo
Keyword(s):  
Particulate Matter ◽  
Respiratory Tract ◽  
Niger Delta ◽  
Respiratory Tract Infections ◽  
World Health ◽  
Chronic Obstructive ◽  
Delta Region ◽  
Niger Delta Region ◽  
Tract Infections ◽  
Pm2.5 Concentration

Due to the visibility of soot in the environment of the Niger Delta especially Rivers State that has led to the increase of  espiratory Tract Infections (RTIs) in the region, this study was undertaken to determine the relationship between Particulate Matter (PM2.5) concentration and the incident of Respiratory Tract Infections (RTIs) in selected urban centres of the Niger Delta. Data on RTIs were collected from the Hospital Management Boards of the Ministries of Health of Rivers, Bayelsa and Delta States and the data for PM2.5 were remotely sensed from 2016 to 2019, and subsequently analyzed with ANOVA and Spearman’s rank correlation statistics. The findings of this study revealed that there was significant variation in the occurrence of PM2.5 across the selected urban centres in the Niger Delta Region. The PM2.5 for the reviewed years was far above the World Health Organization (WHO) annual permissible limit of 10 µg/m3 thereby exacerbating Respiratory Tract Infections (RTIs).The epidemiology of the RTIs showed that there are basically four (4) prominent RTI diseases: Asthma, Tuberculosis, Pneumonia and Chronic Obstructive Pulmonary Disease (COPD). The result of this study showed that the concentration of PM2.5 varies in all the selected cities, and the mean monthly variation (2016-2019) showed that Port Harcourt had 47.27 µg/m3 for January while Yenagoa and Asaba had 46 µg/m3 and 47.51 µg/m3 respectively for January; while the lowest mean value in the cities were seen within the month of September and October, which also had a strong seasonal influence on the concentration of PM2.5. The concentration of PM2.5 and the numbers of RTIs also gradually increases in the study areas from 2016 to 2019. The study recommends that the necessary regulatory bodies should closely monitor the activities of the companies likely to cause such pollution; guild them through their operations and give prompt sanctions and heavy fines to defaulters of the accepted standards.

scholarly journals Prevalence, Antimicrobial Susceptibility Pattern, and Associated Factors of Urinary Tract Infections among Adult Diabetic Patients at Metu Karl Heinz Referral Hospital, Southwest Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Tesfaye Gutema ◽  
Fitsum Weldegebreal ◽  
Dadi Marami ◽  
Zelalem Teklemariam
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Antimicrobial Susceptibility ◽  
Diabetic Patients ◽  
Susceptibility Pattern ◽  
Southwest Ethiopia ◽  
Antimicrobial Susceptibility Pattern ◽  
Tract Infections

Urinary tract infection causes considerable morbidity in diabetic patients and if complicated, can cause severe renal damage and life-threatening infections. The escalating antimicrobial resistance rate among bacteria over the past years is another concern in the treatment of urinary tract infections. This study investigated the prevalence, antimicrobial susceptibility pattern of the isolates and associated factors of urinary tract infection among adult diabetic patients attending Metu Karl Heinz Referral Hospital, Southwest Ethiopia. An institutional-based cross-sectional study was conducted among 233 adult diabetic patients selected using simple random sampling technique. Data were collected using a structured questionnaire. Clean-catch midstream urine samples were investigated for the presence of pathogenic bacteria and their antimicrobial susceptibility pattern using recommended culture methods. Data were entered, cleaned, and analyzed using the Statistical Program for Social Sciences version 21.0. Statistical significance was set at ap-value < 0.05. The prevalence of urinary tract infection was 16.7% (95%, CI: 12.0, 21.5). The predominant isolates wereEscherichia coli(25.6%) andKlebsiellaspp. (20.5%).E. coliisolates showed higher sensitivity to ceftriaxone (80%), ciprofloxacin (70%), and gentamycin (70%), but resistant to tetracycline (60%).Staphylococcus aureuswas sensitive to amoxicillin-clavulanic acid (85.7%), and gentamycin (57.1%), while resistant to tetracycline (85.7%), nitrofurantoin (85.7%), and ampicillin (71.4%). The odds of developing urinary tract infections were significantly higher in diabetic females (AOR: 3.56, 95% CI: 1.44, 8.76), those who were not able to read and write (AOR: 2.55, 95% CI: 1.19, 5.49) and those with a history of urinary tract infection (AOR: 2.31, 95% CI: 1.09, 4.90) compared with their counterparts. In this study, the prevalence of urinary tract infection among diabetic patients was relatively comparable with the previous studies conducted in Ethiopia. Management of urinary tract infection in diabetic patients should be supported with culture and antimicrobial susceptibility testing.

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