Effects of different manufacturing methods on pharmaceutical properties and release kinetic models of ketoprofen sustained-release microparticles

Photocrosslinkable polyanhydrides that undergo surface erosion are suitable materials for controlled-release drug delivery systems. Investigating the impact of different parameters on their erosion behavior is essential before use in drug delivery systems. Although their synthesis is well-established, parameters that may substantially affect the erosion of thiol-ene polyanhydrides including temperature and pH of the media, the geometry of the polymers, and the media shaking rate (the convective force for the polymer erosion), have not yet been studied. This study explores the effects of different environmental and geometric parameters on mass loss (erosion) profiles of polyanhydrides synthesized by thiol-ene photopolymerization. A comparative study on several release kinetic models fitting is also described for a better understanding of the polymer erosion behavior. The results demonstrated that although the temperature was the only parameter that affected the induction period substantially, the mass-loss rate was influenced by the polymer composition, tablet geometry, temperature, pH, and mass transfer (shaking) rate. With regard to geometrical parameters, polymers with the same surface area to volume ratios showed similar mass loss trends despite their various volumes and surface areas. The mass loss of polyanhydride tablets with more complicated geometries than a simple slab was shown to be non-linear, and the kinetic model study indicated the dominant surface erosion mechanism. The results of this study allow for designing and manufacturing efficient delivery systems with a high-predictable drug release required in precision medicine using surface-erodible polyanhydrides.

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Release Kinetic Models of Vanillin and Physicomechanical Properties of Thermoplastic Starch and Chitosan Nanocomposite Films: Effects of Mixing Order

Journal of Packaging Technology and Research ◽

10.1007/s41783-020-00084-y ◽

2020 ◽

Vol 4 (1) ◽

pp. 13-22 ◽

Cited By ~ 2

Author(s):

Nichrous Mlalila ◽

Askwar Hilonga ◽

Lilian Kaale ◽

Hulda Swai

Keyword(s):

Kinetic Models ◽

Thermoplastic Starch ◽

Physicomechanical Properties ◽

Nanocomposite Films ◽

Release Kinetic ◽

Release Kinetic Models

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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOSULPIRIDE BY USING NATURAL POLYMER

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.17475 ◽

2017 ◽

Vol 10 (5) ◽

pp. 285

Author(s):

S Shanmugam

Keyword(s):

Drug Release ◽

Sustained Release ◽

Xanthan Gum ◽

Diffusion Mechanism ◽

Matrix Tablets ◽

In Vitro Dissolution ◽

Release Kinetic ◽

Natural Polymers ◽

In Vitro Drug Release

Objective: The objective of the present study was to develop sustained release matrix tablets of levosulpiride by using natural polymers.Method: The tablets were prepared with different ratios of Chitosan, Xanthan gum and Guar gum by wet granulation technique. The solubility study of the levosulpiride was conducted to select a suitable dissolution media for in vitro drug release studies.Results: Fourier transform infrared (FTIR) study revealed no considerable changes in IR peak of levosulpiride and hence no interaction between drug and the excipients. DSC thermograms showed that no drug interaction occurred during the manufacturing process. In vitro dissolution study was carried out for all the formulation and the results compared with marketed sustained release tablet. The drug release from matrix tablets was found to decrease with increase in polymer ratio of Chitosan, Xanthan gum and Guar gum.Conclusion: Formulation LF3 exhibited almost similar drug release profile in dissolution media as that of marketed tablets. From the results of dissolution data fitted to various drug release kinetic equations, it was observed that highest correlation was found for First order, Higuchi’s and Korsmeyer equation, which indicate that the drug release occurred via diffusion mechanism. Keywords: Levosulpiride, sustained release tablets, natural polymers, in vitro drug release studies

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Investigation into the Controlled-Release Kinetic Models of Rose Perfume in SBA-15 and KIT-6

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.955-959.399 ◽

2014 ◽

Vol 955-959 ◽

pp. 399-402

Author(s):

Yi Feng Yu ◽

Ai Bing Chen ◽

Ting Ting Xing ◽

Yun Hong Yu ◽

Hai Jun Lv

Keyword(s):

Controlled Release ◽

Pore Diameter ◽

Slow Release ◽

Release Kinetic ◽

Incipient Wetness Impregnation ◽

Impregnation Method ◽

Release Agent ◽

Release Data ◽

Release Kinetic Models ◽

New System

A new system for the controlled release of rose perfume is presented. Mesoporous SBA-15 and KIT-6 materials as controlled-release agent are synthesized via hydrothermal method. Rose perfume was introduced into the pores of SBA-15 and KIT-6 via the incipient wetness impregnation method. This silica reservoir maintained a slow release of rose perfume over more than 10h. Rose perfume release was controlled by configurational diffusion in the SBA-15 and KIT-6 pores having free diameters of less than 12 nm. The release of rose perfume was tuned by adapting pore diameter and temperature. By fitting the release data, the results show that the release actions of rose perfume in SBA-15 and KIT-6 are consistent with Korsmeyer-Peppas model and First-order’model respectively.

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Improving of the accuracy of in vitro-in vivo linear correlation using kinetic models for ultra sustained release theophylline tablets

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/bf03220183 ◽

2003 ◽

Vol 28 (4) ◽

pp. 301-307 ◽

Cited By ~ 4

Author(s):

E. Karasulu ◽

S. Aktogu ◽

H. Y. Karasulu ◽

A. Aydogdu ◽

I. Tuglular ◽

...

Keyword(s):

Sustained Release ◽

Linear Correlation ◽

Kinetic Models ◽

Sustained Release Theophylline

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Drug Release Kinetic Analysis and Prediction of Release Data via Polymer Molecular Weight in Sustained Release Diltiazem Matrices

Drug Research ◽

10.1055/s-0033-1353186 ◽

2013 ◽

Vol 64 (03) ◽

pp. 118-123 ◽

Cited By ~ 3

Author(s):

K. Adibkia ◽

S. Ghanbarzadeh ◽

G. Mohammadi ◽

H. Khiavi ◽

A. Sabzevari ◽

...

Keyword(s):

Molecular Weight ◽

Drug Release ◽

Sustained Release ◽

Kinetic Analysis ◽

Release Kinetic ◽

Polymer Molecular Weight ◽

Release Data ◽

Drug Release Kinetic

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Synthesis of Hydrogel Films Based on PVA, PVP, Starch and Keratin Extracted From Chicken Feathers Wastes for the Potential Biomedical Applications

10.20944/preprints202110.0044.v1 ◽

2021 ◽

Author(s):

Mohamed Saad Bala Husain ◽

Basma Yahya Al-Ashwal ◽

Arun Gupta ◽

Swati Sharma ◽

Venugopal Jayarama Reddy ◽

...

Keyword(s):

Biomedical Applications ◽

Research Study ◽

Zero Order ◽

Release Kinetic ◽

Chicken Feathers ◽

First Order ◽

Release Studies ◽

The Fourier Transform ◽

Release Kinetic Models ◽

Hydrogel Films

The aim of this research study was to develop hydrogels samples for using in potential biomedical applications. Hydrogels consisting of different volumes of keratin, polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP), and starch. The keratin is derived from the chicken was the primary material on the hydrogels due to attractively for the potential wound healing application. The hydrogel samples were made by using the freeze‑thawing method, and they were examined using the Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), porosity amusement, swelling ratio and keratin release kinetic models that analyzed using (zero-order, first-order Higuchi and Korsmeyer-Peppas models). These results were indicated that feather keratin could use with formulated hydrogels suitably for controlled keratin release studies .

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MODULATORY EFFECT OF POLYMER TYPE AND CONCENTRATION ON DRUG RELEASE FROM SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE: A COMPARATIVE RELEASE KINETIC STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i9.38500 ◽

2020 ◽

pp. 132-140

Author(s):

AHMED M AGIBA ◽

WAGEEH ABDEL HAKEEM ◽

ASHRAF G ZAYED

Keyword(s):

Drug Release ◽

Sustained Release ◽

Patient Compliance ◽

Release Kinetics ◽

Chronic Stable Angina ◽

Kinetic Studies ◽

Matrix Tablets ◽

Release Kinetic ◽

Carnauba Wax ◽

The Matrix

Objective: Ranolazine (RZ), antianginal drug indicated for the treatment of chronic stable angina pectoris, was formulated into sustained-release matrix tablets and optimized to improve patient compliance and achieve controlled release over a certain period. Methods: Different formulations were prepared by wet- and melt-granulation techniques. Excipients at different ratios as Eudragit® L100-55, Methocel™ E5, Avicel® PH-101, and carnauba wax powder were used to develop a ternary polymeric matrix system for the controlled delivery of RZ. The prepared formulations were subjected to granulometric and characteristic studies. Comparative dissolution and release kinetic studies of the selected formulation and the reference product, Ranexa® extended-release film-coated tablets, Gilead Sciences, Inc., USA, were further carried out to ensure product similarity. Results: The optimum pH-dependent to pH-independent polymers ratio was 1:1.3 (w/w). Extragranular carnauba wax in a concentration of 32.50 mg/tablet (2.50 gm% w/w) was the key excipient in controlling drug release kinetics by forming waxy matrix granules which prevent rapid dissolution. Modulation of the microenvironmental pH using a potent alkalinizing agent was very effective for controlling drug release patterns in different dissolution media from pH 1.2–6.8. Conclusion: The release of RZ from the matrix tablets was controlled for a period of 24 h, and thereby expected to provide patient compliance with minimal side effects.

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Formulation and Development of Metoprolol Succinate Sustained Release Matrix tablet using Remusatia vivipara tubers mucilage

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00942 ◽

2021 ◽

pp. 5405-5410

Author(s):

Ganesh N. Sharma ◽

Mayur R. Bhurat ◽

Vijay M. Shastry ◽

Birendra Shrivastava

Keyword(s):

Drug Release ◽

Sustained Release ◽

Tablet Formulation ◽

Matrix Tablets ◽

Release Kinetic ◽

Order Kinetic ◽

Reference Formulation ◽

Metoprolol Succinate ◽

Sustained Release Tablet ◽

Release Tablet

The purpose of this research was to formulate and evaluate sustained release tablet by using novel polymer Remusatia vivipara tubers mucilage. Currently natural gums and mucilages are being used extensively comparable to synthetic drug release modifiers. Natural plant materials possess various advantages. These are very cheap, biocompatible, biodegradable and free from side effects. In present research Metoprolol succinate matrix tablets were prepared by using Remusatia vivipara tubers mucilage. For the formulation of sustained release matrix tablets, direct compression method was used. The formulated matrix tablets were then evaluated for thickness, diameter, hardness, weight variation, friability, drug content, swelling index, in-vitro drug release and stability studies. The formulated sustained release tablet passed all tests required. The dissolution profile of prepared tablets showed sustained release of drug up to 11 hours compared to the reference tablet formulation PROLOMET XI 100. Drug release data were then fitted in to release kinetic models such as zero order kinetic, first order kinetic, Higuchi model and Korsmeyer-Peppas model to study the release pattern of drug from each formulation. The prepared sustained release tablet formulation was compared with marketed formulation (reference formulation) for drug release study and factor f1 (difference factor) and f2 (similarity factor) were determined. From this study it can be concluded that as the concentration of Remusatia vivipara mucilage increases, there is decrease in the rate of drug release from the formulation. The best formulation was found to be F3 which consists of 20% Remusatia vivipara mucilage but did not give comparable drug release profile to the reference formulation with factor f1 69.4 % and f2 34.8%. But it can be said that Remusatia vivipara gum mucilage can be used in tablet formulation to give sustained release effect up to 10 hours or in combination with other natural gum mucilage it may enhance the release retardant effect of drug up to or more than 20 hrs. The release kinetic study showed that the prepared sustained release tablet formulation shows anomalous (non-fickian) diffusion pattern and follows both diffusion controlled and swelling controlled mechanisms for drug release.

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Formulation and evaluation of sustained release saxagliptin microspheres by ionotropic gelation method

International Journal of Bioassays ◽

10.21746/ijbio.2017.03.0010 ◽

2017 ◽

Vol 6 (03) ◽

pp. 5328

Author(s):

Madhuri Latha Thadanki*

Keyword(s):

Drug Release ◽

Sustained Release ◽

Sodium Alginate ◽

In Vitro Study ◽

Entrapment Efficiency ◽

Release Kinetic ◽

Flow Properties ◽

Ionotropic Gelation ◽

Drug Entrapment Efficiency

The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of an antidiabetic agent, saxagliptin. Saxagliptin microspheres were formulated using sodium alginate as the controlled release polymer by ionotropic gelation technique. The polymer sodium alginate alone and along with different coating polymers like pectin, ethyl cellulose was used in different ratios (1:1,1:1.5, 1:2 ) to formulate batches F1 to F9. The resulting microspheres were evaluated for particle size, densities, flow properties, morphology, recovery yield, drug content, drug entrapment efficiency and in vitro drug release behavior. The formulated microspheres were discrete, spherical with relatively smooth surface, and with good flow properties. The drug entrapment efficiency obtained in the range 70.4% to 95.2%.Among different formulations, the fabricated microspheres of batch F3 had shown the optimum percent drug encapsulation of microspheres and the sustained release of the saxagliptin for about 9 h. In vitro study showed that drug release slowly increases as the pH of the medium is increased. Release pattern of saxagliptin from microspheres of batch F3 followed Higuchi model and zero-order release kinetic model. The value of ‘n’ was found to be 0.867. The data obtained thus suggest that a microparticulate system can be successfully designed for sustained delivery of saxagliptin and to improve dosage form characteristics for easy formulation.

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