scholarly journals INCORPORATING AN OUTSOURCING STRATEGY AND IN-HOUSE QUALITY ASSURANCE INTO THE PRODUCTION-SHIPMENT DECISION MAKING

2021 ◽  
pp. 1-9
Author(s):  
Singa Wang Chiu ◽  
Yi-Ying Li ◽  
Victoria Chiu ◽  
Hong-Dar Lin
Keyword(s):  
Quality Assurance ◽  
Real Life ◽  
Optimization Method ◽  
Batch Size ◽  
Depth Information ◽  
Business Environments ◽  
Managerial Decisions ◽  
Real Life Situation ◽  
The Impact

To stay competitive in turbulent business environments, manufacturing firms’ managers today constantly seek ways to reduce order response time, smooth production schedules, ensure the quality of their products, and lower overall making and shipping costs. This study incorporates an outsourcing strategy and in-house quality assurance into a production-shipment problem to address the aforementioned operational goals. The objectives are to simultaneously find the optimal fabrication batch size and frequency of delivery that minimize the system’s relevant costs and reveal in-depth information regarding the impact of diverse system parameters on the optimal policy and system cost. This study develops a model and uses the optimization method to resolve the problem. The research results facilitate managerial decisions in such a real-life situation.

Impact on OS of 2nd and 3rd generation TKI in EGFR mt+ and ALK+ patients: Results of the NOWEL network.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e20560-e20560 ◽  
Author(s):  
Julia Roeper ◽  
Maria Netchaeva ◽  
Anne Christina Lueers ◽  
Ursula Stropiep ◽  
Cora Hallas ◽  
...  
Keyword(s):  
Real Life ◽  
Stage Iv ◽  
Cancer Centers ◽  
Real Life Setting ◽  
Effective Choice ◽  
Detection Of Mutations ◽  
The Impact ◽  
Choice Of Therapy ◽  
Generation Sequencing

e20560 Background: Available clinical research data shows that early mutation testing for patients with NSCLC stage IV could lead to an effective choice of therapy for patients with proven mutations. Targeted therapies achieve a higher ORR, PFS, OS and a better quality of life than chemotherapy in mt+ patients. With the advent of 2nd and 3rd generation TKI´s effective in 1st generation TKI resistant tumors, we wanted to study the impact of these drugs on the outcome of patients in a real life setting in 3 lung cancer centers. Methods: 1383 patients from the three cancer centers diagnosed with NSCLC stage IV (UICC 7) were examined. Methods for the detection of mutations included Sanger Sequencing, hybridization based COBAS testing as well as hybrid cage next generation sequencing. Results: 880/1383 (64%) consecutive patients with non-squamous cell NSCLC from the cancer centers were studied for the presence of tumor mutations, especially for EGFR and ALK mutations. The EGFR mutation rate was 16.6% (141/880), and the ALK-translocation rate 3.8% (24/635). Median OS in EGFR mt+ patients was 31 (n = 78) vs. 32 (n = 38) vs. 16 (n = 14) months respectively (center 1 vs. center 2 vs. center 3). Median OS in ALK mt+ patients was 25 (n = 17) months in center 1 and 11 (n = 5) months in center 2 (p < 0.05). Use of 3rd generation TKI Osimertinib (n = 17) lead to a significantly higher OS (n = 17, median OS 67 mo) than the use of only 1st and 2nd generation TKI (n = 113, median OS 24 mo, p < 0.000). Similarly, use of 2nd and 3rd generation ALKi impacted significantly on median OS: Crizotinib alone n = 7, 17 months, Crizotinib followed by Ceritinib and/or Brigatinib (n = 9) median OS not reached, p < 0.001. Conclusions: Smalldifferences in OS were observed, depending on the treatment centers, but the use of multiple EGFR and ALK-I impacted highly significantly on the outcome of patients with EGFR and ALK-alterations in a real life setting.

scholarly journals The Impact of Social Cognition on the Real-Life of People with Epilepsy

2021 ◽  
Vol 11 (7) ◽  
pp. 877
Author(s):  
Arminas Jasionis ◽  
Kristijonas Puteikis ◽  
Rūta Mameniškienė
Keyword(s):  
Social Cognition ◽  
Interpersonal Relationships ◽  
Real Life ◽  
Life Outcomes ◽  
Level Of Education ◽  
The Mind ◽  
Patients With Epilepsy ◽  
The Impact ◽  
Strange Stories Test

Background. Previous research has demonstrated the impairment of social cognition (SC) in people with epilepsy. It is associated with worse social functioning and quality of life; however, the influence on real-life outcomes is unknown. The purpose of this study was to investigate how SC is associated with epilepsy variables and real-life outcomes (education, employment and relationships) among patients with epilepsy (PWE). Methods. Eighty-one PWE completed tasks of theory of mind (ToM) (faux pas recognition (FPRT) and Happé Strange Stories test (HST)) and emotion recognition (ER) (Reading of the Mind in the Eyes (RMET)). Variables reflecting their education, employment and relationship status were treated as endpoints in search of association with SC. Data from a matched group (n = 30) of healthy controls (HCs) were used for comparison of ToM abilities. Results. ToM scores were lower among PWE as compared to HCs (U = 1816.0, p < 0.0001 (HST), U = 1564.5, p = 0.020 (FPRT)). All SC tests were associated with the level of education (OR = 1.22, 95% confidence interval (CI) = 1.09 to 1.36 (RMET), OR = 1.20, 95% CI = 1.02 to 1.40 (HST), OR = 0.93, 95% CI = 0.87 to 1.00 (FPRT)). The results of ToM and ER testing were not associated with employment (χ2 = 33.423, p < 0.0001) if adjusted for the level of education (B = 0.804, OR = 2.23 (95% CI = 1.33 to 3.76), p = 0.002). SC abilities did not differ between PWE who were single and those in a relationship (U = 858.5, p = 0.541 (HST)), t= −1.236, p = 0.220 (RMET), U = 909.5, p = 0.271 (FPRT)). Conclusion. Better social cognition skills are linked to a higher level of education among PWE. SC probably has less influence on professional achievements and interpersonal relationships.

Quality Assurance in Computer-Assisted Translation in Business Environments

2021 ◽  
pp. 247-270
Author(s):  
Sanja Seljan ◽  
Nikolina Škof Erdelja ◽  
Vlasta Kučiš ◽  
Ivan Dunđer ◽  
Mirjana Pejić Bach
Keyword(s):  
Quality Assurance ◽  
Error Detection ◽  
Collaborative Work ◽  
Computer Assisted ◽  
Translation Memory ◽  
Terminology Extraction ◽  
Business Environments ◽  
Counting Data ◽  
Data Driven Decisions

Increased use of computer-assisted translation (CAT) technology in business settings with augmented amounts of tasks, collaborative work, and short deadlines give rise to errors and the need for quality assurance (QA). The research has three operational aims: 1) methodological framework for QA analysis, 2) comparative evaluation of four QA tools, 3) to justify introduction of QA into CAT process. The research includes building of translation memory, terminology extraction, and creation of terminology base. Error categorization is conducted by multidimensional quality (MQM) framework. The level of mistake is calculated considering detected, false, and not detected errors. Weights are assigned to errors (minor, major, or critical), penalties are calculated, and quality estimation for translation memory is given. Results show that process is prone to errors due to differences in error detection, harmonization, and error counting. Data analysis of detected errors leads to further data-driven decisions related to the quality of output results and improved efficacy of translation business process.

Approaches to Measuring the Impact of Music Therapy and Music Activities on People Living With Dementia

2019 ◽  
pp. 171-196
Author(s):  
Becky Dowson ◽  
Orii McDermott
Keyword(s):  
Music Therapy ◽  
Outcome Measures ◽  
Quantitative Research ◽  
Psychological Symptoms ◽  
Real Life ◽  
Evidence Base ◽  
People With Dementia ◽  
The Impact ◽  
Music Activities

This chapter provides an introduction to the evaluation of music activities and music therapy for people with dementia. We outline some of the main challenges and considerations involved in choosing or using outcome measures. An overview of common outcome measures used in current research, including those for behavioral and psychological symptoms, quality of life, physiological changes, cognitive function, and music-related behaviors, is provided. Two music-therapy case studies are presented as real-life examples of how to select clinically relevant measures. Clinicians have long argued that some clinically meaningful changes may not always be measurable. We propose that when insights obtained from high-quality qualitative and mixed methods studies are added to the evidence base of quantitative research, it will lead to a deeper understanding of the benefits that music can have in the lives of people living with dementia.

Robust Fluid Topology Optimization Using Polynomial Chaos Expansions: TOffee

2018 ◽  
Author(s):  
A. Gaymann ◽  
F. Montomoli ◽  
M. Pietropaoli
Keyword(s):  
Topology Optimization ◽  
Boundary Conditions ◽  
Gas Turbines ◽  
Real Life ◽  
Optimization Method ◽  
Robust Topology Optimization ◽  
Pressure Losses ◽  
Polynomial Chaos Expansions ◽  
The Impact ◽  
Optimized Geometries

The paper presents an innovative solution to robust topology optimization developed for components that can be manufactured by additive manufacturing. Topology optimization has been used in fluid dynamics to optimize geometries based on a target set of performances required for the flow paths. These target performances can be defined as pressure losses or heat exchanges for example, and multiple optimized geometries can be found in the literature. However, none of these cases considered the impact of stochastic variations and are based on a deterministic optimization. It means the optimization has been done for a single boundary condition value. Would this boundary be random, as it is the case in real life gas turbines, then the optimized geometry, optimized for a single set of boundary conditions, will underperform. Robust topology optimization obtains a geometry able to cope with these random variations. The robust optimization method has been implemented in an in-house solver TOffee and relies on a multi-objective function. 2D and 3D robust optimized geometries are obtained and their performance compared to deterministic cases over a range of boundary conditions. Superiority of robust geometries as compared to deterministic geometries is shown. Robust topology optimization presents a great interest in the gas turbine industry due to the greater performance obtained by the optimized geometries while taking into consideration random variations of boundary conditions, making the simulations closer to real life conditions. For the first time in this work it is shown a fluid topology optimization solution with sedimentation that are inherently able to cope with uncertainty.

A tisket a tasket what happened to Market Basket?

2016 ◽  
Vol 12 (3) ◽  
pp. 399-421
Author(s):  
Susan Bosco ◽  
Diane M. Harvey
Keyword(s):  
Organizational Behavior ◽  
Corporate Culture ◽  
Real Life ◽  
Content Type ◽  
Market Basket ◽  
Secondary Sources ◽  
Behavior Issues ◽  
Real Life Situation ◽  
Primary Focus ◽  
The Impact

Synopsis The saga of Market Basket took place over a period of months during which a significant upheaval occurred in the long-successful business. The turmoil drew in a broad range of stakeholders. In a rare chain of events, non-unionized workers and managers engineered a change in senior management of the company. Their willingness to sacrifice their livelihoods in support of one person exemplifies the impact that can be made by a single, authentic, leader. This case draws upon secondary sources which provide insight into broad panoply of business and organizational behavior issues. The primary focus of the case, however, is leadership. Research methodology This case was developed using secondary sources and court documents that reported on the events that precipitated the problems at Market Basket as well as the strike and aftermath. Relevant courses and levels Management principles, organizational behavior. All undergraduate class levels would be appropriate. Theoretical bases This case exemplifies these three major theories in a real-life situation: stakeholder theory, corporate culture theory, organizational commitment.

scholarly journals Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern

2021 ◽  
Author(s):  
Fiolet ◽  
Yousra Kherabi ◽  
Conor MacDonald ◽  
Jade Ghosn ◽  
Nathan Peiffer-Smadja
Keyword(s):  
South Africa ◽  
Herd Immunity ◽  
Real Life ◽  
Cost Effective ◽  
Phase Iii ◽  
Real Life Data ◽  
National Drug ◽  
Phase Iii Trials ◽  
The Impact

Vaccines are critical cost-effective tools to control the COVID-19 pandemic. However, the emergence of more transmissible SARS-CoV-2 variants may threaten the potential herd immunity sought from mass vaccination campaigns.The objective of this study was to provide an up-to-date comparative analysis of the characteristics, adverse events, efficacy, effectiveness and impact of the variants of concern (Alpha, Beta, Gamma and Delta) for fourteen currently authorized COVID-19 vaccines (BNT16b2, mRNA-1273, AZD1222, Ad26.COV2.S, Sputnik V, NVX-CoV2373, Ad5-nCoV, CoronaVac, BBIBP-CorV, COVAXIN, Wuhan Sinopharm vaccine, QazCovid-In, Abdala and ZF200) and two vaccines (CVnCoV and NVX-CoV2373) currently in rolling review in several national drug agencies.Overall, all COVID-19 vaccines had a high efficacy against the traditional strain and the variants of SARS-CoV-2, and were well tolerated. BNT162b2, mRNA-1273 and Sputnik V had the highest efficacy (&gt;90%) after two doses at preventing symptomatic cases in phase III trials. Efficacy was ranging from 10.4% for AZD1222 in South Africa to 50% for NVX-CoV2373 in South Africa and 50 % for CoronaVac in Brazil, where the 501YV.2 and P1 variants were dominant. Seroneutralization studies showed a negligible reduction in neutralization activity against Alpha for most of vaccines, whereas the impact was modest for Delta. Beta and Gamma exhibited a greater reduction in neutralizing activity for mRNA vaccines, Sputnik V and CoronaVac. Regarding observational real-life data, most studies concerned the Pfizer and Moderna vaccines. Full immunization with mRNA vaccines effectively prevents SARS-CoV-2 infection against Alpha and Beta. All vaccines appeared to be safe and effective tools to prevent symptomatic and severe COVID-19, hospitalization and death against all variants of concern, but the quality of evidence greatly varied depending on the vaccines considered. There are remaining questions regarding specific populations excluded from trials, the duration of immunity and heterologous vaccination. Serious adverse event and particularly anaphylaxis (2.5-4.7 cases per million doses among adults) and myocarditis (3.5 cases per million) for mRNA vaccines ; thrombosis with thrombocytopenia syndrome for Janssen vaccine (3 cases per million) and AstraZeneca vaccine (2 cases per million) and Guillain-Barre syndrome (7.8 cases per million) for Janssen vaccine are very rare. COVID-19 vaccine benefits outweigh risks, despite rare serious adverse effect.

scholarly journals On the Relationship between the Economic Indicators Basis and the Parameters of Managerial Decisions Development in an Organization

2019 ◽  
Vol 29 (1) ◽  
pp. 155-165
Author(s):  
Tatуana Alexandrova
Keyword(s):  
Economic Analysis ◽  
Advantages And Disadvantages ◽  
Managerial Decisions ◽  
Analysis Methodology ◽  
Eurasian Economic Union ◽  
Border Trade ◽  
Analytical Work ◽  
The Impact ◽  
The Relationship

The article deals with one of the key problems of the economic analysis methodology, i.e. with defining the basis of comparison of indicators and methods to obtain them. In the course of the research, the procedure of intercompany comparison was studied. The bases of comparison are defined; their advantages and disadvantages are singled out. The conditions under which it is advisable to use a certain basis of comparison when conducting economic analysis are formulated. Special attention is paid to the impact of the selected bases of comparison on the analysis reliability, as well as on the speed and quality of decision-making. The choice of alternative management solutions based on the use of different bases of indicators comparison is substantiated. Export activities of a Eurasian Economic Union enterprise involved in cross-border trade are analyzed as an example. The results of this research can be used in the analytical work of the organization to improve the reliability assessment of economic performance and the effectiveness of the managerial decisions development.

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