scholarly journals Obesity and schizophrenia: New drugs, new hopes

2020 ◽  
Vol 52 (1-2) ◽  
pp. 113-130
Author(s):  
Čedo Miljević ◽  
Olivera Vuković
Keyword(s):  
Metabolic Syndrome ◽  
General Population ◽  
Life Span ◽  
New Drugs ◽  
Population Prevalence ◽  
Key Factor ◽  
Schizophrenic Patients ◽  
Prevalence Of Obesity ◽  
Treatment Of Obesity

Obesity is one of the leading problems in our society. The spread of obesity in developed societies is reaching pandemic lengths. In schizophrenic patients obesity raises an important issue. Patients suffering from schizophrenia have a shorter life span compared to the general population. Prevalence of obesity in schizophrenic patients is high. Obesity is the key factor in developing a metabolic syndrome. Metabolic syndrome is a frequent somatic complication in schizophrenia. Nowadays, it is clear that metabolic syndrome shortens the lifespan of people who developed an illness. Because of this, the treatment of obesity represents a major problem. Review of currently approved medications for treatment of obesity is the goal of this paper.

Obesity and metabolic syndrome in Brazilian patients with bipolar disorder

2009 ◽  
Vol 21 (2) ◽  
pp. 84-88 ◽  
Author(s):  
Karla Mathias de Almeida ◽  
Márcia B. de Macedo-Soares ◽  
Cilly Kluger Issler ◽  
José Antonio Amaral ◽  
Sheila C. Caetano ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bipolar Disorder ◽  
General Population ◽  
Medication Use ◽  
Density Lipoprotein ◽  
Heart Association ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
High Fasting Glucose ◽  
Prevalence Of Obesity

Objective:We aimed to determine the prevalence of obesity and metabolic syndrome (O/MetS) in a sample of Brazilian outpatients with bipolar disorder.Methods:Eighty-four patients with bipolar disorder were evaluated. We used the definition of MetS established in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, modified by the American Heart Association (AHA). Patients were classified as obese if their body mass index (BMI) was ≥ 30 kg/m2.Results:We found that 28.6% of our sample met the AHA criteria for MetS and 35.7% were obese. The percentage of patients meeting each criterion of the AHA was as follows: 46% for abdominal obesity; 44% for hypertriglyceridemia or cholesterol-lowering medication use; 26% for low high-density lipoprotein cholesterol or being on a lipid-lowering medication; 45% for hypertension; and 20% for high fasting glucose or anti-diabetic medication use.Conclusions:The prevalence of obesity in our sample of outpatients with bipolar disorder was higher than that observed for the general population of Brazil. The rate of MetS was similar to that observed for the general population. Our data indicate the need for prevention, early detection and treatment of O/MetS in patients with bipolar disorder.

scholarly journals Hvordan etablere en sunn livsstil hos en overvektig inaktiv kvinne med psykisk utviklingshemning

2015 ◽  
Vol 11 (1) ◽  
pp. 180�
Author(s):  
Christine Tørris ◽  
Mette Kristin Rach ◽  
Line Margrethe Solhaug
Keyword(s):  
Physical Activity ◽  
Intellectual Disability ◽  
Waist Circumference ◽  
General Population ◽  
Life Span ◽  
Health Risks ◽  
Healthy Lifestyle ◽  
Overweight And Obesity ◽  
Behavioural Analysis ◽  
Prevalence Of Obesity

<strong>How to establish a healthy lifestyle in an overweight, inactive woman with an intellectual disability</strong><br />Overweight and obesity are associated with increased health risks and shortened life span. The prevalence of overweight and obesity is increasing, and a higher prevalence of obesity has been observed in persons with intellectual disability than in the general population. In this study, we want to establish a healthy lifestyle with a healthy diet and increased physical activity in an obese, inactive women with intellectual disability. Using interventions based on applied behavioural analysis, the women have established new habits in terms of diet and increased physical activity. The number of hours with physical activity per week has doubled, and both weight and waist circumference decreased during the eight weeks of the study. She maintained her new healthy lifestyle, after the study. More research is needed in interventions that can help reduce obesity in persons with intellectual disability.

scholarly journals The Prevalence of Obesity and Metabolic Syndrome in the Korean Military Compared with the General Population

2018 ◽  
Vol 33 (25) ◽  
Author(s):  
Jung Hwan Lee ◽  
Da Hea Seo ◽  
Min Jung Nam ◽  
Geon Hui Lee ◽  
Dong Hee Yang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
General Population ◽  
Prevalence Of Obesity

Approaches for the Development of Drugs for Treatment of Obesity and Metabolic Syndrome

2016 ◽  
Vol 22 (7) ◽  
pp. 895-903 ◽  
Author(s):  
Maksim L. Maksimov ◽  
Andrey A. Svistunov ◽  
Vadim V. Tarasov ◽  
Vladimir N. Chubarev ◽  
Marco Ávila-Rodriguez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Treatment Of Obesity

scholarly journals Prevalence of Metabolic Syndrom in Three Urban Communities of Dhaka City

1970 ◽  
Vol 2 (2) ◽  
pp. 44-48 ◽  
Author(s):  
Shurovi Sayeed ◽  
Akhter Banu ◽  
Parvin Akter Khanam ◽  
Sharmina Alauddin ◽  
Sabrina Makbul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Urban Communities ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Urban Population ◽  
Population Characteristics ◽  
Dhaka City ◽  
Fasting Plasma ◽  
Prevalence Of Obesity ◽  
The Mean

Bangladeshis are prone to develop type 2 diabetes mellitus (T2DM), hypertension (sHTN and dHTN) and atherosclerotic heart diseases, observed more predominantly in the urban population. Though metabolic syndrome (MetS) is a related disorder, there are few studies in this regard. The prevalence of obesity, T2DM and MetS in three urban communities of Bangladesh were addressed in this study. Nine hundred non-slum urban households in three Dhaka City Wards were randomly selected. One member (age ≥ 25y) from each household was invited for investigation with an overnight fast. Socio-demographic information as well as height, weight, waist-girth, hip-girth and blood pressure were measured. Fasting plasma glucose (FPG), total cholesterol (chol), triglycerides (TG) and high-density lipoproteins-c (HDL) were estimated. A total of 705 (m / f = 239 / 466) subjects volunteered for the study. The mean value with 95% confidence interval (CI) of age was 42.4 (40.9 - 43.1) years for men and 37.8 (36.8 - 38.7) for women. The mean (CI) body mass index (BMI) was 21.0 (20.6 - 21.5) and 22.6 (22.2 - 22.9) and waist hip ratio (WHR) was 0.84 (0.83 - 0.84) and 0.82 (0.81 - 0.83), respectively for men and women. The mean (CI) FPG (fasting plasma glucose) was 5.5 (5.2 - 5.7) for men and 5.2 (5.0 - 5.4) for women. The prevalence of obesity (BMI ≥ 25.0) was 21%, T2DM (FPG ≥ 6.1 mmol/l) was 22.2%, triglyceridemia (TG ≥ 150mg/dl) was 45.1% and low HDL-c (HDL<40mg/ dl) was 43.8%. The crude prevalence of MetS varied based on different cluster combinations, being the lowest (0.3%) recommended by WHO cluster (FPG + BMI + SBP/DBP) and the highest (8.7%) by International Diabetes Federation (IDF) cluster (waist + FPG + HDL). The MetS was found higher in male than female by NCEP criteria and higher in female than male by IDF criteria. The study revealed an increased prevalence of obesity, T2DM and MetS in the urban communities. It also revealed that T2DM and MetS are moderately common and of growing healthcare burden in the rapidly growing urban population. Additionally, the study observed the wide ranging prevalence rates of MetS in the same study population indicating the need to establish a consistent and useful MetS-cluster depending on population characteristics. Ibrahim Med. Coll. J. 2008; 2(2): 44-48 Key Words: Metabolic syndrome, urban, diabetes, hypertension, dyslipidemia   doi: 10.3329/imcj.v2i2.2936

scholarly journals MRD-Based Therapeutic Decisions in Genetically Defined Subsets of Adolescents and Young Adult Philadelphia-Negative ALL

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2108
Author(s):  
Manuela Tosi ◽  
Orietta Spinelli ◽  
Matteo Leoncin ◽  
Roberta Cavagna ◽  
Chiara Pavoni ◽  
...  
Keyword(s):  
Residual Disease ◽  
Lymphoblastic Leukemia ◽  
Survival Rates ◽  
Philadelphia Chromosome ◽  
Current Treatment ◽  
New Drugs ◽  
Term Survival ◽  
Therapeutic Decisions ◽  
Key Factor ◽  
Combined Strategy

In many clinical studies published over the past 20 years, adolescents and young adults (AYA) with Philadelphia chromosome negative acute lymphoblastic leukemia (Ph− ALL) were considered as a rather homogeneous clinico-prognostic group of patients suitable to receive intensive pediatric-like regimens with an improved outcome compared with the use of traditional adult ALL protocols. The AYA group was defined in most studies by an age range of 18–40 years, with some exceptions (up to 45 years). The experience collected in pediatric ALL with the study of post-induction minimal residual disease (MRD) was rapidly duplicated in AYA ALL, making MRD a widely accepted key factor for risk stratification and risk-oriented therapy with or without allogeneic stem cell transplantation and experimental new drugs for patients with MRD detectable after highly intensive chemotherapy. This combined strategy has resulted in long-term survival rates of AYA patients of 60–80%. The present review examines the evidence for MRD-guided therapies in AYA’s Ph− ALL, provides a critical appraisal of current treatment pitfalls and illustrates the ways of achieving further therapeutic improvement according to the massive knowledge recently generated in the field of ALL biology and MRD/risk/subset-specific therapy

scholarly journals To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Maryam Zare Jeddi ◽  
Rozita Soltanmohammadi ◽  
Giulia Barbieri ◽  
Aline S. C. Fabricio ◽  
Gisella Pitter ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
General Population ◽  
Meta Analysis ◽  
Small Body ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Epidemiologic Evidence ◽  
Adults And Children ◽  
Meta Analyses

Abstract Exposure to per- and polyfluoroalkyl substances (PFAS), ubiquitous persistent environmental contaminants, has led to substantial global concern due to their potential environmental and human health effects. Several epidemiological studies have assessed the possible association between PFAS exposure and risk of metabolic syndrome (MetS), however, the results are ambiguous. The aim of this study was to assess the current human epidemiologic evidence on the association between exposure to PFAS and MetS. We performed a systematic search strategy using three electronic databases (PubMed, Scopus, and Web of Science) for relevant studies concerning the associations of PFAS with MetS and its clinical relevance from inception until January 2021. We undertook meta-analyses where there were five or more studies with exposure and outcomes assessments that were reasonably comparable. The pooled odd ratios (ORs) were calculated using random effects models and heterogeneity among studies was assessed by I2 index and Q test. A total of 12 cross-sectional studies (10 studies on the general population and two studies in the occupational settings) investigated the association between PFAS exposure and MetS. We pooled data from seven studies on the general population for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) and five studies for perfluorohexanesulfonate (PFHxS) and perfluorononanoic acid (PFNA). Predominately, most studies reported no statistically significant association between concentrations of PFAS and MetS. In the meta-analysis, the overall measure of effect was not statistically significant, showing no evidence of an association between concentrations of PFOA, PFOS, PFNA, and PFHxS and the risk of MetS. Based on the results of the meta-analysis, current small body of evidence does not support association between PFAS and MetS. However, due to limited number of studies and substantial heterogeneity, results should be interpreted with caution. Further scrutinizing cohort studies are needed to evaluate the association between various and less well-known PFAS substances and their mixture with MetS and its components in both adults and children in different settings.

The epidemiology of contact allergy in the general population – prevalence and main findings

2007 ◽  
Vol 57 (5) ◽  
pp. 287-299 ◽  
Author(s):  
Jacob Pontoppidan Thyssen ◽  
Allan Linneberg ◽  
Torkil Menné ◽  
Jeanne Duus Johansen
Keyword(s):  
General Population ◽  
Contact Allergy ◽  
Population Prevalence
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