scholarly journals Treatment of periodontal disease using xanthan based chlorhexidine gel

2021 ◽  
Vol 17 (2) ◽  
pp. 326-330
Author(s):  
Kumar Manish ◽  
Keyword(s):  
Periodontal Disease ◽  
Clinical Parameters ◽  
Gingival Index ◽  
Gi Bleeding ◽  
Clinical Attachment Level ◽  
Group A ◽  
Microbial Analysis ◽  
Group B ◽  
Attachment Level ◽  
Chlorhexidine Gel

People of all ages are suffering from periodontal disease. It causes indirect damage in the oral cavity. It is of interest to evaluate the efficacy of xanthan-based chlorhexidine gel (Xan-CHX) in patients with mild-severe chronic periodontitis. Five patients with 60 sites were divided in two groups. Group A (treated with SRP) and group B (treated with Chlosite i.e., SRP + CHL). The recorded clinical parameters were Plaque index (PI), Gingival index (GI), Bleeding index (BI), and Clinical attachment Level (CAL) with sub gingival plaque subjected to microbial analysis. Significant reduction was observed in both groups. However, group B (treated with Chlosite i.e., SRP + CHL) showed statistically significant improvement on above mentioned parameters as compared to group A. Data suggest that in the treatment of periodontal disease (viz. PI, GI, BI and CAL) combination of SRP and Chlosite showed added benefits over only SRP.

scholarly journals Treatment of periodontal disease using xanthan based chlorhexidine gel

2021 ◽  
Vol 17 (2) ◽  
pp. 326-330
Author(s):  
Kumar Manish ◽  
Keyword(s):  
Periodontal Disease ◽  
Clinical Parameters ◽  
Gingival Index ◽  
Gi Bleeding ◽  
Clinical Attachment Level ◽  
Group A ◽  
Microbial Analysis ◽  
Group B ◽  
Attachment Level ◽  
Chlorhexidine Gel

People of all ages are suffering from periodontal disease. It causes indirect damage in the oral cavity. It is of interest to evaluate the efficacy of xanthan-based chlorhexidine gel (Xan-CHX) in patients with mild-severe chronic periodontitis. Five patients with 60 sites were divided in two groups. Group A (treated with SRP) and group B (treated with Chlosite i.e., SRP + CHL). The recorded clinical parameters were Plaque index (PI), Gingival index (GI), Bleeding index (BI), and Clinical attachment Level (CAL) with sub gingival plaque subjected to microbial analysis. Significant reduction was observed in both groups. However, group B (treated with Chlosite i.e., SRP + CHL) showed statistically significant improvement on above mentioned parameters as compared to group A. Data suggest that in the treatment of periodontal disease (viz. PI, GI, BI and CAL) combination of SRP and Chlosite showed added benefits over only SRP.

scholarly journals Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation

2004 ◽  
Vol 18 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Solange Alonso Vergani ◽  
Emílio Barbosa e Silva ◽  
Adriana Helena Vinholis ◽  
Rosemary Adriana Chiérici Marcantonio
Keyword(s):  
Periodontal Disease ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Gingival Index ◽  
Clinical Attachment Level ◽  
Group I ◽  
Probing Depth ◽  
Chronic Periodontal Disease ◽  
Attachment Level ◽  
Systemic Metronidazole

The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II, and probing depth (p = 0.0124) between Group I and the others. We conclude that the use of systemic metronidazole did not produce additional effects on the microbiological conditions of these patients with chronic periodontal disease.

scholarly journals Evaluation of periodontal condition and risk in patients with chronic kidney disease on hemodialysis

2017 ◽  
Vol 15 (2) ◽  
pp. 173-177 ◽  
Author(s):  
Yeon Jung Kim ◽  
Luciana Martins de Moura ◽  
Christiane Peres Caldas ◽  
Caroline Perozini ◽  
Gilson Fernandes Ruivo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
High Risk ◽  
Kidney Disease ◽  
Periodontal Disease ◽  
Gingival Index ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Severe Periodontal Disease ◽  
Periodontal Risk ◽  
Attachment Level

ABSTRACT Objective To establish a profile of periodontal conditions in chronic kidney disease patients on hemodialysis and their periodontal risk. Methods We included 115 patients on hemodialysis. Clinical periodontal parameters assessed were: plaque index, gingival index, probing depth and clinical attachment level. Patients were classified according to presence/absence and severity of periodontal disease and periodontal risk. Results In 107 dentate patients (93%) the plaque index was 1.53±0.78, the gingival index was 0.95±0.85, the probing depth was 2.2±0.6mm and the clinical attachment level was 3.18±1.75mm. We observed that 1 patient (0.94%) did not have periodontal disease, 55 patients (51.40%) had slight, 28 (26.17%) moderate and 23 (21.49%) severe periodontal disease. Among 107 patients, 37 (34.58%) had low risk, 35 (32.71%) moderate risk and 35 (32.71%) high risk. Patients with severe periodontal disease showed 104.5 more chance of high risk compared with low risk individuals (odds ratio: 104.5; 95%CI: 10.7-1017.2; p<0.0001). Conclusion Most of patients with chronic renal disease presented periodontal disease, indicating the presence of chronic inflammatory and infection process that may influence in systemic conditions. A prevention and interventionist approach in this population is needed, especially to emphasize the importance of oral health. The periodontal risk assessment is a useful tool to create individualized periodontal therapies and to improve general health condition.

scholarly journals Evaluation of Plaque Removal Efficacy of Dental Floss with/without Chlorhexidine Gel Coating in Patients with Gingivitis - A Clinical and Microbological Study

2020 ◽  
Vol 8 (D) ◽  
pp. 118-123
Author(s):  
Monika Pal ◽  
Santhosh Kumar ◽  
Padmaja A. Shenoy ◽  
T. A. K. Chaitanya ◽  
G. Pratibha ◽  
...  
Keyword(s):  
Plaque Index ◽  
Controlled Clinical Trial ◽  
Microbiological Analysis ◽  
Gingival Index ◽  
Sample Collection ◽  
Dental Floss ◽  
Supragingival Plaque ◽  
Group A ◽  
Group B ◽  
Chlorhexidine Gel

BACKGROUND: Chlorhexidine has shown anti-plaque and antimicrobial effects when used as a mouthwash and appears to be effective when used as a topical antiseptic agent. AIM: The present study aimed to compare the efficacy of chlorhexidine gel coated dental floss with that of uncoated dental floss. METHODS: This parallel, single-blinded, randomized controlled clinical trial Included 30 patients with moderate to severe gingivitis. The total population was randomly divided into three groups, with ten patients in each group. Group A received dental floss with 1% chlorhexidine gel, and Group B received only dental floss, while in Group C no dental floss was provided. All thirty volunteers were provided with standard toothpaste and toothbrush. Clinical parameters such as gingival index, plaque index, and bleeding index were recorded along with supragingival plaque sample collection for microbiological culture. Subjects were recalled after 15 days and clinical and microbiological analysis was performed. All parameters were re-assessed at the follow up visit after two weeks. RESULTS: All the groups showed a significant reduction in values of plaque index, gingival index, and bleeding index, as well as the microbial counts post-enrollment in the study. A significant reduction in the bleeding indices was noticed in Group A in comparison to C (p < 0.05). CONCLUSIONS: The use of dental floss coated with 1% chlorhexidine gluconate gel was effective as an interproximal aid for patients with moderate to severe gingivitis.

scholarly journals Can preservative Nisin preserve periodontium?

2019 ◽  
pp. 21-24
Author(s):  
Rohit Shah ◽  
Rutuja Dhonde ◽  
Dipika Mitra ◽  
Silvia Rodrigues ◽  
Gaurav Shetty ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Test Group ◽  
Post Treatment ◽  
Local Drug Delivery ◽  
Clinical Parameters ◽  
Gingival Index ◽  
Root Planing ◽  
Group 15 ◽  
Group A ◽  
Group B

Brief Background: Nisin’ is found naturally in dairy products and is also used as a preservative in food and beverages. It shows a rapid and broad spectrum activity against both gram-negative and gram-positive bacteria and hence could be used as a local drug delivery agent. Aim: To evaluate the clinical efficacy (Gingival Index GI, Probing Pocket Depth PPD, (Relative Attachment level RAL) of Scaling Root Planing (SRP) alone versus SRP with Nisin gel as LDD in pocket reduction therapy at baseline and after 3 months. Methodology: 30 sites in patients with chronic periodontitis with 5-7mm PPD were selected after taking informed consent. It was a split mouth study. Sites were divided into Group A Test group (15 sites) treated with SRP + LDD of Nisin gel and Group B control group (15 sites) treated with SRP alone. Clinical parameters were recorded at baseline and post treatment at 3 months. Results: It was observed that there was an improvement in clinical parameters in both the groups from baseline to 3 months post treatment, with Group A Test Group showing superior results. There was statistically significant improvement in Gingival Index in Group A as compared to Group B. PPD and RAL did not show statistically significant difference in both the groups. Summary and Conclusions: Nisin improves periodontal health and hence can be potentially used as an LLD agent. Keywords: Nisin, Preservative, Local drug delivery, Scaling root planing.

scholarly journals Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the Anti-Inflammatory Effects of Ozone Application

Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 625
Author(s):  
Marco Colombo ◽  
Simone Gallo ◽  
Alessandro Garofoli ◽  
Claudio Poggio ◽  
Carla Renata Arciola ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Antimicrobial Properties ◽  
Experimental Treatment ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Beneficial Effects ◽  
Probing Pocket Depth ◽  
Chronic Periodontal Disease ◽  
Attachment Level ◽  
Chlorhexidine Gel

The search for new topical treatments able to display not only antimicrobial properties but also a multiplicity of other beneficial effects while expressing safe cytocompatibility toward host tissues is being progressively developed. Antiseptics represent an aid to the gold standard nonsurgical treatment Scaling-and-Root-Planing (SRP) for periodontal disease. This split-mouth study aims to assess the efficacy of the ozonized gel GeliO3 (Bioemmei Srl, Vicenza, Italy) plus SRP (experimental treatment), with respect to SRP + chlorhexidine gel. Ten participants were treated with SRP + chlorhexidine gel (control sites) and with SRP + ozone gel (trial sites). After 1 (T1) and 3 months (T2) from baseline (T0), patients were revisited. At each time-point, the following indexes were assessed: probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and bleeding on probing (BoP). It has been assessed that the use of the ozonized gel in addition to SRP did not show significant differences if compared to conventional SRP + chlorhexidine. Chlorhexidine was found to be more effective than ozone in reducing CAL and GI at T2. Ozone deserves consideration for its wide applicability in several clinical fields. In this connection, we also glance at the latest research on ozone therapy.

Role of Interleukin- 34 together with Receptor Activator of Nuclear Factor kB ligand and Osteoprotegrin levels in Periodontal Disease

2021 ◽  
Vol 15 (7) ◽  
pp. 1521-1522
Author(s):  
Noor Ul Amin ◽  
I. Saleem Qureshi ◽  
Sana Naeem ◽  
S. Hassan Jan ◽  
Kamal Khan ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Control Group ◽  
Gingival Index ◽  
Disease Group ◽  
Clinical Attachment Level ◽  
Group I ◽  
Group Ii ◽  
Crevicular Fluid ◽  
Attachment Level

Aim: To compare the levels and relative ratios of Interleukin-34, osteoprotegrin, and factor kB ligand in the crevicular fluid of individuals with periodontal disease. Study design & setting: Randomized Clinical Trial, Frontier Medical And Dental College, Abbotabad Methodology: We enrolled 15 healthy subjects (Group I), 15 patients with chronic periodontal disease (Group II) and 15 patients with aggressive periodontal disease (Group III). At baseline and six weeks after NSPT, crevicular fluid and clinical measures were made. The GCF IL-34, factor kB ligand, and osteoprotegrin levels were measured by using ELISA and their relative ratios were computed. Result: Group II and III had significantly higher crevicular fluid IL-34 and factor kB ligand levels than the Control group (I), although crevicular fluid with osteoprotegrin levels was significantly decreased (P<0.05). GCF, IL-34, and RANKL levels reduced in Groups II and III six weeks after NSPT, although OPG concentrations increased statistically (P<0.05). Significantly positive association was observed between IL-34 and factor kB ligand, clinical attachment level, and gingival index, but not with osteoprotegrin. Conclusion: Gingival crevicular fluid IL-34 levels were elevated in individuals with periodontal disease and lowered during non surgical intervention, and its levels correlated positively with the factor kB ligand and osteoprotegrin ratios, clinical attachment level, and gingival index. Keywords: Periodontitis, IL-34, osteoprotegrin

scholarly journals Clinical and Microbiological Evaluation of Local Doxycycline and Antimicrobial Photodynamic Therapy during Supportive Periodontal Therapy: A Randomized Clinical Trial

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 277
Author(s):  
Raluca Cosgarea ◽  
Sigrun Eick ◽  
Ionela Batori-Andronescu ◽  
Søren Jepsen ◽  
Nicole B. Arweiler ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Bacterial Species ◽  
Periodontal Therapy ◽  
Local Drug Delivery ◽  
Control Group ◽  
Periodontal Pathogens ◽  
Supportive Periodontal Therapy ◽  
Group A ◽  
Group B ◽  
Attachment Level

The aim of this study was to evaluate the clinical and microbiological effects of subgingival instrumentation (SI) alone or combined with either local drug delivery (LDD) or photodynamic therapy (PDT) in persistent/recurrent pockets in patients enrolled in supportive periodontal therapy (SPT). A total of 105 patients enrolled in SPT were randomly treated as follows: group A (n = 35): SI +PDT and 7 days later 2nd PDT; group B (n = 35): SI+LDD; group C (n = 35): SI (control). Prior intervention, at 3 and 6 months after therapy, probing pocket depths, clinical attachment level, number of treated sites with bleeding on probing (n BOP), full mouth plaque and bleeding scores (gingival bleeding index, %BOP) were recorded. At the same time points, 8 periodontopathogens were quantitatively determined. All three treatments resulted in statistically significant improvements (p < 0.05) of all clinical parameters without statistically significant intergroup differences (p > 0.05). Several bacterial species were reduced in both test groups, with statistically significantly higher reductions for LDD compared to PDT and the control group. In conclusion, the present data indicate that: (a) In periodontal patients enrolled in SPT, treatment of persistent/recurrent pockets with SI alone or combined with either PDT or LDD may lead to comparable clinical improvements and (b) the adjunctive use of LDD appears to provide better microbiological improvements for some periodontal pathogens than SI alone or combined with PDT.

scholarly journals Aspectos clínicos, microbiológicos e tratamento periodontal em pacientes fumantes portadores de doença periodontal crônica: revisão da literatura

2016 ◽  
Vol 73 (4) ◽  
pp. 325
Author(s):  
Gabriela Alessandra Da C. Galhardo Camargo ◽  
Mariana Gouvea Latini Abreu ◽  
Renata Dos Santos ◽  
Marcio Alves Crespo ◽  
Leticia De Faria Wenderoscky
Keyword(s):  
Gingival Recession ◽  
Periodontal Therapy ◽  
Clinical Aspects ◽  
Gingival Index ◽  
Periodontal Pathogens ◽  
Clinical Attachment Level ◽  
Qualitative And Quantitative ◽  
Probing Depth ◽  
Microbiological Parameters ◽  
Attachment Level

Objective: the aim of this study was to evaluate, through literature review, clinical aspects (plaque index, gingival index, probing depth, gingival recession and clinical attachment level) and microbiological (qualitative and quantitative presence of periodontal pathogens) in smokers patients and the response to periodontal therapy. Material and Methods: it was selected scientific articles published between the years 1978 and 2014. We were selected scientific articles from MEDLINE, PUBMED and LILACS databases. Results: there are controversies between tobacco and clinical and microbiological parameters. Conclusion: based on the evaluated studies we can conclude that there are significant clinical and microbiological differences in smoking patients and impaired response to periodontal therapy.

scholarly journals Association between schizophrenia and periodontal disease in relation to cortisol levels: an ELISA-based descriptive analysis

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Bariah Fahad Albahli ◽  
Najd Mohammed Alrasheed ◽  
Raghad Saleh Alabdulrazaq ◽  
Dhafer S. Alasmari ◽  
Muzammil Moin Ahmed
Keyword(s):  
Periodontal Disease ◽  
Descriptive Analysis ◽  
Clinical Attachment Loss ◽  
Schizophrenic Patients ◽  
Group A ◽  
Schizophrenic Group ◽  
Cortisol Levels ◽  
Group B ◽  
Study Participants ◽  
Shared Risk

Abstract Background Schizophrenia is a chronic psychosis marked by multiple bioenvironmental and immunological dysregulation with its intricate role in etiopathogenesis of periodontal disease remaining unclear. Hence, the aim of this study is to determine the association between periodontal disease and schizophrenia in relation with cortisol levels. Methods The study is in descriptive design comprised of 40 subjects randomly selected (20 schizophrenic patients as Group A and 20 healthy volunteers as group B). All the study participants underwent complete periodontal examination including scoring of gingival index (GI), plaque index (PI), Probing depths (PD) and clinical attachment loss (CAL). Salivary cortisol levels are estimated using ELISA. Link between schizophrenia and periodontal disease is described in relation to cortisol levels with elimination of other shared risk factors, such as tobacco smoking and xerostomia. Results Significant higher values of periodontal parameters are observed in Group A with schizophrenic patients (GI 2.467 ± 0.528; PI 2.402 ± 0.526; PD 2.854 ± 0.865; CAL 1.726 ± 3.096) than Group B with healthy subjects (GI 0.355 ± 0.561; PI 0.475 ± 0.678; PD 1.493 ± 0.744; CAL 0.108 ± 0.254). However, cortisol levels are lower in schizophrenic group (0.190 ± 0.059) than non-schizophrenic group (0.590 ± 0.228) ruling out the possible role of cortisol in periodontal disease severity associated with schizophrenic patients. Conclusion Findings of this study, provides ground evidence for consideration of schizophrenia as a risk factor for periodontitis and demands greater emphasis on management of schizophrenic patients in dental setting similar to other comorbid disorders such as diabetes mellitus and also incorporating periodontal care measures in the clinical guidelines for schizophrenia management.

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