scholarly journals An Integrated Analysis of the Genome-Wide Profiles of DNA Methylation and mRNA Expression Defining the Side Population of a Human Malignant Mesothelioma Cell Line

2016 ◽  
Vol 7 (12) ◽  
pp. 1668-1679 ◽  
Author(s):  
Myung-Chul Kim ◽  
Na-Yon Kim ◽  
Yu-Ri Seo ◽  
Yongbaek Kim
Keyword(s):  
Dna Methylation ◽  
Mrna Expression ◽  
Cell Line ◽  
Malignant Mesothelioma ◽  
Side Population ◽  
Integrated Analysis ◽  
Genome Wide ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell

scholarly journals A subset of microRNAs defining the side population of a human malignant mesothelioma cell line

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42847-42856 ◽  
Author(s):  
Myung-Chul Kim ◽  
Na-Yon Kim ◽  
Yu-Ri Seo ◽  
Yongbaek Kim
Keyword(s):  
Cell Line ◽  
Malignant Mesothelioma ◽  
Side Population ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell

scholarly journals β-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion

Oncogene ◽  
2003 ◽  
Vol 22 (39) ◽  
pp. 7922-7930 ◽  
Author(s):  
Noriyasu Usami ◽  
Yoshitaka Sekido ◽  
Osamu Maeda ◽  
Kazuhito Yamamoto ◽  
John D Minna ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Line ◽  
Malignant Mesothelioma ◽  
Homozygous Deletion ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell

Establishment and Characterization of a Human Malignant Mesothelioma Cell line (HMMME)

Human Cell ◽  
2003 ◽  
Vol 16 (4) ◽  
pp. 231-239 ◽  
Author(s):  
Isamu ISHIWATA ◽  
Chieko ISHIWATA ◽  
Mitsuru ANZO ◽  
Rie MINAMI ◽  
Kazushige KIGUCHI ◽  
...  
Keyword(s):  
Cell Line ◽  
Malignant Mesothelioma ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell

scholarly journals Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line

Oncotarget ◽  
2017 ◽  
Vol 8 (21) ◽  
pp. 34405-34422 ◽  
Author(s):  
Laura Masuelli ◽  
Monica Benvenuto ◽  
Enrica Di Stefano ◽  
Rosanna Mattera ◽  
Massimo Fantini ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Malignant Mesothelioma ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell

First Molecular Cytogenetic Characterization of Murine Malignant Mesothelioma Cell Line AE17 and In Silico Translation to the Human Genome

2017 ◽  
Vol 12 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Eva Kubicova ◽  
Vladimir Trifonov ◽  
Fran Borovecki ◽  
Thomas Liehr ◽  
Martina Rincic ◽  
...  
Keyword(s):  
Human Genome ◽  
Cell Line ◽  
Malignant Mesothelioma ◽  
In Silico ◽  
Molecular Cytogenetic ◽  
Mesothelioma Cell Line ◽  
Cytogenetic Characterization ◽  
Mesothelioma Cell

scholarly journals Hydrocortisone-induced increase of PDGF β-receptor expression in a human malignant mesothelioma cell line

1992 ◽  
Vol 200 (1) ◽  
pp. 83-88 ◽  
Author(s):  
M.A. Versnel ◽  
M.J. Bouts ◽  
A.W. Langerak ◽  
Th. H. vander Kwast ◽  
H.C. Hoogsteden ◽  
...  
Keyword(s):  
Cell Line ◽  
Malignant Mesothelioma ◽  
Receptor Expression ◽  
Mesothelioma Cell Line ◽  
Mesothelioma Cell ◽  
Β Receptor

scholarly journals Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer

2020 ◽  
Vol 19 ◽  
pp. 153303382098379
Author(s):  
Xiying Yu ◽  
Ying Teng ◽  
Xingran Jiang ◽  
Hui Yuan ◽  
Wei Jiang
Keyword(s):  
Dna Methylation ◽  
Stem Cells ◽  
Esophageal Cancer ◽  
Cancer Stem Cells ◽  
Side Population ◽  
Methylation Status ◽  
Methylation Profile ◽  
Cpg Dinucleotides ◽  
Genome Wide ◽  
Differentially Methylated Genes

Background: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. However, the methylation profile of esophageal CSCs remains unknown. Methods: Side population (SP) cells were isolated from esophageal squamous cell carcinoma (ESCC) cell lines KYSE150 and EC109. Sphere-forming cells were collected from human primary esophageal cancer cells. SP cells and sphere-forming cells were used as substitutes for cancer stem-like cells. We investigated the genome-wide DNA methylation profile in esophageal cancer stem-like cells using reduced representation bisulfite sequencing (RRBS). Results: Methylated cytosine (mC) was found mostly in CpG dinucleotides, located mostly in the intronic, intergenic, and exonic regions. Forty intersected differentially methylated regions (DMRs) were identified in these 3 groups of samples. Thirteen differentially methylated genes with the same alteration trend were detected; these included OTX1, SPACA1, CD163L1, ST8SIA2, TECR, CADM3, GRM1, LRRK1, CHSY1, PROKR2, LINC00658, LOC100506688, and NKD2. DMRs covering ST8SIA2 and GRM1 were located in exons. These differentially methylated genes were involved in 10 categories of biological processes and 3 cell signaling pathways. Conclusions: When compared to non-CSCs, cancer stem-like cells have a differential methylation status, which provides an important biological base for understanding esophageal CSCs and developing therapeutic targets for esophageal cancer.

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

Epigenomics ◽  
2021 ◽  
Author(s):  
Beatriz Garcia-Ruiz ◽  
Manuel Castro de Moura ◽  
Gerard Muntané ◽  
Lourdes Martorell ◽  
Elena Bosch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Bipolar Disorder ◽  
Mrna Expression ◽  
Gene Expression Analysis ◽  
Mrna Levels ◽  
Healthy Controls ◽  
Genome Wide ◽  
Isoform Expression

Aim: To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. Materials & methods: Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. Results: DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. Conclusion: DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination.

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