scholarly journals Ozone therapy in multiple disabled children

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Rajeshwari Buch
Keyword(s):  
Gaba Receptors ◽  
Conventional Treatment ◽  
Muscle Tone ◽  
Genetic Disorder ◽  
Memory Loss ◽  
Multiple Disabilities ◽  
The Body ◽  
Invasive Technique ◽  
Ozone Therapy ◽  
Antioxidants Activity

Multiple disabilities is term for child with several disabilities sensory associated with motor disabilities. Growing number of children are presented with development issues caused by cerebral palsy , autism, learning disabilities, ADHD, Genetic disorder , global delayed development . Problem of this children are multifold and affects the daily life of whole family No such conventional treatment can cure these problems these problems. They are treating specific symptoms of Autism and global delay improve the child functioning and helping them in daily activity . It is ethically correct to take advantage of ozone therapy when the best orthodox treatment has failed . Anecdotal study was done in 47 children ranging from 8months to 12 yrs of age with multiple disabilities . Along with conventional treatment and various therapy like occupational therapy , physio therapy , sensory integration, speech therapy, ozone therapy i.e rectal insufflation (10mcg to 80mcg per kg) ear insufflation (10mcg / 120ml for 5 to 10 mins ) were given. In selected cases S/C injection, vacuum massage, matra basti with Ayurvedic medicated ghrut like “Bhrami Ghruth, Ashwagandha Ghruth, Mahakalyank Ghruth”. The rectal insufflation of ozone is a systemic routed which dissolves quickly in the luminal contents of the bowel, where mucoprotiens and other secretory products with antioxidants activity readily react with ozone to produce reactive oxygen species (ROS) and lipid peroxidation products. These compound penetrate the muscular mucosa and enter the circulation of venous and lymphatic capillaries. This non-invasive technique can be used without risk in pediatric and elderly patients. Ear insufflation through capillaries of ear: it is believed that it is absorbed, it secretes hormone endorphin which gives cool & calm effect which improves the quality of sleep. Vacuum increases the blood flow and ozone can react better and S/C injection improves local blood circulation . Herbal drugs like centella acitica(Brahmi) shows significant improvement in neuron function in areas of the brain associated with learning and memory useful in ADHD. “Withenia Somnifera (Ashwagandh)” shows high affinity for GABA receptors that is helpful in memory loss, anxiety and ADHD “Ghrut” is a detoxifying agent makes the organ soft increases intelligence refine the intellect (dhi), improve the memory(Smruti), increases digestive AGNI ,cools the body and gives synergistic effect with ozone application (Yogwahi) OBSERVATION : 1.       Improvement in Alertness, immunity, Digestion 2.       Weight Gain 3.       Improvement in muscle tone that enables child to perform daily physical activity  It is very early to arrive at any conclusion, But results are encouraging and Very Safe

Osteopathic support of sportsmen during the annual training process

2020 ◽  
pp. 37-43 ◽  
Author(s):  
R. A. Yakupov ◽  
G. I. Safiullina ◽  
A. A. Safiullina ◽  
E. R. Burganov
Keyword(s):  
Musculoskeletal Diseases ◽  
Muscle Tone ◽  
The Body ◽  
Training Process ◽  
Health Maintenance ◽  
Osteopathic Treatment ◽  
Leading Position ◽  
Myofascial Syndrome ◽  
Sports Activities ◽  
Timely Treatment

Introduction. Modern sports places high demands on the functional systems of the body at all stages of the training and competitive processes. High loads create signifi cant background for the occurrence of musculoskeletal diseases, among which the myofascial syndrome (MFS) holds the leading position. MFS negatively affects the functional readiness of the sportsman′s body and is a risk factor for injuries of the musculoskeletal system. In this regard, timely treatment of MFS is important. It creates the conditions for the improvement of sports achievements, for health maintenance and sports longevity. Treatment of patients with MFS should include methods that normalize trophism and muscle tone. Given the problem of doping, the use of non-drug methods, including osteopathy, is preferable. The goal of research — to develop a system of monitoring and osteopathic correction of myofascial disorders (MFD) and to introduce it into the practice of medical and biological support for sportsmen of different categories and levels during the annual training process.Materials and methods. 93 sportsmen (45 women and 48 men), mean age 22,1±1,1 years, representing diffe rent sports were examined. The essence of the proposed system is regular clinical and electroneurophysiological monitoring of the body condition and preventive correction of myofascial disorders in order to exclude their infl uence on the success of sports activities.Results. It was established that the proposed system of monitoring and osteopathic correction led to a signifi cant reduction in clinical and electroneurophysiological manifestations both in local and in extensive forms of myofascial disorders, which allowed to maintain the optimal functional readiness of sportsmen throughout the entire annual training cycle.Conclusion. The system of monitoring and correction of MFS with the use of osteopathic treatment can be one of the elements of medical and biological support for sportsmen during the annual training process.

Correction of cytochemical changes in patients with occupational allergodermatosis

2020 ◽  
pp. 661-661
Author(s):  
E. K. Krasavina ◽  
I. V. Yatsyna
Keyword(s):  
Recovery Period ◽  
The Body ◽  
Ozone Therapy

Professional allergodermatoses are accompanied by cytochemical and immunochemical changes in the body of patients. The use of ozone therapy techniques in this category of patients can accelerate the recovery period and normalize the above indicators.

Mechanisms and practical use of the bactericidal effects of ozone and ozonated oils

2020 ◽  
pp. 45-52
Author(s):  
S. Schetinin
Keyword(s):  
Inflammatory Diseases ◽  
Aerobic Metabolism ◽  
Active Oxygen ◽  
The Body ◽  
Bactericidal Action ◽  
Ozone Therapy ◽  
Energy Substrates ◽  
Bactericidal Effects ◽  
Viral Nature

The analysis of the clinical and immunological effectiveness of ozone therapy is carried out. The mechanism of the bactericidal action of ozone in the treatment of infectious and inflammatory diseases of a bacterial and viral nature is analyzed. Ozonation of oils leads to the formation of a complex and heterogeneous cascade of components. Ozonides provide the body with some prolonged supply of active oxygen to maintain aerobic metabolism and the required level of energy substrates.

scholarly journals The effects of nano-curcumin as a nutritional strategy on clinical and inflammatory factors in children with cystic fibrosis: the study protocol for a randomized controlled trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Saeedeh Talebi ◽  
Mahammad Safarian ◽  
Mahmood Reza Jaafari ◽  
Seyed Javad Sayedi ◽  
Zahra Abbasi ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Controlled Trial ◽  
Genetic Disorder ◽  
The Body ◽  
Inflammatory Factors ◽  
Secondary Outcome ◽  
Nasopharyngeal Swab ◽  
Nutritional Strategy ◽  
Cftr Protein ◽  
The Impact

Abstract Background Cystic fibrosis (CF) is a genetic disorder, which is caused by the CFTR protein defects. Along with CFTR dysfunction, inflammation plays a key role in the disease outcomes. Inflammation may develop due to the internal dysfunction of the CFTR protein or external factors. Curcumin affects the CFTR protein function primarily as a corrector and potentiator and secondary as an anti-inflammatory and antimicrobial agent. The present study aims to assess the impact of nano-curcumin on clinical and inflammatory markers in children with CF. Methods This prospective, double blind control trial will be conducted at the Akbar Children’s Hospital in Mashhad, Iran. Children with CF will be enrolled based on the eligibility criteria. Placebo and curcumin with the maximum dose of 80 mg considering the body surface of the patients will be administrated for 3 months. The primary outcome is to evaluate inflammation based on serum interleukin-6, interleukin-10, and hs-CRP, stool calprotectin, and neutrophil count of nasopharyngeal swab. The secondary outcome involved clinical assessment via spirometry, anthropometrics, and quality of life. They will be assessed before and after 3 months. Discussion Due to the multifarious effects of curcumin on CF disease, it could be proposed as a nutritional strategy in the treatment of cystic fibrosis. Trial registration Iranian Registry of Clinical Trials IRCT20200705048018N1. Registered on July 10, 2020.

scholarly journals Hyaluronate/black phosphorus complexes as a copper chelating agent for Wilson disease treatment

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Seong-Jong Kim ◽  
Hye Hyeon Han ◽  
Sei Kwang Hahn
Keyword(s):  
Targeted Delivery ◽  
Wilson Disease ◽  
Copper Ions ◽  
Binding Capacity ◽  
Genetic Disorder ◽  
Chelating Agent ◽  
Black Phosphorus ◽  
The Body ◽  
Copper Binding

Abstract Background Wilson disease (WD) is a genetic disorder of copper storage, resulting in pathological accumulation of copper in the body. Because symptoms are generally related to the liver, chelating agents capable of capturing excess copper ions after targeted delivery to the liver are highly required for the treatment of WD. Methods We developed hyaluronate-diaminohexane/black phosphorus (HA-DAH/BP) complexes for capturing copper ions accumulated in the liver for the treatment of WD. Results HA-DAH/BP complexes showed high hepatocyte-specific targeting efficiency, selective copper capturing capacity, excellent biocompatibility, and biodegradability. HA enhanced the stability of BP nanosheets and increased copper binding capacity. In vitro cellular uptake and competitive binding tests verified targeted delivery of HA-DAH/BP complexes to liver cells via HA receptor mediated endocytosis. The cell viability test confirmed the high biocompatibility of HA-DAH/BP complexes. Conclusion HA-DAH/BP complexes would be an efficient copper chelating agent to remove accumulated copper in the liver for the WD treatment.

The effect of dry needling of myofascial trigger points on muscle stiffness and motoneuron excitability in healthy subjects

2021 ◽  
pp. 096452842110275
Author(s):  
Carolina Jiménez-Sánchez ◽  
Julio Gómez-Soriano ◽  
Elisabeth Bravo-Esteban ◽  
Orlando Mayoral-del Moral ◽  
Pablo Herrero-Gállego ◽  
...  
Keyword(s):  
Muscle Tone ◽  
Intervention Group ◽  
Trigger Points ◽  
Muscle Stiffness ◽  
Invasive Technique ◽  
Control Group ◽  
Dry Needling ◽  
Myofascial Trigger Points ◽  
Motoneuron Excitability

Background: Myofascial trigger points (MTrPs) are hypersensitive nodules in a taut band (TB) of skeletal muscle. Dry needling (DN) is an invasive technique recommended for the treatment of MTrPs. However, to our knowledge, no studies have investigated the influence of the DN technique on modification of muscle stiffness and neurophysiological properties of MTrPs. Objective: The objective was to examine the effect of DN on muscle stiffness and motoneuron excitability of a latent medial MTrP (nodule and TB) of the soleus muscle in non-injured subjects. Methods: A double-blinded randomised controlled trial of 46 subjects with latent medial MTrPs of the soleus was conducted, in which all received one session of DN. The intervention group (n = 23) were subjected to DN into the MTrP (the nodule), while the control group (n = 23) were subjected to DN into the TB. Assessment was carried out at baseline (pre-test), after the intervention (post-test) and 1 week after the intervention (follow-up). Biomechanical variables (muscle resistive force at 10°/s and 180°/s, muscle extensibility and strength), as measured with an isokinetic dynamometer, and neurophysiological variables (H-reflex), were recorded. Results: There were no statistically significant differences in biomechanical or neurophysiological assessments between groups. Considering the intra-group analysis, subjects in the intervention group exhibited increased maximal isometric voluntary force to ankle plantarflexion (MIVFp) at both post-intervention and follow-up assessment (p < 0.0125; 0.2 < d < 0.5), while no changes were found in the control group. Conclusion: One session of DN targeting latent MTrPs did not change muscle stiffness, muscle extensibility or motoneuron excitability. Further research on subjects with muscle tone disorders should be considered to better address the impact of DN on muscle tone. Trial registration number: NCT02575586 (ClinicalTrials.gov).

scholarly journals Neuroprotective and anti-ageing role of leptin

2012 ◽  
Vol 49 (3) ◽  
pp. R149-R156 ◽  
Author(s):  
Jaume Folch ◽  
Ignacio Pedrós ◽  
Iván Patraca ◽  
Francesc Sureda ◽  
Fèlix Junyent ◽  
...  
Keyword(s):  
Cognitive Process ◽  
Memory Loss ◽  
The Body ◽  
Physiological Effects ◽  
Systematic Exploration ◽  
Major Interest ◽  
Long Form ◽  
Key Pathways ◽  
Primary Risk Factor

Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downstream molecules involved in key pathways related to cell survival such as STAT3, PI3K, MAPK, AMPK, CDK5 and GSK3β. Collectively, these pathways act in a coordinated manner and form a network that is fully involved in Lep physiological response. Although the major interest in Lep is related to its role in the regulation of energy balance, and since resistance to Lep affects is the primary risk factor for obesity, the interest on their effects on brain cognition and neuroprotection is increasing. Thus, Lep and Lep mimetic compounds now await and deserve systematic exploration as the orchestrator of protective responses in the nervous system. Moreover, Lep might promote the activation of a cognitive process that may retard or even partially reverse selected aspects of Alzheimer's disease or ageing memory loss.

Methods of application of ozone therapy for the treatment of peri-implantation mucositis

2021 ◽  
pp. 80-84
Author(s):  
Iu. A. Makedonova ◽  
D. V. Mikhalchenko ◽  
O. Yu. Afanaseva ◽  
S. V. Stavskaya ◽  
D. Yu. Dyachenko ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Bone Destruction ◽  
The Body ◽  
Positive Trend ◽  
Ozone Therapy ◽  
Dental Implantation ◽  
Initial Stage ◽  
Local Exposure ◽  
Single Idea ◽  
Prosthetic Complications

At the dental reception, complications after dental implantation in the form of mucositis and peri-implantitis are becoming more and more common. There are quite a lot of risk factors for the development of inflammation of the parotid tissue, there is no single idea about the etiopathogenesis of the above pathology. Mucositis refers to the initial stage of peri-implantitis development and is reversible. The specialist should promptly diagnose the development of the inflammatory potential and start treatment, in order to prevent the development of bone destruction around the implants. One of the methods of local exposure to the lesion is ozone therapy.Goal. This paper describes the method of treatment of peri-implantation mucositis by ozone therapy.Materials and methods. In patients with peri-implantation mucositis, the inflammatory peri-implantation tissue was ozonated directly in the oral cavity with the Ozotron device in order to relieve inflammation and improve microcirculation in the oral cavity. Before performing oral ozonation, all patients underwent a general clinical examination to identify contraindications to this method. It also describes in detail the scheme that prevents the penetration of ozone into the body and prevents its ingestion.Results. During ozonation, a positive trend was obtained in the treatment of post-prosthetic complications during dental implantation. The developed scheme of ozonation in the oral cavity stops the inflammation of the peri-implantation tissue. Side effects and complications during ozone therapy directly in the oral cavity were not detected.Conclusions. The inclusion of ozone therapy in the treatment regimen of patients with peri-implantation mucositis is an appropriate and justified physiotherapy method. 

scholarly journals Possibility of oxygen-ozone therapy in the geriatric patient

Ozone Therapy ◽  
2017 ◽  
Vol 1 (3) ◽  
pp. 53
Author(s):  
Marianno Franzini ◽  
Giulia Ionita
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Minimally Invasive ◽  
Elderly Patients ◽  
Geriatric Patient ◽  
Multidisciplinary Care ◽  
Invasive Technique ◽  
Ozone Therapy ◽  
Muscular Pain ◽  
Care Of Elderly

In the context of multidisciplinary care of elderly patients, this work will want to consider the presence of osteo-articular and muscular pain, mostly chronic, of these subjects. The treatment has made use of oxygen-ozone therapy, given the absence of side effects of this minimally invasive technique, and the possibility of its use simultaneously with an already established poly-drug therapy, as typically found in the geriatric patient.

scholarly journals Sickle Cell Disease: An Overview of Oral Health Considerations for Pediatric Patients

2021 ◽  
Vol 2 (3) ◽  
pp. 9-17
Author(s):  
Dafni Eleftherou ◽  
Aristidis Arhakis ◽  
Sotiria Davidopoulou
Keyword(s):  
Oral Health ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Pediatric Patients ◽  
Genetic Disorder ◽  
The Body ◽  
Common Finding ◽  
Cell Disease ◽  
Preventive Dental Care ◽  
Periodontal Inflammation

Aim: This literature review aims to update the evidence for orofacial manifestations and current treatment recommendations for children and adolescents with sickle cell disease. Background: Sickle cell disease is a frequent hemoglobinopathy and a life-threatening genetic disorder. The lifelong condition is characterized by chronic hemolytic anemia and vaso-occlusive crisis that may occur in a variable range of clinical presentations in different regions of the body, including the oral cavity. Review results: This review explored the most common orofacial alterations of pediatric patients with SCD. Dental caries is a common finding in SCD pediatric patients, especially in those who are socio-economically vulnerable. Moreover, malocclusions occur in high prevalence in SCD pediatric patients. Other oral health complications seen in SCD patients include periodontal inflammation, bone changes, infections, mental nerve neuropathy, facial overgrowth, delayed tooth eruption, dental anomalies, pulp necrosis, soft tissue alterations and salivary changes. Dental infections may trigger a vaso-occlusive crisis leading the patient to a higher probability on arriving in hospital emergency departments and in need for further hospital admission to deal with the correlated complications. Thus, preventive dental care and non-invasive dental procedures are the principal focus in SCD patients in order to avoid possible subsequent complications. Conclusion: The review showed that in pediatric patients with SCD the risk for orofacial manifestations and complications depends not only on the presence of SCD but also on other confounding factors such as oral hygiene, diet habits and social conditions. Moreover, more well-designed epidemiological studies are necessary to assess the real link between SCD disease and its impact on stomatognathic health.

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