scholarly journals Assessment of Cerebrovascular Dynamics and Cognitive Function with Acute Aerobic Exercise in Persons with Multiple Sclerosis

2021 ◽  
Author(s):  
Wesley K. Lefferts ◽  
Alexander J. Rosenberg ◽  
Elizabeth C. Schroeder ◽  
Georgios Grigoriadis ◽  
Brian M. Sandroff ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Reaction Time ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Cognitive Performance ◽  
Relapsing Remitting ◽  
Artery Stiffness ◽  
Cerebrovascular Hemodynamics

Abstract Background: Cognitive dysfunction in multiple sclerosis (MS) may partially stem from inadequate cerebral blood flow. Cerebral blood flow and cognitive function improve with aerobic exercise in healthy adults. The effect of aerobic exercise on cerebrovascular hemodynamics and cognitive performance in persons with MS is unclear. The acute effect of aerobic exercise versus quiet rest on cerebrovascular hemodynamics and cognitive performance in relapsing-remitting MS was examined. Methods: Sixteen adults with relapsing-remitting MS underwent cerebrovascular hemodynamics and cognitive performance testing before, 2 minutes after, and 30 minutes after aerobic exercise (20-minute treadmill walking, 60% peak oxygen consumption) and a time-matched seated control. Brachial blood pressure was obtained via an oscillometric cuff. Right middle cerebral artery (MCA) blood velocity was measured via transcranial Doppler and used to calculate mean velocity, pulsatility index (PI), and conductance. Carotid artery stiffness was measured via ultrasonography and tonometry. Cognitive performance (accuracy, reaction time) was assessed using a modified flanker task. Results: Exercise elicited significant increases in mean pressure and carotid artery stiffness and decreases in MCA conductance at 2 minutes after exercise, which subsided by 30 minutes (P < .05). Exercise did not significantly alter MCA PI. Flanker reaction time decreased during posttesting in both conditions (P < .05). There were no condition × time interactions for cognitive performance. Conclusions: Persons with MS seem resilient to exercise-induced acute changes in MCA PI despite transient carotid stiffening, potentially via reductions in MCA conductance. These data suggest that changes in cognitive performance after acute aerobic exercise are not directly related to transient cerebrovascular responses in persons with MS.

scholarly journals Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer

2020 ◽  
Vol 29 (2) ◽  
pp. 162-169
Author(s):  
Yejin Kang ◽  
Ruda Lee ◽  
Moon-Hyon Hwang ◽  
Myong-Joo Lim
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Young Adults ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Color Word ◽  
Cycle Ergometer ◽  
Moderate Intensity ◽  
Post Exercise

PURPOSE: This study aimed to compare the acute effects of different types (treadmill vs. cycle) of moderate-intensity aerobic exercise on cerebral blood flow and cognitive function in young adults.METHODS: By a randomized crossover study design, ten participants were initially assigned to either treadmill exercise (TE; n=5) or cycle ergometer exercise (CE; n=5) and then they performed the other with seven-day wash-out period. Both exercises were implemented at the target heart rate corresponding to 70% of heart rate reserve for 30 minutes. Cognitive function was assessed by the Stroop Color-Word test at pre- and post-exercise. Cerebral blood flow was continuously monitored using near-infrared spectroscopy technique during rest, cognitive function test (CFT), and exercise.RESULTS: There was a significant group by time interaction in tissue saturation index (TSI) (<i>p</i>=.046). Post-hoc analysis presented that TSI at post-exercise CFT was higher than during exercise in TE (<i>p</i>=.02). In both exercises, TSI at pre-exercise CFT significantly increased compared to the resting value (<i>p</i>=.001). Cerebral oxyhemoglobin level was significantly increased during exercise and at post-exercise CFT compared to the resting value in both exercises (<i>p</i><.001). The reaction time for certain cognitive tasks such as color, word with matched color, word with color interference, and color with word interference was improved after both exercises (<i>p</i><.05).CONCLUSIONS: One-bout of moderate-intensity aerobic exercise acutely improves cerebral blood flow and cognitive function even in healthy young adults. Exercise types with the same intensity do not seem to make meaningful difference in the positive effects of aerobic exercise.

scholarly journals Altered Arterial Stiffness, Cerebral Blood Flow and Cognitive Function in Young Smokers in Response to One-Bout of Aerobic Exercise: MICE vs. HIIE

2020 ◽  
Vol 29 (3) ◽  
pp. 307-315
Author(s):  
Jisun Hwang ◽  
Ruda Lee ◽  
Jin-Su Kim ◽  
Moon-Hyon Hwang
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Arterial Stiffness ◽  
Aerobic Exercise ◽  
Augmentation Index ◽  
Moderate Intensity ◽  
Significant Group ◽  
Positive Effects ◽  
Young Smokers

PURPOSE: This study aimed to compare the acute effects of high-intensity interval exercise (HIIE) with moderate-intensity continuous exercise (MICE) on arterial stiffness, cerebral blood flow and cognitive function in young smokers.METHODS: Young smokers (23.1 years & 7.2 pack years) were randomly assigned to either MICE (n=5) or HIIE (n=4) group. MICE was implemented at 70% of HRmax for 30 minutes. HIIE was performed at 70% and 90% of HRmax for 24 minutes. Central artery stiffness was assessed by aortic pulse wave velocity (cfPWV), augmentation index (AIx) at pre and post-exercise, and 30 minutes, 1 hour, 2 hours, 24 hours following the exercises. Cerebral blood flow was continuously monitored using near-infrared spectroscopy technique before and during exercise, and at 30 minutes, 1 hour, 2 hours, and 24 hours following the exercises. Cognitive function was assessed by Stroop Color-Word test at pre-exercise, and 30 minutes and 24 hours following the exercises.RESULTS: There was no significant group by time interaction in cfPWV, AIx, cerebral blood flow (HbO2) level, and cognitive function. Compared with MICE, cfPWV was increased (p=.01) at 30 minutes but AIx was decreased (p=.02) at 1 hour following HIIE. When MICE and HIIE combined, arterial stiffness and cerebral blood flow measures, and cognitive function parameters were improved following even one-bout of exercise (p≤.049). Change in AIx was associated with change in cognitive function at 30 minutes following the exercises (r=.69, p=.06).CONCLUSIONS: Even one-bout of either MIIE or HIIT acutely improves aortic wave reflection, cerebral blood flow and cognitive function in young smokers. The intensity of aerobic exercise does not seem to make meaningful differences in the positive effects on arterial stiffness, cerebral blood flow, and cognitive function in young smokers if both exercises have the same volume.

scholarly journals Does Self-Efficacy Affect Cognitive Performance in Persons with Clinically Isolated Syndrome and Early Relapsing Remitting Multiple Sclerosis?

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Peter Joseph Jongen ◽  
Keith Wesnes ◽  
Björn van Geel ◽  
Paul Pop ◽  
Hans Schrijver ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Reaction Time ◽  
Cognitive Performance ◽  
Self Efficacy ◽  
Clinically Isolated Syndrome ◽  
Time Variability ◽  
Reaction Time Variability ◽  
Relapsing Remitting ◽  
Disease Impact ◽  
Relapsing Remitting Multiple Sclerosis

In persons with multiple sclerosis (MS) a lowered self-efficacy negatively affects physical activities. Against this background we studied the relationship between self-efficacy and cognitive performance in the early stages of MS. Thirty-three patients with Clinically Isolated Syndrome (CIS) and early Relapsing Remitting MS (eRRMS) were assessed for self-efficacy (MSSES-18), cognition (CDR System), fatigue (MFIS-5), depressive symptoms (BDI), disease impact (MSIS-29), and disability (EDSS). Correlative analyses were performed between self-efficacy and cognitive scores, and stepwise regression analyses identified predictors of cognition and self-efficacy. Good correlations existed between total self-efficacy and Power of Attention (r= 0.65;P< 0.001), Reaction Time Variability (r= 0.57;P< 0.001), and Speed of Memory (r= 0.53;P< 0.01), and between control self-efficacy and Reaction Time Variability (r= 0.55;P< 0.01). Total self-efficacy predicted 40% of Power of Attention, 34% of Reaction Time Variability, and 40% of Speed of Memory variabilities. Disease impact predicted 65% of total self-efficacy and 58% of control self-efficacy variabilities. The findings may suggest that in persons with CIS and eRRMS self-efficacy may positively affect cognitive performance and that prevention of disease activity may preserve self-efficacy.

scholarly journals Acute Effect of Moderate-intensity Aerobic Exercise on Cerebral Blood Flow and Cognitive Function in Young Adults: Treadmill vs. Cycle Ergometer

2020 ◽  
Vol 29 (2) ◽  
pp. 162-169
Author(s):  
Yejin Kang ◽  
Ruda Lee ◽  
Moon-Hyon Hwang ◽  
Myong-Joo Lim
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Young Adults ◽  
Cerebral Blood Flow ◽  
Cognitive Function ◽  
Aerobic Exercise ◽  
Color Word ◽  
Cycle Ergometer ◽  
Moderate Intensity ◽  
Post Exercise

PURPOSE: This study aimed to compare the acute effects of different types (treadmill vs. cycle) of moderate-intensity aerobic exercise on cerebral blood flow and cognitive function in young adults.METHODS: By a randomized crossover study design, ten participants were initially assigned to either treadmill exercise (TE; n=5) or cycle ergometer exercise (CE; n=5) and then they performed the other with seven-day wash-out period. Both exercises were implemented at the target heart rate corresponding to 70% of heart rate reserve for 30 minutes. Cognitive function was assessed by the Stroop Color-Word test at pre- and post-exercise. Cerebral blood flow was continuously monitored using near-infrared spectroscopy technique during rest, cognitive function test (CFT), and exercise.RESULTS: There was a significant group by time interaction in tissue saturation index (TSI) (<i>p</i>=.046). Post-hoc analysis presented that TSI at post-exercise CFT was higher than during exercise in TE (<i>p</i>=.02). In both exercises, TSI at pre-exercise CFT significantly increased compared to the resting value (<i>p</i>=.001). Cerebral oxyhemoglobin level was significantly increased during exercise and at post-exercise CFT compared to the resting value in both exercises (<i>p</i><.001). The reaction time for certain cognitive tasks such as color, word with matched color, word with color interference, and color with word interference was improved after both exercises (<i>p</i><.05).CONCLUSIONS: One-bout of moderate-intensity aerobic exercise acutely improves cerebral blood flow and cognitive function even in healthy young adults. Exercise types with the same intensity do not seem to make meaningful difference in the positive effects of aerobic exercise.

scholarly journals N-acetyl cysteine administration affects cerebral blood flow as measured by Arterial Spin Labeling MRI in patients with multiple sclerosis

Heliyon ◽  
2021 ◽  
pp. e07615
Author(s):  
Shiva Shahrampour ◽  
Justin Heholt ◽  
Andrew Wang ◽  
Faezeh Vedaei ◽  
Feroze B. Mohamed ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Acetyl Cysteine

Cognitive performance and cerebral blood flow in essential hypotension

2004 ◽  
Vol 41 (6) ◽  
pp. 905-913 ◽  
Author(s):  
Stefan Duschek ◽  
Rainer Schandry
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Performance

High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

2017 ◽  
Vol 24 (12) ◽  
pp. 1635-1644 ◽  
Author(s):  
Philipp Zimmer ◽  
Wilhelm Bloch ◽  
Alexander Schenk ◽  
Max Oberste ◽  
Stefan Riedel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Matrix Metalloproteinases ◽  
Aerobic Exercise ◽  
Cognitive Performance ◽  
Verbal Memory ◽  
High Intensity ◽  
Controlled Trial ◽  
Exercise Programme ◽  
Healthy Elderly ◽  
The Impact

Background: Aerobic exercise can improve cognitive performance in healthy elderly people. Objective: The aim of this study was to investigate the influence of a 3-week high-intensity aerobic exercise programme (high-intensity training group (HIT)) on cognitive performance in persons with multiple sclerosis (MS) compared with a standard exercise programme (control training (CT)). Methods: A total of 60 persons with MS (Expanded Disability Status Scale (EDSS): 1.0–6.5) were randomized to a HIT group (3×/week for 20 minutes, including five 3-minute exercise intervals at 80% of peak oxygen uptake (VO2-peak)) or a CT group (continuously 5×/week for 30 minutes/session at 65% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS at entry ( t0) and discharge ( t1). Furthermore, VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and -9 were measured. Results: Compared to CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both groups. Secondary outcomes indicated significant improvements in VO2-peak and a significant reduction in MMP-2 in the HIT group only. Conclusion: HIT represents a promising strategy to improve verbal memory and physical fitness in persons with MS. Further research is needed to determine the impact of exercise on biomarkers in MS.

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