scholarly journals Transdisciplinary approach to solving conservation challenges: A case of Budongo Conservation Field Station, Uganda

2016 ◽  
Author(s):  
Caroline Asiimwe ◽  
Geoffrey Muhanguzi ◽  
Eric Okwir ◽  
Paul Okimat ◽  
Andrew W Bugenyi ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Holistic Approach ◽  
Mitigation Measures ◽  
Anthropogenic Factors ◽  
Human Populations ◽  
Gastrointestinal Infections ◽  
Severe Injuries ◽  
Transdisciplinary Approach ◽  
Field Station ◽  
Budongo Forest

The conservation of chimpanzees (Pan troglodytes) faces complex and dynamic threats, deriving mostly from anthropogenic factors such as high density and poverty in local human populations. One specific threat is poaching, which contributes to both permanent physical disabilities in chimpanzees and cross-species disease transmission. In the Sonso chimpanzee community, Budongo forest, Uganda, over 20% chimpanzees are permanently disabled by indiscriminate poachers’ snare-trap. While severe injuries can sometimes result in death, little is known about the long-term health impacts of poaching to chimpanzees or possible effective mitigation measures. To combat and monitor the complexities of conservation threats, a holistic transdisciplinary approach is required and as a result, the Budongo Conservation Field Station (BCFS) has implemented a comprehensive strategy. Instead of focusing solely on chimpanzee health, our multi-faced tit-for-tat approach also incorporates education and action measures for local communities living adjacent to the forest. To reduce poaching, we provide alternative livelihood sources, veterinary services and education while concurrently employing their local indigenous knowledge of poaching practices to more effectively locate snares/traps in the forest. To mitigate disease transmission across species, beneficiaries in incentive programs must have functional sanitation facilities. To consistently monitor threats and conservation impacts, we routinely collect data on snare recovery and infectious disease prevalence in chimpanzees, humans and livestock. Our preliminary results, since the programs’ inception, show a reduction in respiratory and gastrointestinal infections coupled with an increase in snare recovery from the forest. These findings suggest that our holistic approach is effective in mitigating the threats to chimpanzees in Budongo forest.

scholarly journals Transdisciplinary approach to solving conservation challenges: A case of Budongo Conservation Field Station, Uganda

2016 ◽  
Author(s):  
Caroline Asiimwe ◽  
Geoffrey Muhanguzi ◽  
Eric Okwir ◽  
Paul Okimat ◽  
Andrew W Bugenyi ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Holistic Approach ◽  
Mitigation Measures ◽  
Anthropogenic Factors ◽  
Human Populations ◽  
Gastrointestinal Infections ◽  
Severe Injuries ◽  
Transdisciplinary Approach ◽  
Field Station ◽  
Budongo Forest

The conservation of chimpanzees (Pan troglodytes) faces complex and dynamic threats, deriving mostly from anthropogenic factors such as high density and poverty in local human populations. One specific threat is poaching, which contributes to both permanent physical disabilities in chimpanzees and cross-species disease transmission. In the Sonso chimpanzee community, Budongo forest, Uganda, over 20% chimpanzees are permanently disabled by indiscriminate poachers’ snare-trap. While severe injuries can sometimes result in death, little is known about the long-term health impacts of poaching to chimpanzees or possible effective mitigation measures. To combat and monitor the complexities of conservation threats, a holistic transdisciplinary approach is required and as a result, the Budongo Conservation Field Station (BCFS) has implemented a comprehensive strategy. Instead of focusing solely on chimpanzee health, our multi-faced tit-for-tat approach also incorporates education and action measures for local communities living adjacent to the forest. To reduce poaching, we provide alternative livelihood sources, veterinary services and education while concurrently employing their local indigenous knowledge of poaching practices to more effectively locate snares/traps in the forest. To mitigate disease transmission across species, beneficiaries in incentive programs must have functional sanitation facilities. To consistently monitor threats and conservation impacts, we routinely collect data on snare recovery and infectious disease prevalence in chimpanzees, humans and livestock. Our preliminary results, since the programs’ inception, show a reduction in respiratory and gastrointestinal infections coupled with an increase in snare recovery from the forest. These findings suggest that our holistic approach is effective in mitigating the threats to chimpanzees in Budongo forest.

Interactions between ecological and socio-economic drivers of Buruli ulcer burden in Sub-Saharan Africa: opportunities for an improved control

2018 ◽  
Author(s):  
Andes Garchitorena ◽  
Matthew H. Bonds ◽  
Jean-Francois Guégan ◽  
Benjamin Roche
Keyword(s):  
Socioeconomic Factors ◽  
Disease Transmission ◽  
Access To Health Care ◽  
Buruli Ulcer ◽  
Mycobacterium Ulcerans ◽  
Sub Saharan Africa ◽  
Aquatic Environments ◽  
Human Populations ◽  
Complex Interactions ◽  
Sub Saharan

This chapter provides an overview of the complex interactions between ecological and socioeconomic factors for the development and control of Buruli ulcer in Sub-Saharan Africa. We review key ecological and evolutionary processes driving the environmental persistence and proliferation of Mycobacterium ulcerans, the causative agent, within aquatic environments, as well as transmission processes from these aquatic environments to human populations. We also outline key socioeconomic factors driving the economic and health burden of Buruli ulcer in endemic regions, revealed by reciprocal feedbacks between poverty, disease transmission from exposure aquatic environments and disease progression to severe stages owing to low access to health care. The implications of such insights for disease control, both in terms of limitations of current strategies and directions for the future, are discussed.

Dynamics of an infection age-space structured cholera model with Neumann boundary condition

2021 ◽  
pp. 1-30
Author(s):  
WEIWEI LIU ◽  
JINLIANG WANG ◽  
RAN ZHANG
Keyword(s):  
Vibrio Cholerae ◽  
Disease Transmission ◽  
Global Attractivity ◽  
Neumann Boundary ◽  
Reaction Diffusion ◽  
Human Populations ◽  
Global Dynamics ◽  
Infection Age ◽  
Reaction Diffusion Model ◽  
Disease Persistence

This paper investigates global dynamics of an infection age-space structured cholera model. The model describes the vibrio cholerae transmission in human population, where infection-age structure of vibrio cholerae and infectious individuals are incorporated to measure the infectivity during the different stage of disease transmission. The model is described by reaction–diffusion models involving the spatial dispersal of vibrios and the mobility of human populations in the same domain Ω ⊂ ℝ n . We first give the well-posedness of the model by converting the model to a reaction–diffusion model and two Volterra integral equations and obtain two constant equilibria. Our result suggest that the basic reproduction number determines the dichotomy of disease persistence and extinction, which is achieved by studying the local stability of equilibria, disease persistence and global attractivity of equilibria.

scholarly journals Modeling the impact of school reopening and contact tracing strategies on Covid-19 dynamics in different epidemiologic settings in Brazil

2021 ◽  
Author(s):  
Marcelo Eduardo Borges ◽  
Leonardo Souto Ferreira ◽  
Silas Poloni ◽  
Ângela Maria Bagattini ◽  
Caroline Franco ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Transmission Rate ◽  
Disease Incidence ◽  
Demographic Data ◽  
School Closure ◽  
Mitigation Measures ◽  
Contact Tracing ◽  
School Closures ◽  
Infection Transmission ◽  
The Impact

Among the various non–pharmaceutical interventions implemented in response to the Covid–19 pandemic during 2020, school closures have been in place in several countries to reduce infection transmission. Nonetheless, the significant short and long–term impacts of prolonged suspension of in–person classes is a major concern. There is still considerable debate around the best timing for school closure and reopening, its impact on the dynamics of disease transmission, and its effectiveness when considered in association with other mitigation measures. Despite the erratic implementation of mitigation measures in Brazil, school closures were among the first measures taken early in the pandemic in most of the 27 states in the country. Further, Brazil delayed the reopening of schools and stands among the countries in which schools remained closed for the most prolonged period in 2020. To assess the impact of school reopening and the effect of contact tracing strategies in rates of Covid–19 cases and deaths, we model the epidemiological dynamics of disease transmission in 3 large urban centers in Brazil under different epidemiological contexts. We implement an extended SEIR model stratified by age and considering contact networks in different settings – school, home, work, and elsewhere, in which the infection transmission rate is affected by various intervention measures. After fitting epidemiological and demographic data, we simulate scenarios with increasing school transmission due to school reopening. Our model shows that reopening schools results in a non–linear increase of reported Covid-19 cases and deaths, which is highly dependent on infection and disease incidence at the time of reopening. While low rates of within[&ndash]school transmission resulted in small effects on disease incidence (cases/100,000 pop), intermediate or high rates can severely impact disease trends resulting in escalating rates of new cases even if other interventions remain unchanged. When contact tracing and quarantining are restricted to school and home settings, a large number of daily tests is required to produce significant effects of reducing the total number of hospitalizations and deaths. Our results suggest that policymakers should carefully consider the epidemiological context and timing regarding the implementation of school closure and return of in-person school activities. Also, although contact tracing strategies are essential to prevent new infections and outbreaks within school environments, our data suggest that they are alone not sufficient to avoid significant impacts on community transmission in the context of school reopening in settings with high and sustained transmission rates.

scholarly journals Do chimpanzee pant hoots have semantic content?

2021 ◽  
Author(s):  
Petar Gabrić
Keyword(s):  
Scientific Literature ◽  
Animal Cognition ◽  
A Priori ◽  
Semantic Content ◽  
Field Station ◽  
Pant Hoot ◽  
Important Addition ◽  
Semantic Compositionality ◽  
Budongo Forest ◽  
Existing Data

I read with great interest the exciting study by Leroux et al. [(2021) Anim Behav 179, 49–50] who investigated the nature of pant-hoot–food-call combinations in a community of wild chimpanzees (Pan troglodytes schweinfurthii) at the Budongo Conservation Field Station, Budongo Forest, Uganda. The authors propose, among others, that they reveal the first evidence that wild chimpanzees are able “to combine meaning-bearing units into larger structures” (i.e., that they are capable of semantic compositionality and, by extension, syntax). Their analysis represents an important addition to a growing body of research and discussions on communicational combinatoriality in wild primates and specifically apes, and, by extension, extinct hominins. Incidentally, I have recently published a paper in Animal Cognition in which I also suggested, based on a reanalysis of existing data, that wild chimpanzees can display semantic compositionality and syntax in their communication [Gabrić (2021) Anim Cogn, online ahead of print]. In the present commentary, I argue that Leroux et al.’s (2021) interpretation of the data may be ungrounded given that (1) unlike for food calls, there is currently very little if any indication in the scientific literature that pant-hoots have semantic content (i.e., are meaningful) and given that (2) Leroux et al. (2021) did not investigate their a priori assumption that the observed pant-hoots are in fact semantic. Since pant-hoots feature prominently in the chimpanzee vocal repertoire and the debate on their eventual semanticity is still wide open, this represents a fine opportunity to revisit this issue in the context of Leroux et al.’s (2021) study. Their paper further raises several other less significant questions.

scholarly journals Combating Cholera

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 589 ◽  
Author(s):  
Brian Y. Hsueh ◽  
Christopher M. Waters
Keyword(s):  
Vibrio Cholerae ◽  
Disease Transmission ◽  
Phage Therapy ◽  
Emerging Technologies ◽  
Oral Rehydration Therapy ◽  
Health Surveillance ◽  
Human Populations ◽  
Flexible Approach ◽  
Oral Rehydration ◽  
Current Therapies

Cholera infections caused by the gamma-proteobacterium Vibrio cholerae have ravaged human populations for centuries, and cholera pandemics have afflicted every corner of the globe. Fortunately, interventions such as oral rehydration therapy, antibiotics/antimicrobials, and vaccines have saved countless people afflicted with cholera, and new interventions such as probiotics and phage therapy are being developed as promising approaches to treat even more cholera infections. Although current therapies are mostly effective and can reduce disease transmission, cholera outbreaks remain deadly, as was seen during recent outbreaks in Haiti, Ethiopia, and Yemen. This is due to significant underlying political and socioeconomic complications, including shortages of vaccines and clean food and water and a lack of health surveillance. In this review, we highlight the strengths and weaknesses of current cholera therapies, discuss emerging technologies, and argue that a multi-pronged, flexible approach is needed to continue to reduce the worldwide burden of cholera.

scholarly journals Coronavirus Disease Pandemic (COVID-19): Challenges and a Global Perspective

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 519 ◽  
Author(s):  
Yashpal Singh Malik ◽  
Naveen Kumar ◽  
Shubhankar Sircar ◽  
Rahul Kaushik ◽  
Sudipta Bhat ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Point Of Care ◽  
Genomic Analysis ◽  
Basic Amino Acid ◽  
The Elderly ◽  
Reservoir Host ◽  
Global Perspective ◽  
Mitigation Measures ◽  
Comparative Genomic ◽  
Viral Agent

The technology-driven world of the 21st century is currently confronted with a major threat to humankind, represented by the coronavirus disease (COVID-19) pandemic, caused by the severe acute respiratory syndrome, coronavirus-2 (SARS-CoV-2). As of now, COVID-19 has affected more than 6 million confirmed cases and took 0.39 million human lives. SARS-CoV-2 spreads much faster than its two ancestors, SARS-CoV and Middle East respiratory syndrome-CoV (MERS-CoV), but has low fatality rates. Our analyses speculate that the efficient replication and transmission of SARS-CoV-2 might be due to the high-density basic amino acid residues, preferably positioned in close proximity at both the furin-like cleavage sites (S1/S2 and S2’) within the spike protein. Given the high genomic similarities of SARS-CoV-2 to bat SARS-like CoVs, it is likely that bats serve as a reservoir host for its progenitor. Women and children are less susceptible to SARS-CoV-2 infection, while the elderly and people with comorbidities are more prone to serious clinical outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The cohesive approach amongst researchers across the globe has delivered high-end viral diagnostics. However, home-based point-of-care diagnostics are still under development, which may prove transformative in current COVID-19 pandemic containment. Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures.

Multi-scale spatial analysis of human alveolar echinococcosis risk in China

Parasitology ◽  
2003 ◽  
Vol 127 (S1) ◽  
pp. S133-S141 ◽  
Author(s):  
F. M. DANSON ◽  
A. J. GRAHAM ◽  
D. R. J. PLEYDELL ◽  
M. CAMPOS-PONCE ◽  
P. GIRAUDOUX ◽  
...  
Keyword(s):  
Spatial Data ◽  
Disease Transmission ◽  
Spatial Scales ◽  
Regional Scale ◽  
Central China ◽  
Spatial Data Analysis ◽  
Transmission Risk ◽  
Spatial Proximity ◽  
Human Populations ◽  
Remotely Sensed Data

Risk factors for the transmission of Echinococcus multilocularis to humans operate at a range of spatial scales. Over a large area, such as China, regional scale risk is correlated with variation in climatic conditions because of its effect on the spatial distribution of landscapes that can support E. multilocularis transmission in wildlife hosts and the probability of egg survival. At a local scale of a few kilometres, or tens of kilometres, transmission risk is related to the spatial proximity of human populations and landscapes with active transmission. At the patch scale, when considering individual villages or households, human behavioural factors are important and for individuals genetic and immunological factors play a role. Satellite remote sensing can provide landscape information at a range of spatial scales and provide a spatial framework within which to examine transmission patterns. This paper reviews the application of remotely sensed data and spatial data analysis to develop a better understanding of disease transmission and shows how such data have been used to examine human alveolar echinocossosis infection patterns, at a range of spatial scales, in an endemic area in central China.

scholarly journals Home invasion of triatomines increases the risk of Chagas disease transmission in the Brazilian Amazon

2020 ◽  
Author(s):  
BRUNA DANIELE LISBOA MOTA ◽  
Vera da Costa Valente ◽  
Francisco Lúzio de Paula Ramos ◽  
Sebastião Aldo da Silva Valente ◽  
Ana Yecê das Neves Pinto
Keyword(s):  
Chagas Disease ◽  
Disease Transmission ◽  
Parasitic Infection ◽  
Cross Sectional Study ◽  
Asymptomatic Infection ◽  
The State ◽  
Human Populations ◽  
Positive Serology ◽  
Cross Sectional ◽  
Vector Behaviour

Abstract Chagas disease is a parasitic infection with a large reemergent rates in some Amazon regions with usual features of outbreaks of the acute disease mainly by oral transmission. The main vectors of Trypanosoma cruzi are hematophagous insects, the triatomines. Some of them can establish themselves in human dwellings and their annexes but others are mostly wild. In the state of Pará, few records have been made about the occurrence of those wild vectors in fortuitous contact with inhabitants in riverside regions in the Amazon. These vector behaviours have been studied by our group since 2006, trying to explain their role in transmission of the silent disease or asymptomatic infection. The objective of this study is to describe the epidemiological profile of populations exposed to random triatomine home invasion in riverside areas with this registered occurrence. This is a cross-sectional study developed in Abaetetuba city, in the state of Pará, where we conducted a seroepidemiologic survey in inhabitants that registered triatomine home invasion. The results demonstrated that triatomine invasions occur especially in the in-home environment and in the rural zone. The genus Rhodnius was the most found in residences of the municipalities. Direct contact through the vector was reported by 15.55% of the total participants, and an unusual vector behaviour were observed during the day. Despite this small casuistic, 0.47% of the enrolled inhabitants had positive serology IgG anti- T. cruzi antibodies. We confirm one occurrence of asymptomatic infection in a child and, also, favourable links to the Chagas disease transmission chain. Faced with the scarcity of information on triatomine aggression in the Amazon, the authors recommended an entomological study of greater scope in those areas. The record of unusual vector behaviour and the serological surveillance of human populations under this risk may constitute a new tool for the early detection of silent infections and reinforce the knowledges about the behaviour of invading insects. At the same time, health education can assist in strategies for the prevention of Chagas' disease.

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