scholarly journals Prediction of the stability of proteins by computational approaches: a case report

2018 ◽  
Author(s):  
Bernardina Scafuri ◽  
Angelo Facchiano ◽  
Anna Marabotti
Keyword(s):  
Case Report ◽  
Protein Stability ◽  
Protein Sequence ◽  
Genotypic Variation ◽  
Missense Mutations ◽  
Computational Approaches ◽  
The Past ◽  
The Stability ◽  
The Impact

The prediction of the stability of a protein is a very important issue in computational biology. Indeed, missense mutations are frequently associated to a change in protein stability, leading usually to destabilization, unfolding and aggregation. However, the direct measurement of the effect of mutations on proteins' stability is often impaired by the large number of mutations that can affect a protein sequence. Therefore, predicting the impact of a mutation on this feature is of remarkable interest to infer the phenotypic effects associated to a genotypic variation. For this reason, many different predictors of the effects of mutations on protein stability have been developed during the past years, and they are available online as Web servers. In the present work, we applied several tools based on different approaches to predict the stability of three proteins involved in the different forms of the rare disease galactosemia, and we compare their different results, describing also the problems that we had to face, the solutions that we have adopted and the lessons learnt from this case study.

scholarly journals Prediction of the stability of proteins by computational approaches: a case report

2018 ◽  
Author(s):  
Bernardina Scafuri ◽  
Angelo Facchiano ◽  
Anna Marabotti
Keyword(s):  
Case Report ◽  
Protein Stability ◽  
Protein Sequence ◽  
Genotypic Variation ◽  
Missense Mutations ◽  
Computational Approaches ◽  
The Past ◽  
The Stability ◽  
The Impact

The prediction of the stability of a protein is a very important issue in computational biology. Indeed, missense mutations are frequently associated to a change in protein stability, leading usually to destabilization, unfolding and aggregation. However, the direct measurement of the effect of mutations on proteins' stability is often impaired by the large number of mutations that can affect a protein sequence. Therefore, predicting the impact of a mutation on this feature is of remarkable interest to infer the phenotypic effects associated to a genotypic variation. For this reason, many different predictors of the effects of mutations on protein stability have been developed during the past years, and they are available online as Web servers. In the present work, we applied several tools based on different approaches to predict the stability of three proteins involved in the different forms of the rare disease galactosemia, and we compare their different results, describing also the problems that we had to face, the solutions that we have adopted and the lessons learnt from this case study.

scholarly journals The Impact of the COVID-19 on Economic Sustainability—A Case Study of Fluctuation in Stock Prices for China and South Korea

2021 ◽  
Vol 13 (12) ◽  
pp. 6642
Author(s):  
Jialei Jiang ◽  
Eun-Mi Park ◽  
Seong-Taek Park
Keyword(s):  
South Korea ◽  
Stock Prices ◽  
Economic Sustainability ◽  
Response Patterns ◽  
Global Impact ◽  
The Past ◽  
Stock Indices ◽  
The Stability ◽  
The Impact

The coronavirus disease (COVID-19) pandemic has had a global impact on lives, livelihoods, and economies. This study investigates whether a contagious infectious disease can affect the prices of the Chinese and Korean stock markets. Specifically, we aim to discover discrepancies in the impact of COVID-19 on the stock prices of China and South Korea through panel data. To test these discrepancies, we first regressed the stock indices on confirmed cases and deaths. We then validated the stability of coefficients over the past days. The empirical results show that (1) responses of stock indices are stable and impulsive and (2) response patterns toward COVID-19 events considerably vary across nations, especially in the counties such as China and South Korea.

scholarly journals IMPACT OF MEMENTO VALUE ON THE PERCEPTION OF CULTURAL HERITAGE: CASE STUDY OF THE MODERN MOVEMENT AND DIALECT OF KAUNAS / ATMINTIES VERTĖ SUVOKIANT KULTŪROS PAVELDĄ: MODERNIZMO JUDĖJIMO IR JO KAUNIETIŠKOJO DIALEKTO ATVEJO TYRIMAS

2018 ◽  
Vol 10 (0) ◽  
pp. 1-7
Author(s):  
Huriye Armagan DOGAN
Keyword(s):  
Built Environment ◽  
Cultural Heritage ◽  
Empirical Approach ◽  
The Past ◽  
Space And Time ◽  
The Impact ◽  
Modern Movement

Memento value in heritage is one of the most essential characteristics facilitating the association between the environment and its users, by connecting structures with space and time, moreover, it helps people to identify their surroundings. However, the emergence of the Modern Movement in the architectural sphere disrupted the reflection of memory and symbols which serve to root the society in its language. Furthermore, it generated an approach that stood against the practice of referring to the past and tradition, which led to the built environment becoming homogeneous and deprived of memento value. This paper focuses on the impact of memento value on the perception and evaluation of cultural heritage. Furthermore, it investigates the notions which are perceived to influence the appraisal of cultural heritage by applying them to the Kaunas dialect of the Modern Movement with an empirical approach.

Utility privatisation in Sub-Saharan Africa: a case study of water

2003 ◽  
Vol 41 (4) ◽  
pp. 507-531 ◽  
Author(s):  
Kate Bayliss
Keyword(s):  
Financial Management ◽  
Development Policy ◽  
Sub Saharan Africa ◽  
The Past ◽  
Economic Context ◽  
The Poor ◽  
Privatisation Process ◽  
Sub Saharan ◽  
The Impact

Over the past twenty years, the focus of development policy has shifted from the state to the private sector. Privatisation is now central to utility reform in much of SSA. This paper sets out developments in water privatisation and reviews the evidence regarding its impact. Water privatisation has been carried out to some degree in at least fourteen countries in the region, and many other governments are at various stages in the privatisation process. However, in some cases privatisation has been difficult to achieve, and a few countries have successfully provided water under public ownership. Evidence on the impact of privatisation indicates that the performance of privatised utilities has not changed dramatically, but that enterprises have continued to perform well, or not so well, depending both on their state when they were privatised and on the wider economic context. The evidence points to internal improvements in terms of financial management. However, governments face considerable difficulties in attracting investors and regulating private utilities. Furthermore, privatisation fails to address some of the fundamental constraints affecting water utilities in SSA, such as finance, the politicised nature of service delivery, and lack of access for the poor. A preoccupation with ownership may obscure the wider goals of reform.

scholarly journals International Non-Governmental Organizations (INGOS) and Their Impact on The Democratization of Developing Countries: The Case of Nigeria

2020 ◽  
Author(s):  
Saied Sulaiman
Keyword(s):  
Developing Countries ◽  
Conference Proceedings ◽  
Standard Form ◽  
Host Countries ◽  
End Of History ◽  
The Past ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
The Impact

The paper examines the impact of INGOs on the democratization of developing countries. Following the ‘end of history,’ the INGOs multiplied globally, and the number of aids to developing countries was given through them in billions of dollars in the past three decades. It is envisaged that with the increase in their population, the developing countries will be better off with a standard form of living that is attributable to standard democratization. However, despite the billions of dollars spent, the citizens of the developing countries are still worse in poverty, poor leadership, and corruption. On the contrary, some countries, including Nigeria, are threatening legislation that will curtail the INGOs, sighting their opacity and lack of tangible results as reasons. The research used Nigeria as a case study to analyze the methods, approaches, and the capacity of these INGOs and how they affect the democratization of their host countries. Through a review of existing records, non-participatory observations, and reviews of conference proceedings. The paper analyzed the parallel gaps that exist by arguing that, taking a broad, multi-disciplinary method from the various works of literature studied will provide essential conceptual and practical insights that can inform current debates.

scholarly journals EMPIRICAL STUDY ON ALTERNATIVES FOR SAVING AND INVESTING IN THE POSTPANDEMIC PERIOD. CASE STUDY: ROMANIA

2021 ◽  
Vol S.I. (2) ◽  
pp. 27-40
Author(s):  
Alexandru Mihai Alexandru Mihai ◽  
◽  
Ruxandra DINULESCU ◽  
Florin PUCHEANU ◽  
◽  
...  
Keyword(s):  
Empirical Study ◽  
The Past ◽  
Trading Market ◽  
Before And After ◽  
Double Approach ◽  
Potential Risks ◽  
Potential Strategy ◽  
The Impact

This paper develops investigations in the field of saving and investing techniques related to the impact of the COVID19 pandemic on the Romanian trading market. The study focuses particularly on the alternatives for accumulation of money capital which can lead to a positive long-term return. The research aims to investigate the available current services and opportunities in the Romanian investment market and their returns after the pandemic. Towards this objective, the study presents the past returns for several products and the users potential risks. Furthermore, an investigation is conducted based on the latest statistics whereas different variants of portfolios are presented. Unlike most of the previous studies, this analysis has a double approach: evaluating viable alternatives depending on several characteristics and simultaneously developing a long-term potential strategy that could be used to ensure the financial future of an individual in the period of the outbreak of the COVID19 pandemic. This contribution provides an initial analysis of the saving and investing market of Romania before and after the pandemic.

scholarly journals StabilitySort: assessment of protein stability changes on a genome-wide scale to prioritise potentially pathogenic genetic variation

2021 ◽  
Author(s):  
Aaron Chuah ◽  
Sean Li ◽  
Andrea Do ◽  
Matt A Field ◽  
T. Daniel Andrews
Keyword(s):  
Genetic Variation ◽  
Protein Stability ◽  
Missense Mutations ◽  
Link Type ◽  
Genome Wide ◽  
Pathogenic Variation ◽  
A Genome ◽  
Human Proteins ◽  
Wide Scale ◽  
The Stability

AbstractSummaryMissense mutations that change protein stability are strongly associated with human inherited genetic disease. With the recent availability of predicted structures for all human proteins generated using the AlphaFold2 prediction model, genome-wide assessment of the stability effects of genetic variation can, for the first time, be easily performed. This facilitates the interrogation of personal genetic variation for potentially pathogenic effects through the application of stability metrics. Here, we present a novel algorithm to prioritise variants predicted to strongly destabilise essential proteins, available as both a standalone software package and a web-based tool. We demonstrate the utility of this tool by showing that at values of the Stability Sort Z-score above 1.6, pathogenic, protein-destabilising variants from ClinVar are detected at a 58% enrichment, over and above the destabilising (but presumably non-pathogenic) variation already present in the HapMap NA12878 genome.Availability and ImplementationStabilitySort is available as both a web service (http://130.56.244.113/StabilitySort/) and can be deployed as a standalone system (https://gitlab.com/baaron/StabilitySort)[email protected]

A case study of unquiet translators

Target ◽  
2021 ◽  
Author(s):  
Esther Monzó-Nebot
Keyword(s):  
Cultural Change ◽  
Work Processes ◽  
Gray Area ◽  
The Social ◽  
The Face ◽  
The Stability ◽  
The Impact ◽  
Shed Light ◽  
Made In

Abstract Remarkable efforts have been made in Translation and Interpreting Studies to test the subservient habitus hypothesis formulated by Simeoni (1998) in his seminal work. In the face of increasing evidence that translators tend to reproduce a given society’s or community’s prevalent norms and contribute to the stability of such norms (Toury 1978), subversive translation practices have been reported (Delabastita 2011; Woods 2012) and indeed promoted as a way of fostering social and cultural change (Levine 1991; Venuti 1992). However, insights into how translators’ subservient or subversive habitus develop and depart from each other are still lacking. In order to shed light on this gray area, this article scrutinizes the contrasts between the habitus of professional legal translators who acquiesce to and who reject the norms governing their positions in the field. Special attention is given to those who decide to abandon the translation field. Their behavior is examined by relating habitus to forms of socialization and studying the implications of their strategies. Based on a case study drawn from interview data, this article focuses on the social practices of resistance and rebellion vis-à-vis subservience, and the impact of both on translation workplaces, work processes, and translators’ futures.

Bootlegging Experimental Film

2017 ◽  
pp. 81-105
Author(s):  
Erika Balsom
Keyword(s):  
Moral Rights ◽  
Experimental Film ◽  
Medium Specificity ◽  
The Past ◽  
The Impact

This chapter explores the ambivalence of the copy by examining the impact of low-quality, unauthorized digital bootlegs on the domain of experimental film, an area of practice that has historically exhibited a strong investment in medium specificity and the moral rights of the filmmaker. I confront these issues through a case study of Josiah McElheny’s The Past Was A Mirage I’d Left Far Behind (2010), a year-long installation at the Whitechapel Gallery in London that consisted of copies of historical abstract films taken from UbuWeb – an online repository of low-definition files posted without permission of the filmmakers – and projected onto prismatic screens.

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