scholarly journals The effects of aerobic exercise on biochemical parameters in individuals with CKD on hemodialysis: A longitudinal study

2020 ◽  
Vol 30 (2) ◽  
pp. 251-259
Author(s):  
Fabiano Santana de Oliveira ◽  
Mauro José De Deus Morais ◽  
Luiz Carlos De Abreu ◽  
Andrés Ricardo Pérez-Riera ◽  
Vitor E. Valenti ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Blood Parameters ◽  
Control Group ◽  
Post Exercise ◽  
Before And After ◽  
Registration Date

Background: Chronic kidney disease is directly related to cardiovascular disorders. Guided physical exercises significantly improve the adverse effects of dialytic treatment. Objective: To analyze changes in biochemical parameters of subjects with chronic kidney disease undergoing moderate exercise during hemodialysis. Methods: This is an experimental study composed of 54 subjects submitted to hemodialysis, split into a control group and a group with intervention. The experimental group underwent three weekly sessions of aerobic exercise, performed during hemodialysis sessions, with a duration of 30 minutes, for 12 weeks. The blood parameters of both groups were compared. Results: Statistically significant differences were observed between pre (p=0.001) and post-exercise protocol for urea (p=0.006), calcium (p=0.001), alanine aminotransferase (p=0.020) and sodium (p=<0.001). In the control group, we observed significant differences for the calcium variable (p<0.001), alanine aminotransferase (p=0.024), hematocrit (p=0.015), calcium vs phosphorus (p=0.018), and sodium (p=0.023), before and after the period. Conclusion: Aerobic training during hemodialysis was able to maintain blood level stability in patients with chronic kidney disease, both during and at the end of the protocol, even considering increased blood flow. This trial is registered in the Brazilian registry of clinical Trials - number RBR-7354r6. Registration date: July 5, 2018 at 12:59 PM. Last Update: July 24, 2018 at 10:24 AM. Identification of the test - UTN Number: U1111-1216-8272.

scholarly journals Intermittent hemodialysis in dogs with chronic kidney disease stage III

2017 ◽  
Vol 47 (10) ◽  
Author(s):  
Alessandra Melchert ◽  
Silvano Salgueiro Geraldes ◽  
André Nanny Le Sueur Vieira ◽  
Regina Kiomi Takahira ◽  
Paulo Roberto Rodrigues Ramos ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Kidney Injury ◽  
Electrolyte Imbalance ◽  
Stage Iii ◽  
Disease Stage ◽  
Control Group ◽  
Intermittent Hemodialysis ◽  
Before And After

ABSTRACT: Intermittent hemodialysis (IHD) is a form of renal replacement that is used in veterinary medicine for cases involving drug removal, electrolyte imbalance, acute kidney injury, and chronic kidney disease (CKD). The aim of the present study was to verify the efficacy of IHD in dogs with CKD staged at grade III and to evaluate the effect of IHD on quality of life. Twelve dogs with CKD at stage III met the inclusion criteria and were divided equally into two groups. The control group (n=6) received only clinical treatment and intravenous fluid therapy, and the hemodialysis group (n=6) received clinical and IHD treatments. Blood samples were collected before and after treatments in both groups. We evaluated complications and clinical parameters of IHD every 30 minutes. Hemodialysis decreased serum urea, creatinine, and phosphorus. Despite the evident removal of nitrogen compounds, dialysis treatment did not increase survival time in these patients. The results of this study do not support the early use of dialysis in dogs with chronic kidney disease stage III.

scholarly journals Effectiveness of Nursing Intervention Strategies on Physiological and Psychosocial Problems among Patients with Chronic Kidney Disease in Selected Hospital of Kashmir

2020 ◽  
Vol 09 (01) ◽  
pp. 1-12
Author(s):  
Dilshada Wani ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Psychosocial Problems ◽  
Nursing Intervention ◽  
Health Problems ◽  
Intervention Strategies ◽  
Physiological Parameters ◽  
Control Group ◽  
Experimental Group

Background:Chronic Kidney Disease (CKD) is a worldwide serious condition associated with increased premature mortality, decreased quality of life and increased health-care expenditures. Learning about issues such as: disease process, strict adherence to renal diet, exercises and relaxation therapies in addition to adherence the medical treatment have helped chronic kidney disease patients to self regulate and improve their physical and social functioning. With this background the investigator got strongly convinced to design some evidence based ‘Nursing intervention strategies’ for CKD patients through clinical research to alleviate their sufferings with better clinical outcomes. Methodology:A quasi-experimental study based upon two group pre-test post-test control group design was conducted on 200 adult chronic kidney disease patients (100=experimental group and 100=control group) with an aim to evaluate the effectiveness of ‘Nursing intervention strategies’ in improving their physiological and psychosocial problems in nephrology ward of a tertiary care hospital of Jammu and Kashmir i.e. Sher-i-Kashmir Institute of Medical Sciences (SKIMS) from 5th March 2012 to 31st July 2013. Result: The findings revealed that the subjects in experimental group who received the ‘Nursing Intervention Strategies’ for two weeks within hospital as well as at home till first follow up visit had shown a significant (p ≤ 0.05) improvement in 9 health problems, 11 biochemical parameters, 5 physiological parameters and 2 psychosocial parameters than the subjects in control group who reported improvement in: only 6 health problems; 5 biochemical parameters and 3 physiological parameters. Conclusion: It can be concluded that ‘Nursing Intervention Strategies’ such as: Dietary advice, progressive muscle relaxation, deep breathing, leg massaging, leg elevation and talk therapy were effective in reducing the magnitude of physiological and psychosocial problems among chronic kidney disease patients. However the long term efficacy of these strategies needs to be investigated.

scholarly journals Metabolomic and biochemical characterization of a new model of the transition of acute kidney injury to chronic kidney disease induced by folic acid

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7113
Author(s):  
Marlene Marisol Perales-Quintana ◽  
Alma L. Saucedo ◽  
Juan Ricardo Lucio-Gutiérrez ◽  
Noemí Waksman ◽  
Gabriela Alarcon-Galvan ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Folic Acid ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Kidney Injury ◽  
Renal Diseases ◽  
Control Group ◽  
Organic Osmolytes ◽  
Histological Classification

Background Renal diseases represent a major public health problem. The demonstration that maladaptive repair of acute kidney injury (AKI) can lead to the development of chronic kidney disease (CKD) and end-stage renal disease has generated interest in studying the pathophysiological pathways involved. Animal models of AKI–CKD transition represent important tools to study this pathology. We hypothesized that the administration of multiple doses of folic acid (FA) would lead to a progressive loss of renal function that could be characterized through biochemical parameters, histological classification and nuclear magnetic resonance (NMR) profiling. Methods Wistar rats were divided into groups: the control group received a daily intraperitoneal (I.P.) injection of double-distilled water, the experimental group received a daily I.P. injection of FA (250 mg kg body weight−1). Disease was classified according to blood urea nitrogen level: mild (40–80 mg dL−1), moderate (100–200 mg dL−1) and severe (>200 mg dL−1). We analyzed through biochemical parameters, histological classification and NMR profiling. Results Biochemical markers, pro-inflammatory cytokines and kidney injury biomarkers differed significantly (P < 0.05) between control and experimental groups. Histology revealed that as damage progressed, the degree of tubular injury increased, and the inflammatory infiltrate was more evident. NMR metabolomics and chemometrics revealed differences in urinary metabolites associated with CKD progression. The main physiological pathways affected were those involved in energy production and amino-acid metabolism, together with organic osmolytes. These data suggest that multiple administrations of FA induce a reproducible model of the induction of CKD. This model could help to evaluate new strategies for nephroprotection that could be applied in the clinic.

scholarly journals Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients

2020 ◽  
Vol 318 (1) ◽  
pp. F76-F85
Author(s):  
Patrick J. Highton ◽  
Alice E. M. White ◽  
Daniel G. D. Nixon ◽  
Thomas J. Wilkinson ◽  
Jill Neale ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Tissue Factor ◽  
Control Group ◽  
Monocyte Subset ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
The Impact

Renal transplant recipients (RTRs) and patients with nondialysis chronic kidney disease display elevated circulating microparticle (MP) counts, while RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and MPs is unknown in RTRs. Fifteen RTRs [age: 52.8 ± 14.5 yr, estimated glomerular filtration rate (eGFR): 51.7 ± 19.8 mL·min−1·1.73 m−2 (mean ± SD)] and 16 patients with nondialysis chronic kidney disease (age: 54.8 ± 16.3 yr, eGFR: 61.9 ± 21.0 mL·min−1·1.73 m−2, acting as a uremic control group), and 16 healthy control participants (age: 52.2 ± 16.2 yr, eGFR: 85.6 ± 6.1 mL·min−1·1.73 m−2) completed 20 min of walking at 60–70% peak O2 consumption. Venous blood samples were taken preexercise, postexercise, and 1 h postexercise. Leukocytes and MPs were assessed using flow cytometry. Exercise increased classical ( P = 0.001) and nonclassical ( P = 0.002) monocyte subset proportions but decreased the intermediate subset ( P < 0.001) in all groups. Exercise also decreased the percentage of platelet-derived MPs that expressed tissue factor in all groups ( P = 0.01), although no other exercise-dependent effects were observed. The exercise-induced reduction in intermediate monocyte percentage suggests an anti-inflammatory effect, although this requires further investigation. The reduction in the percentage of tissue factor-positive platelet-derived MPs suggests reduced prothrombotic potential, although further functional assays are required. Exercise did not cause aberrant immune cell activation, suggesting its safety from an immunological standpoint (ISRCTN38935454).

scholarly journals Investigation of hallmarks of carbonyl stress and formation of end products in feline chronic kidney disease as markers of uraemic toxins

2018 ◽  
Vol 21 (6) ◽  
pp. 465-474 ◽  
Author(s):  
Emanuela Valle ◽  
Liviana Prola ◽  
Diana Vergnano ◽  
Roberta Borghi ◽  
Fiammetta Monacelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Advanced Oxidation ◽  
Treated Group ◽  
Control Group ◽  
Advanced Oxidation Protein Products ◽  
Significant Difference ◽  
End Products

Objectives Cats are commonly affected by chronic kidney disease (CKD). Many reactive carbonyl intermediates and end products originating from the oxidative stress pathways are recognised as uraemic toxins and may play a role in CKD progression. The aim of the present study is to confirm whether carbonyl end-product formation is higher in cats affected by CKD and to assess whether an angiotensin-converting enzyme inhibitor (ACEi) might affect these hallmarks. Methods Twenty-two cats were divided into three groups: a control group (CG), cats with CKD and cats with CKD treated with an ACEi. Serum levels of pentosidine, carboxymethyllysine, advanced oxidation protein products, malondialdehyde, methylglyoxal and hexanoyl-lysine were measured. In addition, biochemical parameters and systolic blood pressure were evaluated. After checking for normality, comparisons between groups were performed followed by multiple comparison tests. P values ⩽0.05 were considered significant. Correlations between concentrations of the considered biomarkers and of the other metabolic parameters were investigated. Results Advanced oxidation protein products, malondialdehyde and hexanoyl-lysine concentrations were significantly higher in CKD and ACEi-treated groups compared with the CG ( P <0.05). Carboxymethyllysine increased in the ACEi-treated group when compared with the CG, whereas intermediate values of these biomarkers were found in the CKD group ( P <0.05). The ACEi-treated group showed the highest values of carboxymethyllysine, advanced oxidation protein products and hexanoyl-lysine. By contrast, the CKD group had the highest concentration of malondialdehyde. No statistically significant difference was found in the levels of pentosidine or methylglyoxal. End products correlated with creatinine and urea and with each other. Conclusions and relevance Significantly high concentrations of both intermediate and end products of carbonyl/oxidative stress were detected in CKD cats. This is the first study to have concurrently taken into account several uraemic toxins and biochemical parameters in cats affected by CKD.

scholarly journals Perubahan tingkat fatigue melalui latihan Progressive Muscle Relaxation (PMR) pada pasien Gagal Ginjal Kronis yang menjalani hemodialisa

2019 ◽  
Author(s):  
Santi Herlina
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Relaxation ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Progressive Muscle Relaxation ◽  
Control Group ◽  
Before And After

Fatigue is a major complaint of patients undergoing long-term hemodialysis, which has a high value, so it will affect the quality of life of patients. The purpose of this study was to determine the influence of PMR on the level of fatigue in patients with chronic kidney disease undergoing hemodialysis. This study used a quasi experiment design approach pretest-posttest control group. The number of respondents in the study were 32 patients divided into 2 groups: the 16 intervention group and 16 control group. The research concludes that there are significant differences on the level of fatigue in the intervention group between before and after PMR with p = 0.000. Suggested training PMR can be used as an independent nursing intervention in reducing fatigue in patients with chronic kidney disease undergoing hemodialysis.

scholarly journals THE EFFECTIVENESS OF BENSON’S RELAXATION THERAPY TO DECREASE THE LEVEL OF INSOMNIA ON CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS

2016 ◽  
Vol 1 (1) ◽  
pp. 61
Author(s):  
Dwi Retno Sulistyaningsih ◽  
Erna Melastuti
Keyword(s):  
Chronic Kidney Disease ◽  
Treatment Group ◽  
Kidney Disease ◽  
Sleep Disorder ◽  
Severity Index ◽  
Routine Care ◽  
Control Group ◽  
Relaxation Techniques ◽  
Before And After ◽  
Quasi Experimental

AbstractAlmost 50 – 80 % patients with chronic kidney disease undergoing hemodialysis were reported to sleep disorder.  Insomnia is the highest prevalence  sleep disorder in the dialysis patients. This study aims to determine the effectiveness of Benson’s relaxation of the level of patients’ insomnia with chronic kidney disease in dyalisis patients. The design of this study is quasi-experimental with pretest-posttest design with control group. Fourty-two hemodyalisis patiens were recruited purposively from the hemodyalisis Islamic Hospital, Sultan Agung , Semarang. The sample was divided into two groups (treatment and control). Patients in the treatment group received Benson’s relaxation techniques during hemodialysis for 4 weeks and the control group received routine care. The insomnia severity index was used to measure  insomnia level. The result showed that there was significantly different score of insomnia level before and after relaxation Benson in the treatment group (p = 0.000). This study found that relaxation Benson seemed to be effective in decreasing the level of insomnia on chronic kidney disease patients undergoing hemodyalisis. Key words: Benson relaxation, insomnia, hemodialysis, chronic kidney disease

scholarly journals Exercise Affects Cardiopulmonary Function in Patients with Chronic Kidney Disease: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Hongchang Yang ◽  
Xueping Wu ◽  
Min Wang
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Data Extraction ◽  
Meta Analysis ◽  
Peak Oxygen Uptake ◽  
Control Group ◽  
Cardiopulmonary Function ◽  
Before And After ◽  
Mean Differences ◽  
Meta Analyses

This study aimed to comprehensively assess the effects of exercise on cardiopulmonary function indices in patients with chronic kidney disease (CKD). A literature review was performed by searching literatures in PubMed and Embase before June 2016. Studies were selected based on predefined inclusion and exclusion criteria, followed by data extraction and a quality assessment of the included studies using the Cochrane Collaboration’s tool. Correlations between exercise and cardiopulmonary function indices [pulse wave velocity, respiratory exchange ratio, and peak oxygen uptake (VO2 peak)] were then evaluated using mean differences and 95% confidence intervals. All meta-analyses were conducted using R 3.12 software. Finally, five eligible studies involving 179 CKD patients were included. After intervention, a heterogeneity test showed that the VO2 peak values of the treatment group were greater than those of the control group, whereas no significant differences were found for the other indices. However, a sensitivity analysis showed inconsistent results both before and after intervention. Thus, we concluded that exercise might play an important role in improving the VO2 peak values in CKD patients. Additional studies are needed to verify this conclusion.

scholarly journals Serum Interleukin-17 Alterations in Patients With Chronic Kidney Disease Undergoing Eight Weeks of Aerobic Training

2021 ◽  
Vol 6 (2) ◽  
pp. 69-73
Author(s):  
Arman Jalili ◽  
Ali Asghar Ravasi ◽  
Sirous Choobineh ◽  
Ali Alidadi ◽  
Rahman Suri ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Training ◽  
Control Group ◽  
P Value ◽  
Interleukin 17 ◽  
Maximal Heart Rate ◽  
Mean Values ◽  
Before And After ◽  
The Mean

Introduction: Regular physical activities may have effect on the course of chronic kidney disease (CKD). Here, we aimed to ascertain the changes of serum interleukin-17 (IL-17) following eight weeks of aerobic training in CKD patients. Methods: The CKD patients referred to Zahedan Edalat Clinic and Ali-Ibn Abi Talib hospital in Zahedan city (Iran) were enrolled. Sixty patients aged between 30 and 50 years old were chosen by a random method and assigned into the control and intervention groups (each group constituted 30 people). In this study, aerobic exercises were performed at 50%–80% of the maximal heart rate. Peripheral blood was obtained one day before the beginning of exercise and one day after the end of the intervention. Serum IL-17 level was quantified using a commercial specific ELISA kit. Results: The mean values of IL-17 in CKD patients before and after 8 weeks of aerobic exercise were 1.67 ± 0.403 pg/mL and 1.58 ± 0.170 pg/mL in the intervention group (P value= 0.039) whereas the mean values of IL-17 in the control group before and after the intervention were 1.31 ± 0.529 pg/mL and 1.35 ± 0.505 pg/mL (P value= 0.794).Conclusion: Eight weeks of aerobic training can significantly reduce serum IL-17, an inflammatory marker, in CKD patients.

scholarly journals Studies on Biochemical Changes and Prolactin Level Evaluation in Patients with Chronic Kidney Disease

2019 ◽  
Author(s):  
Foyzur Rahman ◽  
Faisal Kabir ◽  
Sawgat Rezwan
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prolactin Level ◽  
Biochemical Parameters ◽  
Hormone Secretion ◽  
Public Health Problem ◽  
Serum Prolactin ◽  
Control Group ◽  
World Population ◽  
Prolactin Hormone

AbstractBackgroundChronic kidney disease (CKD) is progressive loss in kidney function over a period of months or years. CKD is an internationally recognized public health problem affecting 5–10% of the world population and day-by-day the number of cases are increasing at an alarming rate. In CKD, raised levels of prolactin in blood may cause vascular derangements which might lead to worse cardiovascular consequences in CKD patients.ObjectivesTo assess serum creatinine, hemoglobin (Hb), urea, red blood cell (RBC), protein creatinine ratio (PCR) and prolactin in CKD patients.Material and MethodsThis study included 110 patients, 61 were males and 49 were females and their age range 1 to more than 60 years. The control group also consisted of same number of participants as the patients; who were free from signs and symptoms of kidney disease and prolactin hormone disorders.ResultsThe study shows that all the biochemical parameters in CKD patients were found to be significantly high compared with control group (P<0.001). Serum prolactin concentrations in CKD patients were also increased significantly compared with control group (P≤ 0.05). It was found that level of prolactin hormone secretion was higher in male CKD patients than male control.ConclusionAlthough males are more prone to chronic kidney disease, but the percentage of females is not negligible. All the biochemical parameters and prolactin level changed significantly in the CKD patients. It is interesting that in case of CKD, male’s prolactin secretion becomes higher.

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