scholarly journals Studies on Biochemical Changes and Prolactin Level Evaluation in Patients with Chronic Kidney Disease

2019 ◽  
Author(s):  
Foyzur Rahman ◽  
Faisal Kabir ◽  
Sawgat Rezwan
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prolactin Level ◽  
Biochemical Parameters ◽  
Hormone Secretion ◽  
Public Health Problem ◽  
Serum Prolactin ◽  
Control Group ◽  
World Population ◽  
Prolactin Hormone

AbstractBackgroundChronic kidney disease (CKD) is progressive loss in kidney function over a period of months or years. CKD is an internationally recognized public health problem affecting 5–10% of the world population and day-by-day the number of cases are increasing at an alarming rate. In CKD, raised levels of prolactin in blood may cause vascular derangements which might lead to worse cardiovascular consequences in CKD patients.ObjectivesTo assess serum creatinine, hemoglobin (Hb), urea, red blood cell (RBC), protein creatinine ratio (PCR) and prolactin in CKD patients.Material and MethodsThis study included 110 patients, 61 were males and 49 were females and their age range 1 to more than 60 years. The control group also consisted of same number of participants as the patients; who were free from signs and symptoms of kidney disease and prolactin hormone disorders.ResultsThe study shows that all the biochemical parameters in CKD patients were found to be significantly high compared with control group (P<0.001). Serum prolactin concentrations in CKD patients were also increased significantly compared with control group (P≤ 0.05). It was found that level of prolactin hormone secretion was higher in male CKD patients than male control.ConclusionAlthough males are more prone to chronic kidney disease, but the percentage of females is not negligible. All the biochemical parameters and prolactin level changed significantly in the CKD patients. It is interesting that in case of CKD, male’s prolactin secretion becomes higher.

scholarly journals Studies on Biochemical Changes and Prolactin Level Evaluation in Patients with Chronic Kidney Disease

KYAMC Journal ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 90-94
Author(s):  
Md Foyzur Rahman ◽  
Md Sawgat Rezwan ◽  
Md Faisal Kabir
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prolactin Level ◽  
Biochemical Parameters ◽  
Public Health Problem ◽  
Serum Prolactin ◽  
Control Group ◽  
World Population ◽  
College Hospital ◽  
Prolactin Hormone

Background: Chronic kidney disease (CKD) is progressive loss in kidney function over a period of months or years. CKD is an internationally recognized public health problem affecting 5-10% of the world population and day-by-day the number of cases are increasing at an alarming rate. This study was conducted in Khwaja Yunus Ali Medical College Hospital in Enayetpur, Sirajganj. Objectives: To assess serum creatinine, hemoglobin (Hb), urea, red blood cell (RBC), protein creatinine ratio (PCR) and prolactin in CKD patients. Material and Methods: This study included 110 patients, 61 were males and 49 were females and their age range 1 to more than 60 years.The control group also consisted of same number of participants as the patients, who were free from signs and symptoms of kidney disease and prolactin hormone disorders. Results: The study shows that all the biochemical parameters in CKD patients were found to be significantly high compared with control group (P<0.001). Serum prolactin concentrations in CKD patients were also increased significantly compared with control group (P<0.05). It was found that male CKD patients secret more prolactin hormone than male control. Conclusion: Although males are more prone to chronic kidney disease, but the percentage of females is not negligible. All the biochemical parameters and prolactin level changed significantly in the CKD patients. It is interesting that in case of CKD, male's prolactin secretion becomes higher. KYAMC Journal Vol. 10, No.-2, July 2019, Page 90-94

scholarly journals Effectiveness of Nursing Intervention Strategies on Physiological and Psychosocial Problems among Patients with Chronic Kidney Disease in Selected Hospital of Kashmir

2020 ◽  
Vol 09 (01) ◽  
pp. 1-12
Author(s):  
Dilshada Wani ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Psychosocial Problems ◽  
Nursing Intervention ◽  
Health Problems ◽  
Intervention Strategies ◽  
Physiological Parameters ◽  
Control Group ◽  
Experimental Group

Background:Chronic Kidney Disease (CKD) is a worldwide serious condition associated with increased premature mortality, decreased quality of life and increased health-care expenditures. Learning about issues such as: disease process, strict adherence to renal diet, exercises and relaxation therapies in addition to adherence the medical treatment have helped chronic kidney disease patients to self regulate and improve their physical and social functioning. With this background the investigator got strongly convinced to design some evidence based ‘Nursing intervention strategies’ for CKD patients through clinical research to alleviate their sufferings with better clinical outcomes. Methodology:A quasi-experimental study based upon two group pre-test post-test control group design was conducted on 200 adult chronic kidney disease patients (100=experimental group and 100=control group) with an aim to evaluate the effectiveness of ‘Nursing intervention strategies’ in improving their physiological and psychosocial problems in nephrology ward of a tertiary care hospital of Jammu and Kashmir i.e. Sher-i-Kashmir Institute of Medical Sciences (SKIMS) from 5th March 2012 to 31st July 2013. Result: The findings revealed that the subjects in experimental group who received the ‘Nursing Intervention Strategies’ for two weeks within hospital as well as at home till first follow up visit had shown a significant (p ≤ 0.05) improvement in 9 health problems, 11 biochemical parameters, 5 physiological parameters and 2 psychosocial parameters than the subjects in control group who reported improvement in: only 6 health problems; 5 biochemical parameters and 3 physiological parameters. Conclusion: It can be concluded that ‘Nursing Intervention Strategies’ such as: Dietary advice, progressive muscle relaxation, deep breathing, leg massaging, leg elevation and talk therapy were effective in reducing the magnitude of physiological and psychosocial problems among chronic kidney disease patients. However the long term efficacy of these strategies needs to be investigated.

scholarly journals Metabolomic and biochemical characterization of a new model of the transition of acute kidney injury to chronic kidney disease induced by folic acid

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7113
Author(s):  
Marlene Marisol Perales-Quintana ◽  
Alma L. Saucedo ◽  
Juan Ricardo Lucio-Gutiérrez ◽  
Noemí Waksman ◽  
Gabriela Alarcon-Galvan ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Folic Acid ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Kidney Injury ◽  
Renal Diseases ◽  
Control Group ◽  
Organic Osmolytes ◽  
Histological Classification

Background Renal diseases represent a major public health problem. The demonstration that maladaptive repair of acute kidney injury (AKI) can lead to the development of chronic kidney disease (CKD) and end-stage renal disease has generated interest in studying the pathophysiological pathways involved. Animal models of AKI–CKD transition represent important tools to study this pathology. We hypothesized that the administration of multiple doses of folic acid (FA) would lead to a progressive loss of renal function that could be characterized through biochemical parameters, histological classification and nuclear magnetic resonance (NMR) profiling. Methods Wistar rats were divided into groups: the control group received a daily intraperitoneal (I.P.) injection of double-distilled water, the experimental group received a daily I.P. injection of FA (250 mg kg body weight−1). Disease was classified according to blood urea nitrogen level: mild (40–80 mg dL−1), moderate (100–200 mg dL−1) and severe (>200 mg dL−1). We analyzed through biochemical parameters, histological classification and NMR profiling. Results Biochemical markers, pro-inflammatory cytokines and kidney injury biomarkers differed significantly (P < 0.05) between control and experimental groups. Histology revealed that as damage progressed, the degree of tubular injury increased, and the inflammatory infiltrate was more evident. NMR metabolomics and chemometrics revealed differences in urinary metabolites associated with CKD progression. The main physiological pathways affected were those involved in energy production and amino-acid metabolism, together with organic osmolytes. These data suggest that multiple administrations of FA induce a reproducible model of the induction of CKD. This model could help to evaluate new strategies for nephroprotection that could be applied in the clinic.

scholarly journals Investigation of hallmarks of carbonyl stress and formation of end products in feline chronic kidney disease as markers of uraemic toxins

2018 ◽  
Vol 21 (6) ◽  
pp. 465-474 ◽  
Author(s):  
Emanuela Valle ◽  
Liviana Prola ◽  
Diana Vergnano ◽  
Roberta Borghi ◽  
Fiammetta Monacelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Advanced Oxidation ◽  
Treated Group ◽  
Control Group ◽  
Advanced Oxidation Protein Products ◽  
Significant Difference ◽  
End Products

Objectives Cats are commonly affected by chronic kidney disease (CKD). Many reactive carbonyl intermediates and end products originating from the oxidative stress pathways are recognised as uraemic toxins and may play a role in CKD progression. The aim of the present study is to confirm whether carbonyl end-product formation is higher in cats affected by CKD and to assess whether an angiotensin-converting enzyme inhibitor (ACEi) might affect these hallmarks. Methods Twenty-two cats were divided into three groups: a control group (CG), cats with CKD and cats with CKD treated with an ACEi. Serum levels of pentosidine, carboxymethyllysine, advanced oxidation protein products, malondialdehyde, methylglyoxal and hexanoyl-lysine were measured. In addition, biochemical parameters and systolic blood pressure were evaluated. After checking for normality, comparisons between groups were performed followed by multiple comparison tests. P values ⩽0.05 were considered significant. Correlations between concentrations of the considered biomarkers and of the other metabolic parameters were investigated. Results Advanced oxidation protein products, malondialdehyde and hexanoyl-lysine concentrations were significantly higher in CKD and ACEi-treated groups compared with the CG ( P <0.05). Carboxymethyllysine increased in the ACEi-treated group when compared with the CG, whereas intermediate values of these biomarkers were found in the CKD group ( P <0.05). The ACEi-treated group showed the highest values of carboxymethyllysine, advanced oxidation protein products and hexanoyl-lysine. By contrast, the CKD group had the highest concentration of malondialdehyde. No statistically significant difference was found in the levels of pentosidine or methylglyoxal. End products correlated with creatinine and urea and with each other. Conclusions and relevance Significantly high concentrations of both intermediate and end products of carbonyl/oxidative stress were detected in CKD cats. This is the first study to have concurrently taken into account several uraemic toxins and biochemical parameters in cats affected by CKD.

PO5-2: Serum prolactin level in chronic kidney disease

2014 ◽  
Vol 24 ◽  
pp. S52
Author(s):  
O. Vasilkova ◽  
M. Szhmailik ◽  
K. Zekenova ◽  
T. Mokhort
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Prolactin Level ◽  
Serum Prolactin ◽  
Serum Prolactin Level

scholarly journals Effect of ADMA levels on severity of erectile dysfunction in chronic kidney disease and other risk factors

2016 ◽  
Vol 10 (1-2) ◽  
pp. 41 ◽  
Author(s):  
Kaan Gökçen ◽  
Hakan Kılıçarslan ◽  
Burhan Coşkun ◽  
Alparslan Ersoy ◽  
Onur Kaygısız ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Erectile Dysfunction ◽  
Kidney Disease ◽  
Erectile Function ◽  
Serum Prolactin ◽  
Control Group ◽  
Total Testosterone ◽  
Group 2 ◽  
And Control ◽  
Group 1

Introduction: Hormonal, neurogenic, vasculogenic, and psychogenic impairments, as well as endothelial dysfunction may play a role in erectile dysfunction (ED) in patients with chronic kidney disease (CKD). Asymmetrical dimethylarginine (ADMA) is an inhibitor of nitric oxide, which is the key element of ED. ADMA levels are increased in CKD. We aimed to evaluate the effect of serum ADMA, prolactin, testosterone, and hemoglobin levels on erectile function of patients with CKD and control subjects.Methods: A total of 42 men with CKD and 25 age-matched controls were enrolled. The patients with CKD were categorized into group 1 and group 2 based on whether they had ED according to their response to International Index of Erectile Function questionnaire (IIEF-EFD). Group 3 was a control group. Serum ADMA, total testosterone prolactin, and hemoglobin levels of the patients were evaluated.Results: Serum ADMA, testosterone, and hemoglobin levels were similar between group 1 and 2, serum prolactin level was significantly high in group 1 than in group 2 or 3 (control group). There was no correlation between ADMA levels and IIEF-EFD scores of patients with CKD.Conclusions: The results of this study suggest serum ADMA level is not related with ED in patients with CKD. Also, low testosterone and hemoglobin levels were not significant factors. High levels of serum prolactin are related with ED in patients with CKD.

scholarly journals The Effect of Vitamin E and PMSG Treatment during Breeding Season on some Biochemical Parameters and Reproductive Trails for two Breeds of Sheep

2017 ◽  
Vol 30 (2) ◽  
pp. 83-90
Author(s):  
Waleed Y. Kassim
Keyword(s):  
Vitamin E ◽  
Breeding Season ◽  
Biochemical Parameters ◽  
Treated Group ◽  
Serum Prolactin ◽  
Control Group ◽  
Control Groups ◽  
College Of Agriculture ◽  
Zinc Concentrations ◽  
Prolactin Hormone

This study was conducted in the animal field of College of Agriculture, University of Basrah from 17 May to 15 October 2015, to investigate the influence of treatment of vitamin E and PMSG during breeding season on some biochemical parameters and reproductive characteristics in sheep. A total of 48 ewes included 24 Arabi and 24 Najdi, ewes from each breed were divided randomly into two groups, 12 ewes as control group and 12 ewes as treatment group with vitamin E and PMSG. The results showed an improving the weights at pre-parturition and post-parturition, twice percentage and placenta characteristics in treated group for each breeds compared with control groups. The fertility was high in Arabi treated group in comparison with Najdi breed. However, Najdi was significant improved in placenta characteristics in comparison with Arabi breed. Glucose, vitamin C and zinc concentrations in serum were significant increase in serum during post-parturition in both two breeds. Serum prolactin hormone concentration significant decreased during breeding and pre- parturition periods compared with post-parturition in both two breeds. Arabi ewes showed a significant increase in glucose allantois fluid and a significant decrease in cholesterol allantois fluid compared with Najdi ewes.

scholarly journals Comparative study of renal function test and thyroid hormone in chronic kidney disease

2020 ◽  
Vol 8 (6) ◽  
pp. 427-431
Author(s):  
Nitesh Singhal ◽  
◽  
Dr. R.D. Mathur ◽  
Dr. Ajay Kumar Bhargava ◽  
Dr. Deepak Gupta ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Thyroid Hormone ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Serum Urea ◽  
Function Test ◽  
Healthy Control

Introduction: Biochemical parameters (urea, creatinine, uric acid, T3, T4, TSH) important inprognosis, monitoring of thyroid dysfunction, and chronic kidney disease. The present study wasattempted to analyze these parameters in CKD patients and a healthy control group. Materials andmethods: Fifty healthy control and 5o were chronic kidney disease subjects were taken serum urea,creatinine uric acid analyzed on the auto analyzer and T3, T4, TSH estimated on immunoassayanalyzer. Ethical permission was taken from the institutional ethical committee. Results: Level ofurea, creatinine, uric acid, and thyroid hormone T3, T4, TSH were found to be significant in thepresent study when compared with the control group. (Þ<0.0001). Conclusion: It was observedthat levels of urea, creatinine, uric acid, and T3, T4, TSH deranged value found in chronic kidneydisease subjects.

scholarly journals The effects of aerobic exercise on biochemical parameters in individuals with CKD on hemodialysis: A longitudinal study

2020 ◽  
Vol 30 (2) ◽  
pp. 251-259
Author(s):  
Fabiano Santana de Oliveira ◽  
Mauro José De Deus Morais ◽  
Luiz Carlos De Abreu ◽  
Andrés Ricardo Pérez-Riera ◽  
Vitor E. Valenti ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Alanine Aminotransferase ◽  
Biochemical Parameters ◽  
Blood Parameters ◽  
Control Group ◽  
Post Exercise ◽  
Before And After ◽  
Registration Date

Background: Chronic kidney disease is directly related to cardiovascular disorders. Guided physical exercises significantly improve the adverse effects of dialytic treatment. Objective: To analyze changes in biochemical parameters of subjects with chronic kidney disease undergoing moderate exercise during hemodialysis. Methods: This is an experimental study composed of 54 subjects submitted to hemodialysis, split into a control group and a group with intervention. The experimental group underwent three weekly sessions of aerobic exercise, performed during hemodialysis sessions, with a duration of 30 minutes, for 12 weeks. The blood parameters of both groups were compared. Results: Statistically significant differences were observed between pre (p=0.001) and post-exercise protocol for urea (p=0.006), calcium (p=0.001), alanine aminotransferase (p=0.020) and sodium (p=<0.001). In the control group, we observed significant differences for the calcium variable (p<0.001), alanine aminotransferase (p=0.024), hematocrit (p=0.015), calcium vs phosphorus (p=0.018), and sodium (p=0.023), before and after the period. Conclusion: Aerobic training during hemodialysis was able to maintain blood level stability in patients with chronic kidney disease, both during and at the end of the protocol, even considering increased blood flow. This trial is registered in the Brazilian registry of clinical Trials - number RBR-7354r6. Registration date: July 5, 2018 at 12:59 PM. Last Update: July 24, 2018 at 10:24 AM. Identification of the test - UTN Number: U1111-1216-8272.

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