scholarly journals The Cholesterol Lowering Effects of Eurycoma longifolia Jack (Tongkat Ali) Root Extract in Male Rats

2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Ghasak G Faisal ◽  
Ghazi F Najmuldeen ◽  
Zurainie Abllah ◽  
Ali S Radeef
Keyword(s):  
Male Rats ◽  
Root Extract ◽  
Cholesterol Lowering ◽  
Eurycoma Longifolia ◽  
Eurycoma Longifolia Jack

scholarly journals Changes in Leptin in Relation to Increased Testosterone Levels Associated with Eurycoma Longifolia Jack (Tongkat Ali) Root Extract Consumption in Male Rats

2017 ◽  
Vol 9 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Ghasak Ghazi Faisal ◽  
Mainul Haque ◽  
Ghazi Faisal Najmuldeen ◽  
Basma Ezzat Al-Ahmad ◽  
Ali Sabri Radeef ◽  
...  
Keyword(s):  
Male Rats ◽  
Root Extract ◽  
Testosterone Levels ◽  
Eurycoma Longifolia ◽  
Eurycoma Longifolia Jack

scholarly journals PENGARUH PEMBERIAN EKSTRAK AKAR PASAK BUMI (EURYCOMA LONGIFORA JACK) TERSTANDAR TERHADAP GAMBARAN HISTOPATOLOGIK TESTIS TIKUS WISTAR

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Condro Suro Miyarso ◽  
Tri Cahyani Widiastuti ◽  
Naelaz Zukhruf Wakhidatul Kiromah
Keyword(s):  
Body Weight ◽  
Testosterone Level ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Histopathological Changes ◽  
Group Iii ◽  
Eurycoma Longifolia ◽  
Group I ◽  
Eurycoma Longifolia Jack

The root of pasak bumi (Eurycoma longifolia, Jack) is one of plant from Indonesia known as aphrodisiac. The study about its standardized extract as aphrodisiac was show increasing libido, testosterone level, FSH and LH on male rats. This study was conducted to evaluate testosterone level and histopathological changes of the testes of male rats of standardized extract of pasak bumi root. There are 50 old male rats which ages 3-4 months old divided to five groups. Group I as negative control was administered aquadestilata. Group II as positive control was administered testosterone (Andriol®). Group III, IV and V ware given standardized extract of pasak bumi root at the dose 50, 100 and 200 mg/kg body weight Respectively. The extract was given orally twice a day for six days and forty nine days and then the testes was taken out on 7th and 50th day. The histopathological of the testes was evaluated using quantitative parameter by the presence of testes weight, number and diameter of Leydig cells. Testosterone level was taken on 7th and 50th day used ELISA method. The results were analyzed using parametric test, one way ANOVA (P<0,05), post hoc Dunnet (2-sided) (P < 0,05). The result of this study shows that the standardized extract of pasak bumi root was not effect on histopathological changes of the testes but it could increased the level of testosterone m at the dose 100 and 200 mg/kg body weight.  Key word : Eurycoma longifolia, Jack, aphrodisiac, histopathological testes testosteron

scholarly journals The Cytotoxic Effect of Eurycoma longifolia Jack Root Extract on The Prostate Adenocarcinoma PC-3 Cells through Apoptosis Enhancement

2020 ◽  
Vol 8 (A) ◽  
pp. 317-322
Author(s):  
Eka Yudha Rahman ◽  
Kusworini Kusworini ◽  
Mulyohadi Ali ◽  
Basuki Bambang Purnomo ◽  
Nia Kania
Keyword(s):  
Prostate Cancer ◽  
Prostate Adenocarcinoma ◽  
Root Extract ◽  
Active Compounds ◽  
Eurycoma Longifolia ◽  
Subject Examination ◽  
Adenocarcinoma Cells ◽  
Significant Difference ◽  
Eurycoma Longifolia Jack ◽  
Common Malignancy

BACKGROUND: Prostate cancer is the second most common malignancy in men and has become the sixth leading cause of death in males worldwide. Eurycoma longifolia Jack root has active compounds, namely, quassinoids, eurycomanone, and canthine, which have potential as detoxicants, free radical antioxidants, and anticancer. AIM: This study aimed to analyze the potential of the active compounds in E. longifolia Jack root in induce apoptosis in the prostate adenocarcinoma PC-3 cells. METHODS: E. longifolia root active compounds were obtained by extracting them using ethanol solvent. The culture of prostate cancer PC-3 cell line was obtained from androgen-independent prostate adenocarcinoma with bone metastasis use as subject. Examination of the potency of E. longifolia root extract was conducted by observing the cells undergoing apoptosis with TUNEL assay. RESULTS: One-way ANOVA test showed that the increase in apoptotic cells was associated proportionally with the concentration levels of E. longifolia root extract and showed a significant difference (α < 0.05). CONCLUSION: The higher the dose of E. longifolia root extract, the higher will be the apoptotic level of adenocarcinoma cells PC3. E. longifolia extract is potentially used in the treatment of prostate cancer by inducing apoptotic mechanisms.

scholarly journals In Vitro Antibacterial Activity of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Faisal GG ◽  
Zakaria SM ◽  
Najmuldeen GF
Keyword(s):  
Antibacterial Activity ◽  
Ethanolic Extract ◽  
Inhibition Zone ◽  
Root Extract ◽  
Bacterial Strains ◽  
Gram Positive ◽  
Eurycoma Longifolia ◽  
Herbal Plants ◽  
Eurycoma Longifolia Jack

Introduction: Currently, researchers are aiming to explore herbal plants to replace synthetic drugs because herbal plants contain high active compounds and fewer side effects. Our study was done to determine the antibacterial activity of Eurycoma longifolia Jack (E. longifolia) root using ethanol based extract. Methods: Five types of pathogenic bacterial strains were used; Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa). Disc diffusion assay and Minimum Inhibitory Concentration (MIC) tests were used to determine the inhibition zone and turbidity of suspension which reflects the antibacterial activity of the extract. Results: The ethanolic extract of E. longifolia Jack root extract showed positive results against Gram-positive bacteria (S. aureus and B. cereus) and Gramnegative (S. typhi). B.cereus and S.typhi showed inhibition zone values of 11.76mm and 14.33mm at the extract concentration of 150mg/ml that were higher than the positive control values (9.00, 12.67mm) respectively. However, E. coli and P. aeruginosa did not show any inhibition by the ethanol-based extract. Conclusion: From the results we can conclude that E.Longifolia root extract possesses antibacterial activity that can be further explored to produce new medicinal products.

423. Effects of Eurycoma longifolia Jack on spermatogenesis and sperm counts of male rats treated with oestradiol

2008 ◽  
Vol 20 (9) ◽  
pp. 103
Author(s):  
A. Norhazlina ◽  
A. Wan Nurul Heriza ◽  
M. Norfilza ◽  
P. Moratv
Keyword(s):  
Cell Count ◽  
Sperm Count ◽  
Treated Group ◽  
Spermatogenic Cell ◽  
Male Rats ◽  
Control Group ◽  
Root Extract ◽  
Healthy Male ◽  
Eurycoma Longifolia ◽  
Sperm Counts

Eurycoma longifolia has been known for its aphrodisiac effects in male. Our previous study showed that with the dosage of 8 mg/kg bodyweight (BW) Eurycoma longifolia root extract increased plasma total testosterone levels in male rats when given for 14 days. Oestrogen is a potent inhibitor for testosterone production and spermatogenesis. The aim of the present study is to determine the effects of Eurycoma longifolia (8 mg/kg BW) on the spermatogenic cell count and sperm count of testosterone-suppressed male rats. Adult male Sprague-Dawley healthy male rats weighed 200–250 g were treated with, either control vehicle (no active ingredients given), oestradiol (500 mg/kg BW), Eurycoma longifolia (8 mg/kg BW) or combination of Eurycoma longifolia and oestradiol for fourteen consecutive days. Results showed that sperm count and spermatogenic cell count were increased in Eurycoma longifolia treated group compared with control group (P < 0.05) and to oestradiol treated group (P < 0.05). While in oestradiol treated group, sperm count and spermatogenic cell count were reduced significantly (P < 0.05) compared with control group. Combination of Eurycoma longifolia and oestradiol did not affect sperm count and spermatogenic cell count when compared with control group but they were significantly increased compared with oestradiol treated group (P < 0.05). Thus, the study has shown that Eurycoma longifolia is potentially capable to suppress harmful effects of oestradiol on spermatogenesis and sperm counts in healthy male rats when given for fourteen consecutive days.

scholarly journals Increase in Bcl2 expression of penile and prostate cells of Sprague Dawley male rats following treatment with buceng (combination of Pimpinella alpina molk with Eurycoma longifolia Jack)

2015 ◽  
Vol 24 (1) ◽  
pp. 8-13
Author(s):  
Taufiqurrachman Nasihun
Keyword(s):  
Male Rats ◽  
Sprague Dawley ◽  
Significance Level ◽  
Eurycoma Longifolia ◽  
Sprague Dawley Rats ◽  
Group A ◽  
Eurycoma Longifolia Jack ◽  
Group B ◽  
Per Oral ◽  
Bcl2 Expression

Background: Treatment with buceng combination of Eurycoma longifolia Jack and Pimpinella alpine Molk has been proven to increase testosterone level, decrease apoptosis and caspase3 expression. Bcl2 is an antiapoptotic protein found in cytoplasm which inhibits cells apoptosis. This study was aimed to investigate the effect of buceng on Bcl2 expression on penile and prostate tissues of the rats. Methods: In this experimental study, 24 male Sprague Dawley rats of 90 days old, weighing ± 300 grams, were randomly assigned into four groups. Group A, normal rats. Group B, castrated rats and treated with buceng 100 mg/day, per oral (Cast-Bcg); Group C, castrated rats and treated with 2 ml of water as placebo against buceng (Cast-Plac). Group D, castrated rats, treated with mesterolone 6.75 mg/day, per oral, as exogenous testosterone (Cast-Mest). All rats were treated for 30 days. Manova test was used to analyze the different expression of Bcl2 among groups with significance level at p ≤ 0.05. Results: Castration was associated with significant decrease of Bcl2 expression in the penile and prostate tissues (53.0 and 50.9%, respectively) compared to normal rats (82.6 and 84.2%, respectively, p < 0.001). Treatment with mesterolone reversed Bcl2 expression (77.1 and 78.1%) to a near normal level. The same level of Bcl2 expression was also observed with buceng treatment (73.8 and 78.2%).Conclusion: The treatment with buceng could enhance Bcl2 expression in penile and prostate tissues, comparable to normal rats and mesterolone treated rats.

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