scholarly journals Risk Assessments of Aspartame, Acesulfame K, Sucralose and Benzoic Acid from Soft Drinks, “Saft”, Nectar and Flavoured Water

2020 ◽  
pp. 66-68
Author(s):  
Inger-Lise Steffensen ◽  
Jan Alexander ◽  
Mona-Lise Binderup ◽  
Ellen Merete Bruzell ◽  
Knut Helkås Dahl ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Food Safety ◽  
Benzoic Acid ◽  
Food Additives ◽  
Age Groups ◽  
Daily Intake ◽  
Average Concentration ◽  
Soft Drinks ◽  
The Other ◽  
Average Content

The Norwegian Scientific Committee for Food Safety (Vitenskapskomiteen for mattrygghet, VKM), Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food and Cosmetics, has at the request of the Norwegian Food Safety Authority (Mattilsynet) conducted a risk assessment of the intense sweeteners aspartame, acesulfame K and sucralose and the preservative benzoic acid from soft drinks, “saft”, nectar and flavoured water.  The risk assessment includes exposure assessments and the calculated exposures are compared to the acceptable daily intake (ADI) for the respective sweeteners and benzoic acid. VKM was also requested to compare the current calculated intake of aspartame, acesulfame K and benzoic acid to the calculated intake reported by VKM in 2007 (from the VKM report «Impact on health when sugar is replaced with intense sweeteners in soft drinks, «saft» and nectar») (VKM, 2007). Exposure calculations were made for four different scenarios with varying concentrations of added sweeteners (either the average concentration or the highest reported concentration for the respective sweetener) and varying consumption of beverages with sweeteners (either the actual reported consumption of beverages added sweetener or the assumption that all reported beverages were added sweeteners). Scenario 1 gives the best estimate of the current situation in the population (average content  of sweeteners/benzoic acid, actual reported consumption), scenarios 2-4 is based on one or both of the following assumptions: only beverages added sweeteners are consumed, the beverages consumed are added the highest reported value of the sweeteners (scenario 2: average content of sweeteners/benzoic acid, all consumed beverages contain sweeteners; scenario 3: highest reported content of sweeteners/benzoic acid, actual reported consumption; scenario 4: highest reported content of sweeteners/benzoic acid, all consumed beverages contain sweeteners).   In the current risk assessment, the intake of sweeteners and benzoic acid for two-year-old children and 18-70 year old men and women were calculated. Due to lack of new dietary surveys, the other age groups of children and adolescents were excluded. The estimated intake of aspartame, acesulfame K and sucralose was below the ADI for all age groups, both for mean and high consumers in all scenarios. When it comes to benzoic acid, the calculated mean and high intake for adults was below the ADI in all scenarios. The mean intake for 2year-olds was below ADI in all scenarios, as was the intake for high consumers among the 2year-olds in scenarios 1 and 2. However, high consumers among the two-year-old children in scenario 3 and 4 reached the ADI. Due to differences in the way the calculations were done in the current opinion and in 2007, it was not possible to compare the current calculated intake of aspartame, acesulfame K and benzoic acid to the calculated intakes reported by VKM in 2007. VKM concludes that for all age groups in all scenarios the intake of sweeteners is well below the established ADI values, thus, there is no concern related to the intake of the sweeteners aspartame, acesulfame K or sucralose. VKM further concludes that the benzoic acid intake in 2-year-old-children, in scenarios 3 and 4, is of concern as it reaches ADI for high consumers of soft drinks, “saft” and flavoured water, although the ADI is not a threshold for toxicity. For the other age groups, there is no concern related to the intake of benzoic acid from beverages. However, it should be noted that a considerable intake of benzoic acid also is expected from other sources such as food and cosmetics. High consumers of soft drinks, “saft” or flavoured water in all age groups could be at risk for approaching or exceeding ADI if the exposures from foods are taken into account. This is especially of concern for 2-year-old children, since high consumers of soft drinks and “saft” already have reached the ADI. 

scholarly journals Az intenzív édesítőszerek biztonságossága

2016 ◽  
Vol 157 (Supplement 1) ◽  
pp. 14-28 ◽  
Author(s):  
Andrea Lugasi
Keyword(s):  
Risk Assessment ◽  
Food Safety ◽  
Coming Out ◽  
Food Additives ◽  
The Other ◽  
Assessment Procedure ◽  
Daily Consumption ◽  
Low Calorie ◽  
Eu Legislation ◽  
Food Law

Nowadays low calorie or intesive sweeteners are getting more and more popular. These sweeteners can be placed to the market and used as food additives according to the recent EU legislation. In the meantime news are coming out one after the other stating that many of these artificial intensive sweeteners can cause cancer – the highest risk has been attributed to aspartam. Low calorie sweeteners, just like all the other additives can be authorized after strickt risk assessment procedure according to the recent food law. Only after the additive has gone through these procedure can be placed to the list of food additives, which contains not only the range of food these additives can be used, but also the recommended highest amount of daily consumption. European Food Safety Authority considering the latest scientific examination results, evaluates regularly the safety of sweeteners authorized earlier. Until now there is no evidence found to question the safety of the authorized intensive sweeteners. Orv. Hetil., 2016, 157(Suppl. 1), 14–28.

Contents and Risk Assessment of Heavy Metals in Marine Invertebrates from Korean Coastal Fish Markets

2014 ◽  
Vol 77 (6) ◽  
pp. 1022-1030 ◽  
Author(s):  
JONG SOO MOK ◽  
JI YOUNG KWON ◽  
KWANG TAE SON ◽  
WOO SEOK CHOI ◽  
SUNG RIM KANG ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Risk Assessment ◽  
Marine Invertebrates ◽  
Marine Invertebrate ◽  
Food Additives ◽  
Daily Intake ◽  
Hazard Index ◽  
Human Consumption ◽  
Expert Committee ◽  
Consumer Safety

The concentrations of the heavy metals cadmium (Cd), mercury (Hg), lead (Pb), chromium, silver, nickel, copper, and zinc in the edible portions of 105 marine invertebrates representing 16 mollusk and crustacean species were accurately determined to evaluate their hazard for human consumption. The samples were collected in 2011 from major fish markets on the coast of Korea and analyzed for Hg using a direct Hg analyzer and for other metals using inductively coupled plasma mass spectrometry. Estimated dietary exposure (EDE) was determined, and a risk assessment was made of the heavy metals to provide information concerning consumer safety. The Cd concentrations, which were the highest for the three hazardous metals (Cd, Hg, and Pb), were significantly higher (P < 0.05) in the bivalves and crabs than in the gastropods and cephalopods. However, the concentrations of these metals in all samples were within the regulatory limits set by Korea and other countries. The EDE was compared with the provisional tolerable daily intake (PTDI) adopted by the Joint FAO/WHO Expert Committee on Food Additives or the U.S. Environmental Protection Agency. The EDE of Cd, Hg, and Pb for each class of marine invertebrate were 0.07 to 2.64, 0.01 to 0.43, and 0.001 to 0.16% of the PTDI, respectively. The total EDE of Cd, Hg, and Pb for marine invertebrates accounted for 4.03, 0.96, and 0.21%, respectively, of the PTDI. The EDE of other metals in each class of marine invertebrate was less than 2% of the PTDI. The hazard index is a reasonable parameter for assessing the risk of heavy metal consumption associated with contaminated food. In the present study, the hazard index for all of the species was less than 1.0, which indicates that the intake of heavy metals from consumption of these marine invertebrates does not represent an appreciable hazard to humans.

scholarly journals Non-Carcinogenic Health Risk Assessment due to Fluoride Exposure from Tea Consumption in Iran Using Monte Carlo Simulation

2019 ◽  
Vol 16 (21) ◽  
pp. 4261 ◽  
Author(s):  
Mohammad Amin Karami ◽  
Yadollah Fakhri ◽  
Shahabaldin Rezania ◽  
Abdol Azim Alinejad ◽  
Ali Akbar Mohammadi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Environmental Protection Agency ◽  
Hazard Quotient ◽  
Age Groups ◽  
Fluoride Concentration ◽  
Daily Intake ◽  
Carcinogenic Risk ◽  
Fluoride Exposure

Excessive intake of fluoride can cause adverse health effects. Consumption of tea as a popular drink could be a potential source of fluoride exposure to humans. This research aimed to evaluate the fluoride concentration in tea among the Iranian people using the available data in the literature and to assess the health risk related to the consumption of tea in men, women, and children. The health risk assessment was conducted using the chronic daily intake and hazard quotient according to the approach suggested by the Environmental Protection Agency. The fluoride content in published studies varied noticeably, ranging from 0.13 to 3.27 mg/L. The results revealed that the hazard quotient (HQ) in age groups of women (21–72 years) and children (0–11 years) was within the safe zone (HQ < 1) which showed that there was no potential of non-carcinogenic risk associated with drinking tea in these groups. However, in one case of the men (21–72 years), the HQ > 1 which shows a probable risk of fluorosis. The order of non-carcinogenic health risks in the studied groups was in the order of men > women > children. The results of this can be useful for organizations with the responsibility of human health promotion.

scholarly journals Public Health and Paediatric Risk Assessment of Aluminium, Arsenic and Mercury in Infant Formulas Marketed in Nigeria

2020 ◽  
Vol 20 (1) ◽  
pp. 63 ◽  
Author(s):  
Zelinjo N. Igweze ◽  
Osazuwa C. Ekhator ◽  
Ify Nwaogazie ◽  
Orish E. Orisakwe
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Food Additives ◽  
Daily Intake ◽  
The Body ◽  
World Health ◽  
Expert Committee ◽  
Infant Formulas ◽  
Tolerable Daily Intake ◽  
Potentially Toxic Metals

Objectives: Infant formulas are useful alternatives to breast milk in many circumstances but may pose health risks to infants and children due to contamination by potentially toxic metals. This study aimed to determine the aluminium, arsenic and mercury concentrations and carry out an exposure health risk assessment in commonly consumed infant formulas in Nigeria. Methods: Different brands of both locally manufactured and imported infant formulas were purchased in March 2017 from stores in Port Harcourt, Nigeria. Analysis of metals in the samples was performed by atomic absorption spectrophotometry. The health risk was assessed by comparing estimated daily intake of aluminium, arsenic and mercury with the provisional tolerable daily intake acceptable by the Joint Food and Agricultural Organization/World Health Organization Expert Committee on Food Additives (JECFA). Results: A total of 26 infant formulas were analysed. The levels of arsenic were higher in cereal-based formulas compared to milkbased formulas, but the difference was not significant (P >0.05). The intake levels of aluminium, arsenic and mercury in infant formulas were found to be 8.02–14.2%, 437.1–771% and 23.7–41.8% of the provisional tolerable daily intake JECFA threshold values, respectively. Conclusion: Commonly consumed infant formulas in Nigeria may add to the body burden of arsenic in children.Keyword: Infant Formulas; Toxicity Test; Aluminum; Arsenic; Mercury; Health Risk Appraisal; Child Health; Nigeria.

scholarly journals Estimation of daily intake of polychlorinated biphenyls not similar to dioxins (NDL-PCB) from fish consumption in Spain in different population groups

2018 ◽  
Vol 21 (16) ◽  
pp. 2959-2968 ◽  
Author(s):  
Maria Morales-Suárez-Varela ◽  
Nuria Lopez Santana ◽  
Pedro Marti Requena ◽  
Mª Isabel Beser Santos ◽  
Isabel Peraita-Costa ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Fish Consumption ◽  
Age Groups ◽  
Daily Intake ◽  
Average Concentration ◽  
Spanish Population ◽  
Tolerance Limits ◽  
Population Groups ◽  
Fish Samples ◽  
Nutritional Benefits

AbstractObjectiveTo assess the daily intake of polychlorinated biphenyls not similar to dioxins (NDL-PCB) derived from fish consumption in Spain and compare it with tolerance limits in order to establish a safe threshold so that the nutritional benefits derived from fish consumption may be optimized.DesignAnalysis of NDL-PCB in fish samples and ecological study of the estimated intake of NDL-PCB from fish consumption in different Spanish population groups.SubjectsNational representative sample of the Spanish population.ResultsThe intake of NDL-PCB was estimated in two different scenarios: upper bound (UB) and lower bound (LB). Estimating intake using the average concentration of NDL-PCB found in the fish samples, the intake for ‘other children’ is estimated as: 1·80 (UB) and 5·33 (LB) ng/kg per d at the 50th percentile (P50); 7·39 (UB) and 21·94 (LB) ng/kg per d at the 95th percentile (P95) of fish consumption. Estimated NDL-PCB intake shoots up in the toddler group, reaching values of 30·43 (UB) and 90·37 (LB) ng/kg per d at P95. Estimated intake values are lower than those previously estimated in Europe, something expected since in previous studies intake was estimated through total diet. In adults, our estimated values are 1·59 (UB) and 4·72 (LB) ng/kg per d at P50; 4·95 (UB) and 14·72 (LB) ng/kg per d at P95.ConclusionsNDL-PCB concentration in fish is under the tolerance limits in most samples. However, daily intake in consumers of large quantities of fish should be monitored and special attention should be given to the youngest age groups due to their special vulnerability and higher exposure.

scholarly journals Occurrence and Risk Assessment of Fumonisin B1 and B2 Mycotoxins in Maize-Based Food Products in Hungary

Toxins ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 709 ◽  
Author(s):  
Andrea Zentai ◽  
Mária Szeitzné-Szabó ◽  
Gábor Mihucz ◽  
Nóra Szeli ◽  
András Szabó ◽  
...  
Keyword(s):  
Food Additives ◽  
Daily Intake ◽  
Fumonisin B1 ◽  
Food Products ◽  
Average Concentration ◽  
Expert Committee ◽  
Food Category ◽  
Potential Health ◽  
Dietary Record ◽  
Two Samples

Fumonisins are toxic secondary metabolites produced mainly by Fusarium verticillioides and Fusarium proliferatum. Their toxicity was evaluated, and health-based guidance values established on the basis of both Joint FAO/WHO Expert Committee on Food Additives (JECFA) and European Food Safety Authority (EFSA) recommendations. This study presents the results of fumonisin analyses in different maize- and rice-based food products in Hungary and the potential health risk arising from their dietary intake. In total, 326 samples were measured in 2017 and 2018 to determine fumonisins B1 and B2 levels. Three-day dietary record data were collected from 4992 consumers, in 2009. For each food category, the average concentration values were multiplied by the relevant individual consumption data, and the results were compared to the reference values. With respect to the maximum limits, one maize flour, two maize grits, and two samples of other maize-based, snack-like products had total fumonisin content minimally exceeding the EU regulatory limit. The mean daily intake for all maize-product consumers was 0.045–0.120 µg/kg bw/day. The high intake (95 percentile) ranged between 0.182 and 0.396 µg/kg bw/day, well below the 1 µg/kg bw/day tolerable daily intake (TDI) established by EFSA. While the intake calculations resulted in comforting results, maize-based products may indeed be contaminated by fumonisins. Therefore, frequent monitoring of fumonisins’ levels and evaluation of their intakes using the best available data are recommended.

scholarly journals UJI KADAR SAKARIN PADA MINUMAN RINGAN BERMEREK YANG BEREDAR DI KOTA PEKANBARU

2018 ◽  
Vol 3 (1) ◽  
pp. 14-17
Author(s):  
Karolina Rosmiati
Keyword(s):  
Random Sampling ◽  
Soft Drink ◽  
Food Additives ◽  
Daily Intake ◽  
Soft Drinks ◽  
Manufacturing Industries ◽  
Artificial Sweetener ◽  
Green Fluorescence ◽  
Plastic Packaging ◽  
Qualitative Test

Food addtives plays an important role in the production of  beverages to improve the quality, taste and shelf life of beverages products significantly. Saccharin is widely used as artificial sweetener in soft drinks manufacturing industries, including branded soft drinks with plastic packaging. The purpose of this research was to determine the levels of saccharin in branded soft drinks with plastic packaging sold at Pasar Kodim Pekanbaru. The samples were collected by purposive random sampling. five samples were analyzed by qualitative test using resorcinol reagent and quantitative test with alkalimetric titration methods. The qualitative test showed that all  samples were positive for saccharin indicated by the changes of color turning green fluorescence. The level of saccharin in the samples ranged between 160 – 580 mg/kg of ingredients. The higest  levels of saccharin (580 mg/kg) was assayed in sample E, and the smallest level ( 160 mg/kg)was assayed in sample B and C. According to Permenkes no.722/Menkes/Per/IX/1988 concerning food additives, maximal saccharin levels allowed in soft drink was 300 mg/kg of ingredients or 5 mg/kg of body weight. Only one sample (sample E) exceeded the limit of maximal saccharin levels allowed in soft drink. Samples A, B, C, dan D that had been tested could be considered as safe to be consumed, but the daily intake should be in caution.    

scholarly journals Assessment of Benefits and Risks of Probiotics in Processed Cerealbased Baby Foods Bifidobacterium Lactis Bb12

2021 ◽  
pp. 58-60
Author(s):  
Ragnhild Halvorsen ◽  
Judith Narvhus ◽  
Jørgen Lassen ◽  
Tore Midtvedt ◽  
Jarle Rugtveit ◽  
...  
Keyword(s):  
Small Intestine ◽  
Immune System ◽  
Food Safety ◽  
Health Effects ◽  
Age Groups ◽  
Daily Intake ◽  
Positive Health ◽  
Bifidobacterium Lactis ◽  
Small Children ◽  
Baby Foods

The Norwegian Scientific Committee for Food Safety (VKM) has appointed an ad hoc-group of experts to answer a request from the Norwegian Food Safety Authority regarding benefit and risk assessment of B. lactis Bb12 in baby foods focusing on the age groups 4-6 months, 612 months and 1-3 years. This assessment is based on the literature provided by the notifier as well as that found by a MEDLINE search.    An notification for use of processed cereal-based baby foods (from now on called cereals) intended for infants and small children supplemented with the microorganism Bifidobacterium lactis (B. lactis) Bb12 in Norway initiated this work.     Studies of potential hazards and positive health effects from cereals containing B. lactis Bb12 intended for infants and young children have not been reported in the available literature. However, reports on safety of and positive health effects from infant and follow on formula supplemented with B. lactis Bb12 are available and have been assessed by VKM. In most of these clinical studies B. lactis Bb12 was administered in combination with other probiotic strains.   Clinical studies report no serious adverse events of infant formula supplemented with B. lactis Bb12. The effect of long term daily consumption of such supplemented formula by the actual age groups is not known.   A few studies have demonstrated some effect of supplementing baby food with probiotics, including B. lactis Bb12, on diarrhoea and atopic eczema while other studies do not show such effects. Thus, the scientific evidence for a favourable effect of supplementing formula or solid food with B. lactis Bb12, is weak and in some cases lacking.    There are no studies demonstrating a positive effect of cereals supplemented with B. lactis Bb12 intended for infants and small children.   Several health claims related to probiotics have been assessed by EFSA, including claims on reduction of gastro-intestinal discomfort, normal functioning of the alimentary tract, building of the natural intestinal barrier, improvement of the general immunity, mental and cognitive developments of children and immune system of children during growth. In the opinions so far, EFSA has concluded that a cause and effect relationship has not been established between the consumption of the probiotic containing products and the claimed effect. None of the products assessed so far contained B. lactis Bb12 (1 November 2009).   Commercially produced cereals are frequent given to infants and small children in Norway from an early age and this is particularly important for the establishment of the intestinal bacterial flora and the development of the intestinal mucosal immune system. According to the notifier, one portion (25gram) of the cereal powder contains 1 x 109 B. lactis Bb12 in monoculture. Taking into consideration that the daily intake is often greater than one portion of cereals, even in infants below 6 months of age, this would represent a daily intake of 1-2 x 109 cfu B. lactis Bb12 for an infant 4-6 months and even more in infants above 6 months. If a considerable amount of the B. lactis Bb12 survives the transport to the small intestine, it would represent a dominating and monocultural supply, often several times a day, to the small intestine.  The immaturity and vulnerability of the intestinal microbiota and the immune system makes the two lowest age groups, 4 – 6 and 6 – 12 months, at the highest risk of unwanted health effects due to the daily intake of probiotics.  

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