scholarly journals Cutaneous Side Effect of Hydroxurea in a Sickle Cell Anaemia Child-A Case Report

2019 ◽  
pp. 1-6
Author(s):  
A. O. Salako ◽  
S. O. Ogunmefun ◽  
O. W. Aworanti
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Sickle Cell ◽  
Side Effect ◽  
Low Dose ◽  
Sickle Cell Anaemia ◽  
Skin Lesions ◽  
Cutaneous Lesions ◽  
Care Givers ◽  
Cutaneous Side Effect

Background: Hydroxyurea (HU) has redefined the quality of life of children with sickle cell anaemia and their care givers. Despite the acclaimed benefits of HU, the drug could be associated with variable side effects affecting different systems in the human body, including the skin and integuments. The aim of this report is to raise the awareness about the less common side effects of HU. Case Report: A 5-year 8 months old homozygous sickle cell anaemia child presented with pruritic hyperpigmented lesions on the trunk, arms and the legs, four weeks after commencement of HU. HU was initially discontinued for two weeks and thereafter recommenced with a different brand but there was worsening skin lesions despite at a daily low dose of 10 mg/kg. The rashes eventually resolved with low dose once in 3 days HU therapy.  She had recurrent episodes of acute painful crisis; average of three [3] episodes per year warranted hospital admission prior to commencement, but with HU therapy, there has been significant improvement in the crisis. Discussion: Cutaneous lesions are uncommon side effect of hydroxyurea. This side effect is dependent on genetic predisposition and photosensitivity. However, with the established benefit of HU in the management sickle cell anaemia, it is important for the sickle cell experts to continue to monitor closely the children for both the common and rare side effects and to individualize therapy to ensure maximal benefit with minimal or no side effects.

Can low-dose propranolol induce a manic syndrome? Case report of an unexpected side effect

2013 ◽  
Vol 25 (3) ◽  
pp. 184-186 ◽  
Author(s):  
Mahin Eslami Shahrbabaki ◽  
Fariborz Estilaee ◽  
Amir Eslami Shahrbabaki
Keyword(s):  
Single Dose ◽  
Case Report ◽  
Side Effects ◽  
Panic Disorder ◽  
Side Effect ◽  
Adrenergic Receptor ◽  
Low Dose ◽  
Manic Symptoms ◽  
Rare Side Effect ◽  
Adrenergic Antagonists

ObjectivesPropranolol, the first discovered b-adrenergic receptor antagonist, has been prescribed by physicians in various fields for more than three decades. It has been applied for treating psychiatric disorders including schizophrenia, mania and anxiety disorders, as well as for controlling withdrawal symptoms or other side effects.MethodsWe describe the case of an 11-year-old boy with bipolar-I disorder comorbid with panic disorder who developed manic symptoms with a single dose of 10 mg of propranolol.Results and ConclusionAlthough depression is a better-known side effect of b-adrenergic antagonists, clinicians should take mania as a rare side effect into consideration as well.

Skin lesions and G-CSF in patients with malignant diseases. Malignancy or cutaneous side-effect?

1996 ◽  
Vol 32 (3) ◽  
pp. 554-555 ◽  
Author(s):  
A. Loraas ◽  
S.D. Fossa ◽  
S. Franzen ◽  
G. S˦ter ◽  
L. Rode
Keyword(s):  
Side Effect ◽  
Skin Lesions ◽  
Malignant Diseases ◽  
Cutaneous Side Effect

Priapism in sickle cell anaemia: a case report

1991 ◽  
Vol 11 (4) ◽  
pp. 371-372 ◽  
Author(s):  
M. El Mauhoub ◽  
S. El Bargathy ◽  
H. S. Sabharwal ◽  
V. P. Aggarwal ◽  
K. El Warrad
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anaemia

Bilateral profound sudden sensorineural hearing loss presenting a diagnostic conundrum in a child with sickle cell anaemia

2008 ◽  
Vol 123 (7) ◽  
pp. 811-816 ◽  
Author(s):  
A D Mace ◽  
M S Ferguson ◽  
M Offer ◽  
K Ghufoor ◽  
M J Wareing
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sensorineural Hearing Loss ◽  
Sickle Cell ◽  
Cochlear Implantation ◽  
World Literature ◽  
Sickle Cell Anaemia ◽  
Early Recognition ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

AbstractObjective:To present the first published case of a child with bilateral profound sudden sensorineural hearing loss found in association with sickle cell anaemia, and to demonstrate the importance of early recognition, investigation and empirical treatment of sudden sensorineural hearing loss.Method:Case report and review of world literature.Case report:The authors present the case of a seven-year-old child with known sickle cell anaemia, who presented with bilateral profound sensorineural hearing loss developing over a period of five days. There was a history of ophthalmological disease in the preceding weeks, and inflammatory markers were raised. The differential diagnosis included a vaso-occlusive or inflammatory aetiology such as Cogan's syndrome, and treatment for both was instigated. Hearing thresholds did not recover, and the patient underwent cochlear implantation 12 weeks later.Conclusion:Sudden sensorineural hearing loss has a variable aetiology and is rare in children. Immediate treatment for all possible aetiologies is essential, along with targeted investigations and early referral for cochlear implantation if no recovery is demonstrated.

scholarly journals Sickle cell anaemia in vaso-occlusive crisis and acute fatty liver of pregnancy: a case report

2020 ◽  
Vol 54 (3) ◽  
pp. 201-203
Author(s):  
Michael Ezeanochie ◽  
Oghenefegor Olokor ◽  
Ofure Yamah
Keyword(s):  
Case Report ◽  
Fatty Liver ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Elevated Serum ◽  
Simultaneous Occurrence ◽  
Published Data ◽  
Care Providers ◽  
Delay In Diagnosis ◽  
Acute Fatty Liver

Acute fatty liver of pregnancy (AFLP) is an uncommon condition that manifests in the third trimester of pregnancy.Its association with vaso-occlusive crisis from Sickle Cell Anaemia is not common. Published data on the simultaneous occurrence of these two conditions is rare, hence this case report. A 32-year-old gravida 3 para 1+1 lady, with Sickle Cell Anaemia, had a vaso-occlusive crisis in association with AFLP at 32 weeks’ gestation, and the outcome of her management was successful. AFLP is a rare late-gestational event affecting about 1 in 10,000 to 15,000 pregnancies. The exact aetiology is not known. Profound hypoglycaemia and jaundice with elevated serum transaminases are recognized features of AFLP.These features may also be seen in haemoglobinopathies. The simultaneous occurrence of AFLP and Sickle Cell Anaemia may result in overlap of symptoms and delay in diagnosis and treatment. Therefore, maintaining a high index of suspicion is key. The cornerstone for treatment remains prompt delivery and supportive care. AFLP can coexist with Sickle cell crises. It is important that care providers, especially in populations with high burden of Sickle Cell Anaemia, consider this as a differential diagnosis, especially when the jaundice is associated with profound or recurring episodes of hypoglycaemia. Prompt diagnosis and delivery in a multidisciplinary approach is important to avoid adverse maternal and foetal outcomes.Keywords: Vaso-occlusive crises, acute fatty liver of pregnancy, hypoglycaemia, Sickle-cell anaemiaFunding: No funding sources

Tropicamide eye drops reduce clozapine-induced hypersalivation: A case report

2016 ◽  
Vol 33 (S1) ◽  
pp. S543-S544 ◽  
Author(s):  
O. Kilic ◽  
H.M. Ozturk ◽  
E. Ata
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Side Effect ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Short Form ◽  
Eye Drops ◽  
Oral Application ◽  
Competing Interest ◽  
Pressure Changes

IntroductionClozapine-induced sialorrhea (CIS) is a common, treatment-limiting and stigmatizing side effect. All systemic agents that are used for hypersalivation may increase clozapine side effects such as blood pressure changes, constipation, or arrythmias. Oral application of topical anti-muscarinic agents may be a low side effect option for treatment of CIS.ObjectiveThe aim of this case report was to propose an off-label treatment of tropicamide drops to CIS and to stimulate further investigation.Case reportA 33-year-old male inpatient with schizophrenia has been on clozapine 800 mg and amisulpride 600 mg/day. His drooling was occasional and severe as drool drips off his chin during the day and night. Wet area over the pillow, visual analog scale (VAS), the short form of health survey (SF-36), UKU side effect rating scale, scale for the assessment of negative symptoms (SANS), scale for the assessment of positive symptoms (SAPS) were applied at baseline and in one-week intervals. Oral application of one drop of tropicamide % 0.5 (5 mg/mL) to left and one drop to right side before going to bed in the first week and two drops to each side were administered subsequently. Informed consent was given by the patient.ResultsNo psychological, neurological, autonomic and other side effects were observed associated with tropicamide. On VAS, the patient rated hypersalivation 5/7 at baseline, 4/7 after one drop each, 3/7 after two drops each.ConclusionsThe reduction of CIS by oral use of tropicamide eye drops is promising and should be explored with randomized controlled trials.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Polyuria and vaso-occlusive crises in sickle cell anaemia — A case report

2013 ◽  
Vol 24 ◽  
pp. e174
Author(s):  
J. Jácome ◽  
I. Terrahe ◽  
C. Rodrigues ◽  
V. Kryvonos ◽  
P. Mendonça ◽  
...  
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anaemia

scholarly journals Rapid-onset supraventricular tachycardia following clozapine initiation and its management with verapamil: a case report

2019 ◽  
Vol 6 (2) ◽  
pp. 547
Author(s):  
Afnan A. Alwabili
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Adverse Effects ◽  
Supraventricular Tachycardia ◽  
Low Dose ◽  
Rapid Onset ◽  
Treatment Resistant ◽  
Early Stages ◽  
Drug Of Choice ◽  
Cardiovascular Side Effects

Clozapine is the drug of choice for treatment-resistant schizophrenia. However, the use of clozapine is limited by its serious adverse effects, which often underlie its discontinuation. The cardiovascular side effects that raise safety concerns include tachycardia, myocarditis and cardiomyopathy. The development of clozapine-induced tachycardia is usually observed on higher dosage especially at early stages of treatment. Here, author presented the case of a patient with treatment-resistant schizophrenia who developed asymptotic supraventricular tachycardia despite low dose of clozapine at the second day of treatment. Additionally, author explored the possibility of clozapine re-challenge in combination with verapamil treatment.

scholarly journals Case Report: Mastocytosis: The Long Road to Diagnosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Tiago Azenha Rama ◽  
Diana Martins ◽  
Nuno Gomes ◽  
Jorge Pinheiro ◽  
Ana Nogueira ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Case Report ◽  
Mast Cells ◽  
Allergic Sensitization ◽  
Skin Lesions ◽  
Normal Serum ◽  
Cutaneous Lesions ◽  
History Of ◽  
Exercise Induced ◽  
Low Prevalence

Mastocytosis is a heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells. Patients mainly present with either cutaneous lesions, anaphylaxis, or both. Its low prevalence and unusual features often hinder its diagnosis for several years. We report the case of an 18-year-old male who was referred to our department with a long-standing history of atypical skin lesions, allergic rhinitis, exercise-induced bronchoconstriction and what was believed to be food-related flushing and anaphylaxis, that was later diagnosed with mastocytosis. This case illustrates the need to consider investigating for mastocytosis when recurrent anaphylaxis is present, especially in the presence of atypical skin lesions, even if normal serum basal tryptase levels and allergic sensitization are present.

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