Evaluation of Acute Painful Episodes with Foetal Hemoglobin Level and Other Haematological Parameters in Sickle Cell Patients in Abuja Nigeria

Introduction: Heterogeneity in sickle cell anaemia manifestations ranges from near asymptomatic cases to severe illness. Objective: This study determined the relationship between foetal haemoglobin F level, other haematological parameters and acute painful episode score of sickle cell disease patients in FCT Abuja Nigeria. Methods: 60 Sickle cell patients were selected for the study. 20 severe crises, 20 non-severe crisis SS were enrolled in the study. Control group comprised 20 apparently healthy haemoglobin AA individuals. Data were analysed descriptively. Results: Hb F level increased significantly in non-severe crisis sickle cell anaemia (7.12%± 3.6) and severe crisis (5.30%±2.3) groups, compared to the control group (0.32±1.8). This trend was also observed in RDW, MCHC and MCV. The mean Hb concentration and haematocrit (Hct) were significantly lower for both non- severe crisis and severe crisis SCA groups. There was no significant correlation between HbF and any of the haematological parameters in both non severe crisis and severe crisis groups. Patients with SCA had higher levels of HbF than matched controls. HbF had no correlation with any of the haematological parameters in both severe and non-severe SCA groups studied. Conclusion: Further studies should focus on environmental factors contributing to this variability.

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Assessment of Some Haemostatic Parameters in Sickle Cell Anaemia Subjects Resident in Rivers and Bayelsa States

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i1130925 ◽

2021 ◽

pp. 53-64

Author(s):

Barinaaziga S. Mbeera ◽

Susanna O. Akwuebu ◽

A. C. U. Ezimah ◽

Nancy C. Ibeh ◽

Evelyn M. Eze

Keyword(s):

Steady State ◽

Sample Size ◽

Sickle Cell ◽

Teaching Hospital ◽

Sickle Cell Anaemia ◽

Control Group ◽

Port Harcourt ◽

The Mean ◽

The University ◽

D Dimer

Aim: The aim of this study was to assess some haemostatic parameters in sickle cell anaemia subjects in Rivers and Bayelsa States. Study Design: This study is a cross-sectional observational study. Place and Duration of Study: This study was carried out at the University of Port Harcourt Teaching Hospital, Rivers State, and the Federal Medical Centre, Yenagoa, Bayelsa State, between the months of February and August, 2020. Methodology: A total of four hundred and fifty (450) subjects with age range of 1-50 years were randomly selected. There were about 200 registered patients (adults and children alike) at the sickle cell clinics of the University of Port Harcourt Teaching Hospital, and the Federal Medical Centre, Yenagoa, with an average of 4 new patients per month. The sample size was obtained using a prevalence of sickle cell anaemia of 2% and the sample size was calculated using Cochran sample size formula. Five milliliters (5ml) of venous blood sample was withdrawn from the peripheral vein in the upper limb of subjects using a standard venipuncture technique. The sample was rocked gently to mix and kept at room temperature and the haemostatic parameters (vWF, FVIII, D-dimer, L-arginine, fibrinogen, ADAMTS13) were assayed quantitatively with Bioassay Technozym kit using Microplate Reader (Labtech microplate auto ELISA plate reader, an IS0 13485:2003 CE and WHO compliance Co., Ltd. Shanghai International Holding Corp. GmbH; Europe) calibrated to a wavelength of 450 nm with strict adherence to the manufacturer's instructions, while PT and APTT were analysed with Fortress reagent and Uniscope SM801A Laboratory using water bath.Data management and statistical analyses were conducted using Statistical Analyses System SAS 9.4 (SAS Institute, Cary, North Carolina, USA) and p values less than .05were considered statistically significant. Results: The results showed the mean comparison of haemostatic parameters in sickle cell anaemia and control subjects. The comparison of haemostatic parameters showed significant(p<.05) increasesand decreases inVaso-Occlusive Crisis (VOC) and steady state respectively compared with the control group. There was statistically significantreduction in the mean comparison of L-Arginine (p<.01) in VOC) condition than steady state in relation to the control group in our study population, while D-Dimer, ADAMTS13 were also significantly reduced statistically (p<.01) in VOC condition than steady state compared with the control group. However, the mean FVIII inhibitor, Fibrinogen, PT (INR) and APTT were significantly higher (p<.01) in VOC than steady state when compared to controls with normal haemoglobin (HbAA).Correlations of haemostaticparameters by sickle cell anaemia subjects’ condition showed more significant positive correlations in VOC than steady state. Conclusion: This study showed a heightened hypercoagulability in Sickle Cell Snaemia(SCA)subjects, and further pave way for better understanding particularly the diagnostic variables underlying SCA, specific to each subject condition (steady state and VOC). Subjects with SCA, particularly during VOC, undergo significant haemostatic alterations that increase their risk of developing coagulation activation-related complications. Thus, though selected markers of coagulation were significantly different between the subject conditions, they were often significantly higher in the SCA.

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Evaluation of Changes in Haematological Parameters of Sickle Cell Anaemia Subjects in Rivers and Bayelsa States

International Blood Research & Reviews ◽

10.9734/ibrr/2021/v12i230147 ◽

2021 ◽

pp. 14-23

Author(s):

B. S. Mbeera ◽

S. O. Akwuebu ◽

A. C. U. Ezimah ◽

N. C. Ibeh ◽

E. M. Eze

Keyword(s):

Steady State ◽

Sample Size ◽

Sickle Cell ◽

Sickle Cell Anaemia ◽

Haemoglobin Concentration ◽

Haematological Parameters ◽

Control Group ◽

Port Harcourt ◽

Rivers State ◽

And Control

Aim: The aim of this study was to evaluate changes in some haematological parameters in sickle cell anaemia subjects in Rivers State. Study Design: This study is a cross-sectional observational study. Place and Duration of Study: University of Port Harcourt Teaching Hospital, Rivers State, and the Federal Medical Centre, Yenagoa, Bayelsa State, between the months of February and August, 2020. Methodology: A total of four hundred and fifty (450) subjects with age range of 1-50 years were randomly selected. There are about 200 registered patients (adults and children alike) at the sickle cell clinics of the University of Port Harcourt Teaching Hospital, and the Federal Medical Centre, Yenagoa, with an average of 4 new patients per month. The sample size was obtained using a prevalence of sickle cell anaemia of 2% and the sample size was calculated using Cochran sample size formula. Five milliliters (5ml) of venous blood sample was withdrawn from the peripheral vein in the upper limb of subjects using a standard venipuncture technique. The sample was rocked gently to mix and kept at room temperature and the haematological parameters were analyzed within 4 hours of samples collection. The haematological parameters: total white blood cell count (WBC), red blood cell count (RBC), Haemoglobin concentration (Hb), Haematocrit, mean cell volume (MCV), mean cell haemoglobin (MCH), mean cell haemoglobin concentration (MCHC), red cell distribution width (RDW-CV), Platelet count (PLT), MPV, Neutrophils, Lymphocyte, Monocyte, Eosinophils, and Basophils) were analyzed using Mindray BC-6800 auto Haematology analyzer system. Data management and statistical analyses were conducted using Statistical Analyses System SAS 9.4 (SAS Institute, Cary, North Carolina, USA) and p values less than .05 were considered statistically significant. Results: The results showed the mean comparison of haematological parameters in sickle cell anaemia and control subjects. The mean comparison of Haemoglobin F was significantly reduced statistically (p<.05) in vaso-occlusive crises (VOC) condition than steady state compared with the control group. There was increase trend of haematological parameters showing statistically significant difference across the subject conditions compared with the control. There were exceptions in few cases especially in lymphocytes which was not significant (p>.05) in the steady state and vaso-occlusive crisis compared with the control. Similarly, Neutrophils was not significant (p>.05) in the steady state and vaso-occlusive crisis compared with the control. Furthermore, Basophils was more significant (p<.05) in the steady state than in the vaso-occlusive crisis and control groups. Similarly, absolute eosinophil was less significant statistically (p<.05) in the steady state and vaso-occlusive crisis than in the control group. Conclusion: This study has shown that there are changes in haemtological parameters between SCA subjects and control subjects and the VOC and steady state sickle cell anaemia (SCA) subjects.

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A PRELIMINARY ANTHROPOMETRIC STUDY OF THE RELATIONSHIP BETWEEN DERMATOGLYPHICS AND SICKLE CELL ANAEMIA

International Journal of Anatomy and Research ◽

10.16965/ijar.2020.167 ◽

2020 ◽

Vol 8 (4.1) ◽

pp. 7753-7760

Author(s):

James Nketsiah ◽

◽

Chrissie Stansie Abaidoo ◽

Adjei-Antwi Collins ◽

◽

...

Keyword(s):

Key Words ◽

Sickle Cell ◽

Sickle Cell Anaemia ◽

Diagnostic Value ◽

Control Group ◽

Control Groups ◽

Ridge Count ◽

And Control ◽

The Relationship ◽

Anthropometric Study

Dermatoglyphics have been utilized as models for the diagnosis of vast genetic conditions due to their relationship with the genetic make-up of an individual. However, little studies have been conducted worldwide trying to ascertain the relationship between dermatoglyphics and sickle cell anaemia. Therefore, the present study aimed at generating baseline data to elucidate the possible diagnostic value of dermatoglyphics for earlier detection and screening of Sickle Cell Anaemia (SCA) in Ghana. A total of 400 participants including 200 SCA patients from Komfo Anokye Teaching Hospital and 200 control group (CG) from KNUST were recruited for this study. The palmprints and fingerprints of the participants were taken and the sickling status of the control group was determined. Distribution of the three major fingerprint patterns, PIC patterns, ATD angle and total finger ridge count (TFRC) were determined. Loop dominated in both the SCA and control groups followed by whorl and arch. PIC 300 dominated in the SCA group while PIC 310 dominated in the control group, this was statistically significant. Also, the study recorded 5 unreported PIC’s (PIC 400, PIC 410, PIC 430, PIC 500 and PIC 510) in the Ghanaian population. The SCA group recorded a mean ATD angle of 43.62o while the control group recorded 41.61o, this was statistically significant. The SCA group recorded a mean TFRC of 67.17 while the control group recorded 78.49. The results of the present study have shown that, there is a relationship between dermatoglyphics and SCA and this will serve as a reliable indicator for earlier detection and screening of sickle cell anaemia especially in neonates. KEY WORDS: Dermatoglyphics, sickle cell anaemia, Ghana.

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Enhanced Hypercoagulability in Sickle Cell Anaemia Patients with Chronic Leg Ulcers

Advances in Hematology ◽

10.1155/2020/5157031 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

David Sackey ◽

Yvonne Dei-Adomakoh ◽

Edeghonghon Olayemi

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Antiplatelet Agents ◽

Organ Damage ◽

Leg Ulcers ◽

Chronic Complications ◽

The Mean ◽

Hb Concentration ◽

Chronic Leg Ulcers

Sickle Cell Anaemia (SCA) is associated with a hypercoagulable state resulting in a predisposition to venous thromboembolism. With improvements in the quality of care, more patients with SCA survive into adulthood with an associated increase in the frequency of end-organ damage and chronic complications such as chronic leg ulcers (CLUs). These ulcers rarely occur in the first decade of life and are recurrent, painful, and slow-to-heal. This study tested the hypothesis that coagulation is enhanced in SCA patients with CLU. 145 participants (50 SCA with CLU, 50 SCA without CLU, and 45 with haemoglobin AA) were assessed to determine their coagulation profile using selected tests of coagulation. The SCA with the CLU group had the lowest mean haemoglobin (Hb) concentration. SCA patients with and without CLUs had elevated mean platelet counts, shorter mean aPTT, and marginally prolonged mean PT compared to HbAA patients. SCA with CLUs patients had a significantly shortened aPTT than those without CLUs ( p = 0.035) and HbAA ( p = 0.009). There were significant differences in the mean PT between SCA with CLUs patients and HbAA ( p = 0.017); SCA without CLU and HbAA ( p = 0.014). SCA with and without CLUs patients had higher mean D-dimer levels compared to HbAA. There was a negative correlation between Hb concentration and duration of CLU (r = -0.331, p = 0.021). In conclusion, our study demonstrates a heightened hypercoagulability in SCA patients with CLUs. We did not test for platelet activation, and it is not clear what role, if any, the enhanced hypercoagulability plays in the pathogenesis of CLUs in SCA. It will be useful to ascertain if antiplatelet agents or/and anticoagulants quicken the healing of CLUs in SCA patients.

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Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

Journal of Human Growth and Development ◽

10.7322/jhgd.127681 ◽

2017 ◽

Vol 27 (1) ◽

pp. 91 ◽

Cited By ~ 1

Author(s):

Ingrid Cristiane Pereira Gomes ◽

Hugo Nivaldo Melo ◽

Suyaluane Italla Amana Melo ◽

Nelmo Vasconcelos de Menezes ◽

Tulio Vinicius Paes Dantas ◽

...

Keyword(s):

Sickle Cell ◽

Sickle Cell Anaemia ◽

Pubertal Development ◽

Hereditary Diseases ◽

Control Group ◽

Age At Menarche ◽

Prospective Longitudinal Study ◽

Cellular Expression ◽

Z Scores ◽

Prospective Longitudinal

Introduction: Hereditary haemoglobinopathies are the most common group of monogenic hereditary diseases in the world. Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. Objective: The evaluation of the growth pattern and pubertal development of a group of patients with sickle-cell anaemia (SCA) from childhood to adulthood. Method: Thirty patients with SCA between the ages of 10 and 23 years were evaluated in a prospective longitudinal study at three points in time (Te1: 2005; Te2: 2010 and Te3: 2015) and compared with controls. Anthropometric, pubertal and hormonal evaluations were carried out. Age- and gender-specific Z-scores for weight, height and BMI (body mass index) were calculated according to the reference growth standards. Results: Thirty patients with SCA (mean age = 13.93 years) were evaluated at Te1 and 26 patients (mean age = 25.08 years) at Te3. The SCA group lower showed Z-scores for weight (p = 0.0002), height (p = 0.0184) and BMI (p = 0.0011) than the control group at Te1. At Te3, there was no difference in height, but weight (p = <0.0001) and BMI (p = <0.0001) were lower in the SCA group. Men showed greater weight commitment than women at the three study times (Te1: p = 0.0340, Te2: p = 0.0426 and Te3: p = 0.0387) and lower BMI in Te3 (p = 0.0155) in the SCA group. There was a significant increase in weight when comparing Te1 with Te3 (p = 0.0009) and in height when comparing Te1 with Te2 (p = 0.0292) and with Te3 (p = 0.0003) in the SCA group. There was a significant increase in weight when comparing Te1 and Te3 (p = 0.0009) and in height when comparing Te1 and Te2 (p = 0.0292) and Te3 (p = 0.0003) in the SCA group. At Te1, 14 cases and 2 controls were prepubertal. Bone age was delayed in 12 patients. Age at menarche was delayed and lower in the SCA group (mean = 15 years). Five patients had gestated, but no patient had experienced fatherhood. At Te1, TSH levels were higher (p = 0.0080) and T3 levels were lower (p = 0.0020) in the SCA group. At Te3, LH and FSH levels were higher in men with SCA (p = 0.0014; p; 0.0002). IGF-I levels were lower in cases both at Te1 (p = 0.0002) and at Te3 (p = 0.0032). Conclusions: Patients with SCA showed growth impairment and pubertal delay compared with healthy controls. However, albeit belatedly, they reached normal sexual maturation and height in adulthood. Women with SCA showed no fertility problems. The findings highlight the need to investigate the intention of paternity and fertility among men with SCA.

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Relationship Between Salivary Nitric Oxide Concentration and Dental Caries in Children: A Systematic Review and Meta-Analysis

Iranian Journal of Pediatrics ◽

10.5812/ijp.107050 ◽

2020 ◽

Vol In Press (In Press) ◽

Author(s):

Nadia Elyassi ◽

Ali Malekzadeh Shafaroudi ◽

Pegah Nasiri ◽

Mahmood Moosazadeh ◽

Azam Nahvi

Keyword(s):

Nitric Oxide ◽

Nitrous Oxide ◽

Dental Caries ◽

Meta Analysis ◽

Control Group ◽

Analysis Study ◽

Oxide Concentration ◽

The Mean ◽

The Relationship ◽

Nitrous Oxide Concentration

Context: Conflicting results have been reported in the literature concerning the relationship between salivary nitrous oxide concentration and dental caries in children. Metaanalysis studies aim to combine different studies and reduce the difference between the parameters by increasing the number of studies involved in the analysis process. Objectives: Accordingly, this meta-analysis study aimed at determining the relationship between salivary nitrous oxide concentration and dental caries in children. Methods: Databases were searched using the keywords “nitric oxide”, “salivary”, “Caries”, “DMFT Index”, “children”, “early childhood caries” and OR, AND and NOT operators. Quality assessment was then performed based on the Newcastle-Ottawa scale (NOS) checklist. The standardized mean difference (SMD) of DMFT, dmft, and salivary nitric oxide (NO) concentration was estimated. Results: Seven studies made a comparison between the mean salivary NO concentration in children with dental caries and that in the control group. In four studies, the mean salivary NO concentration in children with dental caries was lower, as compared to that in the control group. This difference was significant in all four studies. Also, the mean standardized difference of the salivary NO index was also estimated to be -0.11 (CI 95%: -1.77, 1.55). Conclusions: This meta-analysis study demonstrated that salivary NO concentration was not significantly related to dental caries. Moreover, since salivary NO concentration is affected by various factors, it is not sufficient to determine the likelihood of the incidence of caries.

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Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

10.21203/rs.3.rs-59394/v1 ◽

2020 ◽

Author(s):

Yuan-jing Leng ◽

Hai-bin Zhou ◽

Jiang-ling Fu ◽

Wen-juan Wang

Keyword(s):

Healthy Subjects ◽

Characteristic Curve ◽

Urinary Stone ◽

Urinary Stones ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Healthy Control ◽

The Mean ◽

The Difference ◽

The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

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An Investigation of the Relationship between Involvement Sites in Vitiligo Patients and Autoimmune Diseases and Hematological Parameters

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol04-i10/769 ◽

2019 ◽

Vol 4 (10) ◽

Cited By ~ 1

Author(s):

Ebru KARAGUN

Keyword(s):

Hematological Parameters ◽

Fasting Blood Glucose ◽

Unknown Etiology ◽

Control Group ◽

Endocrine Disorders ◽

Positive Correlation ◽

Lymphocyte Ratio ◽

History Of ◽

The Mean ◽

The Relationship

Aim-Objectives: Vitiligo is an acquired idiopathic disease which progresses with melanocyte destruction and is clinically characterized by depigmented lesions of unknown etiology. Vitiligo may be coexistence with a autoimmune and endocrine disorders. This study examined the sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vitamin B12 and fasting blood glucose (FBG) values, and thrombocyte-to-lymphocyte ratio(TLR), neutrophil-to-lymphocyte ratio(NLR), the mean platelet volume(MPV) the correlation of depigmented lesions with the extent of body involvement sites(IS). Materials and Method: The study enrolled 67 patients aged 0‒65 who were diagnosed with non-segmental generalized vitiligo and in whom an increase in lesions had been observed in the last six months. The IS of the lesions in the patients were evaluated as IS ˂10%(1st group), 10%‒20% (2nd group), 20% - 30%(3rd group), 30% - 40%(4th group), 40% ‒50 %(5th group), and ˃50%(6th group). The control group consisted of patients who had presented to the outpatient clinic having had no history of vitiligo detected in themselves nor in their families. Results: No significant correlation was found between IS and sT3, fT4, TSH, Anti-TPO, Anti-Tg, Vit. B12, PBG or MPV. A moderately positive correlation was found between IS and duration (p <0.05) and a mildly positive correlation between IS and NLR and TLR (p <0.05). Conclusion: This study show that every patient diagnosed with vitiligo, independent of the IS, should undergo examination for autoimmune disease. A mild positive correlation between VTA and NLO-TLO was found to be an indicator of increased inflammation in vitiligo patients as the extent of lesions increased.

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Antithyroid Effect of Chlorpropamide?

Human Toxicology ◽

10.1177/096032718300200112 ◽

1983 ◽

Vol 2 (1) ◽

pp. 149-153 ◽

Cited By ~ 1

Author(s):

J. Feely ◽

S. McLaren ◽

A.M.M. Shepherd ◽

D. Maclean ◽

I.H. Stevenson ◽

...

Keyword(s):

Matched Control ◽

Control Group ◽

Diabetic Patients ◽

Matched Control Group ◽

Serum Thyroxine ◽

Chronic Therapy ◽

The Mean ◽

Clinically Significant ◽

The Relationship ◽

Plasma Chlorpropamide

1 The relationship between plasma chlorpropamide concentration and thyroid function was examined in 87 maturity onset diabetic patients receiving chronic therapy. 2 Although plasma chlorpropamide concentration was weakly negatively correlated with serum thyroxine (r= 0.33, P< 0.01) the mean serum thyroxine and thyrotrophin (TSH) were not different from that of a matched control group of diabetics treated with diet alone. 3 Serum thyroxine was negatively correlated with the duration of diabetes in both groups. 4 These results suggest that chlorpropamide does not have a clinically significant antithyroid effect.

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The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria

Advances in Hematology ◽

10.1155/2015/386451 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Musa A. Sani ◽

James O. Adewuyi ◽

Abiola S. Babatunde ◽

Hannah O. Olawumi ◽

Rasaki O. Shittu

Keyword(s):

Sickle Cell ◽

Serum Ferritin ◽

Transferrin Receptor ◽

Sickle Cell Anaemia ◽

Iron Status ◽

Serum Transferrin ◽

Cross Sectional ◽

Serum Transferrin Receptor ◽

Iron Deficient ◽

The Mean

Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria.Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects.Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL). The mean serum transferrin receptor of the patients (4.24 ± 0.17 μg/mL) was higher than that of the controls (3.96 ± 0.17 μg/mL) (p=0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 μg/mL) was significantly lower than that of the control (1.82 ± 0.18 μg/mL) (p=0.031).Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.

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