scholarly journals Review for Analytical Methods for the Determination of Mefenamic Acid

2021 ◽  
pp. 426-437
Author(s):  
T. V. Ashira ◽  
T. Mohamed Rafeeque ◽  
Saba Maanvizhi ◽  
S. Kathirvel ◽  
P. C. Indukala ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Analytical Methods ◽  
High Performance ◽  
Active Pharmaceutical Ingredient ◽  
Review Article ◽  
Computer Assisted ◽  
Extensive Literature ◽  
Pharmaceutical Dosage Forms ◽  
Layer Chromatography

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. Although, several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods were reported in the literature, HPLC stands out first for the quantification of MFA.

Analytical Methods Practiced to Quantitation of Rifampicin: A Captious Survey

2020 ◽  
Vol 16 ◽  
Author(s):  
Rajendra Muljibhai Kotadiya ◽  
Foram Narottambhai Patel
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Analytical Methods ◽  
Bacterial Infections ◽  
High Performance ◽  
Drug Product ◽  
Extensive Literature ◽  
Legionnaires Disease ◽  
Instrumental Methods ◽  
Layer Chromatography

Background: Rifampicin (RIF), also known as rifampin, a bactericidal antibiotic having broad antibacterial activity against various gram-positive and gram-negative bacteria act by inhibiting DNA dependent RNA polymerase. RIF has been administered in different dosage forms like tablets, capsules, injections, oral suspension, powder etc. for the treatment of several types of bacterial infections, including tuberculosis, Mycobacterium avium complex, leprosy and Legionnaires’ disease. Introduction: To ensure the quality, efficacy, safety and effectiveness of RIF drug product, effective and reliable analytical methods are utmost important. To quantify RIF for quality control or pharmacokinetic purposes, alternative analytical methods have been developed along with the official compendial methods. Method: In this review paper, an extensive literature survey was done to gather information on various analytical instrumental methods used so far for RIF. Result: These methods were high-performance liquid chromatography (42%), hyphenated techniques (18%), spectroscopy (15%), high-performance thin-layer chromatography or thin-layer chromatography (7%) and miscellaneous (18%). Conclusion: All these methods were selective and specific for the RIF analysis.

scholarly journals Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 731 ◽  
Author(s):  
Juszczak ◽  
Zovko-Končić ◽  
Tomczyk
Keyword(s):  
Liquid Chromatography ◽  
Medicinal Plants ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Analytical Methods ◽  
High Performance ◽  
Biological Effects ◽  
Immunomodulatory Activity ◽  
Layer Chromatography

Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin are often used in the treatment of hypertension, inflammatory diseases, and even cancer. However, to establish the quality of such preparations, appropriate analytical methods should be used. Therefore, the present paper provides the first comprehensive review of the current analytical methods that were developed and validated for the quantitative determination of luteolin and its C- and O-derivatives including orientin, isoorientin, luteolin 7-O-glucoside and others. It provides a systematic overview of chromatographic analytical techniques including thin layer chromatography (TLC), high performance thin layer chromatography (HPTLC), liquid chromatography (LC), high performance liquid chromatography (HPLC), gas chromatography (GC) and counter-current chromatography (CCC), as well as the conditions used in the determination of luteolin and its derivatives in plant material.

Green Analytical Methods in Analysis of Aflatoxins

2016 ◽  
Vol 842 ◽  
pp. 172-181
Author(s):  
Sana Ali
Keyword(s):  
Analytical Methods ◽  
High Performance ◽  
Point Of View ◽  
Free Sample ◽  
Highly Sensitive ◽  
Carcinogenic Effects ◽  
Layer Chromatography ◽  
Nanogram Level ◽  
Animal Consumption

The detection and determination of aflatoxins at nanogram level is important from human health point of view. Aflatoxins exhibit acute toxicity demonstrating teratogenic, mutagenic and carcinogenic effects. Amongst the available aflatoxins, B1, B2, G1, G2, M1 and M2 have been the more frequently analysed aflatoxins by chromatographic, spectroscopic and immuochemical methods. Because of the presence of aflatoxins at trace level in food and feedstuff used for human and animal consumption, new analytical methods have been designed for sensitive and selective detection and quantification of aflatoxins. Each of the employed analytical methods, described herein, such as thin layer chromatography, high performance liquid chromatography, gas chromatography and immunochemical methods, among others, has inherent merits and demerits in aflatoxins analysis. This chapter critically examines each of the analytical methods currently in use in the analysis of aflatoxins. Deviating from the earlier approaches, this chapter focuses on the need of methodologies that have negligible environmental impact. Though most of the existing methods are highly sensitive and reasonably safer to use but still there is the need of development of new green methodologies focusing on the reduction of solvent consumption, replacement of environmentally hazardous solvents with more benign alternatives, miniaturization of instrumentation and solvent-free sample preparation.

scholarly journals Overview of the Determination of Captopril Levels in Pharmaceutical Preparations and Biological Matrices

2021 ◽  
Vol 6 (4) ◽  
pp. 1-11
Author(s):  
Nanda Aflyona Darma ◽  
Roslinda Rasyid ◽  
Harrizul Rivai
Keyword(s):  
High Performance ◽  
Pharmaceutical Preparations ◽  
Analytical Techniques ◽  
Review Article ◽  
Biological Matrices ◽  
Pharmaceutical Dosage Forms ◽  
Analytical Technique ◽  
Data Collection Process ◽  
Uv Visible

Captopril is the most commonly prescribed ACE-Inhibitor class of drugs because it is easily accessible and affordable. Therefore, to ensure drug quality, captopril levels were determined. This review article aims to provide an overview of the various analytical techniques that have been carried out in selecting the groups of captopril in both pharmaceutical dosage forms and biological matrices. Some of these analytical methods include the UV-Visible spectrophotometric method, high-performance liquid chromatography (HPLC), voltammetry, and flow injection. The data collection process in this review article is to collect research journals through trusted sites in the last ten years (2011-2021) with the search keywords "Determination of Captopril," "Analysis of Captopril on Pharmaceutical Preparations," and Analysis of Captopril on Biological Matrices." From the data that has been collected, the voltammetric method is the most widely used analytical technique in determining captopril for both pharmaceutical preparations and biological matrices in the last ten years.

scholarly journals A Compact Analytical Profile of Aripiprazole: Analytical Methodologies

2021 ◽  
pp. 7-19
Author(s):  
O. V. Athira ◽  
Muhamed Rishad ◽  
K. Anand Babu ◽  
K. Praseetha ◽  
. Indukala ◽  
...  
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
Dosage Forms ◽  
Mixed Effects ◽  
Review Article ◽  
Computer Assisted ◽  
X Ray Diffraction ◽  
Pharmaceutical Dosage Forms ◽  
X Ray ◽  
Chemical Technique ◽  
Published Research

Aripiprazole (APZ) is an antipsychotic drug that belongs to benzisoxazole derivatives and is used to treat schizophrenia as well as acute manic or mixed effects in patients with bipolar 1 disorder. APZ is used to treat certain mental, mood disorders such as bipolar disorder, Schizophrenia, Tourette's syndrome, and irritability associated with autistic disorder. It may also be used in combination with other medication to treat depression. The present review article would be useful for prospective studies for researchers interested in APZ formulation production and quality management. Using a thorough computer assisted literature survey; this review touches upon the various reported analytical methods for the quantification of APZ both in API (Active Pharmaceutical Ingredient) and pharmaceutical dosage forms. The present write-up also encompasses the various published research articles like Spectroscopy techniques, X- Ray Diffraction (XRD), Electro Chemical Technique, Differential Scanning Calorimeter (DSC) and Capillary Electrophoresis. This is the first review article in this series with focus on the analytical profile of APZ. Although, several methods were reported in the literature, HPLC stands out first for the quantification of APZ.

scholarly journals Overview of the Determination of Clonidine Levels in Pharmaceutical Preparations

2021 ◽  
Vol 6 (4) ◽  
pp. 12-24
Author(s):  
Rahma Yuni Safitri ◽  
Roslinda Rasyid ◽  
Regina Andayani ◽  
Harrizul Rivai
Keyword(s):  
Quality Assurance ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
High Performance ◽  
Raw Materials ◽  
Pharmaceutical Preparations ◽  
Review Article ◽  
Layer Chromatography

Clonidine is an α2-central agonist class of drugs widely used to treat cardiovascular diseases such as hypertension, heart attacks and help prevent strokes. The quality and safety of a drug preparation can be proven by testing the drug's quality assurance. In drug quality assurance, it is necessary to determine drug levels. Therefore, it is essential to look at the determination of clonidine levels in raw materials, mixtures, and pharmaceutical preparations. It is collecting data in this review article through trusted sites such as Google Scholar with the search keywords "clonidine hydrochloride," "clonidine analysis in pharmaceutical preparations" with a span of the last ten years (2010-2020). This review article aims to provide an overview of the various analytical techniques used to determine clonidine both in single substance form and in the pharmaceutical dosage form. Several analytical methods, such as UV-Visible spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC), have been reported to determine clonidine in the form of raw materials, mixtures, and pharmaceutical preparations. Overall, the determination of clonidine levels has been carried out by various analytical methods, including spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC). Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentration. The HPLC-MS method has unique advantages and sensitivity in the analysis of clonidine in pharmaceutical preparations.

scholarly journals Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

2021 ◽  
Vol 6 (7) ◽  
pp. 1-13
Author(s):  
Tiara Fitrizal ◽  
Sestry Misfadhila ◽  
Harrizul Rivai
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Pharmaceutical Preparations ◽  
Review Article ◽  
Biological Matrices ◽  
Layer Chromatography

Chlortalidone is a compound that is often used in the pharmaceutical world as an oral drug to treat hypertension. This review article discusses the summary of methods for determining the concentration of chlorthalidone in pharmaceutical preparations and biological matrices. We took the data collected in this review article was taken through trusted sites such as Google Scholar with the search keywords "chlorthalidone determination," "pharmaceutical preparations," and "biological matrices," with a period of the last twenty years (2001-2021). This review article aims to provide an overview of the assay used to determine the concentration of chlorthalidone either in the form of a single substance or pharmaceutical dosage forms. Overall, the determination of chlorthalidone levels has been carried out using various analytical methods. Including spectrophotometry, high-performance liquid chromatography (HPLC), chemometrics and thin-layer chromatography (TLC) - densitometric, capillary zone electrophoresis (CZE) methods, spectrofluorimetric methods, liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) methods, ultrafast liquid chromatography (UFLC), supercritical fluid chromatography method and high-performance thin-layer chromatography (HPTLC)-densitometric method. Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentrations up to the nanogram level.

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