scholarly journals Povidone Iodine Ointment vs Cadexomer Iodine Ointment in Management of the Chronic Wound: A Study Protocol

2021 ◽  
pp. 33-37
Author(s):  
Shubham Gupta ◽  
Raju Kamalrao Shinde ◽  
Sangita Shinde
Keyword(s):  
Health Care ◽  
Wound Healing ◽  
Granulation Tissue ◽  
Health Care Professionals ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Povidone Iodine ◽  
Wound Management ◽  
Tissue Formation ◽  
Granulation Tissue Formation

Introduction: Chronic wound and its care has always been a health burden for patient, health care professionals and the entire health care system. There have been certain topical preparations available in market today for application in chronic wound management. In our study, we are comparing effects of cadexomer and povidone iodine ointment in context of reduction in bacterial overload, slough reduction, facilitations of granulation tissue formation, reduction in size of the wound and ultimately in percentage of wound healing and its cost of management. Aim: Comparison of outcome of Povidone Iodine Ointment and Cadexomer iodine Ointment in management of the wound. Methodology: This cross section observational study has been conducted among 40 patients diagnosed as chronic wound with 20 patients in each group. Student’s paired t-test and Pearson’s Correlation Coefficient is being used as statistical analysis. Results: The percentage of patient treated with cadexomer iodine ointment shows significantly (p<0.05) higher rate of wound healing along with significant reduction in bacterial overload and promotion of granulation tissue formation. Conclusion: Cadexomer as a vector with iodine ointment shows higher rate of reduction of biofilm, slough and debris with better rate of promotion of granulation tissue formation, thus leading to increased and effective rate of healing of wound as well as cost effective management of chronic wounds.

A comparative study of phenytoin dressing versus honey dressing in the treatment of cronic ulcers in tertiary care hospital

2021 ◽  
Vol 19 (1) ◽  
pp. 05-09
Author(s):  
Sandesh M ◽  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Chronic Wounds ◽  
Tertiary Care ◽  
Skin Grafting ◽  
Care Hospital ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Diabetic Ulcers

Background: Diabetic foot infections are the leading cause of hospitalization morbidity and mortality in diabetics worldwide In India it accounts for 20% of hospitalizations. honey has been investigated to treat ulcers like pressure ulcers, venous ulcers, diabetic ulcers, traumatic wounds and burns. Phenytoin is also now known to promote wound healing and can be an alternative to normal saline specifically in chronic wounds related to diabetes. The present study compares these two modalities in management of diabetic ulcers. Objective: To compare the efficacy of topical phenytoin vs topical honey in chronic diabetic ulcers in terms of rate of wound healing, granulation tissue formation and quality of graft bed for skin grafting. Methods: A comparative prospective study of 50 patients with chronic diabetic ulcers selected based on a predefined criteria divided into two groups: Group A (Phenytoin group) (n=25) and Group B (honey group) (n=25). Final wound area was measured on 30th day. Comparison between the wound size reduction among two groups done at end of 30th day. Outcome was measured in terms of wound reduction, granulation tissue formation and quality of bed for skin grafting between the two groups. Results: This study has shown faster rate of wound healing, better granulation tissue formation and quality graft bed for skin grafting in patients who received topical phenytoin dressing as compared to topical honey dressing.

scholarly journals Effectivity of topical mangosteen pericarp extract cream on wound healing in Swiss albino mice

2019 ◽  
Vol 92 (2) ◽  
Author(s):  
Hilda Brigitta Sombolayuk ◽  
Khairuddin Djawad ◽  
Siswanto Wahab ◽  
Upik A. Miskad ◽  
Gemini Alam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Inflammatory Cells ◽  
Control Group ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Swiss Albino Mice ◽  
Accelerate Wound Healing ◽  
Acute Wound ◽  
Albino Mice

Wound healing is a complex physiological process consisting of four phases: coagulation, inflammation, proliferation and migration, and remodeling, each with distinct characteristics. Studies have suggested that mangosteen pericarp extract (MPE) may accelerate wound healing. However, the mechanism has not been fully understood. This study aims to evaluate the effect of MPE cream in various concentrations in acute wound healing of albino mice, both histologically and macroscopically. Thirty-two healthy female Swiss albino mice, aged 6-9 weeks, weight 20-30 g, were included in this study. The samples were randomly divided into eight groups each consisting of 4 mice. The first four groups were treated with MPE cream 5%, 10%, and 20%, and no medication (control group), respectively, and were sacrificed after three days. The other four groups received the same application and were sacrificed after 8 days. Wound bed diameter was measured and biopsy from the skin lesion was performed for histopathologic examination. Mann-Whitney test was used to analyze the diameter of the wound bed and histopathological findings of granulation tissue formation, reepithelialization, and inflammation, with P<0.05 considered as significant. MPE cream significantly improved wound healing by increasing granulation tissue formation, and reepithelialization. In addition, MPE cream application was also shown to decrease the number of inflammatory cells, particularly in 5% and 10% concentrations, both in the 3-day and 8-day groups. MPE cream application can accelerate wound healing and thus can be used in acute wound treatment.

Chronic wounds: the challenges of appropriate management

2019 ◽  
Vol 24 (Sup9) ◽  
pp. S26-S32 ◽  
Author(s):  
Leanne Atkin
Keyword(s):  
Wound Healing ◽  
Health Services ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Wound Management ◽  
Product Selection ◽  
Wound Assessment ◽  
Moisture Balance ◽  
Selection For ◽  
Chronic Wound Management

The immense burden imposed by chronic wounds—those persisting over 6 weeks despite active intervention—on patients and health services is well recognised. There are various reasons for why a wound fails to progress towards closure, and clinicians must investigate the underlying cause of wound chronicity, as this information guides the management of such wounds. The TIME framework (T=tissue; I=infection/inflammation; M=moisture balance; E=wound edges) is a useful tool for practitioners to systematically undertake wound assessment and product selection. This article discusses chronic wound management based on the TIME framework, examining the aspects to be considered when managing chronic wounds. It also describes the process of dressing selection for overcoming the various barriers to wound healing, specifically discussing the AQUACEL family of dressings.

Biomimetic thermoplastic polyurethane porous membrane with hierarchical structure accelerates wound healing by enhancing granulation tissue formation and angiogenesis

RSC Advances ◽  
2016 ◽  
Vol 6 (101) ◽  
pp. 99595-99603 ◽  
Author(s):  
Qiang Lei ◽  
Zhichao Li ◽  
Rui Xu ◽  
Yuzhen Wang ◽  
Haisheng Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hierarchical Structure ◽  
Granulation Tissue ◽  
Wound Dressing ◽  
Thermoplastic Polyurethane ◽  
Porous Membrane ◽  
Tissue Formation ◽  
Granulation Tissue Formation

Wound dressing with hierarchical structure enhances wound healing.

scholarly journals RapidlyIn SituForming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Bo Zhou ◽  
Jianan Ren ◽  
Chao Ding ◽  
Yin Wu ◽  
Dong Hu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Open Abdomen ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Abdominal Hypertension ◽  
Early Wound

Objective.The purposes of our present study were to evaluate the potential of platelet-rich plasma gel to enhance granulation tissue formation after open abdomen and to examine whether the effect was attributable to stimulating rapid neovascularization.Methods.Twenty-four rats underwent colon ascendens stent peritonitis surgery to induce sepsis, followed by intraperitoneal injection of nitrogen to create intra-abdominal hypertension. Four hours later, laparotomies were performed. The rats were randomized into three groups (n=8for each group): control, platelet-poor plasma (PPP), and platelet-rich plasma (PRP) groups. One week after the treatment, granulation tissue formation and angiogenesis were evaluated by histological and laser Doppler analysis.Results.The resultant platelet count in platelet-rich plasma was higher than that of PPP. The concentrations of platelet-derived growth factor BB, transforming growth factorβ-1, and vascular endothelial growth factor in PRP were significantly higher when compared with that of PPP. Myofibroblast count, granulation tissue thickness, vessel numbers, and blood perfusion were increased in PRP group, followed by PPP group, with control being the least.Conclusion.Rapidlyin situforming platelet-rich plasma gel promoted remarkable neovascularization and early wound healing after open abdomen and may lead to novel and effective treatments for open abdominal wounds.

scholarly journals Effect of Newly Synthesized Polypropylene/Silver Nonwoven Fabric Dressing on Incisional Wound Healing in Rats

2014 ◽  
Vol 2 (3) ◽  
pp. 395-403 ◽  
Author(s):  
Samiha M. Gawish ◽  
Amina A. Gamal El Din ◽  
Hanaa H. Ahmed ◽  
Abdel Razik H. Farrag ◽  
Amira Abou-El Kheir
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Nonwoven Fabric ◽  
Complete Healing ◽  
Albino Rats ◽  
Tissue Formation ◽  
Histopathological Changes ◽  
Granulation Tissue Formation ◽  
Wound Length ◽  
Incision Wound

AIM: The present work aimed to investigate the effect of the antimicrobial nano Ag/polypropylene (PP\Ag) dressing on incisional wound healing on the experimental level.MATERIALS AND METHODS: Male albino rats were divided into, control, PP/Ag dressing, Silver Sulfadiazine (Ag-SD) cream, blank PP dressing and undressed groups. Animals were sacrificed after 5, 10 and 15 days of incisional wound event.RESULTS: Reduction was found in incision wound length in PP/Ag dressed rats, Ag-SD cream treated rats, and blank PP dressed rats after 5, 10 and 15 days compared to undressed rats. Skin of PP/Ag group showed less adverse histopathological changes, enhanced granulation tissue formation, enhanced angiogenesis, accelerated re-epithelialization and quick complete healing; compared to all other groups. Significant decrease in TGF-β level was recorded in PP\Ag and Ag-SD cream groups as compared to blank PP group on day 5. While, significant decrease in TGF-β level was detected in PP\Ag group when compared with undressed and blank PP groups on day 10. TGF-β showed significant in PP\Ag group as compared to undressed, Ag-SD cream and blank PP groups on day 15. CONCLUSION: The present results suggest that PP/Ag dressing enhances, promotes and plays an important role in wound healing.

scholarly journals Telemedicine in Chronic Wound Management: Systematic Review And Meta-Analysis

10.2196/15574 ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. e15574
Author(s):  
Lihong Chen ◽  
Lihui Cheng ◽  
Wei Gao ◽  
Dawei Chen ◽  
Chun Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cohort Studies ◽  
Mobile Phones ◽  
Standard Care ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Meta Analysis ◽  
Wound Management ◽  
Efficacy And Safety ◽  
Chronic Wound Management

Background Chronic wounds have been a great burden to patients and the health care system. The popularity of the internet and smart devices, such as mobile phones and tablets, has made it possible to adopt telemedicine (TM) to improve the management of chronic wounds. However, studies conducted by different researchers have reported contradictory results on the effect of TM on chronic wound management. Objective The aim of this work was to evaluate the efficacy and safety of TM in chronic wound management. Methods We systematically searched multiple electronic databases (MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials [CENTRAL]) to identify eligible studies published from inception to June 12, 2019. Inclusion criteria were randomized controlled trials (RCTs) and interventional cohort studies that investigated the use of TM in chronic wound management. RCT and observational data were analyzed separately. A meta-analysis and qualitative analysis were conducted to estimate endpoints. Results A total of 6 RCTs and 6 cohort studies including 3913 patients were included. Of these, 4 studies used tablets or mobile phones programmed with apps, such as Skype and specialized interactive systems, whereas the remaining 8 studies used email, telephone, and videoconferencing to facilitate the implementation of TM using a specialized system. Efficacy outcomes in RCTs showed no significant differences in wound healing (hazard ratio [HR] 1.16, 95% CI 0.96-1.39; P=.13), and wound healing around 1 year (risk ratio [RR] 1.05, 95% CI 0.89-1.23; P=.15). Noninferiority criteria of TM were met. A decreased risk of amputation in patients receiving TM was revealed (RR 0.45, 95% CI 0.29-0.71; P=.001). The result of cohort studies showed that TM was more effective than standard care (HR 1.74, 95% CI 1.43-2.12; P<.001), whereas the outcome efficacy RR of wound healing around 1 year (RR 1.21, 95% CI 0.96-1.53; P=.56) and 3 months (RR 1.24, 95% CI 0.47-3.3; P=.67) was not significantly different between TM and standard care. Noninferiority criteria of TM were met for wound healing around 1 year in cohort studies. Conclusions Currently available evidence suggests that TM seems to have similar efficacy and safety, and met noninferiority criteria with conventional standard care of chronic wounds. Large-scale, well-designed RCTs are warranted.

scholarly journals Healing Effects of Human Amniotic Membrane and Burned Wool on the Second-degree Burn in Rats

2020 ◽  
Vol 9 ◽  
pp. 1759
Author(s):  
Nader Tanideh ◽  
Farideh Keshavarzi ◽  
Aida Hemat Zadeh ◽  
Sajad Daneshi ◽  
Omid Koohi-Hosseinabadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Granulation Tissue ◽  
Male Rats ◽  
Control Group ◽  
Human Amniotic Membrane ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Degree Burn ◽  
Second Degree

ackground: This study aimed to compare sheep burnt wool and human amniotic membrane (AM) on second-degree burn wound healing in rats. Materials and Methods: Seventy-two adult male rats of Sprague Dawley underwent general anesthesia, and a deep second-degree burn was created on their skin by a hot iron plate. Afterward, human AM, silver sulfadiazine ointment (SSD), and sheep burned wool were used on wound area for burn treatment. On days 7, 14, and 21 of the experiment, the rats were sacrificed, and histopathological assessments were done. Results: Human AM, in comparison with other groups, significantly (P<0.05) showed better improvement in all pathologic variables. Burned wool showed significant improvement compared to the control group on day 7 in the angiogenesis, on day 14 in granulation tissue formation and epithelial formation, and on day 21 in new epithelial formation (P<0.05). Burned wool compared with SSD ointment in granulation tissue formation improved significantly (P<0.05) on days 7 and 14. Also, SSD ointment in comparison with the control group significantly improved (P<0.05) granulation tissue formation and macrophage on day 7. Conclusion: Human AM has a significant effect on the treatment of second-degree burn. Burned wool has a better effect on wound healing than SSD ointment and negative control group without treatment in terms of granulation tissue and epithelium formation. [GMJ.2020;9:e1759]

Effect of Mechanical Debridement and Irrigation With Hypochlorous Acid Wound Management Solution on Methicillin-resistant Staphylococcus aureus Contamination and Healing Deep Dermal Wounds in a Porcine Model

2021 ◽  
Vol 67 (8) ◽  
pp. 24-31
Author(s):  
Stephen Davis ◽  
Joel Gil ◽  
Jie Li ◽  
Colin Simms ◽  
Jose Valdes ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Granulation Tissue ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Hypochlorous Acid ◽  
Wound Management ◽  
Tissue Formation ◽  
Saline Irrigation ◽  
Granulation Tissue Formation ◽  
Methicillin Resistant ◽  
Epithelial Thickness

BACKGROUND: Wound cleansing is an important component of wound management. PURPOSE: This study was conducted to examine the effect of a wound management solution (WMS) containing hypochlorous acid (HOCl) on methicillin-resistant Staphylococcus aureus (MRSA) and healing when used in conjunction with debridement. METHODS: Nineteen (19) deep reticular dermal wounds (22 mm × 22 mm × 3 mm deep) were created on the paravertebral and thoracic areas of 3 female pigs using a specialized electrokeratome. Wounds were separated by at least 5 cm to 7 cm of unwounded skin and inoculated with MRSA. After 72 hours, all wounds were debrided with a curette and irrigated with either the WMS or sterile saline solution twice per day from day 0 to day 4. Wounds then were irrigated once a day until the completion of the study (day 11). Wound tissue specimens were taken using punch biopsy for microbiological and histological analysis on days 4, 8, and 11 post treatment. Percent of wound epithelialized, epithelial thickness (cell layers µm), white cell infiltrate (1 = absent, 2 = mild, 3 = moderate, 4 = marked, 5 = exuberant), and percent of granulation tissue formation were calculated and assessed. Microbiology and histology results were analyzed for significant differences between treatments and among assessment days using one-way analysis of variance and student t-tests. A P value ≤ .05 was considered significant. RESULTS: The WMS effected a bacterial reduction (P ≤ .05) of more than 2.74 ± 0.43 and 1.03 ± 0.22 Log CFU/g in all assessment days compared with baseline before and after debridement, respectively. Percent epithelialization was significantly different between treatments on day 8, only 78.3% and 67.8% for HOCl and saline, respectively (P ≤ .05). No significant differences between treatments were observed for epithelial thickness or granulation tissue formation. CONCLUSION: The combination of debridement and HOCl wound irrigation can significantly reduce MRSA contamination and facilitate the healing process compared to saline irrigation. Clinical studies are needed to confirm these results.

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