Electrocoagulative Surgical Procedure for Treatment of Conjunctivochalasis

Abstract The purpose of this study was to present a new procedure to treat symptomatic conjunctivochalasis (CCh) and to evaluate its efficacy. Forty-two patients with symptomatic CCh refractory to medical management were included on this study. Twenty-two patients (n = 32, eyes; n = 14 women and n = 8 men) underwent the new electrocoagulation procedure (Group I). Twenty patients (n = 27 eyes; n = 11 women and n = 9 men) underwent crescent-shaped conjunctiva resection (Group II). Ocular Surface Disease Index (OSDI) was used to evaluate ocular symptoms. There was a significant difference in mean and SD operation time between Group I (8.67 ± 2.07 minutes) and Group II (20.45 ± 3.98 minutes; P < 0.0001). OSDI scores (mean ± SD) were significantly lower in Group I (28.38 ± 3.14) than Group II (31.62 ± 3.17) at postoperative week 2 (P = 0.0004). No differences in OSDI scores were found between the 2 groups at postoperative week 4 (P = 0.1749) or 8 (P = 0.1483). OSDI scores were significantly lower at postoperative week 8 than at baseline in both Group I (P = 0.0002) and Group II (P = 0.0011). Electrocoagulation of the conjunctiva can successfully treat symptomatic CCh with earlier symptomatic attenuation and less operation time than traditional conjunctiva resection.

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Ocular Surface Disease Severity in Polycystic Ovary Syndrome: is This Really Significant in Daily Life?

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2021.1173 ◽

2021 ◽

pp. 1-7

Author(s):

Demet Yabanoglu ◽

Funda Gode

Keyword(s):

Polycystic Ovary Syndrome ◽

Ocular Surface ◽

Polycystic Ovary ◽

Tear Film ◽

Disease Index ◽

Ocular Surface Disease ◽

Ocular Surface Disease Index ◽

Ovary Syndrome ◽

Group I ◽

Group Ii

OBJECTIVE: The purpose of this study was to ascertain the extent to which the ocular surface of women with polycystic ovary syndrome is impacted. STUDY DESIGN: Included in this case-control study were 23 eyes of 23 patients (Group I) with polycystic ovary syndrome and 10 eyes of 10 healthy subjects (Group II). Polycystic ovary syndrome was diagnosed when two of the following conditions were met: oligo- or anovulation, clinical and/or biochemical signs of hyperandrogenism, and ultrasonographic documentation of polycystic ovaries. Ocular surface disease grading was performed using the Ocular Surface Disease Index questionnaire, slit lamp examination, meibomian gland secretion scoring, tear film breakup time, staining scores of ocular surfaces, the Schirmer's test, and tear osmolarity assessment. RESULTS: The study observed no significant difference in age (p=0.896). Group I was found to have a significantly higher median luteinizing hormone level (p=0.027). The Ocular Surface Disease Index scores in group I were significantly higher than those in group II (p=0.031). The prevalence of anterior blepharitis was significantly greater in group I (p=0.05). Tear film breakup time was higher in group I than in group II (p=0.026). The ocular surface disease severity was found to be significantly higher in group I (p=0.03). In group I, Ocular Surface Disease Index scores were significantly positively correlated with free testosterone, while tear osmolarity was significantly positively correlated with estradiol levels but significantly negatively correlated with dehydroepiandrosterone sulfate levels (p<0.05). CONCLUSIONS: Daily activities appear to be slightly impaired in patients with polycystic ovary syndrome due to ocular surface problems. However, environmental factors (humidity, temperature, etc.) contribute to the aggravation of ocular symptoms. Patients with polycystic ovary syndrome may be referred to an ophthalmologist to preserve ocular surface health.

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Prospective study comparing Xalatan® eye drops and two similar generics as to the efficacy and safety profile

European Journal of Ophthalmology ◽

10.1177/1120672117747030 ◽

2018 ◽

Vol 28 (4) ◽

pp. 378-384 ◽

Cited By ~ 2

Author(s):

Andreas Diagourtas ◽

Kostantinos Kagelaris ◽

Kostantinos Oikonomakis ◽

Andreas Droulias ◽

Nikolaos Kokolakis ◽

...

Keyword(s):

Intraocular Pressure ◽

Safety Profile ◽

Ocular Surface ◽

Disease Index ◽

Ocular Surface Disease ◽

Eye Drops ◽

Efficacy And Safety ◽

Ocular Surface Disease Index ◽

Significant Difference ◽

The Mean

Purpose: To evaluate the efficacy and safety between two generic prostaglandins Lataz–Xalaprost (Greece) and the corresponding original drops (Xalatan®). Material and methods: In this prospective randomized study, 60 patients diagnosed with open-angle glaucoma or ocular hypertension were enrolled, who had never received antiglaucoma treatment. Subjects were divided randomly into three groups (Xalatan, Lataz, and Xalaprost groups) and they were studied over 16 weeks. At each visit, the mean applanation tonometry values and tear break-up time were measured. The Ocular Surface Disease Index questionnaire was used to evaluate patient’s symptoms. Results: There was a statistically significant difference (p < 0.001) in the mean values of the intraocular pressure between the baseline and the last visit (Xalatan group: from 23.11 ± 1.61 mmHg to 15.81 ± 1.22 mmHg, Lataz group: from 23.26 ± 1.33 mmHg to 15.80 ± 1.47 mmHg, and Xalaprost group: from 23.08 ± 1.45 mmHg to 16.08 ± 1.38 mmHg). Both generic eye drops showed mean percentage intraocular pressure reduction comparable to the standards of prostaglandin analogues (Xalatan: 31.57%, Lataz: 32.06%, and Xalaprost: 30.34%). Xalatan reduced the tear break-up time less, followed by Lataz and then by Xalaprost (Xalatan: from 8.5 to 8 s, Lataz: from 8.2 to 7.4 s, and Xalaprost: from 8.7 to 7.7 s). Xalatan presented the best safety profile, followed by Lataz and least was Xalaprost, according to Ocular Surface Disease Index questionnaire’s results. Conclusion: No significant difference was recorded in the effectiveness of each generic prostaglandin compared to the original. Furthermore, no patient had to change medication. The differences that arose in the safety profile of the three eye drops suggest a prompt closer initial monitoring of patients who are administered generic eye drops.

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Feasibility of Endoscopic Thyroidectomy via Axilla and Breast Approaches for Larger Goiters: Widening the Horizons

Journal of Thyroid Research ◽

10.1155/2018/4057542 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Goonj Johri ◽

Gyan Chand ◽

Nitish Gupta ◽

Chaitra Sonthineni ◽

Anjali Mishra ◽

...

Keyword(s):

Endoscopic Thyroidectomy ◽

Operation Time ◽

Vocal Cord Palsy ◽

Perioperative Outcomes ◽

Complication Rates ◽

Group I ◽

Conversion Rates ◽

Significant Difference ◽

Group Ii

Scarless (in the neck) endoscopic thyroidectomy (SET) has evolved into a cosmetically preferred alternative to conventional thyroidectomy (ConT). Recently many of our patients are demanding SET; however their goitres are larger than the recommended size of 4–6 cm. Our aim was to compare the outcomes of ET for small (<6 cm) vs large (≥6 cm) goitres and determine its feasibility in such cases. This is a retrospective analysis of prospectively maintained database of patients undergoing ET. Patients were divided into 2 groups: I, small (<6 cm) and II, large goitres (≥6 cm). Their demographic and clinicopathological profiles, operation time, conversion and complication rates, and hospital stay were compared. 99 patients (101 procedures) were included: group I, 60 patients (61 procedures), and group II, 39 patients (40 procedures). Mean tumor size (± SD) was 4.4 ± 0.9 cm and 6.7 ± 1.1 cm in groups I and II, respectively. The groups were comparable with respect to demographic and clinical profile except for mean duration of goiter [30.1 ± 32.6 months (group I) vs 60.5 ± 102.4 months (group I), p = 0.03] and gland weight [21.5 ± 15.3 grams (group I) vs 62.3 ± 51.3 grams (group II), p = 0.001]. Although there was no significant difference between mean operating times, long term perioperative outcomes, and conversion rates, temporary hypocalcaemia and length of stay were longer in group II. One patient had permanent vocal cord palsy (~1%, 1/101); none had permanent hypoparathyroidism. Our results indicate that ET can be offered to a subset of patients with larger goitres desirous of SET with no significant difference in mean operation time, conversions, and long term postoperative complications in experienced hands.

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Impact of Epiphora on Modified Ocular Surface Disease Index Questionnaire

Medicine & Health ◽

10.17576/mh.2020.1502.21 ◽

2020 ◽

Vol 15 (2) ◽

pp. 236-345

Author(s):

Zeynep Eylül Ercan ◽

Keyword(s):

Ocular Surface ◽

Interpersonal Relations ◽

Daily Life ◽

Disease Index ◽

Ocular Surface Disease ◽

Cold Weather ◽

Ocular Surface Disease Index ◽

Ocular Symptoms ◽

Dry Climates ◽

Lacrimal Drainage

Epiphora (excessive tear production) is a major ocular disturbance, especially among middle aged and older patients. It can be due to lacrimal drainage malfunction of any kind. The aim of this study was to evaluate the effects of epiphora with good passage on lacrimal irrigation on a modified Ocular Surface Disease Index (OSDI) questionnaire. A total of 101 patients (53 males/ 48 females) were included in the study. The modified OSDI questionnaire had 11 items concerning ocular symptoms that affects daily activities. The relationships between the questionnaire score for each question and the clinical features included age, gender and previous cataract surgery. The most affected activities according to modified OSDI were watching television, windy conditions and cold weather (average means of 3.36 + 0.82, 3.42 +±0.86 and 3.40 +±0.88, respectively). Epiphora was found to have a statistically significant effect on daily life, all except with regard to interpersonal relations (p=0.493) with increasing age. Women were found to be experiencing more eye grittiness (p=0.0001), getting more affected during reading (p=0.027), at hot/dry climates (p=0.0001) and believed epiphora has an important impact on interpersonal relations and general happiness (p<0.0001). Pseudophakic patients also showed statistically significant increase of discomfort in daily life questions in 7 of the 11 questions (p<0.0001). This study showed the subjective epiphora related symptoms impact on a modified OSDI. This questionnaire was easy to manage and quick to complete while showing similar results to those that were specifically designed for epiphora with nasolacrimal obstruction. We believe that the results could help to improve overall therapeutic management of patients with epiphora

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Ocular Surface Disease Index and Ocular Thermography in Keratoconus Patients

Journal of Ophthalmology ◽

10.1155/2020/1571283 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Orsolya Németh ◽

Achim Langenbucher ◽

Timo Eppig ◽

Sabine Lepper ◽

Georgia Milioti ◽

...

Keyword(s):

Ocular Surface ◽

Normal Population ◽

Corneal Thickness ◽

Asymmetry Index ◽

Disease Index ◽

Ocular Surface Disease ◽

Ocular Surface Disease Index ◽

Regularity Index ◽

Significant Difference ◽

Eye Opening

Purpose. Keratoconus (KC) has been defined as a “noninflammatory” corneal disease, but recent studies have noted a potential inflammatory origin. We analysed the Ocular Surface Disease Index (OSDI) and ocular surface temperature (OST) in KC patients compared to controls. Patients and Methods. A total of 179 eyes in 90 patients with KC (topographic keratoconus classification 0-1 to 4, age 36.1 ± 12.5 years, 65.9% males) and 82 eyes in 41 controls (age 36.4 ± 12.8 years, 47.6% males) were examined. The participants completed the OSDI questionnaire and underwent corneal topography, tomography, and thermography. Additional outcome measures were vision- and discomfort-related OSDI subscores and mean OST at the corneal centre during 10 seconds of sustained eye opening after blinking. Results. The OSDI score (31.4 ± 22.4 vs. 17.5 ± 17.9) and vision- (17.7 ± 14.6 vs. 10.5 ± 13.2) and discomfort-related (14.3 ± 10.7 vs. 9.4 ± 10.5) OSDI subscores were significantly higher in KC patients than in controls (p<0.001). We found no significant difference in the central corneal OST (34.2 ± 0.6°C vs. 34.2 ± 0.7°C; p=0.41) between the two groups (p≥0.22). The OSDI score and subscores poorly to fairly correlated with the surface asymmetry index (SAI) and surface regularity index (SRI; r > 0.174, p<0.005), but did not correlate with the central corneal OST (r < 0.001). OST also did not correlate with the SAI, SRI, and central corneal thickness (r ≥ −0.086). Conclusion. KC patients had increased OSDI scores and vision- and discomfort-related OSDI subscores without an increase in the OST compared to a normal population. OSDI score/subscores weakly correlate with SAI and SRI but do not correlate with OST in KC patients or controls. Vision- and discomfort-related symptoms of KC have to be managed in parallel in ophthalmological practice, but the necessity of anti-inflammatory treatment cannot be verified through ocular thermography.

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Impact of hemodialysis on the wellbeing of chronic kidney diseases patients: a pre-post analysis

Middle East Current Psychiatry ◽

10.1186/s43045-020-00060-x ◽

2020 ◽

Vol 27 (1) ◽

Author(s):

Um-e-Kalsoom ◽

Sabiha Khan ◽

Israr Ahmad

Keyword(s):

Quality Of Life ◽

Social Support ◽

Perceived Social Support ◽

Kidney Diseases ◽

Chronic Kidney Diseases ◽

Group I ◽

Significant Difference ◽

Group Ii ◽

The Impact

Abstract Background Hemodialysis may have serious psychological impact upon patients suffering from chronic kidney diseases. The aim of the present study is to investigate the impact of hemodialysis on the wellbeing of individuals with chronic kidney diseases (CKD). Result A sample consists of (N = 100) CKD patients referred from neurology ward of Leady Reading Hospital Peshawar. Data was collected from both male (50%) and female (50%) in 2017. Participants were divided into two groups on the basis of pre-set criteria. In group I, individuals with 4–5 stage of CKD referred first time for dialysis treatment were recruited. Group II comprised of CKD patients with 1–3 stage. Demographic data sheet, Pakistan Anxiety and Depression, WHO Quality of Life scale, and Perceived Social support scale (PSS) were used to test the hypotheses. Paired sample t test was use to see the difference between pre- and post-analysis of depression, anxiety, QOL, and PSS in group I (experimental group). Results suggests significant difference on depression (p > .001), anxiety (p > .001), and QOL (p > .001), while no significant difference was reported on perceived social support (p <.673). Findings also indicate no significant difference between group I and group II on QOL depression, anxiety, and PSS. Conclusion The findings concluded that patients under hemodialysis treatment suffered from depression, anxiety, and poor quality of life.

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Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

American Journal of Perinatology ◽

10.1055/s-0040-1722328 ◽

2021 ◽

Author(s):

Mahir Tıraş ◽

Emrah Can ◽

Şahin Hamilçıkan

Keyword(s):

Cord Blood ◽

Total Serum ◽

Healthy Controls ◽

Term Neonates ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Group Ii ◽

Positive Direct ◽

Severe Hyperbilirubinemia

Objective This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. Study Design This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO–DCT), and group III featured 70 healthy controls. COHb was determined by an OSM3 hemoximeter. Results Group I differed from groups II and III for cord blood bilirubin, cord blood hemoglobin, and cord blood hematocrit. Groups I and II had higher mean total serum bilirubin (TSB) levels than group III, while there was no difference in the mean TSB levels between groups I and II. There was no significant difference between the COHb group means for groups I, II, and III (p = 0.98). The area under the receiver operating characteristic curve calculated for group I/group III and group II/group III were found to be 0.62 and 0.54, respectively. Conclusion COHb levels did not prove to be superior to the DCT for predicting the risk of developing severe hyperbilirubinemia in term neonates. Key Points

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Comparison of ocular surface assessment and adherence between preserved and preservative-free latanoprost in glaucoma: a parallel-grouped randomized trial

Scientific Reports ◽

10.1038/s41598-021-94574-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Dai Woo Kim ◽

Jonghoon Shin ◽

Chang Kyu Lee ◽

Myungjin Kim ◽

Sohyeon Lee ◽

...

Keyword(s):

Free Group ◽

Ocular Surface ◽

Open Angle Glaucoma ◽

Drug Tolerance ◽

Adherence Rate ◽

Eye Drops ◽

Ocular Surface Disease Index ◽

Significant Difference ◽

Surface Assessment ◽

Preservative Free

AbstractGiven that nonadherence is related to subject characteristics and drug tolerance and preserved eye drops tend to be more intolerable than preservative-free ones, we conducted a phase 4, parallel-grouped, investigator-blind, active-control, randomized, multicenter study. A total of 51 patients with intraocular pressure (IOP) ≥ 15 mmHg diagnosed with open-angle glaucoma or ocular hypertension were randomly assigned to the preserved latanoprost group (n = 26) and the preservative-free latanoprost group (n = 25). The efficacy variables were corneal/conjunctival staining grade, Ocular Surface Disease Index (OSDI), adherence at 12 weeks after the first administration; corneal/conjunctival staining grade at 4 weeks; and IOP, tear break-up time (TBUT), and hyperemia score at 4 and 12 weeks. The safety variables included visual acuity and drug tolerance questionnaire results. There was no statistically significant difference in corneal/conjunctival staining grade, OSDI, or TBUT between the groups at 4 and 12 weeks. However, the adherence rate was higher and the hyperemia score was lower in the preservative-free group than in the preserved group. The severity and duration of stinging/burning sensation were lower in the preservative-free group than in the preserved group. Overall, preservative-free latanoprost showed better ocular tolerance assessed by hyperemia scores and stinging/burning symptoms following higher adherence than preserved latanoprost.

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Reliability and validity of the Japanese version of the Ocular Surface Disease Index for dry eye disease

BMJ Open ◽

10.1136/bmjopen-2019-033940 ◽

2019 ◽

Vol 9 (11) ◽

pp. e033940 ◽

Cited By ~ 7

Author(s):

Akie Midorikawa-Inomata ◽

Takenori Inomata ◽

Shuko Nojiri ◽

Masahiro Nakamura ◽

Masao Iwagami ◽

...

Keyword(s):

Internal Consistency ◽

Dry Eye ◽

Ocular Surface ◽

Discriminant Validity ◽

Reliability And Validity ◽

Japanese Version ◽

Disease Index ◽

Eye Disease ◽

Ocular Surface Disease Index ◽

Test Retest Reliability

ObjectivesThe Ocular Surface Disease Index (OSDI) questionnaire is widely used to evaluate subjective symptoms of dry eye disease (DED) as a primary diagnostic criterion. This study aimed to develop a Japanese version of the OSDI (J-OSDI) and assess its reliability and validity.Design and settingHospital-based cross-sectional observational study.ParticipantsA total of 209 patients recruited from the Department of Ophthalmology at Juntendo University Hospital.MethodsWe translated and culturally adapted the OSDI into Japanese. The J-OSDI was then assessed for internal consistency, reliability and validity. We also evaluated the optimal cut-off value to suspect DED using an area under the receiver operating characteristic curve (AUC) analysis.Primary outcome measuresInternal consistency, test–retest reliability and discriminant validity of the J-OSDI as well as the optimal cut-off value to suspect DED.ResultsOf the participants, 152 had DED and 57 did not. The J-OSDI total score showed good internal consistency (Cronbach's alpha=0.884), test–retest reliability (interclass correlation coefficient=0.910) and discriminant validity by known-group comparisons (non-DED, 19.4±16.0; DED, 37.7±22.2; p<0.001). Factor validity was used to confirm three subscales within the J-OSDI according to the original version of the questionnaire. Concurrent validity was assessed by Pearson correlation analysis, and the J-OSDI total score showed a strong positive correlation with the Dry Eye-Related Quality-of-Life Score (γ=0.829). The optimal cut-off value of the J-OSDI total score was 36.3 (AUC=0.744).ConclusionsThe J-OSDI was developed and validated in terms of reliability and validity as an effective tool for DED assessment and monitoring in the Japanese population.

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Experimental Study on a Prediction Model of the Shrinkage and Creep of Recycled Aggregate Concrete

Applied Sciences ◽

10.3390/app9204322 ◽

2019 ◽

Vol 9 (20) ◽

pp. 4322 ◽

Cited By ~ 5

Author(s):

Lv ◽

Liu ◽

Zhu ◽

Bai ◽

Keyword(s):

Substitution Rate ◽

Recycled Aggregate Concrete ◽

Recycled Aggregate ◽

Creep Model ◽

Aggregate Concrete ◽

Ordinary Concrete ◽

Group I ◽

Significant Difference ◽

Shrinkage And Creep ◽

Group Ii

The significant difference between recycled aggregate and natural aggregate is the content of the attached mortar layer. With the increase of the replacement rate of recycled aggregate, the shrinkage and creep of recycled aggregate concrete is significantly increased. In this paper, 180-day shrinkage and creep tests of recycled aggregate concrete with different water–cement ratios were designed in order to analyze the effect of the substitution rate and water–cement ratio on shrinkage and creep properties. The results show that the shrinkage strain of recycled aggregate concrete with a substitution rate of 50% and 100% at 180 days is 26% and 48% higher than that of ordinary concrete, respectively, and the growth of group II is 22% and 47%, respectively. When the load was 180 days old, the creep coefficient of recycled aggregate concrete with a substitution rate of 50% and 100% in group I increased by 19.6% and 39.6%, respectively compared with ordinary concrete, and group II increased by 23.6% and 44.3%, respectively. Based on the difference of adhering mortar content, the creeping increase coefficient and shrinkage increase coefficient of the attached mortar were proposed, and a shrinkage and creep model of recycled aggregate concrete was established. When compared with the experimental results, the model calculation results met the accuracy requirements.

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