scholarly journals Serum Levels of High Sensitivity C-reactive Protein in Drug-naïve First-episode Psychosis and Acute Exacerbation of Schizophrenia

2019 ◽  
Vol 17 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Abdullah Bolu ◽  
Mehmet Sinan Aydın ◽  
Abdullah Akgün ◽  
Ali Coşkun ◽  
Beyazıt Garip ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
High Sensitivity ◽  
Serum Levels ◽  
First Episode Psychosis ◽  
First Episode ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Episode Psychosis ◽  
Drug Naïve

scholarly journals Innate Immune Cells and C-Reactive Protein in Acute First-Episode Psychosis and Schizophrenia: Relationship to Psychopathology and Treatment

2019 ◽  
Author(s):  
Johann Steiner ◽  
Thomas Frodl ◽  
Kolja Schiltz ◽  
Henrik Dobrowolny ◽  
Roland Jacobs ◽  
...  
Keyword(s):  
Innate Immunity ◽  
First Episode Psychosis ◽  
Innate Immune ◽  
First Episode ◽  
Antipsychotic Treatment ◽  
C Reactive Protein ◽  
Activation Markers ◽  
Reactive Protein ◽  
Immune System Activation ◽  
Episode Psychosis

Abstract Innate immunity has been linked to initiation of Alzheimer’s disease and multiple sclerosis. Moreover, risk of first-episode psychosis (FEP) and schizophrenia (Sz) is increased after various infections in predisposed individuals. Thus, we hypothesized an analogous role of innate immunity with increased C-reactive protein (CRP) in non-affective psychosis. Differential blood count, CRP, neutrophil and monocyte–macrophage activation markers, cortisol and psychotic symptoms (Positive and Negative Syndrome Scale [PANSS]) were assessed in controls (n = 294) and acutely ill unmedicated FEP (n = 129) and Sz (n = 124) patients at baseline and after 6 weeks treatment. Neutrophils, monocytes, and CRP were increased in patients vs controls at baseline (P < .001), and neutrophil and monocyte counts correlated positively with activation markers. Eosinophils were lower at baseline in FEP (P < .001) and Sz (P = .021) vs controls. Differences in neutrophils (P = .023), eosinophils (P < .001), and CRP (P < .001) were also present when controlling for smoking and cortisol, and partially remitted after antipsychotic treatment. FEP patients with high neutrophils (P = .048) or monocytes (P = .021) had higher PANSS-P scores at baseline but similar disease course. CRP correlated with PANSS-P at baseline (ρ = 0.204, P = .012). Improvement of positive symptoms after treatment correlated with declining neutrophils (ρ = 0.186, P = .015) or CRP (ρ = 0.237, P = .002) and rising eosinophils (ρ = −0.161, P = .036). In FEP, normalization of neutrophils (ρ = −0.231, P = .029) and eosinophils (ρ = 0.209, P = .048) correlated with drug dosage. In conclusion, innate immune system activation correlated with PANSS-P, supporting the immune hypothesis of psychosis. Neutrophil and monocyte counts and CRP levels may be useful markers of disease acuity, severity, and treatment response.

scholarly journals Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients

2012 ◽  
Vol 42 (9) ◽  
pp. 1893-1901 ◽  
Author(s):  
N. Hepgul ◽  
C. M. Pariante ◽  
S. Dipasquale ◽  
M. DiForti ◽  
H. Taylor ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Childhood Maltreatment ◽  
First Episode Psychosis ◽  
First Episode ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Episode Psychosis

BackgroundThe high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls.MethodBody mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors.ResultsPatients with childhood maltreatment had higher BMI [25.0 (s.e.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (s.e.=0.6) mg/dl] when compared with healthy controls [23.4 (s.e.=0.4) kg/m2, p=0.030 and 0.2 (s.e.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (s.e.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (s.e.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue.ConclusionsChildhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.

scholarly journals Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28

2017 ◽  
Vol 22 (6) ◽  
pp. 850-856 ◽  
Author(s):  
K Collste ◽  
◽  
P Plavén-Sigray ◽  
H Fatouros-Bergman ◽  
P Victorsson ◽  
...  
Keyword(s):  
Glial Cell ◽  
First Episode Psychosis ◽  
First Episode ◽  
Cell Marker ◽  
Episode Psychosis ◽  
Drug Naïve

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

The value of calcium and high-sensitivity C-reactive protein serum levels in psoriatic patients

2021 ◽  
Vol 34 (1) ◽  
pp. 56
Author(s):  
ShaimaaB El Hagary ◽  
MohamedA Basha ◽  
WafaaA Shehata ◽  
ImanM Gayed
Keyword(s):  
High Sensitivity ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Protein Serum

scholarly journals Chosen Vascular Risk Markers in Pseudoexfoliation Syndrome: An Age-Related Disorder

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Hanna Lesiewska ◽  
Agnieszka Łukaszewska-Smyk ◽  
Grażyna Odrowąż-Sypniewska ◽  
Magdalena Krintus ◽  
Aneta Mańkowska-Cyl ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Vascular Diseases ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Serum Levels ◽  
Pseudoexfoliation Syndrome ◽  
C Reactive Protein ◽  
Related Disorder ◽  
Reactive Protein ◽  
Age Related

Purpose. To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods. 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results. There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups. High-sensitivity C-reactive protein was not increased in patients with PEX. Conclusions. Our results cast doubt on the opinion on the possible PEX and vascular diseases relation. Further studies on this subject are mandatory.

Sign in / Sign up

Export Citation Format

Share Document