scholarly journals Incidence, Maternal Risk Factors, Microbiological Profile And Antibiotic Sensitivity Pattern in Neonatal Sepsis A Hospital Based Study At Agartala, Tripura.

2017 ◽  
Vol 16 (01) ◽  
pp. 58-63
Author(s):  
Dr.Sanjib K. Debbarma ◽  
Dr.Sujit K. Chakrabarti
Keyword(s):  
Risk Factors ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Microbiological Profile ◽  
Sensitivity Pattern

scholarly journals Neonatal Sepsis: A Profile of a Changing Spectrum

2015 ◽  
Vol 34 (3) ◽  
pp. 207-214
Author(s):  
K Venkatnarayan ◽  
PK Bej ◽  
RK Thapar
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Clinical Diagnosis ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Clinical Criteria ◽  
Common Organism ◽  
Sepsis Screen

Introduction: The clinical features of neonatal sepsis are protean and are based on variety of clinical, demographic and laboratory profile of suspected cases. Objectives: To describe the aforementioned profiles in neonates presenting with clinically suspected sepsis based on pre-defined clinical criteria. Material and Methods: Design: Cross-Sectional Study; Setting: Level-2 NICU, Tertiary Care Hospital; Duration: Jan 2011 to Jul 2012. Subjects: 50 consecutive neonates presenting with any of the predefined clinical criteria were assessed for presence of maternal risk factors and studied with respect to: Gestational age, sepsis screen, clinical profile and antibiotic sensitivity of the organisms cultured. Results: Out of the fifty neonates, 38 (76%) were early onset sepsis. The sepsis screen showed an overall sensitivity of 73%, specificity of 54%; with a positive predictive value of 41% and a negative predictive value of 83%. The most common organism cultured was Staphylococcus aureus followed by E Coli, Pseudomonas, Coagulase Negative Staphylococcus and Group B Streptococcus. Ampicillin and Amikacin fared better than Cefotaxime and Gentamicin for Gram positive and Gram negative organisms, respectively. Overall, 37 babies responded to first line antibiotics and 11 required a change of antibiotics. One required addition of inotropes and two of the neonates died. Conclusion: A clinical diagnosis of sepsis based on predefined clinical criteria along with maternal risk factors, over- treated 27 babies (71%) with EONS and 8 babies (66.6%) with LONS. However, such a clinical diagnosis was supported by a septic screen almost twice as frequently (50% Vs 26.3%) in LONS. Staphylococcus aureus was the most common organism isolated. J Nepal Paediatr Soc 2014;34(3):207-214 DOI: http://dx.doi.org/10.3126/jnps.v34i3.11236  

scholarly journals Frequency of maternal risk factors in diagnosed cases of early neonatal sepsis.

2019 ◽  
Vol 26 (12) ◽  
pp. 2044-2047
Author(s):  
Faraz Ahmed ◽  
Mohsin Ali ◽  
Hussan Ali Sarwar ◽  
Miqdad Haider ◽  
Muhammad Bilal Safdar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Delivery ◽  
Neonatal Sepsis ◽  
Neonatal Morbidity ◽  
Cross Sectional Study ◽  
Maternal Risk Factors ◽  
Cross Sectional ◽  
Maternal Risk ◽  
Early Neonatal Sepsis ◽  
Study Setting

One of the major and important but preventable causes of neonatal morbidity and mortality is Neonatal sepsis. Objectives: To determine the frequency of maternal risk factors in diagnosed cases of early neonatal sepsis. Study Design: Descriptive cross sectional study. Setting: Nursery, Department of Children Hospital and the institute of child health, Lahore. Period: 15-01-2016 to 15-07-2016. Material and Methods: After approval from hospital ethical committee, according to inclusion and exclusion criteria, 250 patients were enrolled in the study from nursery department of children hospital, Lahore. Maternal risk factors i.e. PROM, meconium stained liquor and preterm delivery were recorded along with the demographic information of each case. Results: In our study, out of 250 cases, cases between 1-2 days were 64.8% (n=162) while cases between 3 days of life were 35.2% (n=88), mean+sd was resulted as 2.17+0.69 days. Frequency of maternal risk factors in diagnosed cases of early neonatal sepsis was turned out as 64.8% (n=162) PROM, 29.6% (n=74) meconium stained liquor and preterm delivery was resulted in 21.2% (n=53). Conclusion: The leading maternal risk factor is PROM followed by meconium stained liquor and preterm delivery in diagnosed cases of early neonatal sepsis.

scholarly journals Causative Organisms, Antibiotic Sensitivity Patterns and Risk Factors Associated with Neonatal Sepsis at Moi Teaching and Referral Hospital, Kenya

2020 ◽  
Author(s):  
Benard Mageto Ateka ◽  
Julia Songok ◽  
Winstone Nyandiko
Keyword(s):  
Risk Factors ◽  
Low Income ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Referral Hospital ◽  
Maternal Risk ◽  
Factors Associated ◽  
Hospital Infection Control ◽  
Tertiary Teaching ◽  
Klebsiella Spp

ABSTRACTBackgroundNeonatal bacterial infections have been associated with rising antimicrobial resistance levels. This has led to increasing neonatal morbidity and mortality in poorly resourced health facilities located in low income countries. Local studies on neonatal antibiotic sensitivity patterns and its associated risk factors could inform empirical antibiotic therapy and hospital infection control strategies.PurposeThe study aimed at determining the causative organisms, antibiotic sensitivity patterns and risk factors associated with neonatal sepsis at a tertiary teaching hospital in Western Kenya.Materials and MethodsCross-sectional study among neonates suspected to have sepsis and undergoing treatment at Moi Teaching and Referral Hospital (MTRH’s) newborn unit (NBU) between September 2017 and July 2018. Blood culture tests isolated bacteria and determined their antimicrobial sensitivity. Neonatal and maternal characteristics were obtained through medical chart reviews. Descriptive statistics, Pearson chi-square test of association and odds ratios were adopted.ResultsThe study enrolled 141 neonates, majority (57.4%) of whom were female. The median gestational age and birth weight were 37 (IQR: 22-45) weeks and 2400g (IQR: 800 - 4700) respectively. Of the 151 bacterial isolates identified, 46.4% were Klebsiella spp. followed by Coagulate negative staphylococcus (CoNS) at 27.8%. Klebsiella spp. was sensitive to meropenem, amikacin and cefepime but resistant to ceftriaxone, gentamycin and cefotaxime. However, CoNS was sensitive to vancomycin and penicillin. Both the neonatal and maternal risk factors assessed were not associated with neonatal sepsis.ConclusionThe main bacterial causes of neonatal sepsis were Klebsiella spp. and CoNS which were both sensitivity to meropenem and amikacin.

scholarly journals Faktor Risiko Ibu Dalam Meningkatkan Kejadian Sepsis Neonatorum Di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin

2019 ◽  
pp. 73-83
Author(s):  
Fitri Yuliana ◽  
Mahpolah Mahpolah ◽  
Eriza Nopariyanti
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Case Control ◽  
Maternal Risk Factors ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Maternal Risk ◽  
Purposive Sampling ◽  
Prolonged Labor

Latar Belakang: Penyebab utama kematian bayi baru lahir atau neonatal di dunia antara lain bayi lahir premature 29%, sepsis dan pneumonia 25% dan 23% merupakan bayi baru lahir dengan asfiksia dan trauma. Sepsis neonatorum merupakan salah satu penyakit infeksi yang dapat menyebabkan kematian pada bayi baru lahir, angka kejadian sepsis di Indonesia masih tinggi yaitu 8,7% sampai 30,29% dengan angka kematian 11,56% sampai 49,9%.  Kejadian sepsis neonatorum di RSUD dr. H. Moch. Ansari Saleh pada tahun 2014 sebanyak 2,9%, tahun 2015 sebanyak 1,2%, dan tahun 2016 sebanyak 1,2%.Tujuan: Menganalisis faktor risiko ibu dalam meningkatkan kejadian sepsis neonatorum di RSUD Dr. H. Moch. Ansari Saleh Tahun 2017.Metode: Penelitian kuantitatif dengan rancangan case control. Populasi penelitian ini adalah semua bayi baru lahir yang tercatat di rekam medik RSUD dr. H. Moch Ansari Saleh tahun 2017 sebanyak 4516 orang. Sampel kasus diambil dengan total sampling sebanyak 55 orang sedangkan sampel kontrol diambil dengan teknik purposive sampling sebanyak 55 orang. Data dianalisis menggunakan uji chi-square.Hasil: Faktor risiko ibu yang terjadi selama kehamilan terbukti dapat meningkatkan kejadian sepsis neonatorum yaitu persalinan lama (ρ=0,032 a=0,05), ketuban pecah dini (ρ=0,015 a=0,05), dan usia kehamilan (ρ=0,022 a=0,05). Dari ketiga faktor tersebut ibu yang mengalami ketuban pecah dini merupakan faktor yang paling berisiko menyebabkan sepsis neonatorum dibandingkan dengan yang tidak mengalami ketuban pecah dini (OR = 2,571) sedangkan faktor risiko ibu yang tidak berhubungan adalah infeksi antepartum dan komplikasi kehamilan.Simpulan: Dari lima faktor risiko ibu terdapat tiga faktor yang dapat meningkatkan kejadian sepsis neonatorum yaitu faktor yang paling beresiko adalah ketuban pecah dini dan faktor lainnya adalah persalinan lama dan usia kehamilan. Kata Kunci: Ketuban pecah dini, Persalinan lama, Sepsis neonatorum, Usia kehamilan Mother Risk Factors In Increasing The Incidence Of Neonatal Sepsis At Dr. H. Moch. Ansari Saleh Hospital Of BanjarmasinABSTRACT  Background: The main causes of newborn or neonatal deaths in the world include premature babies 29%, sepsis and pneumonia 25% and 23% are newborns with asphyxia and trauma. Neonatal sepsis is one of the infectious diseases that can cause death in newborns, the incidence of sepsis in Indonesia is still high at 8.7% to 30.29% with a mortality rate of 11.56% to 49.9%. The incidence of Neonatal Sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2014 as much as 2.9%, in 2015 as many as 1.2%, and in 2016 as many as 1.2%.Objective: To analyzing maternal risk factors in increasing the incidence of neonatal sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017.Methods: Quantitative research with case control design. The study population was all newborns recorded in the medical record at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017 as many as 4516 people. Case samples were taken with a total sampling of 55 people while the control samples were taken with a purposive sampling technique of 55 people. Data were analyzed using the chi-square test.Results: Maternal risk factors that occur during pregnancy have been shown to increase the incidence of neonatal sepsis, prolonged labor (ρ=0,032 a=0,05), premature rupture of membranes (ρ=0,015 a=0,05), and gestational age (ρ=0,022 a=0,05). Of the three factors, mothers who experienced premature rupture of membranes were the most at risk for causing neonatal sepsis compared with those who did not experience premature rupture of membranes (OR = 2,571) while unrelated maternal risk factors were antepartum infection and pregnancy complications.Conclusion: Of the five maternal risk factors there are three factors that can increase the incidence of neonatal sepsis, which is the most risky factor is premature rupture of the membranes and other factors are prolonged labor and gestational age.  Key Words: Gestational age, Neonatal sepsis, Premature rupture of membranes, Prolonged labor  

scholarly journals Neonatal outcome of maternal premature rupture of membranes more than 18 hours

2020 ◽  
Vol 9 (2) ◽  
pp. 81-86
Author(s):  
Amshu Shakya ◽  
Sweta Kumari Gupta
Keyword(s):  
Risk Factors ◽  
Respiratory Distress Syndrome ◽  
Neonatal Sepsis ◽  
Distress Syndrome ◽  
Maternal Risk Factors ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Maternal Risk ◽  
History Of ◽  
Study Population

Background: Premature Rupture of Membranes  has been known to complicate pregnancy since ages. Several risk factors may be associated with occurrence of premature rupture of membranes. It is associated with varied neonatal complications, neonatal sepsis and prematurity being the most hazardous ones. Objectives: This study was conducted to evaluate the incidence of neonatal sepsis following premature rupture of membranes, risk factors and neonatal complications associated with premature rupture of membrane of more than 18 hours in the neonates admitted in a tertiary care center. Methodology: Descriptive observational study was undertaken for 18 months from August 2013 to January 2015 in the College of Medical Sciences, Chitwan, Nepal. This study included 82 neonates admitted to the Neonatal Intensive Care Unit with maternal history of premature rupture of membranes of more than 18 hours with medical conditions excluded.  Results: The incidence of premature rupture of membranes in this hospital was 8.9%. Frequently associated maternal risk factors were history of prior abortion (16, 19.5%), urinary tract infection (7, 8.5%), and antecedent coitus (7, 8.5%). In the study population, 68 (83%) neonates had complications and 14 (17%) neonates had no complication. The incidence of neonatal sepsis following PROM in present study was 6.1%. Neonatal sepsis was significantly associated with chorioamnionitis (p<0.001). The most frequently occurring complication was probable neonatal sepsis (53, 64.6%), followed by prematurity (31, 37.8%) and perinatal asphyxia (15, 18.3%). There was a directly proportional relation of neonatal sepsis, chorioamnionitis, respiratory distress syndrome and mortality with duration of premature rupture of membranes. Conclusion: Commonly occurring maternal risk factors with PROM were prior abortion, UTI and antecedent coitus. In the study population, infectious morbidity was highest.  Chorioamnionitis was significantly associated with culture proven neonatal sepsis. Prolonged duration of premature rupture of membranes increased the risk of neonatal sepsis, meningitis, respiratory distress syndrome and perinatal death. Prevention of these risk factors, appropriate and timely management including improved obstetric and neonatal care can provide intact survival of the neonates.

NEONATAL SEPSIS AND RISK FACTORS, STUDY IN IN AVBRH TERTIARY CARE HOSPITAL

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Pramod P. Singhavi
Keyword(s):  
Risk Factors ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Signs And Symptoms ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Late Onset Sepsis ◽  
Early Onset Sepsis ◽  
Meconium Stained Amniotic Fluid

Introduction: Neonatal sepsis can be defined as a clinical condition which is characterized by signs and symptoms of infection in an infant 28 days of life or younger. This is manifested by systemic signs of infection and/ or isolation of a bacterial or other pathogen from the bloodstream. Sepsis is still one of the major causes of morbidity and mortality globally in neonates, despite of recent advances in healthcare units. The incidence of neonatal sepsis by bacteremia in asymptomatic infants is low. In neonatal sepsis we can include septicaemia, pneumonia, meningitis, osteomyelitis, and arthritis and urinary tract infections. The burden for neonatal sepsis was 2,202 (95% CI: 1,099–4,360) per 100,000 live births, with mortality between 11% and 19% and more than 40% of under-five deaths occur in the neonatal period, resulting in 3.1 million new-born deaths each year globally. Material and Methods: The total number neonates admitted in the hospital in given study period was 447, of which 198 were diagnosed for neonatal sepsis by the physician based on the signs and symptoms during admission. The data was collected in three parts: sociodemographic characteristics; maternal information; and part neonatal information for neonatal sepsis. Data was collected in the excel sheet and questionnaires were reviewed and organized by investigators. Results: Of the 198 neonates, 162 (81.8%) infants were in the age range of 0 to 7 days while 36 (18.2%) were aged between 8 and 28 days. Statistically significant difference was observed between early onset and late onset sepsis patients. Out of 198 cases 107 (54%) were male while 91(46%) were female. In early onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 24(14.8%), 21(13.0%), 19(11.7%) and 32 (19.8%) cases respectively. In late onset sepsis cases maternal UTI, Meconium stained amniotic fluid, Multipara and Premature rupture of membrane was seen in 1(2.8%), 2 (5.6%), 4(11.1%) and 2 (5.6%) cases respectively. Maternal risk factors were identified in 104(64.2%) of early onset sepsis cases while maternal risk factors in late onset sepsis cases were 10(27.8%). Culture positivity was observed in 28 (17.3%) cases of early neonatal sepsis while it was 4 (11.1%) in late onset sepsis. Conclusion: There was male preponderance in early as well as late onset neonatal sepsis. Maternal risk identification may help in the early identification and timely empirical antibiotic therapy. The prediction and/ or diagnosis of neonatal sepsis should be bases on culture-independent diagnostics and risk factor-based scoring systems.

scholarly journals Risk Factors and Outcomes of Low Birth Weight Neonates Admitted In a Tertiary Care Center

2020 ◽  
Vol 18 (1) ◽  
pp. 70-73
Author(s):  
Jyoti Adhikari ◽  
Rajesh KC ◽  
Shristi Kharel
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Very Low Birth Weight ◽  
Extremely Low Birth Weight ◽  
Antenatal Visit ◽  
High Morbidity ◽  
Maternal Risk Factors ◽  
Maternal Risk

Introduction: Birth weight <2500 grams, <1500 grams and <1000 grams irrespective of gestational age is low birth weight, very low birth weight and extremely low birth weight respectively. Low birth weight is associated with high morbidity and mortality. Aims: To find out the possible maternal risk factors associated with low birth weight babies, morbidities and mortalities seen in them during their hospital stay. Methods: Hospital based cross sectional observational study was performed in 200 newborns <2500 grams in Nepalgunj Medical College, Kohalpur, Banke, Nepal. Results: Out of 200 neonates 8 (4%), 40 (20%) and 152 (76%) were extremely low birth weight, very low birth weight and low birth weight respectively with Male:Female ratio of 1.12:1. Most common maternal risk factors for low birth weight was Illiterate mothers (88%) followed by preterm delivery (68%). Inadequate antenatal visit was associated with low birth weight (P<0.05). Most common morbidity seen in low birth weight was neonatal sepsis (96%) followed by neonatal jaundice (87%). 44 (22.0%) neonates expired and 156 (78.0%) survived. Neonatal sepsis was most common (36.4%) cause of mortality followed by respiratory distress syndrome (22.7%). Conclusion: Certain measures could be taken to prevent low birth weight deliveries: discouraging delivery at teenage, adequate antenatal visits, avoiding smoking and alcohol during pregnancy. Well trained staffs and better facilities in neonatal intensive care unit could improve the survival and minimize the morbidities in low birth neonates.

Sign in / Sign up

Export Citation Format

Share Document