scholarly journals Pine Bark Extract Protects Against Oxidative Stress Induced By Recurrent Hypoglycemia In Rats.

2017 ◽  
Vol 12 (02) ◽  
pp. 78-83
Author(s):  
Mamdouh Rashad Farag El-Sawi
Keyword(s):  
Oxidative Stress ◽  
Pine Bark ◽  
Bark Extract ◽  
Recurrent Hypoglycemia

scholarly journals Encapsulated Pine Bark Polyphenolic Extract during Gastrointestinal Digestion: Bioaccessibility, Bioactivity and Oxidative Stress Prevention

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 328 ◽  
Author(s):  
Pedro Ferreira-Santos ◽  
Raquel Ibarz ◽  
Jean-Michel Fernandes ◽  
Ana Cristina Pinheiro ◽  
Cláudia Botelho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phenolic Compounds ◽  
Pine Bark ◽  
Bark Extract ◽  
Process Conditions ◽  
Fermented Foods ◽  
Gastrointestinal Digestion ◽  
Beneficial Effects ◽  
Polyphenolic Extract ◽  
Antioxidant And Antimicrobial Activity

Polyphenolic extracts from pine bark have reported different biological actions and promising beneficial effects on human health. However, its susceptibility to environmental stresses (temperature, storage, etc.) and physiological human conditions prequires the development of efficient protection mechanisms to allow effective delivering of functionality. The aim of this work was to encapsulate pine bark extract rich phenolic compounds by spray-drying using maltodextrin, and understand the influence of encapsulation on the antioxidant and antimicrobial activity and bioaccessibility of phenolic compounds during gastrointestinal digestion. The optimized process conditions allowed good encapsulation efficiency of antioxidant phenolic compounds. The microencapsulation was effective in protecting those compounds during gastrointestinal conditions, controlling their delivery and enhancing its health benefits, decreasing the production of reactive oxygen species implicated in the process of oxidative stress associated with some pathologies. Finally, this encapsulation system was able to protect these extracts against acidic matrices, making the system suitable for the nutritional enrichment of fermented foods or fruit-based beverages, providing them antimicrobial protection, because the encapsulated extract was effective against Listeria innocua. Overall, the designed system allowed protecting and appropriately delivering the active compounds, and may find potential application as a natural preservative and/or antioxidant in food formulations or as bioactive ingredient with controlled delivery in pharmaceuticals or nutraceuticals.

scholarly journals Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats

2014 ◽  
Vol 30 (4) ◽  
pp. 174 ◽  
Author(s):  
Je-Won Ko ◽  
In-Chul Lee ◽  
Sung-Hyuk Park ◽  
Changjong Moon ◽  
Seong-Soo Kang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pine Bark ◽  
Bark Extract ◽  
Protective Effects ◽  
And Oxidative Stress

scholarly journals The Effects of a Pine Bark Extract on Exercise Performance and Post Exercise Inflammation, Oxidative Stress, Muscle Soreness and Damage

2018 ◽  
Author(s):  
Randy Aldret ◽  
David Bellar
Keyword(s):  
Oxidative Stress ◽  
Blood Sample ◽  
Muscle Soreness ◽  
Pine Bark ◽  
Bark Extract ◽  
Double Blind ◽  
Post Exercise ◽  
Significant Difference ◽  
Treatment Analysis ◽  
And Oxidative Stress

The purpose of the present study was to examine if 14 days of supplementation with a pine bark extract leading up to and following an exercise test would increase performance and reduce biomarkers associated with muscle damage, inflammation and oxidative stress. The study used a double-blind, placebo controlled, cross-over design. Participants ingested either 800mg pine bark extract or placebo for 14 days prior to the first exercise trial and for 2 days post-exercise. On the exercise day, participants submitted a pre-exercise blood sample, then completed a VO2 peak test until volitional failure. A post-blood sample was collected 1 hour after completion of exercise. Participants returned at 24 & 48 hours after the exercise testing for measures of muscle pain in the lower body using an algometer. Participants then had a 7-day washout period before beginning to crossing over to the alternate treatment. Analysis via ordinal regression demonstrated a significant difference in oxidative stress in the pine bark extract group compared to placebo (ChiSq = 2.63; p = 0.05). The pine bark extract was effective at affording protection from oxidative stress post exercise. Further work should be undertaken to evaluate the findings with other exercise modes or in participants with known metabolic syndrome. 

PSXIII-26 Supplementation with a polyphenolic pine bark extract reduces ammonia nitrogen production in a RUSITEC system as determined by principal component analysis

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 435-436
Author(s):  
Nelson Vera ◽  
Constanza Gutierrez ◽  
Pamela Williams ◽  
Cecilia Fuentealba ◽  
Rodrigo Allende ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Repeated Measures ◽  
Pearson Correlation ◽  
Principal Component ◽  
Component Analysis ◽  
Ammonia Nitrogen ◽  
Pine Bark ◽  
Bark Extract ◽  
Ruminal Fermentation ◽  
Fermentation Parameters

Abstract The aim of the study was to correlate the effects of supplementation with a polyphenolic pine bark extract (PBE) in diets with different forage to concentrate (F:C) ratio on methane (CH4), ammonia nitrogen (NH3–N) production and ruminal fermentation parameters using the Rumen Simulation Technique (RUSITEC). The experimental diets were F:C 70:30 (HF) or F:C 30:70 (HC) with or without 2% PBE on a DM basis. The four diets were isoproteic (15% CP), with similar OM (HF 94% and HC 96%), but different NDF (HF 40% and HC 25%). The treatments, in duplicate, were assigned in an 8 fermenter RUSITEC apparatus. Incubations were run twice, with 5 days of sampling after 10 days adaptation. The experimental design was a 2x2 factorial arrangement in a randomized complete block with repeated measures. Pearson correlation and principal component analysis (PCA) were conducted to elucidate relationships among PBE total polyphenols (TP) and the variables evaluated. The TP was highly correlated with NH3–N (r = –0.98; P < 0.001) and butyrate (r = –0.85; P < 0.001), and had a high correlation with propionate (r = 0.75; P < 0.001) and acetate (r = 0.68; P = 0.001). Correlation with total VFA was moderate (r = –0.59; P = 0.006), and CH4 yield and IVDMD there were not correlated (r ≤ –0.07; P ≥ 0.188). The PCA (KMO = 0.655; BTS < 0.001) shows that 75.2% of the total variation is explained by the first two principal components (PC1 = 46.5% and PC2 = 28.7%). In the score plot, PC1 discriminated between diets with and without PBE, while the PC2 separated based on NDF. The loading plot showed that TP and propionate were clustered, and had inverse directions to NH3–N. In conclusion, the PBE supplementation reduces NH3–N production in a RUSITEC system without decreasing CH4 yield or negatively affecting ruminal fermentation parameters.

Effect of Morus alba root bark extract on gene-level expression of inflammatory markers in rats subjected to ethanol and cerulein induced pancreatitis– influence of heat shock protein 70

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Kavitha Yuvaraj ◽  
Arumugam Geetha
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Morus Alba ◽  
Bark Extract ◽  
Root Extract ◽  
Root Bark ◽  
Nf Kappa B ◽  
Serum Lipase ◽  
Hsp70 Mrna ◽  
Caspase 1

Abstract Background Chronic pancreatitis (CP) is a persistent inflammation of the pancreas clinically presented with severe abdominal pain, progressive fibrosis, and loss of exocrine and endocrine functions. Inflammasomes, cytosolic multiprotein complexes which regulate the formation of proinflammatory cytokines, are influenced by various factors including heat shock proteins (HSPs). Morus alba L., or white mulberry root bark is a valued traditional Asian medicine with a diverse array of phytochemicals. The aim of this investigation was to define the modulatory action of methanolic extract of Morus alba root bark (MEMARB) on NLRP3 inflammasome, and HSPs in pancreas subjected to inflammatory insult. Methods Pancreatitis was induced in male albino Wistar rats by ethanol (0–36%) and cerulein (20 µg/kg b.wt., i.p.) for 5 weeks with or without MEMARB administration. Serum lipase/amylase (L/A) ratio, oxidative stress index (OSI) and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in the pancreas were evaluated. Levels of serum HSP70 was quantified by ELISA. NF-kappa B, NLRP3-ASC, caspase-1, IL-1β, IL-18, and HSP70 gene expression was quantified by quantitative real-time polymerase chain reaction (qPCR). Results L/A ratio and oxidative stress determined in terms of OSI and GSH/GSSG ratio were elevated in pancreatitis-induced rats. The levels were restored in MEMARB co-administered animals. Serum level of HSP70 was increased in pancreatitis-induced animals and dropped significantly in MEMARB co-administrated rats. Pancreatitis-induced group showed increased expression of NF-kappa B, IL-1β, IL-18, caspase-1, NLRP3-ASC and HSP70 mRNA than in MEMARB treated group. Conclusions It can be concluded that the M. alba root extract modulates the expression of HSP70 and NLRP3-ASC which might be attributed to its pancreato-protective effect.

scholarly journals 515 Chronic administration of pine bark extract (flavangenol) attenuates heat shock protins mRNA expression in the chicken brain.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 505-505
Author(s):  
H Yang ◽  
V Chowdhury ◽  
M Bahry ◽  
P Tran ◽  
P Do ◽  
...  
Keyword(s):  
Heat Shock ◽  
Mrna Expression ◽  
Chronic Administration ◽  
Pine Bark ◽  
Bark Extract ◽  
Chicken Brain

scholarly journals Pycnogenol, French Maritime Pine Bark Extract, Augments Endothelium-Dependent Vasodilation in Humans

2007 ◽  
Vol 30 (9) ◽  
pp. 775-780 ◽  
Author(s):  
Kenji NISHIOKA ◽  
Takayuki HIDAKA ◽  
Shuji NAKAMURA ◽  
Takashi UMEMURA ◽  
Daisuke JITSUIKI ◽  
...  
Keyword(s):  
Maritime Pine ◽  
Pine Bark ◽  
Bark Extract

Rhizophora Mucronata Lam. (Mangrove) Bark Extract Prevents Ethanol-induced Liver Injury, Oxidative Stress and Apoptosis in Swiss Albino Mice

2021 ◽  
Author(s):  
Chitra Jairaman ◽  
Sabine Matou-Nasri ◽  
Zeyad I Alehaideb ◽  
Syed Ali Mohamed Yacoob ◽  
Anuradha Venkataraman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Histopathological Examination ◽  
Bark Extract ◽  
High Dose ◽  
Protective Effects ◽  
Rhizophora Mucronata ◽  
Ethanol Intoxication ◽  
Hepatoprotective Effects

Abstract The bark extract of Rhizophora mucronata (BERM) was recently reported for its prominent in vitro protective effects against liver cell line toxicity caused by various toxicants, including ethanol. Here, we aimed to verify the in vivo hepatoprotective effects of BERM against ethanol intoxication. An oral administration of different concentrations (100, 200, and 400 mg/kg) of BERM prior to high-dose ethanol via intraperitoneal injection was performed in mice. On the 7th day, liver and kidney sections were dissected out for histopathological examination. The ethanol intoxication caused large areas of liver necrosis while the kidneys were not affected. Pre-BERM administration decreased ethanol-induced liver injury, as compared to the mice treated with ethanol alone. In addition, the pre-BERM administration resulted in a decrement in the level of ethanol-induced oxidative stress, revealed by a concomitant increase of GSH and a decrease of MDA hepatic levels. The BERM extract also reversed the ethanol-induced liver injury and hepatotoxicity, characterized by the low detection of TNF-α gene expression level and fragmented DNA, respectively. Altogether, BERM extract exerts antioxidative activities and present promising hepatoprotective effects against ethanol intoxication. The identification of the related bioactive compounds will be of interest for future use at physiological concentrations in ethanol-intoxicated individuals.

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