Attention to nanoemulsions has significantly grown in recent years as a result of their unique features like better stability, special appearance, higher performance, and sensorial merits. Chronic injuries are the consequence of a disturbance in the extremely coordinated cataract of wound healing actions. Nevertheless, correlated with variations in the timescales of various physical methods embroiled in tissue renewal, the aggression of the tumor microenvironment, rich in decaying enzymes, as well as its increased pH, demands the use of efficient drug delivery applications. This chapter summarizes that the various stages of wound healing include four phases: hemostatic stage, inflammation, proliferation, and remodeling process, respectively. Moreover, the major reported classes of lipid-based elements were either vesicular (liposome, permeation increased vesicle, etc.), emulsion-based behavior (nano-emulsion and micro-emulsion), or comprise a solid-based liquid matrix in the wound-healing process.